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MPL203T

This document outlines the examination details for the M. Pharmacy Semester-II course on Principles of Drug Discovery at Gujarat Technological University. It includes instructions for the exam, the subject code, date, time, total marks, and a list of questions covering various topics related to drug discovery, including protein structure characterization, drug design techniques, and QSAR methods. Students are required to attempt any five questions and make suitable assumptions where necessary.

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51 views1 page

MPL203T

This document outlines the examination details for the M. Pharmacy Semester-II course on Principles of Drug Discovery at Gujarat Technological University. It includes instructions for the exam, the subject code, date, time, total marks, and a list of questions covering various topics related to drug discovery, including protein structure characterization, drug design techniques, and QSAR methods. Students are required to attempt any five questions and make suitable assumptions where necessary.

Uploaded by

vyasmitali26
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Seat No.: _____ Enrolment No.

_____________

GUJARAT TECHNOLOGICAL UNIVERSITY


M. PHARMACY SEMESTER–II • EXAMINATION – WINTER -2024

Subject Code: MPL203T Date:09/12/2024


Subject Name: Principles of Drug Discovery
Time: 02:30PM TO 05:30PM Total Marks: 80
Instructions:

1. Attempt any five questions.


2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.

Q.1 (a) Discuss applications of NMR and X-ray crystallography in protein structure 06
characterization with suitable examples.
(b) Explain the role of Nucleic acid microarrays technique in drug discovery 05
process?
(c) What is the role of transgenic animals in target validation? 05
Q.2 (a) Describe the levels, domains, motifs & folds of protein structure with diagram. 06
(b) Discuss in details various stages of drug discovery process. 05
(c) Describe threading and homology modeling methods in predicting protein 05
structure.
Q.3 (a) Write a note on HTS technique and its role in rational drug design. 06
(b) Explain concept of pharmacophore mapping and pharmacophore based drug 05
screening.
(c) What is rational drug design? Discuss different rational drug design methods. 05
Q.4 (a) What is molecular docking? Explain different types of docking. Write 06
applications of molecular docking.
(b) What is QSAR? Differentiate QSAR and SAR. 05
(c) Discuss different physicochemical parameters affecting SAR. 05
Q.5 (a) Discuss regression analysis and PLS used in QSAR. 06
(b) Write note on CoMFA and COMSIA techniques. 05
(c) Write approaches of combinatorial chemistry in drug discovery. 05
Q. 6 (a) Discuss the relation between Hansch analysis and Free Wilson analysis. 06
(b) What is denovo drug design? Discuss different types of denovo drug design 05
methods.
(c) What is the advantage and disadvantage of 3DQSAR over QSAR. 05
Q.7 (a) Write short note on I) Zinc finger proteins II) siRNAs 06
(b) Explain the rationale and development of prodrug design with examples. 05
(c) Write short note on In-silico lead discovery techniques. 05

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