H-8514

TotalNo. ofPrinted
Pages: 03

SUBJECT CODE NO:-H-8514

FACULTY OF SCIENCE AND
TECHNOLOGY
B. Pharm (Sem-lV)
Examination May / June- 2023
Medicinal
Chemistry-I
ITime: 3:00 Hours)

Please check whether you |[Link]|

have got the right question paper

N.B
1. Check whether you obtained the correct
2. All questions Questionpaper or not.
are compulsory.
3. Figures to the
right indicate Max. Marks for the question.

QI Solve the following

multiple-choice questions: (1 x 20).
1) Generally,drugs are
absorbed in which form?
a. In ionizedfom
In unionized form
c. In neutral fom In cationic form

d.
2) Prefix -lol is used to denote?
Alpha-blockers Beta-blockers c. Alpha-agonist d. Beta-agonist

3) What sort of receptor is the nicotinic

receptor?
A G-protcin couplcd
a.
receptor b. A kinase linked receptor
c. An intracellular receptor
An ion channel

4)) Biotransformation is chemicalalteration of drug in body that.

Converts non-polar compounds to polar
b. Converts polar compounds to
non-polar
c. Converts polar lipid solublecompounds to
non-polar
d. Converts nonpolar lipid solublecompounds to insoluble
compounds

5) Methyldopa is

a. Para sympathomimetic b. Para sympatholytic

Sympathomimetic d. Sympatholytic

6) The type of ring system found Propranolol?

in

Naphthalene b. Carbazoline c. Imidazoline d. No ring is pressent

7) lonization of drug depends on.

a. pH values b. Solubility c. pKa value both pH and pKa value

19089DIEI7245103693DBDBD2544B52D
 H-8514

8) Which

.
is not an oxidation reaction?
a Dealkylation b. Deamination Azo reduction d. N-oxidation

9) Which one followingis non catecholamine

sympathomimetic drug?
a. Adrenaline Sphedrine c.
Dopamine d Isoprenaline
10) IUPAC name of Dobutamine is
a 442-([4-(4-hydroxyphenyl)butan-2-yl]amino) ethyl)
benzene-1,2-diol
b.
4(2-([4-4-hydroxyphenyl) butan-2-yl] arnino) methyl)
benzene- 1,2- diol
442-{[4-(4-hydroxyphenyl)propan-2-yl]amino) ethyl) benzene-
1,2-diol
d. 442-{(44-hydroxyphenyl)
propan-2-ylJamino} methy)benzene- 1,2-diol

11) Pilocarpine is used for

Glaucoma b. Urinary retention c. Paralytic ileus d. Epilepsy

12) What sort of receptor is the nicotinic

receptor?
a. A G-protein coupled receptor b. A kinase-linked receptor
c. An intracellular receptor An ion channel

13) Which of thefollowingagents is an alpha-2

sclective antagonist?
Yohimbinc b. Tamsulosin c. Tolazoline d. Prazosin

14)Which of the followingdrugs is a nonselective beta receptor antagonist?

a Metoprolol [Link]
Propranolol d. Acebutolol

15)Clinical use of clonidine

[Link]
Antihypertensive c. Antiviral [Link]

16)The type of ring system found in Propranolol?

Naphthalene b. Carbazoline c. Imidazoline d. No ring is present

17)Which of the followingis not a

Barbiturate?
a. Phenobarbital b. Pentobarbital c. Thiopental
Diazepam

18) Metabolism of prontosil I red by

r
a. N-demethylation b.O-demethylation. azo-roduction
d. Cyclisation.
 19)To which H-8514
class of
compounds do adrenaline,
belong?
noradrenaline and dopanine
a. Phenyl
ethylamine
b. Diphenyl
Catecholamines
d. ethylamine
Adrenergic
20)What can be the
correct IUPAC
nomenclature of
a chlorpromazine
hydrochloride?
one;
4-44-(4-Chlorophenyl-4-bydroxypiperidin-1-yl-1-{4-fluorophenyl)
hydrochloride butan-1
b.
10-[3-{4-methyipiperazin-l-yl)
propylj-
phenothiazinc; hydrochloride 2{trifluoromethyl)-
10H
c.

