SAFETY DATA SHEET

Creation Date 02-Nov-2009 Revision Date 31-Jan-2025 Revision Number 10

1. Identification
Product Name Formic acid, OPTIMA LC/MS Grade (99.5%)

Cat No. : A117-50; A117-10X1AMP; A117-1AMP; A117-05AMP; A117-2AMP;

NC1450425; XXA117100ML; NC1484204; XXA1171LI; XXA117FSC1LI;
NC3453457
CAS No 64-18-6
Synonyms Methanoic acid; FA (OPTIMA LC/MS)

Recommended Use Laboratory chemicals.

Uses advised against Food, drug, pesticide or biocidal product use.

Details of the supplier of the safety data sheet

Company
Fisher Scientific Company
One Reagent Lane
Fair Lawn, NJ 07410
Tel: (201) 796-7100

Emergency Telephone Number

CHEMTRECÒ, Inside the USA: 800-424-9300
CHEMTRECÒ, Outside the USA: 001-703-527-3887

2. Hazard(s) identification
Classification
This chemical is considered hazardous by the 2012 OSHA Hazard Communication Standard (29 CFR 1910.1200)

Flammable liquids Category 3

Acute oral toxicity Category 4
Acute Inhalation Toxicity - Vapors Category 3
Skin Corrosion/Irritation Category 1 A
Serious Eye Damage/Eye Irritation Category 1

Label Elements

Signal Word
Danger

Hazard Statements

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Flammable liquid and vapor

Harmful if swallowed
Causes severe skin burns and eye damage
Toxic if inhaled

Precautionary Statements
Prevention
Wash face, hands and any exposed skin thoroughly after handling
Do not eat, drink or smoke when using this product
Use only outdoors or in a well-ventilated area
Do not breathe dust/fume/gas/mist/vapors/spray
Wear protective gloves/protective clothing/eye protection/face protection
Keep away from heat/sparks/open flames/hot surfaces. - No smoking
Keep container tightly closed
Ground/bond container and receiving equipment
Use explosion-proof electrical/ventilating/lighting equipment
Use only non-sparking tools
Take precautionary measures against static discharge
Keep cool
Wear respiratory protection
Response
Immediately call a POISON CENTER or doctor/physician
Inhalation
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing
Immediately call a POISON CENTER or doctor/physician
Skin
IF ON SKIN (or hair): Take off immediately all contaminated clothing. Rinse skin with water/shower
Wash contaminated clothing before reuse
Eyes
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing
Ingestion
Rinse mouth
Do NOT induce vomiting
Fire
In case of fire: Use CO2, dry chemical, or foam for extinction
Storage
Store in a well-ventilated place. Keep container tightly closed
Store locked up
Disposal
Dispose of contents/container to an approved waste disposal plant
Hazards not otherwise classified (HNOC)
Corrosive to the respiratory tract

3. Composition/information on Ingredients
Component CAS No Weight %
Formic acid 64-18-6 >95

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4. First-aid measures
General Advice Immediate medical attention is required. Show this safety data sheet to the doctor in
attendance.

Eye Contact In the case of contact with eyes, rinse immediately with plenty of water and seek medical
advice.

Skin Contact Wash off immediately with plenty of water for at least 15 minutes. Immediate medical
attention is required.

Inhalation Do not use mouth-to-mouth method if victim ingested or inhaled the substance; give
artificial respiration with the aid of a pocket mask equipped with a one-way valve or other
proper respiratory medical device. Remove to fresh air. Immediate medical attention is
required. If not breathing, give artificial respiration.

Ingestion Do NOT induce vomiting. Call a physician or poison control center immediately.

Most important symptoms and Difficulty in breathing. Causes burns by all exposure routes. Symptoms of overexposure
effects may be headache, dizziness, tiredness, nausea and vomiting: Product is a corrosive
material. Use of gastric lavage or emesis is contraindicated. Possible perforation of
stomach or esophagus should be investigated: Ingestion causes severe swelling, severe
damage to the delicate tissue and danger of perforation
Notes to Physician Treat symptomatically

5. Fire-fighting measures

Suitable Extinguishing Media Water spray, carbon dioxide (CO2), dry chemical, alcohol-resistant foam. Water mist may
be used to cool closed containers.

Unsuitable Extinguishing Media No information available

Flash Point 50 °C / 122 °F

Method - No information available

Autoignition Temperature 520 °C / 968 °F

Explosion Limits
Upper 45 vol %
Lower 10 vol %
Sensitivity to Mechanical Impact No information available
Sensitivity to Static Discharge No information available

Specific Hazards Arising from the Chemical

Flammable. Risk of ignition. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back.
Containers may explode when heated.

