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Zinc Oxide Suppository

The document outlines the preparation of zinc oxide suppositories, detailing the ingredients, their functions, and the procedure for making them. Zinc oxide serves as a soothing agent, while glycerin and gelatin contribute to the suppository's texture and effectiveness. Proper storage and dispensing instructions are provided to ensure the quality and usability of the suppositories.

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2K views2 pages

Zinc Oxide Suppository

The document outlines the preparation of zinc oxide suppositories, detailing the ingredients, their functions, and the procedure for making them. Zinc oxide serves as a soothing agent, while glycerin and gelatin contribute to the suppository's texture and effectiveness. Proper storage and dispensing instructions are provided to ensure the quality and usability of the suppositories.

Uploaded by

ehsantrader.81jb
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

26.

ZINC OXIDE SUPPOSITORIES


Aim: To prepare zinc oxide suppositories.
Apparatus: Suppository mould, Beaker, glass rod, spatula.
Category: Astringent and Soothing agent

Formula:
S. No Ingredients Official Formula (B.P) for 4
suppositories
1 Zinc oxide 0.24 gm
2 Gelatin 0.67 gm
3 Glycerin 2.5 ml
4 Purified water 1 ml

Principle: Zinc oxide will act as soothing agent. Glycerin promotes the peristaltic movement of
lower bowel and act as humectants. Gelatin gives stiffness to the suppositories. Zinc oxide is
widely used to treat a variety of skin conditions, including dermatitis, itching due to eczema,
diaper rash and acne.
Procedure: Lubricate the mould with liquid paraffin and keep the mould inverted on the ice.
Heat the glycerin for 100 0 C in a china dish on the water bath. Add the gelatin of the formulation
in china dish and swell in 20ml of distilled water for 30min to make it soft. Add glycerol, and
heat the mixture in water bath to make gelatin dissolve; keep heating until the semisolid gel is
formed. Maintain the base at 100 0 C for one hour, to make it sterilized. Add the required amount
of zinc oxide to the above mixture with continuous stirring to prevent the air entrapment. Pour
this mixture into the moulds of suppository smeared with liquid paraffin immediately. After they
are cooled, scrape off the unnecessary parts. Place the moulds in the refrigerator for 30 minutes.
Finally remove suppositories from moulds and wrapped in butter paper slightly coated with
lubricant to prevent the sticking of suppositories.

Dispensing: Each suppository should be wrapped in grease proof paper or butter paper. Air tight
glass or plastic screw-topped jars are possibly the best choice of container for prepared
suppositories. Cardboard cartons may be used but these offer little protection from moisture or
heat. They are therefore not suitable for hygroscopic materials.
Direction: Zinc oxide suppositories should be moistened with water, before inserting into the
body cavity to enhance the lubrication and decreases irritation.

Storage: Store in a cool place or store in refrigerator.

Auxiliary label: For rectal use only.

Report:

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