BAJIRAOJI KARANJEKAR COLLEGE OF PHARMACY, SAKOLI

GPAT TEST SERIES

TEST CODE: T1

Student Name: Class:

Roll No.

SECTION A: PHARMACOLOGY

1. Choose the antimicrobial which acts by interfering with DNA function in the bacteria:

A. Chloramphenicol B. Ciprofloxacin C. Streptomycin D. Vancomycin

2. Which antibiotic is primarily bacteriostatic but becomes bactericidal at higher

concentrations:

A. Erythromycin B. Tetracycline C. Chloramphenicol D. Ampicillin

3. Widespread and prolonged use of an antibiotic leads to emergence of drug resistant

strains because antibiotics:

A. Induce mutation in the bacteria B. Promote conjugation among bacteria

C. Allow resistant strains to propagate preferentially D. All of the above

4. The most important mechanism of concurrent acquisition of multidrug resistance

among bacteria is:

A. Mutation B. Conjugation C. Transduction D. Transformation

5. Drug destroying type of bacterial resistance is important for the following antibiotics
except:

A. Cephalosporins B. Tetracyclines C. Chloramphenicol D. Aminoglycosides

6. Methicillin resistant staphylococci do not respond to β-lactam antibiotics because:

A. They produce a β-lactamase which destroys methicillin and related drugs

B. They elaborate an amidase which destroys methicillin and related drugs

C. They have acquired penicillin binding protein which has low affinity for β-lactam
antibiotics
 D. They are less permeable to β-lactam antibiotics

7. Select the antibiotic whose dose must be reduced in patients with renal insufficiency:

A. Ampicillin B. Chloramphenicol C. Tobramycin D. Erythromycin

8. Which antimicrobial should be avoided in patients of liver disease:

A. Tetracycline B. Cotrimoxazole C. Cephalexin D. Ethambutol

9. A bactericidal antibiotic has the following characteristic(s):

A. Pronounced post antibiotic effect

B. Large difference between MBC and MIC values

C. Efficacy in the absence of host defence D. All of the above

[Link] drugs are unlikely to effect cure of bacterial infection in the following
category of patients except:

A. Diabetic patients B. Patients with allergic disorders

C. Patients on corticosteroid therapy D. Subacute bacterial endocarditis patients

[Link] drug combinations are aimed at achieving the following except:

A. Faster and more complete elimination of the infecting organism

B. Treat infection when nature and sensitivity of the infecting organism is not definite
C. Prevent emergence of resistant strains

D. Prevent superinfection

[Link] sulfonamides act by inhibiting folate synthesis in bacteria is supported by the

following findings except:

A. Paraaminobenzoic acid antagonises the action of sulfonamides

B. Methionine antagonises the action of sulfonamides

C. Purines and thymidine present in pus antagonise the action of sulfonamides

D. Bacteria that utilise folic acid taken up from the medium are insensitive to
sulfonamides
 13.A higher incidence of adverse effects to cotrimoxazole occurs when this drug is used
for:

A. Typhoid fever B. Whooping cough

C. Pneumocystis carinii pneumonia in AIDS patients D. Chancroid

[Link] the condition in which neither trimethoprim nor sulfamethoxazole alone are
effective, but their combination cotrimoxazole is:

A. Prostatitis B. Lymphogranuloma venereum

C. Pneumocystis carinii pneumonia D. Bacillary dysentery

[Link] the enzyme(s) inhibited by fluoroquinolones:

A. Both 'A' and 'C' B. Topoisomerase II C. Topoisomerase IV D. DNA gyrase

SECTION B: PHARMACEUTICAL ANALYSIS

[Link] of following compound has the highest λmax?

A. CH₃F < CH₃Cl < CH₃I B. CH₃I < CH₃F < CH₃Cl

C. CH₃Cl < CH₃I < CH₃Br D. CH₃I < CH₃Br < CH₃Cl

[Link] value of extinction coefficient more than 100 is known as:

A. Absorbed transition B. Allowed transition

C. Curved transition D. Bonded transition

[Link] shift involves:

A. Increase in intensity of absorption B. Decrease in intensity of absorption

C. Increase in wavelength of maxima absorption

D. Decrease in wavelength of maxima absorption

[Link] shows the following transition in UV spectra:

A. σ → σ* B. π → π* C. n → σ* D. n → π*

[Link] in the extent of conjugation of a double-bonded system results in:

A. Hyperchromic shift B. Hypochromic shift

C. Hypsochromic shift D. Bathochromic shift

 [Link] relationship between absorbance (A) and transmittance (T) can be given by:

A. A = 2 – log% T B. T = 2 – log A C. A = 2 + log T D. T = 2 + log A

[Link] widely used detector in UV spectroscopy is:

A. Bolometer B. Photomultiplier tube C. Photo emissive cell D. Pyroelectric detector

[Link] shows which transition?

A. n → π* B. π → π* C. σ → σ* D. n → σ*

[Link] in conjugation causes:

A. Hypsochromic shift B. Hyperchromic shift

C. Bathochromic shift D. Hypochromic shift

[Link] isomer of olefine has high λmax?

A. trans B. Cis C. Both have same λmax D. Can not say

[Link] is carried out at wavelength:

A. 450 nm B. 680 nm C. 530 nm D. 600 nm

[Link] transition requires the highest energy?

