11/01/2024 A

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MM : 296 MENDELIAN GENETICS Time : 30 Min.

PRINCIPLES OF INHERITANCE AND VARIATION

1. In human beings, which of the following 6. Which one of the following genotypes can
disorders occur due to the dominant allele? produce maximum eight different types of
(1) Sickle cell anaemia gametes?
(2) Cystic fibrosis (1) AaBbcc
(3) Myotonic dystrophy (2) AaBbccDd
(4) Haemophilia (3) AaBbCcDd
(4) AABBccdd
2. All of the following disorders are transferred
from males to both sons and daughters, 7. Thalassemia and sickle cell anaemia are
except similar as
(1) Colour-blindness (1) Genes responsible for both of them are
(2) Phenylketonuria present on chromosome 11
(3) Sickle cell anaemia (2) Both are qualitative problem of
synthesising incorrectly functioning
(4) Thalassemia
globin protein
(3) These are X linked disorders
3. Which of the following is not a recessive (4) These occur due to transversion
Mendelian disorder? mutation
(1) Phenylketonuria
(2) Sickle cell anemia
8. Which of the following features is not true for
(3) Myotonic dystrophy the persons suffering with Down’s
(4) Haemophilia syndrome?
(1) Short stature
4. Which among the following show XO type of (2) Many ‘loops’ on finger tips
sex determination? (3) Trisomy of sex chromosome
(1) Grasshopper (4) Furrowed tongue
(2) Drosophila
(3) Birds 9. Which of the given is not true for Down’s
(4) Humans syndrome?
(1) Occurs due to failure of segregation of
chromatids of an autosome
5. Drosophila melanogaster is used as
material for experimental genetics due to (2) Affected individual have only one copy
some features. Which of the following is one of chromosome 21
among them? (3) Affected individual have short stature
(1) Has large number of chromosomes (4) Its inheritance is not shown via
(2) Has no hereditary variations at all pedigree chart
(3) Can be easily grown in lab on simple
synthetic media 10. The ability of single gene to produce more
(4) Produces only one offspring from than one phenotypes is known as
single mating (1) Pleiotropy
(2) Co-dominance
(3) Multiple allelism
(4) Incomplete dominance

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11. Haplodiploid method of sex determination is 16. The human females with only one X
found in chromosome in their cells
(1) Butterfly (1) Have normal secondary sexual
(2) Honey bee characters
(3) Grasshopper (2) Are fertile but do not have normal
secondary sexual characters
(4) Fruit fly
(3) Are sterile
(4) Lack ovaries
12. In pedigree analysis, the symbol

17. Consider the following Assertion and

shows Reason and choose the correct option.
(1) Affected male Assertion (A) : In sickle cell anaemia, the
(2) Unaffected offspring shape of RBC changes from biconcave disc
to elongated sickle like structure.
(3) Affected individual
Reason (R) : The mutant haemoglobin
(4) Affected female molecule undergoes polymerization under
low oxygen tension causing the change in
13. Mark true (T) or false (F) for the statements shape of RBC.
given below and select the correct option. (1) Both Assertion & Reason are true and
(A) Starch synthesis and seed size in pea the reason is the correct explanation of
seeds is controlled by one gene the assertion
(B) Dominance is not an autonomous (2) Both Assertion & Reason are true but
feature of a gene the reason is not the correct
(C) A single gene product never produce explanation of the assertion
more than one effect (3) Assertion is true statement but Reason
A B C is false
(1) T T F (4) Both Assertion and Reason are false
statements
(2) F T T
(3) T F F
18. According to ‘Law of segregation’
(4) F F T
(1) Two factors of a character get mixed up
(1) (1) in F2 generation
(2) (2) (2) During gamete formation, factors of a
(3) (3) character get mixed up
(4) (4) (3) Factors of a character separate from
each other during gamete formation
(4) Out of two factors for each character,
14. Four genes a, b, c and d are present on a dominant will be able to express in
chromosome. Percentage of recombination F1 generation
between a and b = 20%; a and d = 2%, c
and b = 8% and d and b = 18%. What will be
the sequence of genes on the 19. Select the incorrect one for polygenic
chromosome? inheritance.
(1) adcb (1) Controlled by multiple genes
(2) cdab (2) It also takes into account the influence
(3) dcab of environment
(4) acbd (3) Phenotype reflects contribution of each
allele of the genes
(4) Regarding human skin colour, the
15. In which of the following insects, male
phenotype is only due to dominant
progenies do not receive any set of
alleles in additive manner
chromosomes from their male parent?
(1) Moth
(2) Honey bee 20. What is the ratio of round seeded to green
seeded pea plants in F2 generation of
(3) Drosophila
Mendelian dihybrid cross?
(4) Butterfly
(1) 9 : 1
(2) 3 : 1
(3) 1 : 1
(4) 9 : 7