N,N-dimethyl-3-phenothiazin-10-ylpropan-1-amine;
hydrochloride
3-{2-chlorophenothiazin-10-yl)-N,N-dimcthyipropan-l-
amine;
hydrochloride

02 Solve any two long answer

questions from the following:(2
10).
1) What is Phase-
metabolism? Explain Phase-I
2) Define sedatives and metabolic reactions.
hypnotics. Explain the SAR of
barbiturates. Write the
synthesis ofbarbital.
3) Explain the SAR Morphine with
respectto peripheral
modification. Write the
Synthesis of Fentanyl citrate.

Q3 Solve any seven short answer questions from the

following:(7 05).
1) Give the biosynthesisand metabolism of
nor-adrenaline.
2) Write a note on the nicotinic receptors.
3) Write the synthesisof Propranolol and Tolazoline.
4) Classify adrenergic antagonistswith suitable example in each class along with
Structure.

5) What are narcoticantagonists?Give two examples with structure.

6) Write the class, structure mechanism,and uses of Methyldopa and Ephedrine
7) Define and classify NSAIDS with examples. Give the structure of one drug from
cach class.

8) Give the SAR ofB-adrenergic blocking agents.

9) What are Narcotic antagonists?Write the structure, uses and demeritsof any
two.
 ted ages: 05

SUBJECT CODE NO: -

P-9908
FACULTY OF SCIENCE AND
TECHNOLOGY
B. PHARMACY
(CBCSPattern-2022) SEM IV
Examination May / June - 2024
Medicinal Chemistry -I

ITime: 3:00 Hours

IMax. Marks: 75]

Please check whether
you have got the right question
N. B paper.
1. Check whether you
obtaincd the correct
Question paper or not.
2. All questionsare compulsory.

3.
Figuresto the right indicate Max, Marks for the question

.
Solve the following
multiple-cholcequestions (l x220)
Phase-I metabolism is also called as

a. Synthetic

c. Formation of polar
drug
. Functionalisation

d. All ofthese

2. ldentification of a new chemical entity

asa potential therapeutic agent (From Hit
to Lead) is known as

Drug discovery b. Drug development

c. Both of above d. None of above

3. What sort of receptoris the

muscarinic receptor?

CA G-protein coupled receptor b. A kinaselinked receptor

c. An intracellular receptor d. An ion channel

4. Biotransformationis chemical alteration of drug in body that.

1

Converts non-polar compounds to polar

 b. Converts polar compounds to non-polar
C. Converts polar lipid soluble
compounds to non-polar
d. Converts polar compounds to
insoluble polar
conpounds

5.
Autonomic nervous system is the
part of

t
[Link]
NS
PN!
.Both
d. None ofthese

6. The type of ring

system found in Diazepam?
a. Naphthalene
Q1,4-benzodiazepinc ring
c. Imidazoline
d. No ring is present

7. lonizationof
drug depends on.

pH

'
a.
values
b. Solubility
c. pKa value
both pH and pKa

8, Which is not an oxidation

feacp
on?
a Dealkylation
Deamination
b.
Conjugation d. N-oxidation

9 Beta receptors arepresenton

a. Heart
b. Adipose tissue
c. Bronchi
Al of these

10. Adrenergic receptors are

belonging to

a. catt chàqnel
b. ligand gated

G-protein coypled receptor d. None of these

 11 Methyáopa
Jowers BPby
A Inhibiting dopa decarboxylase in adrenergicnerve
endings
Generating a-mehyl noradrenalinein brain which reducessympathetie
tone

e Generating a-methyl noradrenalinewhich actsaSa false transmiter

peripheral adrenergicnerve endings

d Activating vascular dopamine receptors

[Link] of drug Phenobarbitalisare?

