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Hypersensitivity Type 3

The document discusses Type III immune complex hypersensitivity, which involves the deposition of antigen-antibody complexes in tissues, leading to inflammation and activation of the complement system. It highlights conditions such as serum sickness, rheumatoid arthritis, and hypersensitivity pneumonitis as examples of this hypersensitivity type. The immune response can result in localized or systemic inflammation due to the accumulation of immune complexes.

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haram rehman
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22 views1 page

Hypersensitivity Type 3

The document discusses Type III immune complex hypersensitivity, which involves the deposition of antigen-antibody complexes in tissues, leading to inflammation and activation of the complement system. It highlights conditions such as serum sickness, rheumatoid arthritis, and hypersensitivity pneumonitis as examples of this hypersensitivity type. The immune response can result in localized or systemic inflammation due to the accumulation of immune complexes.

Uploaded by

haram rehman
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

TYPE III immune complex hypersensitivity ,

I a
days o
immune complex
antigen-antibody complex deposits in tissue , activate compliment response .
↓,
lYMPH NODE normally cleared by
macrophages
l ↓

press a
when not
Do
⑧
antigen
Callergen ( APC In cell Bell
9
Igy/plasma
cells
↓
deposit in fissue .

12-4
ANTIGENS

:
(Class switch)
-

foreign serum IgD -


Ig
-
antivenom

(
monoclonal antibodies

%
-

inhaled particles
group strep
A ~
-parts of bacteria ;
.

self en non
self d
↓
Deposit /
ARTHUS REACTION :
ind lammation
caused
by deposition of Immune complexes
at localized site

Hypersensitivity pneumonitis ;

↓
vaccine skin run.
post
antibody a
reaci

w ② deposition
complexes.

compliment activation
of

proinflammatory
opsonization
a
(local
antibodies for treatment
SERUM SICKNESS foreign serum from animal/monoclonal
result in adaptive immone
activation Cy
system
production of antibodies against serum .

①compliment
② immune complex
--
. rheumatoid arthiritis
*T
↓ fibrinoid
- necrosis
·
SLE
T
i ↑
·
post strep glomerulonephritis
- T
Deposit elsewhere ①Systemic Inflammatoryit
in
Y
vessels or

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