Drugs Acting on Autonomic Nervous System

CHOLINERGIC DRUGS
(Cholinomimetic, Parasympathomimetic)

Cholinergic agonists Anticholinesterases

(Choline esters | | Alkaloids Irreversible

Acetylcholine| Muscarine
Methacholine | Pilocarpine
| carbamates e | [ Carbamates| |Organophosphates
Carbachol Arecoline
Bethanechol Physostigmine ov Carbaryl* Dyflos (DFP)
(Eserine) (Sevin) Echothiophate
Neostigmine Propoxur* || Malathion®
Pyridostigmine (Baygon) Diazinon*
Edrophonium (TIK-20)
* Insecticides
£ Nerve gases Rivastigmine Tabun £
for chemical Donepezil Sarin £ ;
warfare Galantamine Soman
 Anticholinergic Drugs [3 |]

ANTICHOLINERGIC DRUGS
(Muscarinic antagonists, Atropinic drugs, Parasympatholytics)

Semisynthetic derivatives Synthetic compounds

Atropine | Atropine methonitrate
|Hyoscine Homatropine
|(Scopolamine) Hyoscine butyl bromide
Ipratropium bromide Cyclopentolate | | Oxybutynin Trihexyphenidyl
Tiotropium bromide Tropicamide Flavoxate (Benzhexol)
Tolterodine Procyclidine
Biperiden

Propantheline Dicyclomine
Oxyphenonium Valethamate
Clidinium Pirenzepine
Pipenzolate methyl bromide
Isopropamide
Glycopyrrolate
[6 | Drugs Acting on Autonomic Nervous System

GANGLIONIC STIMULANTS GANGLIONIC BLOCKING AGENTS

1

Selective nicotinic Il Nonselective/muscarinic Competitive § Persistent depolarizing

agonists agonists blockers
Nicotine (small dose) Acetylcholine Nicotine (large dose)
Lobeline Carbachol Anticholinesterases
Dimethyl phenyl piperazinium Pilocarpine (large dose)
(DMPP) Anticholinesterases
Tetramethyl ammonium (TMA) MCN 343-A
Varenicline

| 1 1
Quaternary Amines Monosulfonium
ammonium comps. Mecamylamine| | GOMP:
Hexamethonium Pempidine Trimethaphan-
Pentolinium camlforsulfonate

Preparations
1. Nicotine transdermal: NICOTINELL-TTS 10, 20, 30 cm? patches releasing 7, 14, 21 mg nicotine per 24 hr
respectively. In those smoking > 20 cigarettes every day—start with 30 ecm? patch, shift to smaller patches every
3-5 days, treat for 3-4 weeks.
2. Nicotine chewing gum: NULIFE 1, 2, 4 mg chewing gum; In those smoking > 20 cigarettes /day—start with
4 mg gum chewed slowly for 30 min when urge to smoke occurs—gradually reduce to 2 mg gum and then 1 mg
gum. In less heavy smokers—start at lower doses.
 Adrenergic Drugs

ADRENERGIC DRUGS
(Sympathomimetics)

rr
| ts |
' Noradrenaline
(Norepinephrine)
Isoprenaline
Salbutamol
Amphetamine
Dexamphetamine
Ritodrine
Isoxsuprine
Ephedrine (Albuterol) Methamphetamine Salbutamol
Dopamine Terbutaline Methylphenidate Terbutaline
Phenylephrine Salmeterol
Methoxamine Formoterol
Mephentermine Bambuterol

Adrenaline Xylometazoline Amphetamine

Isoprenaline Oxymetazoline Fenfluramine
Dobutamine Naphazoline Dexfenfluramine
Phenylephrine Sibutramine
Phenylpropanolamine
Pseudoephedrine
[10 | Drugs Acting on Autonomic Nervous System

ou ADRENERGIC BLOCKING DRUGS

Non equilibrium type Equilibrium type

(Competitive antagonists)

Phenoxybenzamine

Prazosin Yohimbine
Terazosin
Doxazosin
Ergotamine Phentolamine | Chlorpromazine Alfuzosin
\Ergotoxine Tamsulosin

| Dihydroergotamine (DHE)
' Dihydroergotoxine
(Codergocrine)
[12 ] Drugs Acting on Autonomic Nervous System

ADRENERGIC BLOGIING DRUGS

Non selective (fi, + [5,) Cardioselective (f};)

Metoprolol
Atenolol
Acebutolol
Bisoprolol
[Propranolol Pindolol Esmolol
[Sotalol Labetalol Betaxolol
“ISA: Intrinsic Carvedilol Celiprolol
| Timolol
1 sympathomimetic activ Nebivolol
GENERATIONWISE CLASSIFICATION
ADRENERGIC BLOCKING DRUGS
1

(Older, nonselective) (B, or Cardioselective) (With a blocking and/or

Propranolol Metoprolol vasodilator property)
Timolol Atenolol Labetalol
Sotalol Acebutolol Carvedilol
Pindolol Bisoprolol Celiprolol
Esmolol Nebivolol
Betaxolol
(14 | Drugs Acting on Autonomic Nervous System

TOPICAL DRUGS FOR GLAUCOMA

-Adrenergic u-Adrenergic | | Prostaglandin| | Carbonic anhydrase Miotics |

blockers agonists analogues inhibitors ; .
- Pilocarpine
Timolol Dipivefrine Latanoprost Dorzolamide Physostigmine
Betaxolol Apraclonidine Travoprost Brinzolamide Echoth iophate
Levobunolol Brimonidine Bimatoprost _ 1]
Carteolol

