BIOINFORMATICS
2024-2
Course outline
•Instructor: Dam Thuy Hang, C4-201,
[email protected]•Meet every other week on Wednesdays, 4 – 5:30 pm
•Labs: weeks 33-34, 36-38, 7:30 –
11:45 am students bring their
own laptops
•Objectives:
• Students will learn how to efficiently use bioinformatic tools that are freely
available to analyze genes, protein sequences, and genomics data (optional)
• Programming skills are not required for this course
Course outline
• Students will learn how to:
• Retrieve information on genes and proteins from biological databases
• Compare gene and protein sequences
• Predict genes from sequences
• Analyze protein sequences
• Design primers
• Construct and interpret phylogenetic trees
• Textbooks:
• Essential bioinformatics (2006) Jin Xiong, Cambridge University Press
• Bioinformatics and Functional Genomics (2015) Jonathan Pevsner, Wiley Blackwell
• Tin sinh học (2005) Nguyễn Văn Cách, NXB Khoa học và Kỹ thuật Hà Nội
3
Course outline - Lectures
Week Lectures Labs
25 Basics of bioinformatics, biological
databases
27 Sequence alignments
29 Gene prediction
31 Primer design
33 Structural bioinformatics Biological databases
34 Sequence alignments
35 No class - Liberation Day
36 Primer design
37 Phylogeny Gene prediction, genome annotation
38 Structural bioinformatics, Phylogeny
39 Review
41 Review
4
Course outline - Labs
• Lab 1 (Week 33): Biological databases, retrieving sequences of
proteins and nucleotides from NCBI and other relevant databases
• Lab 2 (Week 34): Pairwise and multiple sequence alignment
• Lab 3 (Week 36): Primer design
• Lab 4 (Week 37): gene and protein prediction, genome annotation
• Lab 5 (Week 38): protein structure analysis, phylogeny