Hazardous Combustion Products

Carbon monoxide (CO). Carbon dioxide (CO2). Hydrogen. Thermal decomposition can lead to release of irritating gases and
vapors.
Protective Equipment and Precautions for Firefighters
As in any fire, wear self-contained breathing apparatus pressure-demand, MSHA/NIOSH (approved or equivalent) and full
protective gear. Thermal decomposition can lead to release of irritating gases and vapors.

NFPA
Health Flammability Instability Physical hazards
3 2 1 N/A

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6. Accidental release measures

Personal Precautions Use personal protective equipment as required. Evacuate personnel to safe areas. Keep
people away from and upwind of spill/leak. Ensure adequate ventilation. Remove all
sources of ignition. Take precautionary measures against static discharges.
Environmental Precautions Should not be released into the environment. Do not flush into surface water or sanitary
sewer system. See Section 12 for additional Ecological Information.

Methods for Containment and Clean Soak up with inert absorbent material. Keep in suitable, closed containers for disposal.
Up Remove all sources of ignition. Use spark-proof tools and explosion-proof equipment.

7. Handling and Storage

Handling Use only under a chemical fume hood. Wear personal protective equipment/face protection.
Do not get in eyes, on skin, or on clothing. Do not breathe mist/vapors/spray. Do not ingest.
If swallowed then seek immediate medical assistance. Keep away from open flames, hot
surfaces and sources of ignition. Use only non-sparking tools. Take precautionary
measures against static discharges.

Storage. Keep containers tightly closed in a dry, cool and well-ventilated place. Corrosives area.
Keep away from heat, sparks and flame. Containers should be vented periodically in order
to overcome pressure buildup. Incompatible Materials. Strong oxidizing agents. Metals.
Finely powdered metals. Strong bases.

8. Exposure controls / personal protection

Exposure Guidelines

Component ACGIH TLV OSHA PEL NIOSH Mexico OEL (TWA)

Formic acid TWA: 5 ppm (Vacated) TWA: 5 ppm IDLH: 30 ppm TWA: 5 ppm
STEL: 10 ppm (Vacated) TWA: 9 mg/m3 TWA: 5 ppm TWA: 9 mg/m3
TWA: 5 ppm TWA: 9 mg/m3
TWA: 9 mg/m3

Legend

ACGIH - American Conference of Governmental Industrial Hygienists

OSHA - Occupational Safety and Health Administration
NIOSH: NIOSH - National Institute for Occupational Safety and Health

Engineering Measures Use only under a chemical fume hood. Ensure that eyewash stations and safety showers
are close to the workstation location. Use explosion-proof electrical/ventilating/lighting
equipment. Ensure adequate ventilation, especially in confined areas.

Personal Protective Equipment

Eye/face Protection Wear appropriate protective eyeglasses or chemical safety goggles as described by
OSHA's eye and face protection regulations in 29 CFR 1910.133 or European Standard
EN166. Tight sealing safety goggles. Face protection shield.

Skin and body protection Chemical resistant apron. Boots. Chemical protection suit (EN 14605).

Respiratory Protection Follow the OSHA respirator regulations found in 29 CFR 1910.134 or European Standard
EN 149. Use a NIOSH/MSHA or European Standard EN 149 approved respirator if
exposure limits are exceeded or if irritation or other symptoms are experienced.

Recommended Filter type: Particulates filter conforming to EN 143. Acid gases filter. Type E. Yellow. conforming to
EN14387.

Hygiene Measures Handle in accordance with good industrial hygiene and safety practice.

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9. Physical and chemical properties

Physical State Liquid
Appearance Colorless
Odor pungent
Odor Threshold No information available
pH 2.1 10 g/L aq.sol
Melting Point/Range 8 °C / 46.4 °F
Boiling Point/Range 101 °C / 213.8 °F @ 760 mmHg
Flash Point 50 °C / 122 °F
Evaporation Rate No information available
Flammability (solid,gas) Not applicable
Flammability or explosive limits
Upper 45 vol %
Lower 10 vol %
Vapor Pressure 44 mbar @ 20 °C
Vapor Density No information available
Specific Gravity 1.220
Solubility miscible
Partition coefficient; n-octanol/water No data available
Autoignition Temperature 520 °C / 968 °F
Decomposition Temperature No information available
Viscosity 1.47 mPa.s @ 20 °C
Molecular Formula C H2 O2
Molecular Weight 46.02

10. Stability and reactivity

Reactive Hazard None known, based on information available

Stability Strong reducing agent. Fire and explosion risk in contact with oxidizing agents.
Hygroscopic. heat sensitive. Decomposes to water and carbon dioxide.

