MATERIAL SAFETY DATA SHEET

SECTION 1: IDENTIFICATION OF THE SUBSTANCE/MIXTURE AND OF THE COMPANY/UNDERTAKING

1.1 Product Identifiers

Product Name Curcumin

Brand MP Biomedicals India Pvt Ltd
REACH No NA
CAS-NO 458-37-7

1.2 Relevant identified uses of the substance or mixture and uses advised against

Identified uses Laboratory chemicals, Manufacture of substances

1.3 Details of the supplier of the safety data sheet
Company MP Biomedicals India Pvt Ltd., Inc. Plot no.C-57/3, TTC
Industrial area,
Pawane Village, Near Mayur Cold Storage Turbhe, Navi Mumbai
– 400 705 INDIA
www.mpbio.com
1.4 Emergency telephone
022-27636921/22/24/25
SECTION 2: HAZARS IDENTIFICATION
2.1 Classification of Substance or Mixture
Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

2.2 Label elements

Not a hazardous substance or mixture according to Regulation (EC) No 1272/2008.

2.3 Other Hazards

This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB) at
levels of 0.1% or higher.
SECTION 3: COMPOSITION /INFORMATION ON INGREDIANTS

3.1 Substances
Synonyms Natural Yellow 3
(E,E)-1,7-bis(4-Hydroxy-3-methoxyphenyl)-1,6-heptadiene- 3,5-dione
Diferulylmethane
Diferuloylmethane
Formula C21H20O6
Molecular weight 368,38 g/mol

CAS-No. 458-37-7

EC-No. 207-280-5

SECTION 4: FIRST AID MEASURES

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4.1 Description and First Aid Measures
If inhaled
After inhalation: fresh air.
In case of skin contact
In case of skin contact: Take off immediately all contaminated clothing. Rinse skin with
water/ shower.
In case of eye contact
After eye contact: rinse out with plenty of water. Remove contact lenses.
If swallowed
After swallowing: make victim drink water (two glasses at most). Consult doctor if feeling
unwell.
4.2 Most important symptoms and effects, both acute and delayed
The most important known symptoms and effects are described in the labelling (see section
2.2) and/or in section 11
4.3 Indication of any immediate medical attention and special treatment needed
No data available

SECTION 5: FIREFIGHTING MEASURES

5.1 Extinguishing media
Suitable extinguishing media
Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide.
5.2 Special hazards arising from the substance or mixture
Carbon oxides
Combustible.
Development of hazardous combustion gases or vapours possible in the event of fire.
5.3 Advice for firefighters
In the event of fire, wear self-contained breathing apparatus.
5.4 Further Information
Prevent fire extinguishing water from contaminating surface water or the ground water
system.
SECTION 6: ACCIDENTAL RELEASE MEASURES
6.1 Personal precautions, protective equipment, and emergency procedure
Advice for non-emergency personnel: Avoid inhalation of dusts. Avoid substance contact.
Ensure adequate ventilation. Evacuate the danger area, observe emergency procedures,
consult an expert.
For personal protection see section 8.
6.2 Environmental precautions
Do not let product enter drains.
6.3 Methods and materials for containment and cleaning up
Cover drains. Collect, bind, and pump off spills. Observe possible material restrictions (see
sections 7 and 10). Take up dry. Dispose of properly. Clean up affected area. Avoid
generation of dusts.
6.4 Reference to other sections
For disposal see section 13.
SECTION 7: HANDLING AND STORAGE
7.1 Precautions for safe handling
For precautions see section 2.2.
7.2 Conditions for safe storage, including any incompatibilitie
Storage Condition
Tightly closed. Dry
Recommended storage temperature -20 °C
Store Class
Storage class (TRGS 510): 11: Combustible Solids