A. n → n* B. π → μ* C. σ → σ* D. n → σ*

[Link] organic compound 'X' has an absorption maximum at 217 nm. Its Emax is 16,000.
The absorbance is 0.64 when the cell length is 1 cm. Then molar concentration is:

A. 5 × 10⁻⁵ B. 4 × 10⁻⁵ C. 4 × 10⁻⁴ D. 5 × 10⁻²

[Link] window used in UV is made up of:

A. Quartz B. Glass C. Metal halide D. Both (a) and (b)

[Link] is defined as:

A. log Io/It B. log It/Io C. It/Io D. Io/It

SECTION C: PHARMACEUTICS (SOLUTION, SUSPENSION, EMULSION)

[Link] hydroalcoholic liquids are:

A. Elixirs B. Syrups C. Lotions D. Liniments

[Link] liquid dosage form with immiscible liquids is:

A. Syrup B. Suspension C. Emulsion D. All of the above

[Link] the formulation development of suspension, what type of diameter is important:

A. Sieve B. Stoke's C. Projected D. Length number

[Link] the stability of emulsion, which important instability step should be prevented?

A. Breaking B. Coalescence C. Flocculation D. Creaming

[Link] of the following is an associated colloid:

A. Soap B. Sol of gold C. Proteins D. Starch

[Link] the DLVO theory of colloids, normal thermal motion may be sufficient to overcome
the energy barrier that leads to irreversible particle aggregation. The name of this
energy barrier is:

A. Primary maximum B. Secondary maximum

C. Primary minimum D. Secondary minimum

[Link] of the following is an example of an emulsifier?

A. NaCl B. CaCO₃ C. C₁₅H₃₁COONa D. CH₃COOH

[Link] particle size in suspension is:

A. Less than 10³ nm B. 10² nm C. Greater than 10³ D. 10 nm

[Link] of the following is a clay type of emulsifying agent:

A. Carbopol B. CMC C. Veegum D. Xanthine

[Link] the emulsion globules were perfect sphere of the same size, the volume of disperse
phase should not exceed what percentage of the total volume:

A. 72% B. 74% C. 24% D. 90%

[Link] of the following is not an example of a water-in-oil emulsion?

A. Cod liver oil B. Butter C. Cold cream D. Milk

 42.A suspension is formed from uniform particles of solid, of diameter 10 μm, suspended
in a solvent. What is the best description of this system:

A. Monodisperse and coarse B. Monodisperse and colloidal

C. Polydisperse and coarse D. Polydisperse and colloidal

[Link] suspensions exhibit flow type:

A. Dilatant B. Newtonian C. Plastic D. Pseudoplastic

[Link] of suspension is increased with:

A. Increase in zeta potential B. Decrease in zeta potential

C. No changes in zeta potential D. None of them

[Link] is the difference between vanishing cream and cold cream?

A. Both are examples of oil-in-water emulsions

B. Vanishing cream is an oil-in-water emulsion whereas cold cream is a water-in-oil

emulsion

C. Vanishing cream is a water-in-oil emulsion whereas cold cream is an oil-in-water

emulsion

D. Both are examples of water-in-oil emulsions

SECTION D: PHARMACOGNOSY (VOLATILE OILS)

[Link] formula for isoprene unit is:

A. C₈H₈ B. C₃H₈ C. C₅H₈ D. C₆H₆

[Link] is not an example of ester volatile oil?

A. Gaultheria B. Lavender C. Mustard D. Cinnamon

[Link] is not an example of phenol volatile oil:

A. Clove B. Anise C. Creosote D. Thyme

[Link] grass oil is obtained from:

A. Cymbopogon flexuosus B. Cinnamonum camphora

C. Eucalyptus globulus D. Chenopodium ambrosioides

[Link] source for Nutmeg:

A. Foeniculum vulgare B. Coriandrum sativum

C. Myristica fragrans D. Elettaria cardamomum

[Link], which does not belong to family umbelliferae:

A. Caraway B. Coriander C. Ajowan D. Cardamom

[Link] should contain volatile oil not less than:

A. 1% w/v B. 2% w/v C. 3% w/v D. 5% w/v

[Link] bark does not contain:

A. Cinnamaldehyde B. Tannins C. Coumarin D. Benzaldehyde

[Link] percentage of clove oil in clove should not be less than:

A. 15% B. 10% C. 5% D. 1%

[Link] transverse section of clove is treated with potassium hydroxide solution, it

gives:

A. Strong odor of volatile oil B. H₂S gas is evolved

C. CO₂ is evolved D. Needle shaped crystals of potassium eugenate

[Link] is not used as an adulterant for clove?

A. Mother clove B. Blown clove C. Clove stalk D. Pale clove

[Link] oil, which is not belonging to aldehyde class:

A. Dill oil B. Cinnamon oil C. Lemon grass oil D. Lemon oil

[Link] is sweet odorous constituent of volatile oil of:

A. Rose B. Sandalwood C. Lavender D. Fennel

[Link] is used for the synthesis of:

A. Vitamin C B. Menthol C. Vanillin D. Thymol

[Link]-III with volatile oil will give:

A. Red color B. Yellow color C. Pink color D. Black color