Rajiv Gandhi University of Health Sciences, Kamatak.

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MBBS Phase - II (CBME) Degree Examination - 09-Mar-2022

Time: Three Hours Max. Marks: 100 Marks

MICROBIOLOGY - PAPER II (RS-4)

Q.P. CODE: 1031
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary

LONG ESSAYS 2 x 10 = 20 Marks

1. A 32 year old female was admitted with dysuria (burning micturation) and increased
frequency of micturation from past 2 days. Culture of the urine specimen revealed lactose
fermenting clonies on Mac Conkey agar.
a. What is your clinical diagnosis and probable etiological agents?
b. What are the risk factors associated, pathogenesis and clinical manifestation of this
disease?
c. How will you treat this clinical condition?

2. 29 year old female came to casusalty with complaints of high-grade fever, severe joint pain,
back pain and myalgia. Gradually she developed petechial rashes over the body. On
examination, she was found to have jaundice, hepatomegaly and low platelet count
(30,000/cmm). A tourniquet test done over cubital fossa shows petechial spots.
a. What is the clinical diagnosis and how is this disease transmitted?
b. What is the pathogenesis of this condition?
c. How will you confirm the diagnosis?
d. What are the complications of this infection?

SHORT ESSAYS 8 x 5 = 40 Marks

3. Laboratory diagnosis of faucial diphtheria

4. Laboratory diagnosis and prophylaxis of Japanese B Encephalitis.

5. Laboratory diagnosis of syphilis.
6. Clinical manifestation and laboratory diagnosis of Polio.
7. Mucormyosis.
8. Life cycle and laboratory diagnosis of Toxoplasmosis.
9. Laboratory diagnosis of pulmonary Tuberculosis.
10. Laboratory diagnosis and prophylaxis of Covid 19
SHORT ANSWERS 10 x 3 = 30 Marks
11. Significant bacteriuria.
12. Mention three measures to prevent health care associated infection
13. Laboratory diagnosis of Rabies.
14. Describe microscopic features of Aspergillus spp and draw a neat labelled diagram.
15. Laboratory diagnosis of Gonococcal Urethritis.
16. Neurocysticercosis.
17. Counselling of a health care worker who has sustained a needle stick injury
18. Vincent's angina.
19. Describe DPT vaccine and dosage schedules.
20. Name three agents causing bioterrorism
 Raj iv Gandhi University of Health Sciences, Kamataka
MBBS Phase - II ( CBME) D egree Examina ti on - 16-Ma y-2022

Time : Three Hours Max. Mar ks: 100 Mar ks

MICROBIOLOGY - PAPER II (RS-4)

Q.P. CODE: 1031
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary

LONG ESSAYS 2 x 10 = 20 Ma rks

1. A 28 yr old male presents to the STD clinic with painless genital ulcer with induration and
non tender hard inguinal lymph nodes. He gives history of sexual exposure with a sex worker
a) What is the probable clinical diagnosis?
b) Mention the causes for ulcerative genital infections
c) Discuss t he laboratory diagnosis in the above case scenario
d) Discuss how to prevent STI

2. A 40 yr old factory worker suffering from fever, cough and loss of sense of smell, since three
days. His oxygen sat uration was 91%. CT lungs revealed moderate pneumonia. A
clinical diagnosis of Covid-19 was made
a) Discuss the pathogenesis and laboratory diagnosis of the above
b) Discuss the measures to be taken to prevent spread of infection
c) Mention other two viruses that cause respiratory tract infection

SHORT ESSAYS 8 x 5 = 40 Marks

3. Discuss the pathogenesis and laboratory diagnosis of neonatal meningitis

4. MRI scan of brain in a patient with seizures showed cystic lesions. Cysts on surgical removal
were oval and had bladder like sac. Name two parasites t hat cause cyst ic lesions in brain.
Describe the lifecycle of the parasite causing Neurocysticercosis
S. Discuss the advantages and disadvantages of Injectable and oral polio vaccine
6. Write a note on Pulmonary aspergillosis
7. Name four viral zoonoses. Add a note on Kyasanur forest disease
8. Pathogenesis and laboratory diagnosis of pneumonia due to Haemophllus influenza

9. St andard precautions in health care delivery

10. Causative agents and laboratory diagnosis of Non-Gonococcal urethritis
SHORT ANSWERS 10 x 3 = 30 Marks
11. Mention three Arboviral infections
12. Draw neat labelled picture of CSF Gram's stain in pneumococcal meningitis
13. Name two Prion diseases in humans. Mention a method for dest ruction of Prions

14. Enumerate the three causat ive agents of white discharge per vagina
15. Mention Three modes of t ransmission of Brucellosis
16. Vaccines against influenza viruses
17. Name three zoonot ic parasitic diseases
18. Importance of counselling of health care worker for Needle Stick Injury
19. Pathogenesis of rabies encephalitis

20 . Mention three important predisposing factors for disseminated fungal infections

 QP CODE : 1031
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase - II (CBME) Degree Examination - 15-Feb-2023