Conditions to Avoid Incompatible products. Excess heat. Keep away from open flames, hot surfaces and
sources of ignition. Exposure to moist air or water.

Incompatible Materials Strong oxidizing agents, Metals, Finely powdered metals, Strong bases

Hazardous Decomposition Products Carbon monoxide (CO), Carbon dioxide (CO2), Hydrogen, Thermal decomposition can lead
to release of irritating gases and vapors

Hazardous Polymerization Hazardous polymerization does not occur.

Hazardous Reactions None under normal processing.

11. Toxicological information

Acute Toxicity

Product Information
Oral LD50 Category 4.
Dermal LD50 Based on ATE data, the classification criteria are not met.
Vapor LC50 Category 3.
Component Information
Component LD50 Oral LD50 Dermal LC50 Inhalation
Formic acid 730 mg/kg ( Rat ) Not listed 7.85 mg/l (Rat) 4h OECD 403
Toxicologically Synergistic No information available
Products
Delayed and immediate effects as well as chronic effects from short and long-term exposure

Irritation Causes severe burns by all exposure routes Irritating to respiratory system

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Sensitization No information available

Carcinogenicity The table below indicates whether each agency has listed any ingredient as a carcinogen.

Component CAS No IARC NTP ACGIH OSHA Mexico

Formic acid 64-18-6 Not listed Not listed Not listed Not listed Not listed
Mutagenic Effects No information available

Reproductive Effects No information available.

Developmental Effects No information available.

Teratogenicity No information available.

STOT - single exposure None known

STOT - repeated exposure None known

Aspiration hazard No information available

Symptoms / effects,both acute and Symptoms of overexposure may be headache, dizziness, tiredness, nausea and vomiting:
delayed Product is a corrosive material. Use of gastric lavage or emesis is contraindicated.
Possible perforation of stomach or esophagus should be investigated: Ingestion causes
severe swelling, severe damage to the delicate tissue and danger of perforation

Endocrine Disruptor Information No information available

Component EU - Endocrine Disrupters EU - Endocrine Disruptors - Japan - Endocrine Disruptor

Candidate List Evaluated Substances Information
Formic acid Applicable Not applicable Not applicable
Other Adverse Effects The toxicological properties have not been fully investigated.

12. Ecological information

Ecotoxicity
Contains a substance which is:. Harmful to aquatic organisms. The product contains following substances which are hazardous for
the environment.

Component Freshwater Algae Freshwater Fish Microtox Water Flea

Formic acid EC50 = 25 mg/L/96h Leuciscus idus: LC50 = EC50 = 46.7 mg/L/17h EC50 = 34 mg/L/48h
46-100 mg/L/96h
Persistence and Degradability Miscible with water Persistence is unlikely based on information available.

Bioaccumulation/ Accumulation No information available.

Mobility . Will likely be mobile in the environment due to its water solubility.

Component log Pow

Formic acid -0.54

13. Disposal considerations

Waste Disposal Methods Chemical waste generators must determine whether a discarded chemical is classified as a
hazardous waste. Chemical waste generators must also consult local, regional, and
national hazardous waste regulations to ensure complete and accurate classification.

Component RCRA - U Series Wastes RCRA - P Series Wastes

Formic acid - 64-18-6 U123 -

14. Transport information

DOT

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UN-No UN1779
Proper Shipping Name FORMIC ACID
Hazard Class 8
Subsidiary Hazard Class 3
Packing Group II
TDG
UN-No UN1779
Proper Shipping Name FORMIC ACID
Hazard Class 8
Subsidiary Hazard Class 3
Packing Group II
IATA
UN-No UN1779
Proper Shipping Name FORMIC ACID
Hazard Class 8
Subsidiary Hazard Class 3
Packing Group II
IMDG/IMO
UN-No UN1779
Proper Shipping Name FORMIC ACID
Hazard Class 8
Subsidiary Hazard Class 3
Packing Group II
15. Regulatory Information
United States of America Inventory

Component CAS No TSCA TSCA Inventory notification - TSCA - EPA Regulatory

Active-Inactive Flags
Formic acid 64-18-6 X ACTIVE -

Legend:
TSCA US EPA (TSCA) - Toxic Substances Control Act, (40 CFR Part 710)
X - Listed
'-' - Not Listed

TSCA - Per 40 CFR 751, Regulation of Certain Chemical Not applicable

Substances & Mixtures, Under TSCA Section 6(h) (PBT)

TSCA 12(b) - Notices of Export Not applicable

International Inventories
Canada (DSL/NDSL), Europe (EINECS/ELINCS/NLP), Philippines (PICCS), Japan (ENCS), Japan (ISHL), Australia (AICS), China (IECSC), Korea
(KECL).