A Treatment ofseizures b. Sedation during time of anxicty

c Treatment of Diabetes Both a) and b)

13. Which of the followingagents is an alpha adrencrgicblocker?

b. Tamsulosin
Tolazoline

c. Propranolol Esmolol
d.
14. Which of the following drugs is a nonselective beta adrenergic blocker?

Tolazolinc b. Tamsulosin

d. Phentolamine
Propranolol

[Link] use of Atcenolol

a. Anticancer

c. Antiviral

J6. The type of ring system found in Propranolol?

b. Carbazoline
Naphthalene

c. Imidazoline d. No ring is present

17. Sedative-hypnotic cffect of phenobarbital is through?

 P908

Increase the affinity of GABA for GABA receptors

Decrease the affinity of GABA for GABA receptors
b.

C. G-inhibition

d B-inhibition

18. Metabolism of nicotine by

b. O-demethiylation
N-oxidation
d Cyclasation
c. azo-reduction

is classificd as a
Guanabenz
19,

a. Dual a and b agonist

2 selectiveagonist

d. Selective p2 agonist
c. Nonselective B- agonist

of promazine hydrochloride?
[Link] can be the correct IUPAC nomenclaturc

a. 4-(4-4-Chlorophenyl-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)
butan-1-one; hydrochloride

b. -l-) propyl)-2-trifluoromethyt-1H
10-13-(4-methyipiyeorde
phenothiazine,
h
hydrochloride
c. N, N-dimethyl-3-phenothiazin-10-ylpropan-1-amine,
N-dimethylpropan-l-amine:
3-(2-chlorophenothiazin-10-yl)-N,
hydrochloride

10) 20
long answer qucstions from the following (2
x
Q2 Solve any two
and write SAR of synpathomimetic agents. Give synthesis of 10
1. Define, classify

phenylephrine.

2 Define biotransformation. Explains Principles of Drug metabolism including 10

Phase-I and Phase-Il pathways.

3. Define Antipsychotic, write classification and explain SAR with suitable

Cxamples.
 P-8S14
Total No. ofPrinted Pages:5
SUBJECT CODE NO: -P-8514
FACULTY OF SCIENCE AND
TECHNOLOGY
[Link] (CBCS Patfern 2017) SEMIV
Examination May / June - 2024
Medicinal Chemistry- I

[Time: 3:00 Hours

IMax. Marks:75|
Please check whether you
have got the right qucstionpaper.
NB )Check whether you obtained the
correct Question paper or not.
2) All questions arecormpulsory.
3) Figures to the right indicate Max.
Marks forthequestion.

Q1 Solve the following multiple choice questions (Ix20)

Metabolism ismainly observed in

Liver
b) Hcart
c) Brain
d) Nonc of these

2. Metabolism of Nicotine by

N-oxidation

b) aliphatic hydroxylation
c) azo-reduction

d) Cyclisation

3. Which of the following substance is the first precursor of adrenaline

formation?

Tyrosine
b) Dopamine
c) DOPA
d) Noradrenaline

in binding with a drug is

4. The most significant protein involved

Albumin

b) Glycoprotein

c) Lipoprotein
d) Globulin
 P-8514
5.
Following are the
PhaseI reactions except
a) Oxidative reactions
b) Hydrolytic reactions
c) Reductive rcactions

Conjugation reactions

6. DOPA is an essential natural aming acid and precursor in the biosynthesis

a) Nor-adrenaline

b) Adrenaline

c) Methyldopa

Doparnine

7. Catecholamineincludes the followings

EXPECT
a) Norepinephrine

Ephedrine

) Isoproternol

d) Epinephrine

8. Which of the following is a natural chemical messenger for the adrenerzie

receptor?

a) Acetylcholine

b) Dopamine
c) Serotonin
Noradrenaline

9. To which class of compounds does adrenaline,noradrenaline and dopamine

belong?

