Part D
Dr Chris Gordon
● 1)McGhie, B., Sakoff, J., Gilbert, J., Gordon, C. and
Aldrich-Wright, J. (2023), 'Synthesis and characterisation
of fluorescent novel pt(II) cyclometallated complexes
with anticancer activity', International Journal of
Molecular Sciences, vol 24, no
● 2)Tadros, J., Dankers, C., Jurisinec, A., Menti-Platten,
M., Aldrich-Wright, J. and Gordon, C. (2022), 'A
comparison of immobilised triphenylphosphine and 1-
hydroxybenzotriazole as mediators of catch-and-release
acylation under flow conditions', Chemistry: An Asian
Journal, vol 17, no 5
● 3)Dalton, N., Gordon, C. P., Boyle, T. P., Vandegraaf, N.,
Deadman, J., Rhodes, D., Coates, J., Pyne, S. G., Keller, P.
A., & Bremner, J. B. (2016). The discovery of allyltyrosine
based tripeptides as selective inhibitors of the HIV-1
integrase strand-transfer reaction. Organic and Biomolecular
Chemistry, 14(25), 6010–6023.
https://doi.org/10.1039/c6ob00950f
From the given examples a lot of Dr Chris Gordon’s work has
been primarily focused on medical applications of chemistry.
Where a strong understanding of organic and inorganic
chemistry has allowed him to focus on intricatel molecular and
chemical mechanisms with human cells.
In his work with(1) HIV integrase inhibitors he helped
undertake a structural relationship study (SAR) of O-allyl
tyrosine-based tripeptide to identify specific regions within the
antimicrobial peptide that have inhibiting characteristics
against HIV molecular pathways. Other work with (3) Dr
McGhie focused on medicinal applications of chemistry as
they tested the effectiveness of cytomettaled complexes
toxicity and selectivity against cancer cell batches.
Other work with (2) Dr Tadros, Dr Gordon has participated in
was his work on developing continuous flow chemistry. Where
reactants are pumped into a reaction chamber to catalyze a
reaction. This application allows chemists to optimize, iterate
or go about synthesizing novel compounds in unique ways.
In this paper has medication applications.
Dr Gordon’s work does not directly derive or contribute to
indigenous culture. He could possibly use naturally sourced
compounds from indigenous knowledge to help synthesize
novel compounds with anti-cancer or anti-pathological
characteristics. His work also allows indigenous peoples to
fight chronic diseases such as cancer to keep their culture
alive.
● 4)Raposo, A. and Piller, S. (2018), 'Protein arginine
methylation : an emerging regulator of the cell cycle',
Cell Division, vol 13, no 1 .
Dr Sabine Piller has done important work previously
regarding (4) PRMTS and arginine methylation. Her
understanding of Specifically designed chemical inhibitors
can prevent upregulated proteins known as S-adenosyl-L-
methionine (SAMs) from methylating Arginine amino acids
within proteins that change their behavior and incorrectly
regulate their function. This can cause a multitude of chronic
diseases such as cancer. Proper understanding of this field
may be a lynchpin moment in creating a multitude effective
drugs for a plethora of chronic diseases.