Component CAS No DSL NDSL EINECS PICCS ENCS ISHL AICS IECSC KECL
Formic acid 64-18-6 X - 200-579-1 X X X X X X

KECL - NIER number or KE number (http://ncis.nier.go.kr/en/main.do)

U.S. Federal Regulations

SARA 313
Section 313 of Title III of the Superfund Amendments and Reauthorization Act of 1986 (SARA). This product contains a chemical
or chemicals which are subject to the reporting requirements of the Act and Title 40 of the Code of Federal Regulations, Part 372.

Component CAS No Weight % SARA 313 - Threshold SARA 313 - Reporting

Values % threasholds
Formic acid 64-18-6 >95 1.0 -

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SARA 311/312 Hazard Categories

Should this product meet EPCRA 311/312 Tier reporting criteria at 40 CFR 370, refer to Section 2 of this SDS for appropriate
classifications.

CWA (Clean Water Act)

Component CWA - Hazardous CWA - Reportable CWA - Toxic Pollutants CWA - Priority Pollutants
Substances Quantities
Formic acid X 5000 lb - -

Clean Air Act Not applicable

OSHA - Occupational Safety and Not applicable

Health Administration

CERCLA
This material, as supplied, contains one or more substances regulated as a hazardous substance under the Comprehensive
Environmental Response Compensation and Liability Act (CERCLA) (40 CFR 302) or the Superfund Amendments and
Reauthorization Act (SARA) (40 CFR 355).

Component Hazardous Substances CERCLA Extremely SARA Reportable Quantity

RQs Hazardous Substances (RQ)
RQs
Formic acid 5000 lb - RQ 5000 lb final RQ
RQ 2270 kg final RQ

California Proposition 65 This product does not contain any Proposition 65 chemicals.

U.S. State Right-to-Know

Regulations

Component Massachusetts New Jersey Pennsylvania Illinois Rhode Island

Formic acid X X X - X

U.S. Department of Transportation

Reportable Quantity (RQ): Y
DOT Marine Pollutant N
DOT Severe Marine Pollutant N

U.S. Department of Homeland This product does not contain any DHS chemicals.
Security

Other International Regulations

Mexico - Grade Moderate risk, Grade 2

Authorisation/Restrictions according to EU REACH

Component CAS No REACH (1907/2006) - REACH (1907/2006) - REACH Regulation (EC

Annex XIV - Substances Annex XVII - Restrictions 1907/2006) article 59 -
Subject to Authorization on Certain Dangerous Candidate List of
Substances Substances of Very High
Concern (SVHC)
Formic acid 64-18-6 - Use restricted. See entry -
75.
(see link for restriction
details)

REACH links
https://echa.europa.eu/substances-restricted-under-reach

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Safety, health and environmental regulations/legislation specific for the substance or mixture

Component CAS No OECD HPV Persistent Organic Ozone Depletion Restriction of

Pollutant Potential Hazardous
Substances (RoHS)
Formic acid 64-18-6 Listed Not applicable Not applicable Not applicable

Contains component(s) that meet a 'definition' of per & poly fluoroalkyl substance (PFAS)?
Not applicable

Other International Regulations

Component CAS No Seveso III Directive Seveso III Directive Rotterdam Basel Convention
(2012/18/EC) - (2012/18/EC) - Convention (PIC) (Hazardous Waste)
Qualifying Quantities Qualifying Quantities
for Major Accident for Safety Report
Notification Requirements
Formic acid 64-18-6 Not applicable Not applicable Not applicable Annex I - Y34

16. Other Information

Prepared By Regulatory Affairs
Thermo Fisher Scientific
Email: [email protected]

Creation Date 02-Nov-2009

Revision Date 31-Jan-2025
Print Date 31-Jan-2025
Revision Summary This document has been updated to comply with the US OSHA HazCom 2012 Standard
replacing the current legislation under 29 CFR 1910.1200 to align with the Globally
Harmonized System of Classification and Labeling of Chemicals (GHS).

Disclaimer
The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the
date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage,
transportation, disposal and release and is not to be considered a warranty or quality specification. The information
relates only to the specific material designated and may not be valid for such material used in combination with any other
materials or in any process, unless specified in the text

End of SDS

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