a) Phenylethylamine

b) Diphenyl ethylamine
Catecholamines

d) Adrenergic

10. What parameters are used to understand the behaviour of drug molecules?

a) Hydrogen bonding
b) Protein binding

pka andLogP
d) lonization
 P-5514

antagonist?
is a nonselective beta receptor
Which of the following drugs
11.

a) Metoprolol
b) Atenolol
Propranolol

d) Acebutolol

reactions except
Following are the Phase
I
12.

a) Oxidative reactions

b) Hydrolytic reactions
c) Reductive reactions

Sulphide reactions

13. Phase ll reaction

a) Oxidative
b) Hydrolytic
C4KSNSYvsDRC24NSS3YSD8C
Reductive
Conjugation

-is catecholamine.

a) Alprenol
b) Oxyprenol
C) Sotalol

Isoproterinol

is used for
15.. Pilocarpine
Glaucoma ysDxC23NSNsYsDsCNSR3YSD8C24Ns8YSD8C
b) urinary retention sDscAXS8sYsDsezaxsssYSDKC24
c) paralytic ileus

dy All of above

receptor?
recepter is the nicotinic
[Link] sort of

a) A G-protein coupled receptor

b) A kinase-linked reccptor
c) An intracellular receptor
An ion channel
 is not a Barbiturate?
17. Which of the following

a) Phenobarbital
b) Pentobarbital

c) Thiopcntal
Diazepam

CNS depression as well

classes of drugs
provide global but reversible
18. What
to external
stimuli?
as loss of response

a) Local Anesthetics
b) Opioids
General Anesthetics

d) NSAIDs

for seizures?
can be med clinically
19. Which of the following sedatives

a Lorazepan

) Pentobarbital

Zolpidem
d) Alcohol

hydrochloride?
system is found in Chlorpromazine
20. The type of ring

Phenothiazine

b) Piperizine ring

c) Pyrimidinering
d) Pyridine ring

20
(2 x 10)
long answer questions from the following 10
Q2 Solve any two SAR, and mode of
drugs, give classification,
1. Define parasympathomimetic
action? 10
of
agents with examples, Write SAR
Define and classify antipsychotic
2.

phenothiazine. from 10
examples with one structure
giving
classify sedative hypnotics
3. Define and
each class. Discuss
the SAR of benzodiazepines.
35
from the following (7x05)
Solve any seven short answer questions on drug action. 05
Q3 partition coefficient
the role ofhydrogen bonding and
1. Explain
Write the synthesis 05
cholinergic agents with examples.
2. Write about direct-acting
of carbachol. 05
blocking agents.
3. Give the SAR of B-adrenergic
Total No, 8514
ofPrinted Pages:5

SUBJECT CODE NO:- 8514

FACULTY OF SCIENCE AND
B. Pharmacy TECHNOL0GY
Sem-IV (CBCS)
Eamination March/April-2022
(To be held in
ITime: 3:45 Hour Medicinal JuneJuly-2022)
Chemistry-I

Max. Marks:75|
Plcase check
N.B
) Check whether ou have got the right question naner
obtaincd thecorrect
ii) All questions Question paperor not
arecompulsory
ii)Figures to the right indicate Max.
Marks forthe question

Q.1 Solve the following

multiple-choice questions (1x20)
I. Bio isosterisn 20
conceptis discovered by.
a. Adrian Albert
b. E.W, kosower

Langmuir and Hans Erlenineyer

d. Tecwyn Williams
2. Which drug is lipid-soluble?

a. lonized drug

Unionized drug
c. Cationicdrug
d. Neutral drug
3. Which drug is water-soluble?

Sonizeddrug
5. Unionized drug

c. Cationicdrug
4 Ncutraldrug

4 Which of the followingis not a Bartbiturate?

a. Phenobarbita

b. Pentobarbitalal

e. Thiopental

Diazepam

What is mcaa by the lcad compound in medicinalchemistry?