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21. In ABO blood grouping 26. Which one of the following symbols used in
(1) Allele IA and IB do not produce any human pedigree analysis are correct and
sugar incorrect respectively?
(2) Allele i produces a slightly different
form of sugar (i) — Sex unspecified
(3) A total of four different genotype are
formed Consanguineous
(ii) —
(4) Individuals with AB blood group will mating
never have allele i
Affected parents
(iii) — with normal male
22. Starch synthesis in pea seeds (Pisum child
sativum) is controlled by one gene having
two alleles (B and b). For seed shape, the
gene shows dominance but for starch grain (iv) — Unaffected female
size the alleles show incomplete
dominance. Which of the following trait will
be seen with Bb genotypic combination in (1) (i) & (ii) are correct but (iii) & (iv) are
pea? incorrect
(1) Large starch grains (2) (i) & (iii) are correct but (ii) & (iv) are
incorrect
(2) Wrinkled seeds
(3) (i) & (iv) are incorrect but (ii) & (iii) are
(3) Small starch grains
correct
(4) Round seeds
(4) (i), (ii) & (iv) are correct but (iii) is
incorrect
23. When a cross between pink flowered and
red flowered Snapdragon plant is made, 27. Heterozygous round - yellow seeded pea
what ratio of Pink : Red phenotype could be
plants were self-crossed and total 1600
expected in the offspring?
seeds were collected. What will be the total
(1) 1 : 2 number of seeds with both homozygous
(2) 1 : 1 recessive traits?
(3) 3 : 1 (1) 600
(4) 2 : 1 (2) 100
(3) 300
24. According to Mendelian dihybrid cross, if a (4) 900
cross is made between TTBB and ttbb, the
nature of the F1 -generation will be 28. A male grasshopper
(1) Genotypically TTBB and phenotypically (1) Has same number of chromosomes as
similar to ttbb that in female grasshopper
(2) Genotypically ttbb and phenotypically (2) Produces a single type of gametes
similar to TTBB
(3) Produces two types of gametes which
(3) Genotypically TtBb and phenotypically differ in chromosome number
similar to TTBB
(4) Is homogametic
(4) Genotypically TtBB and phenotypically
similar to ttBb
29. Which of the following scientists used the
frequency of recombination between gene
25. A : Mendel conducted hybridisation pairs as a measure of the distance between
experiments on garden peas for seven years genes?
between 1856-1863.
(1) T.H. Morgan
R : Mendel selected 7-true breeding pea
plant varieties, as pairs which were similar (2) Alfred Sturtevant
except for one character with contrasting (3) Sutton and Boveri
traits. (4) Mendel
(1) Both Assertion & Reason are true and
the reason is the correct explanation of
the assertion 30. How many phenotypes and genotypes are
possible in the F2 -generation of a typical
(2) Both Assertion & Reason are true but
the reason is not the correct Mendelian dihybrid cross?
explanation of the assertion (1) 4 phenotypes and 6 genotypes
(3) Assertion is a true statement but (2) 9 phenotypes and 4 genotypes
Reason is false (3) 4 phenotypes and 9 genotypes
(4) Both Assertion and Reason are the (4) 6 phenotypes and 6 genotypes
false statements

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31. Select the correct option w.r.t. sex linked 38. Sterile females with rudimentary ovaries and
Mendelian disorder 44 + X0 genetic compliment suffer from
(1) Sickle cell anaemia (1) Turner's syndrome
(2) Thalassemia (2) Edward's syndrome
(3) Colour blindness (3) Klinefelter's syndrome
(4) Phenylketonuria (4) Down's syndrome

