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GPAT 2025 Revision Notes

The GPAT 2025 Last Minute Revision Notes cover key topics in Pharmaceutics, Pharmaceutical Chemistry, Pharmacology, Pharmacognosy, and Clinical Trials. Important formulas, drug classifications, and tests are summarized, along with drug sources and clinical trial phases. Additionally, it includes essential mnemonics and ICH guidelines relevant to pharmaceutical studies.

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Priyakshi
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1K views3 pages

GPAT 2025 Revision Notes

The GPAT 2025 Last Minute Revision Notes cover key topics in Pharmaceutics, Pharmaceutical Chemistry, Pharmacology, Pharmacognosy, and Clinical Trials. Important formulas, drug classifications, and tests are summarized, along with drug sources and clinical trial phases. Additionally, it includes essential mnemonics and ICH guidelines relevant to pharmaceutical studies.

Uploaded by

Priyakshi
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd
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GPAT 2025 - Last Minute Revision Notes

1. PHARMACEUTICS

Important Formulas:

- First-order kinetics: Log C = Log C0 - kt/2.303

- Zero-order kinetics: C = C0 - kt

- Half-life (t½): First-order: 0.693/k | Zero-order: C0 / 2k

Key Topics:

- HLB scale: <10 = lipophilic, >10 = hydrophilic

- BCS classification (I - high/high, IV - low/low)

- Emulsions: Oil-in-water vs Water-in-oil

- Sterilization: Moist heat (121°C for 15 mins), Dry heat (160°C for 2 hrs)

- Isotonicity: E-value method, Liso method

2. PHARMACEUTICAL CHEMISTRY

SAR Highlights:

- Sulfonamides: -SO2NH2 essential for activity

- Quinolones: Fluoro group at position 6 enhances potency

- Beta-lactams: 4-membered lactam ring crucial

Tests:

- Aldehydes: Schiff's test

- Phenols: Ferric chloride test (violet color)

- Carboxylic acids: Sodium bicarbonate test (effervescence)


GPAT 2025 - Last Minute Revision Notes

Important Structures:

- Paracetamol, Aspirin, Sulfanilamide, Diazepam, Ciprofloxacin

3. PHARMACOLOGY

Receptors:

- Muscarinic: M1 (CNS), M2 (heart), M3 (glands)

- Adrenergic: Alpha1 (vasoconstriction), Beta2 (bronchodilation)

Important Drugs:

- ACE inhibitors: Captopril - dry cough ADR

- NSAIDs: Inhibit COX enzymes - gastric irritation

- Insulin types: Rapid (Lispro), Short (Regular), Long (Glargine)

Toxicology Mnemonics:

- SLUDGE: Salivation, Lacrimation, Urination, Defecation, GI upset, Emesis

- ABCD: Agitation, Blurred vision, Constipation, Dry mouth

4. PHARMACOGNOSY

Drug Sources:

- Atropa belladonna - Leaves - Tropane alkaloid

- Cinchona - Bark - Quinine (alkaloid)

- Digitalis - Leaves - Cardiac glycoside


GPAT 2025 - Last Minute Revision Notes

Tests:

- Alkaloids: Dragendorff's - orange ppt

- Glycosides: Keller-Killiani test - blue ring

- Tannins: Ferric chloride - blue/green ppt

Terms:

- Adulteration: Substitution, spoilage, deliberate

- Classification: Leaves (Senna), Roots (Ipecac)

5. NIPER & MISCELLANEOUS

Clinical Trials Phases:

- I: Safety (20-80), II: Efficacy (100-300)

- III: Large-scale (1000-3000), IV: Post-marketing

Biotech Keywords:

- rDNA: Insulin, Monoclonal antibodies: -mab (e.g., Trastuzumab)

ICH Guidelines:

- Q8: Pharmaceutical development

- Q9: Quality risk management

- Q10: Pharmaceutical quality system

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