Human Reproduction - Detailed Notes
1. Oogenesis (Formation of Female Gamete)
Oogenesis is the process through which a mature female gamete (egg or ovum) is formed. Starts before birth: some
cells in the ovary called oogonia multiply by mitosis and become primary oocytes. Each primary oocyte is surrounded by
follicle cells to form a primary follicle. It then develops into secondary, tertiary, and eventually a mature Graafian follicle.
The primary oocyte completes meiosis I to form a secondary oocyte and a first polar body. Ovulation releases the
secondary oocyte. If fertilised, it completes meiosis II to form the ovum and a second polar body.
2. Menstrual Cycle (Monthly Reproductive Cycle)
Occurs in primates starting at puberty (menarche) and ends at menopause. Cycle length is around 28 days. Phases:
- Menstrual Phase (1-5 days): Shedding of uterine lining.
- Follicular Phase: Follicle development and estrogen production.
- Ovulation (~Day 14): LH surge causes ovum release.
- Luteal Phase: Corpus luteum secretes progesterone. If no fertilisation, it degenerates, restarting cycle.
3. Fertilisation & Implantation
Sperm meets ovum in fallopian tube. Acrosome enzymes help entry. Meiosis II completes -> zygote formed. Zygote
divides to form morula, then blastocyst. Blastocyst implants into uterine lining. Trophoblast becomes placenta; inner cell
mass forms embryo.
4. Pregnancy
Trophoblast forms chorionic villi which, along with uterine tissue, forms placenta. Placenta exchanges nutrients and
waste, produces hormones (hCG, hPL, estrogen, progesterone). Embryo is connected to placenta by umbilical cord.
5. Embryonic Development
Inner cell mass differentiates into three germ layers:
- Ectoderm -> skin, brain
- Mesoderm -> muscles, bones
Human Reproduction - Detailed Notes
- Endoderm -> digestive and respiratory systems
By week 12: major organs form. Month 5: limbs, hair. Week 24: eyelids form. Month 9: full development.
6. Parturition (Childbirth)
Gestation period ~9 months. Fetal ejection reflex triggers oxytocin release. Oxytocin causes uterine contractions -> baby
is expelled.
7. Lactation
Mammary glands produce milk after birth. First milk is colostrum, rich in antibodies and nutrients, boosting newborn
immunity.