32. Mendel selected pea plant due to many 39. Which of the following cross in pea plant is
reasons. One of those reasons is that considered to be test cross?
(1) It completes its life cycle in one season (1) Rr × rr
(2) It produces few number of seeds (2) Tt × Tt
(3) No plants are true breeding (3) yy × yy
(4) Pea has little number of alternative (4) Rr × RR
traits
40. All the given statements regarding Mendel
33. Select the odd one w.r.t colour blindness are true, except
(1) Failure to discriminate between red (1) Mendel conducted hybridisation
and green colour experiments on garden pea for seven
(2) X-linked recessive years (1856-1863)
(3) It occurs in about 8 percent of males (2) For the first time he applied
mathematical logic and statistical
(4) It occurs in about 4% in female analysis to problems in Biology
(3) His experiments had a very small
34. All of the following were the reasons for use sampling size, which gave greater
of Drosophila as ideal material for genetic credibility to the data that he collected
studies, except (4) Mendel selected 14 true-breeding pea
(1) It can be grown in simple synthetic plant varieties as pairs which were
medium similar except for one character with
(2) Male is larger than female contrasting traits
(3) Easily observable hereditary variations
were present 41. A human male produces sperms with
(4) Single mating produces large number genotype AB and aB in equal proportion.
of progenies The corresponding genotype of that person
should be
(1) AaBb or Aabb
35. Offspring with blood group ‘O’ can not be
produced in cross (2) AaBB or AaBb
(1) A × A (3) AaBb only
(2) A × AB (4) AaBB only
(3) B × B
(4) A × B 42. In a family, father is having B blood group
and mother is of A blood group. If their
children show 50% probability of AB blood
36. Allosomic monosomy is seen in group, it indicates that
(1) Down’s syndrome (1) Both father and mother are
(2) Turner’s syndrome homozygous
(3) Klinefelter’s syndrome (2) Both mother and father are
(4) Edward syndrome heterozygous
(3) Either of the parent is heterozygous
37. Select the correct option w.r.t. multiple (4) Mother has a genotype IA IA and father
alleles of a gene. has genotype IA IB
(1) They affect different characters
(2) Show crossing over between 43. In sickle cell anemia glutamic acid is
themselves replaced by valine. Which of the following
(3) Can be found only when population codons code for glutamic acid and valine
studies are made respectively?
(4) Can be easily studied in an individual (1) GAG and GAA
(2) GAG and GAC
(3) GAG and GUG
(4) GUG and GAG

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44. Which among the given genotypes will 50. Select the incorrect statement w.r.t. typical
produce maximum number of different types test cross.
of gametes? (1) Progenies of such cross can be
(1) AaBbCC analysed to predict the genotype of the
(2) AABbCC test organism
(3) AaBBCc (2) Organism showing a dominant
phenotype is crossed with the
(4) AaBbCc recessive parent
(3) Organisms are self-crossed
45. Read the following statements and select (4) Genotypic ratio is for monohybrid test
the correct option cross will be 1 : 1
A : Presence of only two alleles of a gene is
called multiple allelism.
B : AB blood group in human is a good 51. Skin colour in human, an example of
example of co-dominance. ‘polygenic inheritance’ is controlled by
(1) Both A and B are incorrect (1) 7 pairs of genes
(2) A is correct but B is incorrect (2) 3 pairs of genes
(3) B is correct but A is incorrect (3) 12 pairs of genes
(4) Both A and B are correct (4) 8 pairs of genes

46. XO type of sex-determination in which the 52. Which one is not an autosomal recessive
males have only one X-chromosome disorder?
besides the autosomes whereas females (1) Thalassemia
have a pair of X-chromosomes is shown by
(2) Sickle cell anaemia
(1) Grasshopper
(3) Colourblindness
(2) Drosophila
(4) Phenylketonuria
(3) Humans
(4) Honey bees
53. Which trait is expressed in both homozygous
as well as heterozygous condition?
47. Linkage (1) Green pod
(1) Term was coined by Sutton and Boveri (2) Green seed
(2) Describes the generation of non- (3) Yellow pod
parental gene combinations
(4) Terminal flower
(3) Refers to physical association of genes
on same chromosomes
(4) Is 100% in genes located on different 54. If a colourblind man marries a colourblind
chromosomes woman, what is the probability of their sons
being colourblind?
(1) 25%
48. Four genes a, b, c and d are present on a
(2) 50%
chrosome. Percentage of recombination
between a and b = 20%; a and d = 2%, c (3) 75%
and b = 8% and d and b = 18%. Which of the (4) 100%
following will be the sequence of genes on
chromosome?
55. Match the Column-I with Column-II and
(1) adcb
select the correct option.
(2) cdab Column-I Column-II
(3) dcab Autosomal non- Klinefelter’s
(4) acbd a. (i)
disjunction syndrome
Allosomal non-
b. (ii) Down’s syndrome
49. ‘In any cross, if recombination frequency is disjunction
5%’, it means Flower colour in
c. Multiple allelism (iii)
(1) The distance between the observed Antirrhinum
genes is 5 cM Incomplete Human blood
d. (iv)
(2) Number of recombinants is 5 in 10 dominance group
progenies (1) a(ii), b(i), c(iv), d(iii)
(3) Their crossover value is 1/5 (2) a(iv), b(iii), c(i), d(ii)
(4) Out of total progeny produced, 5 are (3) a(i), b(ii), c(iii), d(iv)
parental types
(4) a(iii), b(iv), c(ii), d(i)