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7.3 Specific end use(s)
Apart from the uses mentioned in section 1.2 no other specific uses are stipulated
SECTION 8: EXPOSURE CONTROLS/PERSONAL PROTECTION
8.1 Control parameters
Ingredients with workplace control parameter
8.2 Exposure controls
Personal Protective Equipment
Eye/face protection
Use equipment for eye protection tested and approved under appropriate government
standards such as NIOSH (US) or EN 166(EU). Tightly fitting safety goggles
Skin protection
This recommendation applies only to the product stated in the safety data sheet,
supplied by us and for the designated use. When dissolving in or mixing with other
substances and under conditions deviating from those stated in EN374 please
contact the supplier of CE-approved gloves (e.g. KCL GmbH, D-36124 Eichenzell,
Internet: www.kcl.de).
Full contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested: KCL 741 Dermatril® L
This recommendation applies only to the product stated in the safety data sheet, supplied
by us and for the designated use. When dissolving in or mixing with other substances and
under conditions deviating from those stated in EN374 please contact the supplier of CE-
approved gloves (e.g. KCL GmbH, D-36124 Eichenzell, Internet: www.kcl.de).
Splash contact
Material: Nitrile rubber
Minimum layer thickness: 0,11 mm
Break through time: 480 min
Material tested:KCL 741 Dermatril® L
Respiratory protection
Where risk assessment shows air-purifying respirators are appropriate use a dust mask
type N95 (US) or type P1 (EN 143) respirator. Use respirators and components tested
and approved under appropriate government standards such as NIOSH (US) or CEN
(EU).
Control of environmental exposure
Do not let product enter drains.
SECTION 9: PHYSICAL AND CHEMICAL PROPERTIES
9.1 Information on basic physical and chemical properties
a) Physical State powder
b) Color No data available
c) Odor No data available
d) Melting Melting point: 183 °C
point/freezing
point
e) Initial boiling No data available
point and boiling
range
f) Flammability No data available
(solid, gas)
g) Upper/lower No data available
flammability or
explosive limit
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 h) Flash point Not applicable
i) Autoignition No data available
temperature
j) Decomposition No data available
temperature
k) pH No data available

l) Viscosity Viscosity, kinematic: No data available

Viscosity, dynamic: No data available
m) Water solubility No data available

n) Partition No data available

coefficient: n-
octanol/water

o) Vapor pressure No data available

p) Density No data available
q) Relative Vapor No data available
density
r) Particle No data available
Characteristics
s) Explosive No data available
properties
t) Oxidizing None
properties

9.2 Other Safety Information

Relative vapor density 12,72 - (Air = 1.0)

SECTION 10: STABILITY AND REACTIVITY

10.1 Reactivity
The following applies in general to flammable organic substances and mixtures: in
correspondingly fine distribution, when whirled up a dust explosion potential may
generally be assumed.
10.2 Chemical stability
The product is chemically stable under standard ambient conditions (room temperature) .
10.3 Possibility of hazardous reactions
Violent reactions possible with:
Strong oxidizing agents
10.4 Conditions to avoid
no information available
10.5 Incompatible material
No data available
10.6 Hazardous decomposition product
In the event of fire: see section 5
SECTION 11: TOXICOLOGICAL INFORMATION
11.1 Information on toxicological effects
Acute toxicity
LD50 Oral - Rat - 12.200 mg/kg
Remarks: (RTECS)
Inhalation: No data available

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 Dermal: No data available
Skin corrosion/irritation
No data available
Serious eye damage/eye irritation
No data available
Respiratory or skin sensitization
No data available
Germ cell mutagenicity
Test Type: Ames test
Test system: Salmonella typhimurium
Result: negative
Remarks: (National Toxicology Program)
Carcinogenicity
No data available
Reproductive toxicity
No data available
Specific target organ toxicity - single exposure
No data available
Specific target organ toxicity - repeated exposure
No data available
Aspiration hazard
No data available
11.2 Additional Information
RTECS: MI5230000
To the best of our knowledge, the chemical, physical, and toxicological properties have not
been thoroughly investigated.
SECTION 12: TOXICOLOGICAL INFORMATION
12.1 Toxicity
No data available
12.2 Persistence and degradability
No data available
12.3 Bioaccumulative potential
No data available
12.4 Mobility in soil
No data available
12.5 Results of PBT and vPvB assessment
This substance/mixture contains no components considered to be either persistent,
bioaccumulative and toxic (PBT), or very persistent and very bioaccumulative (vPvB)
at levels of 0.1% or higher.
12.6 Endocrine disrupting properties
No data available
12.7 Other adverse effects
No data available
SECTION 13: DISPOSAL CONSIDERATION
13.1 WASTE TREEATMENTMETHODS
No data available
SECTION 14: TRANSPORT INFORMATION
14.1 UN number
ADR/RID: - IMDG: - IATA: -
14.2 UN proper shipping name
ADR/RID: Not dangerous goods
IMDG: Not dangerous goods
IATA Not dangerous goods

