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[LG 814] APRIL 2015 Sub. Code: 3814

DOCTOR OF PHARMACY (PHARM. D) DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code: 383814
Time: Three Hours Maximum: 70 marks
Answer All questions
I. Elaborate on: (4 x 10 = 40)

1. With a neat labeled diagram, discuss the principle and various components of
IR spectroscopy.

2. Write the principle and various carrier gases used in GLC.

Explain working principle of any two detectors used in GLC with a neat labeled
diagram.

3. Explain the principle and instrumentation of spectrofluorimeter with a neat diagram.

4. Write the theoretical aspects, indicator and reference electrodes used, methods of
detecting end point in potentiometry.
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II. Write notes on: (6 x 5 = 30)

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1. State and explain fundamental laws of absorption.

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Write its deviations and reasons for the deviations.

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2. What are amperometric titrations?

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Add a note on advantages and applications of amperometric titrations.

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3. Write a note on DTA.

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4. What is validation? Give a brief account of validation of analytical methods.

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5. Describe the principle and various types of ion exchange resins used in ion exchange
chromatography.

6. Explain the principle involved in mass spectroscopy.

List the various types of ions produced in mass spectrum.

*******

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[LH 814] OCTOBER 2015 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS
Q.P. Code : 383814
Time: Three Hours Maximum: 70 marks
Answer ALL questions
I. Elaborate on : (4 x 10 = 40)

1. With a neat labeled diagram, explain the working principle and instrumentation
of HPLC.

2. Explain the principle and instrumentation of AAS.

3. Write in detail the theoretical aspects and applications of NMR.

4. What is thermal analysis? Explain the principle and instrumentation of DSC.

II. Write notes on : (6 x 5 = 30)

1. Explain in detail the various factors affecting fluorescence.

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2. Write a note on monochromator and detectors used in UV spectrophotometer.

r.c

3. Describe the principle and applications of X-ray diffraction.

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4. What are the basic components of HPTLC? Write the advantages and applications
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of HPTLC.
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5. Write a note on optical rotator dispersion and circular dichroism.

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6. Explain the various sample handling techniques adopted in IR spectroscopy.

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*******

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[LI 814] APRIL 2016 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS

Q.P. Code: 383814

Time : Three hours Maximum : 70 Marks

I. Elaborate on: (4 x 10 = 40)

1. Describe the theory and instrumentation of Flame Photometry.

2. Explain the electronic transitions in UV Spectroscopy.

3. Write the principle in Ion exchange Chromatography and the types of Ion
exchange Resin.

4. Explain the theory and factors affecting Fluorescent intensity.

II. Write notes on : (6 x 5 = 30)

om

1. Write a note on sample handling techniques in IR.

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ke

2. With neat labeled diagram, explain any two GC detectors.

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3. Write short notes on Chromophores and Auxochromes.

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4. Explain the theory of Gel Filtration Chromatography.

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5. Write briefly about ICH guidelines.

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6. What is Electrode Potential? Write about reference and indicator Electrode.

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********

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[LJ 814] OCTOBER 2016 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS

Q.P. Code : 383814

Time : Three hours Maximum : 70 Marks

I. Elaborate on: (4 x 10 = 40)

1. Describe the theory and instrumentation of Mass Spectroscopy.

2. What are the sources and types of molecular vibration in IR?

3. What is Chemical Shift and write the factors affecting Chemical Shift.

4. a) Write the preparation of TLC plate, and development techniques in TLC.

b) Write a note on HPTLC.

II. Write notes on: (6 x 5 = 30)

om
r.c

1. Explain the theory of Gel Electrophoresis.

ke

2. Define Beers and Lamberts law and derive the equation.

an

3. Derive Bragg’s law and write its significance.

tR

4. What are the different types of currents in Polarography?

irs

5. Write brief about ISO 9000.

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6. Write about the detection techniques in paper Chromatography.

