LIVER & BILIARY TRACT
1. Causes of unconjugated hyperbilirubinemia include:
A. Cholelithiasis
B. Oral contraceptive pill
C. Gilbert's syndrome
D. Primary biliary cirrhosis
E. Rotor's syndrome
2. Jaundice becomes clinically evident with serum bilirubin level above:
A. 0.5- 1.0 mg/dL
B. 1.0-1.5 mg/dL
C. 1.5-2.0 mg/dL
D. 2.0-2.5 mg/dL
E. All of the above
3. Conjugated bilirubin is:
A. toxic to neonatal brain
B. is not bound to serum albumin
C. is insoluble in aqueous solution
D. is not filtered at the kidney
E. All of the above
4. The following tissue has yellow-green discoloration in jaundice EXCEPT:
A. skin
B. brain
C. liver
D. kidney
E. heart
5. Which is the least common cause of viral hepatitis?
A. hepatitis B
B. hepatitis E
C. Epstein barr virus
D. Cytomegalovirus
E. Adenovirus
6. Which of the following is a DNA virus?
A. Hepatitis A virus
B. Hepatitis B virus
C. Hepatitis C virus
D. Hepatitis D virus
E. Hepatitis E virus
PATHOLOGY - LIVER - MCQ
7. Hepatitis B is:
A. causes by picornavirus
B. spread by fecal-oral route
C. has incubation period of 30-180 days
D. > 50% develops chronic hepatitis
E. fulminant hepatits occurs in up to 10% cases
8. Hepatitis viruses:
A. HAVdoes not cause fulminant hepatitis
B. HAVhas longer incubation period than HCV
C. HCVis the leading cause of chronic hepatitis worldwide
D. HDVsuperinfection is more common than coinfection with HBV
E. Only HBVinfection wi11lead to hepatocellular carcinoma
9. Which of the following statement regarding HAVis FALSE?
A. It accounts for 25% of hepatitis worldwide
B. It replicates in & is released after damaging the hepatic cells
C. It is shed in stool for 2 weeks before & 1 week after onset of jaundice
D. The marker of acute infection is anti-HAVIgM
E. Anti HAVIgG persists for life & confers immunity.
10. Hepatitis B virus is most commonly manifest as:
A. subclinical infection
B. acute hepatitis
C. chronic carrier state
D. chronic active hepatitis
E. fulminant hepatitis
1 1. Hepatitis B virus is found in the following except:
A. saliva
B. serum
C. unne
D. stool
E. tears
12. Which of the following is a marker of recent acute HBVinfection?
A. AntiHBs Antibody (IgG)
B. HBc Ag
C. HBVDNA
D. HbsAg
E. Anti HbcAntibody (IgM)
PATHOLOGY - LIVER - MCQ 2
13. Lowest risk of HCVtransmission is via the following route:
A. direct inoculation
B. blood transfusion
C. vertical transmission
D. sexual transmission
E. all are equally high risk situation
14. Which of the following regarding hepatitis C virus is FALSE?
A. Incubation period is 2-26 weeks
B. HCVRNA persists in> 90% patients with chronic disease
C. Anti-HCVAb (IgG) is protective against re-infection
D. 50% patients with undiagnosed cirrhosis is due to HCVinfection
E. Infection with HCVis characterized by episodic l'AST.
15. Which of the following statement regarding carrier state in viral hepatitis is FALSE?
A. It occurs in HAV, HBV& HCVinfection
B. It is a reservoir of the infection
C. It is more common in vertical transmission of HBVthan in adult HBVinfection
D. Liver biopsy is essentially normal
E. Patient is usually symptom free
16. Which of the following is NOT a symptom of pre-icteric phase of viral hepatitis?
A. malaise, anorexia & weight loss
B. tender hepatomegaly
C. steatorrhoea
D. pruritis
E. all of the above
17. Which of the following is NOT raised in acute viral hepatitis?
A. bilirubin
B. INR
C. ALP
D. Albumin
E. All of the above
18. Causes of chronic hepatitis include the following EX CEPT:
A. Wilson's disease
B. Rotor's syndrome
C. alantiytrypsin deficiency
D. autoimmune hepatitis
E. chronic alcoholism
PATHOLOGY - LIVER - MCQ 3
19. The following drugs induce chronic hepatitis:
A. methotrexate
B. a methyldopa
C. isoniazid
D. all of the above
E. none of the above
20. Which of the following statement regarding chronic hepatitis is FALSE?
A. fatty change in the liver is seen in HCV but not in HBV chronic hepatitis
B. cirrhosis takes> 1Oyears to develop from the onset of viral infection
C. chronic hepatitis is common in acute HBV & HDV co-infection
D. prognosis of chronic hepatitis is ultimately determined by aetiology of hepatitis
E. over 90% of neonates infected with HBV will ultimately develop chronic hepatitis
2 1. Autoimmune hepatitis is associated with:
A. rheumatoid arthritis
B. Sjogren's syndrome
C. Ulcerative colitis
D. Autoimmune thyroiditis
E. All of the above
22. In hepatic failure, there is:
A. predominantly unconjugated hyperbilirubinemia
B. fetor hepaticus is not a constant feature
C. reduced factor II, V VII, IX & X is due to vitamin K malabsorption
D. DIC occurs in hepatic failure due to reduction in clotting factors
E. Spider naevi is due to defective urea cycle
23. In hepatic failure, the following occur due to hyperoestrogenism:
A. palmar erythema
B. spider naevi
C. testicular atrophy
D. all of the above
E. none of the above
24. Most common cause of cirrhosis in Western countries is:
A. alcoholic liver disease
B. viral hepatitis
C. hemachromatosis
D. Wilson's disease
E. Cryptogenic liver disease
PATHOLOGY - LIVER - MCQ 4
ANSWERS:
1. C
2. D
3. B
4. B
5. E
6. B
7. C
8. C
9. B
10. A
1 1. D
12. E
13. D
14. C
15. A
16. A
17. D
18. B
19. D
20. C
2 1. E
22. B
23. D
24. A
PATHOLOGY - LIVER - MCQ 5
