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Insulin Pathway

The document outlines the insulin signaling pathway, detailing the interactions between various proteins and receptors involved in glucose uptake and metabolism. Key components include the insulin receptor, GLUT-4 translocation, and downstream signaling molecules such as PI3K, Akt, and mTOR, which regulate processes like glycogen synthesis and apoptosis. The pathway illustrates the complex network of signaling events triggered by insulin to maintain cellular functions and energy homeostasis.

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sebastiaan dalle
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53 views1 page

Insulin Pathway

The document outlines the insulin signaling pathway, detailing the interactions between various proteins and receptors involved in glucose uptake and metabolism. Key components include the insulin receptor, GLUT-4 translocation, and downstream signaling molecules such as PI3K, Akt, and mTOR, which regulate processes like glycogen synthesis and apoptosis. The pathway illustrates the complex network of signaling events triggered by insulin to maintain cellular functions and energy homeostasis.

Uploaded by

sebastiaan dalle
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

Insulin pathway

SNARE
Glucose
complex Insulin

Cell
Insulin receptor
Lipid rafts membrane

Flotillin SOCS3
SHIP PI3K GAB1
CAP
Cav PIP3 Shc
p85 JAK
Cbl PTEN
GLUT-4 translocation Synip CrKII
C3G APS
NIK
TC10 PDK1/2 IRS-1
SOS
GRB2
ASIP Crk
GLUT-4 CIP4/2
Vesicle P SHP2 IRS-1
PKCɑ PP2A Akt Fyn RAS
P Akt

Apoptosis Bad

P
p70 JNK
P P
Glycogen Glycogen synthase GSK3 Tsc2 PDE3B
synthesis
PKC GRB10 c-Raf
Tsc1
-P Raptor Stress
PP1
eIF4B 4E-BP1 cAMP SGK ENaC P

Sodium MEK1/2
Fatty acid ATP citrate lyase
P
synthesis p70 S6K mTOR ATP transport
Amino
acids PKA Lipolysis P
Protein ERK
synthesis eIF2B rane
emb
lear m
c
Nu
Apoptosis Akt SGK Growth

P P P
FKHR AFX FKHR1 ERK

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