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56. Which one is not an autosomal recessive 61. Study the following pedigree chart and
disorder? choose the correct option regarding it.
(1) Thalassemia
(2) Sickle cell anaemia
(3) Colourblindness
(4) Phenylketonuria

57. Which among the given genotypes will

produce maximum number of different types
of gametes?
(1) AaBbCC (1) It is not applicable for an X-linked
(2) AABbCC recessive disorder
(3) AaBBCc (2) The genotype of A can be XCX
(4) AaBbCc (3) It shows inheritance of a Y-linked
disorder
58. Mark these statements as true (T) or false (F) (4) The genotype of B cannot be aa
and select the correct option.
A. Sickle cell anaemia is classical example 62. In a clinical diagnosis a female ‘A’ was
of frame-shift mutation. identified with absence of secondary sexual
B. Radiations can also act as mutagen. characters and has rudimentary ovaries.
C. Chromosomal aberrations are commonly Which of the given statements can be true
observed in cancer cells. for the female ‘A’?
ABC (1) The chromosome complement of the
(1) T T T female cannot be 44 + X0
(2) T F F (2) The female is suffering from a sex
(3) F T T recessive linked disorder
(4) F T F (3) Mother of this female may be producing
abnormal egg (22 + 0) and father
(1) (1) producing normal sperm (22 + X)
(2) (2) (4) This female may pass this disorder to
(3) (3) her daughters
(4) (4)
63. A pink flowered snapdragon plant is crossed
59. Study the pedigree chart given below. with a red flowered snapdragon plant. Each
individual of F1 generation is then crossed
with white flowered snapdragon plant. What
will be the percentage of plants bearing
white flowers in F2 generation?
(1) 25%
(2) 12.5%

The trait traced in above pedigree chart is (3) 50%

(1) X-linked dominant (4) 6.25%
(2) Y-linked
(3) Autosomal dominant 64.
(4) Autosomal recessive

60. Probability of three sons to a couple is

(1) 1 Above given pedigree chart can show
2

(2) 1 (1) X-linked recessive disorder

4
(2) Autosomal recessive disorder
(3) 1

8 (3) Autosomal dominant disorder

(4) 1 (4) Both (1) and (2)
16

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65. Study the pedigree chart given below and 68.

choose the correct option

Above pedigree chart is true for

a. X-linked recessive inheritance
(1) This shows inheritance of myotonic b. Autosomal recessive inheritance
dystrophy c. Autosomal dominant inheritance
(1) Only a
(2) The genotype of II(F) is Aa
(2) a and b
(3) This shows the inheritance of a
disorder like haemophilia (3) b and c
(4) This can be a Y linked disorder (4) Only b

66. Match the column I with column II and select 69. Choose the correct option regarding the
the correct option. given pedigree
Column I Column II
a. Pleiotropy (i) Human skin
colour
b. Polygenic (ii) Phenylketonuria
inheritance
c. Incomplete (iii) Blood group
dominance ‘ABO’
d. Co- (iv) Gene for starch
dominance grain size in
pea
(1) a(ii), b(i), c(iv), d(iii) (1) This shows autosomal dominant
(2) a(iv), b(iii), c(ii), d(i) disorder
(3) a(iii), b(iv), c(ii), d(i) (2) The genotype of II (Q) is XCX

(4) a(ii), b(iii), c(iv), d(i) (3) The I(R) female is homozygous for the
disorder
(4) The genotype of II(P) is XCXC
67. Examine the pedigree chart given below.

70. Consider the following pedigree chart.

Which of the given disorders is not

applicable in above pedigree. What should be the symbols at the place of
(1) Myotonic dystrophy ‘?’ so that the pedigree may justify the
inheritance of genetic disorders like
(2) Cystic fibrosis
haemophilia?
(3) Sickle cell anaemia (1)
(4) Haemophilia
(2)

(3)

(4)

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71. Study the given pedigree chart and select 73. Examine the pedigree chart given below.
the correct option regarding it.

(1) The trait shown in above pedigree is Which of the given disorders is not
haemophilia applicable in above pedigree.
(2) The genotype of affected female in II (1) Myotonic dystrophy
generation can be aa or Aa (2) Cystic fibrosis
(3) In first generation male cannot be (3) Sickle cell anaemia
carrier for the trait (4) Haemophilia
(4) Gene for above given trait is found in
females only
74. If a character is controlled by four alleles of a
gene, then the possible genotype would be
72. (1) 6
(2) 10
(3) 81
(4) 4

Above pedigree chart is true for

a. X-linked recessive inheritance
b. Autosomal recessive inheritance
c. Autosomal dominant inheritance
(1) Only a
(2) a and b
(3) b and c
(4) Only b