Time: Three Hours Max. Marks: 100 Marks

MICROBIOLOGY - PAPER II (RS-4)
Q.P. CODE: 1031
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat. labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
1. A two year old boy was brought to the hospital with history of high fever with vomiting and
drowsiness. On examination the child has neck rigidity and other signs of meningitis. CSF
examination was suggestive of bacterial meningitis
a) List the bacteria causing acute meningitis
b) Describe the pathogenesis of meningococcal meningitis
c) Describe in detail sample collection and laboratory diagnosis of meningitis
d) Discuss prevention of meningococcal meningitis
2. During the current pandemic, a 32 year old male who travelled from Britain developed
fever, sore throat and loss of smell. On the 6 th day he developed difficulty in breathing and
drop-in oxygen saturation. CT thorax showed patches in lungs
a) Mention the etiological diagnosis
b) Discuss in detail the sample collection and laboratory diagnosis of this patient
c) What precautions are to be followed by health care workers?
d) How to segregate and handle the biomedical waste while caring for this patient?

SHORT ESSAYS 8 x5 = 40 Marks

3.1. Laboratory diagnosis of Bacterial vaginosis.
4.2. Laboratory diagnosis and treatment of Lympho-Granuloma Venereum (LGV).
5.3. Discuss Laboratory diagnosis of urinary tract infections.
6. Discuss pathogenesis, clinical features and laboratory diagnosis of Dengue fever.
7. Laboratory diagnosis of pulmonary TB.
8. Prophylaxis of Poliomyelitis.
9. Laboratory diagnosis and prevention of mucormycosis.
10. Define opportunistic infection and describe predisposing factors involved in opportunistic
disease.

SHORT ANSWERS 10 x 3 = 30 Marks

11. Post exposure prophylaxis of Rabies.
12 . Lesions caused by HSV 2.
13. What is Prion disease? Mention three Prion diseases?
14. Mention three Arboviruses transmitted by mosquitoes
15. Enumerate three bacteria causing zoonosis
16. Laboratory diagnosis of diphtheria
17. Describe Weil-Felix test.
18. Discuss pathogenesis of pulmonary plague
19. Management of needle stick injury.
20. Mention the three components of standard precautions in health care delivery.

Multiple Choice Questions 10 x 1 = 10 Marks

21 i) False statement regarding Japanese B encephalitis
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 QP CODE : 1031
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase - II (CBME) Degree Examination - 26-May-2 023

Time: Three Hours Max. Marks: 100 Marks

MICROBIOLOGY - PAPER II (RS-4)
Q.P. CODE: 1031
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat. labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks
1. A 10 year old boy was brought to the OPD with high grade fever, productive cough with
rusty sputum and difficu lty in breathing for the past two days. Physical examination
showed dull note on percussion. Microscopy of the sputum sample showed plenty of pus
cells and gram positive, lanceolate diplococcic surrounded by a halo
a) What is the clinical diagnosis of this condition and the most likely etiologic agent?
b) How will you confirm the etiologic agent in the laboratory?
c) Describe the virulence factors and the pathogenesis of the etiological agent
d) How will you manage this clinical condition?

2. A 7-month old baby was admitted to the hospital with complaints of high-grade fever,
vomiting, seizure and neck rigidity. CSF sample was collected by lumbar puncture in a
sterile container and sent to the laboratory for biochemical analysis, cell count and culture
and sensitivity testing. Gram's stain revealed, gram negative diplococci

a) What is probable clinical diagnosis?

b) What are the etiological agents?
c) Pathogenesis of this disease
d) Describe the laboratory diagnosis in detail
e) What are the treatment modalities in this case?

SHORT ESSAYS 8 x5 = 40 Marks

3.1. Laboratory diagnosis of syphilis
4.2. Etiology and laboratory diagnosis of Lympho Granuloma Venereum (LGV)
5-3. Etiology, pathogenesis and lab diagnosis of Japanese B encephalitis
6. Standard precautions in health care delivery
7. Pathogenesis and laboratory diagnosis of Covid-19 disease
8. Pathogenesis and laboratory diagnosis of rabies
9. Pathogenesis and laboratory diagnosis of Toxoplasmosis
10. Laboratory diagnosis of Zygomycosis
SHORT ANSWERS 10 x 3 = 30 Marks
11. Laboratory diagnosis of Neuro cysticercosis
12. Name three viruses producing inclusion bodies
13. Mention three complications caused by Zika virus during pregnancy
14. Mention three Oncogenic viruses and the malignant conditions caused by them
15. Laboratory diagnosis of Hydatid disease
16. Mention three deep Mycotic conditions and their causative agents
17. Etiology and laboratory diagnosis of Vincent's angina
18. A 46 year old man from Africa came to the OPD with abdominal pain, Hematuria and Dysuria.
Urine culture showed no growth. Urine wet mount examination revea led oval non operculated
eggs with terminal spine
a) What is the etiological diagnosis?
b) What is the definitive host and intermediate host?