AD6EI0SDE2513826338B621
1B8CCIDE8
 8514
a. A drug-containing clement lcak
b. Leading drug in particular
also of medicine
c.
A compound that acts as a starting point for drug design
A drug that is and development
normally first to be prescribed for a particular
6.
ailment
Biotransformation is the chemical
alterationofthe drug in
the body that
Converts non-polar compounds to polar

b. Converts polar compounds to

non-polar
c. Converts polar lipid-solubie
compounds tonon-polar
d. Converts nonpolar
lipid-soluble compounds to polar or
insoluble compounds
7.
lonization of drug dependson.
a. pH values s

b. Solubility

C. pKa value

both pH and pKa value

8. High plasmaprotein
binding does.

lncreases the volume of distribution ofdnug

b. Facilitates glomerúlar filtration of the drug

c. Facilitates glomerular fltration ofthe drug

.Makes the drug long-acting
9. Which of the following isa natural chemical
messenger for the adrenergic receptor?
a, Acetylcholine

b. Dopamine

Serotonin

Noradrenaline

[Link] ís not an oxidation reaction?

a Dealkylation

b Deamination

Azo reductíon

d. N-oxidatíon

11,Pilocapine is used for..

Glaucoma
 Urinary retention
b.
6 Paralytie ileus

4. lipilepsy
receptor?
is the nicotinic
of recepor
12. What sort
A Gprotein coupled receplor
A
receptor
b. Akinase-linked

. An intracellular receptor

channel
An ion
selective antagonis7
agents is an alpha)
13, Which of the following

Yohimbine

b. Tamsulosin

Tolaoline

beta fecetor antsyniat?

following drugs is nonelective
[Link] of the

A Metoprolol

b. Atenolol

Prupranolol

4 Accutoel

[Link] ue of clonidine

Asthypertentive

Antivial

16. The typ of ting syiem fond in ipanlot

aphheiese
Carbakine

Iidetone

17Which of tefulewing is het & Barbiturste

Prhbhi

AtAEISOE41615484ZICCIDR
 Thiopental

of prtoeit red y
I Metallim
Ndemethyltion
0demehylatlon

#0eetion
d Cyeliation ad dpnie betg
denrenaline, Hsdensline
elass ofeonpounde
19 Te whleh
Phenylethylamine

Dipheny ethylamine
b.

Calecholamines

f ohlorprineine
byuehbe
[Link] can
be the oe UVAC nonenelair
flinnghen) tte
ne,
4hylunypieriia-y)4
4444Chghenyly
hydrehlorde Lphenothiaine
y)pny)24ituiney)
b. 1004 methypipersind
hydoehitde hydrychlotide
10-pnine,
NMdimethrylyhenhiin wninehydruchtoride
0)Hdineidjgenl
342hiotghenothiain

i0)
he fllwing (2
ng eve eetions frn
02 Sove anytwo Give synthesie of phenylephrine
SAR Gfeympathoimetls sgnte
dty aid wrhe ynheie of brbitel
10
L Detis,
d hyhotiss Bapleln the
SAk fbatitrte Write he
of
tetine sedetives
modificstion Wrine the Syntheis
SAR Murphitewih tope tu perighersl
Fplin the

Fetatyl citrte

fom the follkrwing (7 05)

seven sburtanswr
quetios
03 Sove any
Emeste beyntteis e of nsdrenaine,
Enplsin with eramghe
affct bidungiesl sotivit/
2 How deshydrgen emditig gents.
3. Ge the SAR of Bsrenergie beking
ietribntit snd funetim
Write s nohe on their
4 Casity chlicerge receghers

iB4CCiA
AtHE1tE251197K1328421
 -8514
sUBJECT CODE
FACULTY OF SCIENCE NO:-P-8514
AND
[Link](CBCS TECHNOLOGY
Pattern 2017) SEM
Examination IV
May June - 2024
/

Medicinal
Chemistry- L
|Time: 3:00 Hours)

N )
Please check
whether you have
Check whether you
2) All questions
are
got the right
obtained the correct
compulsory
question papcr.
Question paper or not
[Link]|

3) Figuresto the
right indicate Max.
Marks for the
question,

Solve the follewing

multiple choice
questions (l 1 20)
1. Metabolism
is mainly
ebserved in,
Liver
b) Heart
) Brain
d) None of
these

2. Metabolism of Nicotine

N-oxidation
b) aliphatic hydroxylation
c) azo-reduction
d) Cyclisation

Which of the followingsubstance is the first precursor of adrenaline

formation?