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14.3 Transport hazard class(es)
ADR/RID: - IMDG: - IATA: -
14.4 Packaging group
ADR/RID: - IMDG: - IATA: -
14.5 Environmental hazard
ADR/RID: no IMDG Marine pollutant: no IATA: no
14.6 Special precautions for user
No data available
Further information
Not classified as dangerous in the meaning of transport regulations.
SECTION 15: REGULATORY INFORMATION
15.1 Safety, health and environmental regulations/legislation specific for the
substance or mixture
This material safety data sheet complies with the requirements of Regulation (EC) No.
1907/2006.
15.2 Chemical Safety Assessment
For this product a chemical safety assessment was not carried out
SECTION 16: OTHER INFORMATION
Full text of other abbreviations
ADN - European Agreement concerning the International Carriage of Dangerous Goods
by Inland Waterways; ADR - Agreement concerning the International Carriage of
Dangerous Goods by Road; AIIC - Australian Inventory of Industrial Chemicals;
ASTM - American Society for the Testing of Materials; bw - Body weight; CMR -
Carcinogen, Mutagen or Reproductive Toxicant; DIN - Standard of the German
Institute for Standardisation; DSL - Domestic Substances List (Canada); ECx -
Concentration associated with x% response; ELx - Loading rate associated with x%
response; EmS - Emergency Schedule; ENCS - Existing and New Chemical Substances
(Japan); ErCx - Concentration associated with x% growth rate response; GHS -
Globally Harmonized System; GLP - Good Laboratory Practice; IARC - International
Agency for Research on Cancer; IATA - International Air Transport Association; IBC -
International Code for the Construction and Equipment of Ships carrying Dangerous
Chemicals in Bulk; IC50 - Half maximal inhibitory concentration; ICAO - International
Civil Aviation Organization; IECSC - Inventory of Existing Chemical Substances in
China; IMDG - International Maritime Dangerous Goods; IMO - International Maritime
Organization; ISHL - Industrial Safety and Health Law (Japan); ISO - International
Organisation for Standardization; KECI - Korea Existing Chemicals Inventory; LC50 -
Lethal Concentration to 50 % of a test population; LD50 - Lethal Dose to 50% of a test
population (Median Lethal Dose); MARPOL - International Convention for the
Prevention of Pollution from Ships; n.o.s. - Not Otherwise Specified; NO(A)EC - No
Observed (Adverse) Effect Concentration; NO(A)EL - No Observed (Adverse) Effect
Level; NOELR - No Observable Effect Loading Rate; NZIoC - New Zealand Inventory
of Chemicals; OECD - Organization for Economic Co-operation and Development;
OPPTS - Office of Chemical Safety and Pollution Prevention; PBT - Persistent,
Bioaccumulative and Toxic substance; PICCS - Philippines Inventory of Chemicals and
Chemical Substances; (Q)SAR - (Quantitative) Structure Activity Relationship;
REACH - Regulation (EC) No 1907/2006 of the European Parliament and of the
Council concerning the Registration, Evaluation, Authorisation and Restriction of
Chemicals; RID - Regulations concerning the International Carriage of Dangerous
Goods by Rail; SADT - Self-Accelerating Decomposition Temperature; SDS - Safety
Data Sheet; TCSI - Taiwan Chemical Substance Inventory; TECI - Thailand Existing
Chemicals Inventory; TSCA - Toxic Substances Control Act (United States); UN
- United Nations; UNRTDG - United Nations Recommendations on the Transport of
Dangerous Goods; vPvB - Very Persistent and Very Bioaccumulative

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