Department of Pharmacology

Medical College Baroda

Preliminary Theory Examination of IInd MBBS (Aamanya Shah Batch)
Paper - I
Date: 18/11/2024 (Monday)
Time: 02:00 pm to 05:00 pm Maximum Marks: 100
Notes:
 All sections are to be attempted in separate answer sheets.
 Answer to the question should be brief and to the point.
 Draw diagrams and give suitable examples whenever necessary.

SECTION - 1
Q-1: Answer ANY TWO of the following: [2x8 marks = 16 marks]
A. Describe in brief: (1) Factors affecting bioavailability of the drug [4]
(2) Clinically significant implications of plasma protein binding [4]
B. Describe in brief about information obtained from ‘Log Dose Response Curve’ and ‘Quantal Log
Dose Response Curve’ with suitable examples. [8]
C. Describe briefly following factors modifying drug action with suitable examples:
(1) Age [4] (2) Pathological states. [4]
Q-2: Answer ANY TWO of the following: [2x8 marks = 16 marks]
A. A 55 year old man presented with complaints of tightness and discomfort over middle part of chest
which is felt after walking or climbing stairs. This is relieved within 5-10 mins of rest. One or two
episodes occur practically every day. He is a known case of chronic obstructive pulmonary disease
for which he regularly takes 2 inhalations of ipratropium bromide 3 times a day and 2 puff of
salbutamol inhalation for asthma episodes. The pulse is 90/min and BP is 124/82 mm Hg. The resting
ECG is normal but stress test is positive. He is diagnosed a case of Exertional Angina.
1. Enumerate anti-anginal dugs. [3]
2. Which drug is most preferred for acute episode of angina and why? [2]
3. Dose the patient require other drugs on regular basis to prevent episodes of angina? If yes,
which drugs can be given and which drugs should be avoided to him? [3]
B. Mr. Ramesh, a 50-year-old businessman is complaining of mild headache, weakness and
breathlessness. He is a known case of type 2 diabetes mellitus. On examination, his Blood Pressure
is 158/96 mm Hg and Heart Rate is 70/min. He is diagnosed to suffer from Hypertension.
1. Which antihypertensive drug should be prescribed to this patient and why? [2]
2. Write the pharmacological basis, adverse effects and drug interaction of above selected drug.
[2+2+1]
3. Which antihypertensive drugs are contraindicated for this patient? [1]
C. Enumerate the drugs used in Congestive Heart Failure based on goal of drug therapy [4]. Describe
in brief role of Digoxin and β blocker in Congestive Heart Failure. [2+2]

SECTION-2

Q-3: Answer ANY THREE of the following: [3x6 marks = 18 marks]

A. Enlist therapeutic classification of adrenergic drugs [3]. Describe in brief adrenergic response
mediated through β receptors. [3]
B. Compare and Contrast Non-selective β blockers vs Cardio selective β blockers.
C. Classify Mydriatics-Cycloplegic and Vasicoselective drugs [2]. Describe in brief pharmacological
actions of atropine. [4]
D. Describe in brief: (1) Therapeutic uses of anti-cholinesterase agents [3]
(2) Pharmacotherapy of Organophosphate Poisoning [3]

[P.T.O.]
Q-4: Answer ANY FIVE of the following: [5x3 marks = 15 marks]
A. A 20 year-old patient weighing 60 kg is to be prescribed an antiepileptic drug (available as 200 and
400 mg tablets) for generalized tonic-clonic seizures. The pharmacokinetic parameters and
therapeutic plasma concentration of the selected drug are: Target steady-state plasma
concentration (Cpss) - 6 mg/L, Oral Bioavailability (F) - 70%, Volume of distribution (Vd) - 1.4 L/kg.
Clearance (CL) - 80 ml/hr/kg & Plasma half-life (t1/2) - 15 hours.
Define the loading dose and maintenance dose. What should be loading dose and maintenance
dose for this patient?
B. Explain with diagram First Order Elimination Kinetics.
C. Write a short note on Teratogenicity.
D. Write a note on Lidocaine as antiarrhythmic drug.
E. Enlist classification of Anti-arrhythmic drugs.
F. Describe in brief pharmacological basis for use of: (1) Hydrochlorothiazide in Hypertension [1.5]
(2) Acetazolamide in Mountain Sickness. [1.5]

SECTION-3
Q-5: Answer ANY FIVE of the following: [5x4 marks = 20 marks]
A. Describe in brief: (1) Pharmacological basis of use of corticosteroid in bronchial asthma [2].
(2) Advantages of 2nd generation over 1st generation antihistaminics. [2]
B. Give Reasons: (1) Dextromethorphan is preferred over codeine in dry cough [2]
(2) Ipratropium bromide preferred over salbutamol in chronic obstructive pulmonary
disease (COPD). [2]
C. Describe in brief pharmacological actions of Aspirin. [4]
D. (1) Enlist non-biological drugs (DMARDs) used in rheumatoid arthritis [2]. (2) Why allopurinol should
not be started during acute attack of gout? [2]
E. (1) Describe in brief the mechanism of action of Sumatriptan [2]. (2) Why bupivacaine become very
popular in obstetric pain relief by continuous epidural infusion? [2]
F. A male patient is suffering from Hypertension and has prescribed anti-hypertensive drugs. Describe
in brief about methods to improve adherence to therapy. [4] (AETCOM -Compulsory)

SECTION-4
Q-6: Answer ALL FIVE of the following: [5x2 marks = 10 marks]
A. Write in brief mechanism of action [1] and pattern of lipid lowering effects of statins [1].
B. Describe in brief pharmacological basis of use of Alteplase in ST elevation myocardial infarction
(STEMI).
C. Enlist antiplatelet drugs.
D. Why folic acid should never be given alone to patient with vitamin B12 deficiency?
E. Write advantages of Direct factor Xa / Thrombin inhibitors over Warfarin.

Q-7: Answer ALL FIVE of the following: [5x1 mark = 05 marks]

A. Which antihypertensive should be preferred for hypertensive emergency attending myocardial
infarction? Give reason. [0.5+0.5]
B. Justify the role of Tamsulosin in Benign Hypertrophy of Prostate. [1]
C. Which muscle relaxant should be preferred for tracheal intubation? Give reason. [0.5+0.5]
D. Write specific antidote of acute paracetamol poisoning and warfarin toxicity each. [0.5+0.5]
E. Enlist one example of clinically important pharmacokinetic drug interaction. [1]

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