Tyrosine
b) Dopanine
c) DOPA

The most significant protein involved in binding with a drug is

XSSIYSDSC24XS83YSDSC24NXSRIYSDSC24XS83YSDSC24
 5.
Following are the P-8514
Phase I reactions
except
a) Oxidative reactions
b) Hydrolytic
reactions
c)
Reductive reactions

Conjugation rcactions

6. DOPA is an
essential natural
amino acid and precursor in the
biosynthesis
a)
Nor-adrenaline
b) Adrenaline
c) Methyldopa
Dopamine

Catecholamineincludes the
followings EXPECT

a) Norepinephrine

Ephedrine
c) Isoproternol
d) Epinephrine

Which of the following is a natural chemical messenger for the adrenergie

receptor?

a) Acetylcholine

b) Dopamine
c) Serotonin

Norndrenaline

To which class of compounds does

adrenaline, noradrenaline and dopamine
belong?

a) Phenylethylamine
b) Diphenyl ethylamine
Catecholamines
d) Adrencrgic

[Link] parametersare used to understand the behaviour of drug molecules?

a) Hydrogen bonding
b) Protein binding

pKa andLogP
d) lonization

XS8IYSD8C24X583YSDSC24XS83YSD$C24XS83YSD8C4
 ntagonis?
nonselectve beta receptor
the followingdrugs
is a

11, Whlch of

a) Metopolol
b) Alenolol

Propranolol

d) Acebutolol

Phase reactlons except

Following are the
I

12.

a) Oxidative reactions

b) Hydrolytic reactions

c) Reductive reactions

Sulphide reactions

Phase ll reaction
13.

a) Oxidative

b) Hydrolytic

) Reductive

Conjugalion

14.
-scatecholamine.
prenel
b) Oxyprenol
Sotlalol

Isoproterinol

Is used for
I5.. Pilocarpine

Glaucoma

b) urinary rctention

c) paralytic ileus

d) All of above

sort of receptor is the nicotinic receptort

16. What

a) AG-proteincoupled receptor

b) A kinase-linked roceptor

An intracellular receptor
An ion channel
 Barbiturate?
17.

)
Whkch of the

b)
follow lng is

Phenobarbital

Pentobarbital
not

c) Thiopental
Diazepam
depression as
reversibleCNS
W

of drugs provide global but

18. What classes
stimuli?
to external
As loss off response

a) Local Anesthetics
b) Opioids
General Anesthetics

d) NSAIDS
for seizures?
can be med clinically
Which of the following sedatives
19.

) Lorazepan

)
d)
Pentobarbital

Zolpidem
Alcohol

is found in Chlorpromazine hydrochloride?

of ring system
20. The type

Phenothiazine

b) Piperizine ring

Pyrimidinering
d) Pyridine ring

20
10)
the following (2 x

answer questions from

Q2 Solve any two long SAR, and mode of
drugs, give classification,
Definc parasympathomimetic
1.
action? 10
SAR of
antipsychotic agents with examples, Write
2. Define and classify
phenothiazine.
with one structure from 10
classify sedative bypnoticsgiving examples
3. Define and
cach class, Discuss the SAR of benzodiazepines.
35
(7x05)
questions from the following
Q3 Solve any seven short answer
and partition coefficient on drug
action.
Explainthe role of hydrogen bonding
05
L.
the synthesis
agents with examples. Write
2. Write about dircct-acting cholincrgic
of carbachol.

