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Autoimmune Skin Disorders

The document discusses various autoimmune skin disorders including scleroderma, psoriasis, dermatomyositis, epidermolysis bullosa, bullous pemphigoid, and vitiligo. It highlights the nature of these conditions, their effects on the skin and other systems, and mentions treatment options such as corticosteroids and immunomodulatory therapies. Vitiligo is noted as a chronic depigmentation disease affecting melanocytes, with a prevalence of 0.5% in the population.

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Adedamola Adegboye
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58 views64 pages

Autoimmune Skin Disorders

The document discusses various autoimmune skin disorders including scleroderma, psoriasis, dermatomyositis, epidermolysis bullosa, bullous pemphigoid, and vitiligo. It highlights the nature of these conditions, their effects on the skin and other systems, and mentions treatment options such as corticosteroids and immunomodulatory therapies. Vitiligo is noted as a chronic depigmentation disease affecting melanocytes, with a prevalence of 0.5% in the population.

Uploaded by

Adedamola Adegboye
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Autoimmune

Skin Disorders
• scleroderma, psoriasis, dermatomyositis,
epidermolysis bullosa, and bullous
pemphigoid. Vitiligo
• Scleroderma. The skin is just one area that is
affected by scleroderma, which is actually a
widespread condition that affects the
connective tissue
• Dermatomyositis. is primarily muscular in
nature, but because dermatomyositis also
affects the skin, it is sometimes categorized
with skin-related autoimmune conditions.
Dermatomyositis goes hand-in-hand with
polymyositis.
• Epidermolysis bullosa.There are many forms
of epidermolysis bullosa, but only one,
epidermolysis bullosa acquisita, is considered
autoimmune in nature.
• All forms of epidermolysis bullosa cause fluid-
filled skin blisters to develop in response to
injuries.
• Bullous pemphigoid. This chronic
autoimmune disorder involves skin blisters
that range in severity.
Vitiligo
Vitiligo is a chronic depigmentation disease that affects the
melanocytes, and the destruction of the melanocytes is the central
pathological event that causes the depigmentation.
can be a component of multiple autoimmune processes such as
thyroid disease, pernicious anemia, rheumatoid arthritis, lupus, adult
onset autoimmune diabetes, and Addison’s disease
Vitiligo is present in 0.5% of the population is distributed equally in
males and females, and the disease starts during the second decade of
life.
Autoimmune depigmentation is expressed clinically as generalized
vitiligo (GV), which is a result of diverse mechanisms involving multiple
genes and environmental factors that are not well determined.
A major gene involved in vitiligo is TYR (encodes tyrosinase), which is
involved in melanin biosynthesis and is the major GV autoantigen.
Mx
1. Corticosteroids
2. calcineurin inhibitors
3. narrow-band UVB or UBA radiation combined
with the administration of oral
photosensitizing molecules such as psoralen.
4. Immunomodulatory therapies being tried
Mx
• Steroids
• Supportive care

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