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********

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[LK 814] MAY 2017 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS

Q.P. Code : 383814

Time : Three hours Maximum : 70 Marks

I. Elaborate on: (4 x 10 = 40)

1. Explain the principle and instrumentation of Infrared Spectrophotometer with a

neat diagram.

2. Describe the principle and various components of AAS with a neat diagram.

3. Explain the principle and instrumentation of Spectrofluorimeter with a neat

diagram.

4. What is Electrode Potential? Describe the construction and working of hydrogen

electrode and glass electrode.
om

II. Write notes on: (6 x 5 = 30)

r.c
ke

1. Write short notes on the various factors affecting the Fluorescence intensity.
an

2. Explain the principle and applications of Ion exchange Chromatography.

tR

3. Write a note on the theoretical aspects of NMR and ESR.

irs
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4. Explain the following terms:

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a) Chromophore b) Blue shift c) Rf value

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5. Explain the various development techniques and applications of paper

Chromatography.
6. Write brief note on Conductometric titrations.

*********

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[LM 814] MAY 2018 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS

Q.P. Code: 383814

Time : Three hours Maximum : 70 Marks

I. Elaborate on: (4 x 10 = 40)

1. Describe the theory and instrumentation of Flame Photometry.

2. What is thermal analysis? Explain the principle and instrumentation of DSC.

3. Write principle, stationary phase, mobile phase, development techniques and

applications of paper chromatography.

4. Explain the different electronic transitions involved in UV spectrophotometry

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with examples.
r.c

II. Write notes on: (6 x 5 = 30)

ke
an

1. Write a note on DME and Ilkovic equation.

tR

2. Explain the various sources and detectors used in IR spectroscopy.

irs

3. Classify ion exchange resins basing on their structure.

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4. Write a note on optical rotator dispersion and circular dichroism.

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5. Explain the theory of Gel Filtration Chromatography.

6. What is validation? Give a brief account of validation of analytical method
development.

*********

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[LO 814] MAY 2019 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS

Q.P. Code: 383814

Time : Three hours Maximum : 70 Marks

I. Elaborate on: (4 x 10 = 40)

1. With a neat schematic diagram, explain the types of Pumps, Solvent Degassing
system and detectors of HPLC.

2. What is electrophoresis? Explain the various methods of paper electrophoresis.

3. Explain the principle of liquid-liquid partition chromatography and write about the
detection techniques in TLC.
om

4. State Beer’s and Lambert’s law. Explain the effect of solvent on absorption
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spectra. Define Auxochrome and hypsochromic shift.

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II. Write notes on: (6 x 5 = 30)

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tR

1. What are the differences between atomic absorption and flame emission
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spectroscopy?
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2. Write the theory of NMR Spectroscopy.

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3. What is group frequency and finger print region in IR Spectroscopy?

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4. What is quenching? Write about the different types of quenching?

5. Distinguish between polarography and amperometry.
6. Explain the principle and instrumentation of polarimeter.

*******

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[LP 814] OCTOBER 2019 Sub. Code: 3814

PHARM. D DEGREE EXAMINATION

(2009-2010 Regulation)
THIRD YEAR
PAPER II – PHARMACEUTICAL ANALYSIS

Q.P. Code: 383814

Time : Three hours Maximum : 70 Marks

I. Elaborate on: (4 x 10 = 40)

1. Explain the construction and working principle of Spectro fluorimeter.

2. Give an account of theory and applications of X-ray diffraction technique.

3. Explain in detail about ion exchange chromatography.

4. What is thermal analysis? Explain the principle and instrumentation of DSC.

om

II. Write notes on: (6 x 5 = 30)

r.c

1. Write briefly on chemical shift in NMR.

ke
an

2. What are all the validation parameters performed during method development?
tR

3. Write the interference produced in flame photometer. How will you overcome this
irs

problem?
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4. What are the factors affecting electrical conductivity in solution?

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5. Describe the various types of vibration in IR.

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6. Write the reason for deviation of Beer’s law.

*******

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