3. Give the SAR ofB-adrenergicblocking agents.

 H-777
Total No sfPrinted Pages: 05
SUBJECTCODE NO:- H-777
FACULTY OF SCIENCE AND TECHNOLOGY
B. Pharm (IV Sem) (CBCS)
Medicinal Chemistry - I

Time: Three Hours]

(Max. Marks:75]
Please check whether you have
got the right question paper.
LB i) Q. No. I is compulsory.
ii)Solve any two questions
fromQuestion no.2.
iii) Solveany seven
Questions from Question no.3.

1 Answer the following Questions 20

1. Acetyl choline is biosynthesizedfrom

a. L-Cysteine

b. L-Codeine

L-Serine

d. L-Cholic acid

2. What sortof receptor is the nicotinic receptor?

a. A G-protein coupled receptor

b. A kinase linked receptor

C. An intracellular receptor

An ion channel

3. What sort of receptor is the muscarinic receptor?

AG-protein coupled receptor

b. A kinase linked receptor

c. An intracellular receptor

d. d) An ion channel

4. The drug NALAXONE

a. Produces morphine like activity

b. Produces respiratory depression

1
 c. Induces constipation

symptoms in morphine addicts.

Precipitates withdraw

an imidazopyridine derivative?
5. Which of these hypnotic drugs is

a) Pentobarbital

b) Temazepam

Zolpidem

d) Chloral hydrate

6. The following barbiturate has &-24 hours half- life:

a) Secobarbital

b) Thiopental

Phenobarbital

d) Amylobarbitone

7. Flumazenil blocks the actions of.

a) Morphine b) Phenobarbital

Zolpidem d) Thiopental

8. Morphine is the drug of choice for

a. Urinary tract infection Colic pain

C. Bronchial asthma d. Cardiac asthma

9. Aspirin is converted into salicylic acid in your body by which of the following reactions?

Hydrolysis

b. Oxidation

c. Reduction

d. Substitution

10. Which of the followingis a natural chemicalmessenger for the adrenergic

receptor?

a. Acetylcholine

2
 Examination March/April
2019

b. Dopamine

c. Serotonin

Noradrenaline

[Link] ofthe following drugs is a nonselective

alpha receptor antagonist?
a) Prazosin ) Phentolamine

c) Metoprolol c) Reserpine

12. Indicate the alphal-selective antagonist:

a) Phentolamine b) Dihydrocrgotamine

) Prazosin d) Labetalol

13. Which of the following agents is an alpha2-selective antagonist?

Yohimbine b) Tamsulosin

c) Tolazoline d) Prazosin

,
[Link] the reversible nonselective alpha-receptor antagonist, which

Ergotamine

c) Phenoxybenzamine
b) Prazosin

d) Carvedilol
is an ergot derivative:

has very long duration of action:

15. Indicate a beta receptor antagonist, which

b) Propranolol
a)Metoprolol

9 Nadolol d) Pindolol

16. Which of following is B-halo alkyl amine derivative?

Phenotamine b. Tolazoline

Phenoxybenzamine d. None of the above

 Examination March/April 2019

[Link] following structure is of

HO

HO CH,

a. Codeine
b. Hydromorphone

c. Heroin
Morphine

18. Hypnotic drugs are used to

treat:

Sleep disorders b) Parkinsonian disorders

c) Narcolepsy
d) Psychosis

19. Narcoticsdrugs such as

codeine and morphine acts
a. lungs and kidneys
directly on
central
nervous system
c. kidneys and lives d. heart and lungs

20. Narcotics
that arederived from
opium are
codeine and
morphine
b. morphine and endorphin
c. tetracycline
and morphine
d. panadol and
codeine

Q.2 Answer the following

Questions (Any TWO)
1. Give the uses and MOA of Narcotic
drugs in details? Analgesic?
Classify
and Explain
2. Explain Phase-I Narcotic
Reaction and anntagonist
Factors
aspects? affecting drug
metabolism
3. Explainthe including
classification, Mode of steren
actions Dmical
and
SARstudy of
Antipsychoti