19. Laboratory diagnosis of Trichomoniasis

20. A 25 year old female came to the OPD with vaginal itching. On examination there was a white
creamy discharge. The Gram's stain revealed gram positive budding yeast cells

Page 1 of 2
 QP CODE : 1031
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase – II (CBME) Degree Examination - 09-Feb-2024

Time: Three Hours Max. Marks: 100 Marks

MICROBIOLOGY – PAPER II (RS-4)

Q.P. CODE: 1031
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks

1. A 44 old woman presented to casualty with history of recurrent low grade fever and
headache from past 30 days. Patient developed vomiting from past two days. On
examination patient had signs of meningitis. CSF examination revealed the presence of
AFB
a) Diagnose this clinical condition
b) Describe in detail pathogenesis of this condition
c) Discuss the laboratory diagnosis
d) Add a note on DOTS

2. A 65 year old patient visited a hospital with complaints of dry cough, sore throat and
fever. During the visit patient was not wearing any mask. The security guard guided him
to go to the casualty. The resident doctor who was also not wearing the mask, took the
history and examined the patient. His throat swab was sent for COVID-19 testing, which
turned out to be positive. Subsequently the security and the resident doctor also turned
out to be positive for Covid-19.
a) Name four respiratory viruses
b) Discuss the laboratory diagnosis of this disease
c) Identify the infection control breaches
d) Discuss the infection control measures to prevent the transmission along with note
on vaccines

SHORT ESSAYS 8 x 5 = 40 Marks

3. Laboratory diagnosis of faucial diphtheria
4. Pathogenesis and lab diagnosis of trichomoniasis
5. Laboratory diagnosis of UTI
6. Gonococcal uretheritis
7. Laboratory diagnosis of rabies
8. Laboratory diagnosis of pertussis
9. Clinical features and lab diagnosis of brucellosis
10. Chancroid

SHORT ANSWERS 10 x 3 = 30 Marks

11. Enumerate three Oncogenic viruses
12. Mention the clinical types of plague
13. Mention the clinical manifestations of polio
14. Mention three health care associated infections
15. Mention three pulmonary parasites infecting man
16. Mention three viruses casing encephalitis
17. Rhinocerebral mucormycosis
18. Laboratory diagnosis of dengue fever
19. Draw a neat labelled diagram of hydatid cyst
20. Write the components of standard precautions in health care delivery

Page 1 of 2
 QP CODE : 1031
Rajiv Gandhi University of Health Sciences, Karnataka
MBBS Phase – II (CBME) Degree Examination - 10-Jun-2024

Time: Three Hours Max. Marks: 100

MICROBIOLOGY – PAPER II (RS-4)
Q.P. CODE: 1031
(QP contains two pages)
Your answers should be specific to the questions asked
Draw neat, labeled diagrams wherever necessary
LONG ESSAYS 2 x 10 = 20 Marks

1. A lady aged 26 years presented with high grade fever with chills, headache since 4 days. On
examination she had neck stiffness and Kernig’s sign was positive. CSF gram stain showed
gram negative diplococci with adjacent flat surfaces.
a) Identify the causative agent
b) Describe the pathogenesis of this condition
c) Describe laboratory diagnosis of this condition
d) Suggest methods of prevention

2. An adult man presented with fever, breathlessness, dry cough and loss of smell since 4 days.
He had fever, sore throat and running nose in the previous week. RTPCR of nasopharyngeal
swab showed presence of N and RdRp genes.
a) Identify the causative agent
b) Describe laboratory diagnosis of this condition
c) Describe methods of prevention
d) Suggest appropriate management of common biomedical waste generated while
caring for this patient

SHORT ESSAYS 8 x 5 = 40 Marks

3. Pathogenesis and laboratory diagnosis of Japanese encephalitis
4. Laboratory diagnostic strategy of pulmonary tuberculosis as per National Tuberculosis
Elimination Program
5. A lady aged 28 years presented with recurrent multiple painful vesicular lesions of external
genitalia. Giemsa-stained smear of the base of the lesions showed multinucleated giant cells
with faceted nuclei. Describe pathogenesis and laboratory diagnosis of this condition

6. Pathogenesis and laboratory diagnosis of Leptospirosis

7. Clinical features, complications and laboratory diagnosis of Dengue
8. Pathogenesis and laboratory diagnosis of Hydatid cyst disease
9. Risk factors and prevention of CAUTI
10. Oncogenic viruses

SHORT ANSWERS 10 x 3 = 30 Marks

11. Describe the reasons for epidemics and pandemics of influenza
12. Diagnosis of neurocysticercosis
13. Morphology of Corynebacterium diphtheriae
14. Name common infections caused by Aspergillus Spp
15. Significant bacteriuria
16. Laboratory diagnosis of lymphogranuloma venereum
17. Draw a labelled diagram of Trichomonas vaginalis
18. Name three organisms causing nongonococcal urethritis
19. Malignant pustule
20. Describe the ethical considerations while testing for HIV

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