Preparations
1. Timolol: Start with 0.25% eye drops BD, change to 0.5% drops in case of inadequate response. 0.5% OD as gel
forming solution. GLUCOMOL, OCUPRES, IOTIM, LOPRES 0.25% and 0.5% eye drops. TIMOLAST 0.5% gel
forming eye drops (long acting).
Timolol 0.5% + Latanoprost 0.005%: LAPROST PLUS, LATOCHEK-T eye drops.
Betaxolol: 0.5% topically in eye BD; OPTIPRES, IOBET, OCUBETA 0.5% eye drops.
Levobunolol: 0.5% topically in eye OD; BETAGAN 0.5% ophthalmic solution.
SE

Dipivefrine: 0.1% topically in eye BD; PROPINE 0.1% eye drops.

Apraclonidine: 0.5-1.0% topically in eye; ALFADROPS-DS 1% eye drops.
Brimonidine: 0.2% topically in eye TDS;
ALPHAGAN-P, BRIMODIN-P 0.15% eye drops, IOBRIM 0.2% eye drops.
 Autacoids and Related Drugs
HISTANERC AGONISTS

2-Methy] histamine | Dimaprit (R) a-Methylhistamine

Histamine 2-Pyridyl ethylamine | Impromidine Imetit
Betahistine 2-Thizolyl ethylamine

H, ANTAGONISTS
(Conventional antihistaminics)
1

Diphenhydramine Pheniramine 'Chlorpheniramine

Dimenhydrinate Cyproheptadine \Dexchlorpheniramine
Fexofenadine
Promethazine Meclozine (Triprolidine
Hydroxyzine Cinnarizine Clemastine Loratadine
Desloratadine
Cetirizine
Levocetirizine
Azelastine
Mizolastine
Ebastine
[18 | Autacoids and Related Drugs

19. Mizolastine: 10 mg oral; ELINA 10 mg tab.

20. Ebastine: 10 mg oral; EBAST 10 mg tab.
21. Rupatadine: 10 mg oral; RUPAHIST 10 mg tab.
Note: For H,-Antagonists (H,-Antihistaminics) See p. 118, 119.

5-HYDROXY TRYPTAMINE (5-HT) ANTAGONISTS

]

[Eta hry Ketanserin Ondansetron

Ergotamine Ritanserin | Granisetron
Lysergic acid diethyl Clozapine | Tropisetron
amide (LSD) Risperidone | Palonosetron
2-Bromo LSD Ramosetron
Methysergide !
Cyproheptadine
Cinnarizine
 Drugs for Migraine [19 |

DRUGS FOR MIGRAINE

1

Propranolol
(other p blockers)
- Amitriptyline
Paracetamol Metoclopramide : (other TCAs)
Aspirin Domperidone Sumatriptan Flunarizine
Metamizol Prochlorperazine Rizatriptan Valproic acid
Codeine Promethazine Naratriptan Gabapentin
Zolmitriptan :
E . Topiramate
rovatriptan 2
Cyproheptadine

Ibuprofen
Naproxen Ergotamine
Diclofenac Dihydroergotamine
Mephenamic acid (DHE)
 Prostaglandins (PGs) [ 21 |

PROSTAREANDINA (PGs)

Dinoprostone (PGE,) Carboprost (15-methyl PGF, )

Gemeprost Misoprostol (methyl PGE, ester)
Dinoprost (PGF,,) Latanoprost (PGE, analogue)
Alprostadil (PGE) Travoprost
Prostacyclin (PGIl,) Bimatoprost
(Epoprostenol)
 Nonsteroidal Antiinflammatory Drugs/ Antipyretic-Analgesics [ 23 |

NONSTEROIDAL ANTIINFLAMMATORY DRUGS/ANTIPYRETIC-ANALGESICS

1

Preferential COX-2 Selective COX-2

inhibitors inhibitors
Nimesulide Celecoxib
Diclofenac Etoricoxib
Aceclofenac Parecoxib
Meloxicam Analgesic-antipyretics with
Etodolac poor antiinflammatory action

Nonselective COX
inhibitors
Paracetamol Metamizol (Dipyrone)
(Acetaminophen) Propiphenazone

Ibuprofen [Mephenamic | Piroxicam | | Ketorolac Phenylbutazone

Naproxen acid Tenoxicam | | Indomethacin | = Oxyphenbutazone
Ketoprofen Nabumetone
Flurbiprofen
 Antirheumatoid Drugs/Drugs for Gout

ANTIRHEUMATOID DRUGS
1

Disease modifying anti- Adjuvant drugs

rheumatoid drugs (DMARDs) | Prednisolone and other
glucocorticoides

1
Sulfasalazine ie rw eo roquine Leflunomide
Methotrexate Etanercept
Azathioprine Infliximab
Cyclosporine DRUGS il Gout Adalimumab

Acute gout
NSAIDs
EDT
Colchicine
Glucocorticoids
Probenecid Allopurinol
Sulfinpyrazone Febuxostat
Drugs for Respiratory Disorders
DRUGS FOR COUGH
1
Pharyngeal Expectorants Adjuvant
demulcents (Mucokinetics) antitussives

Lozenges Salbutamol
Syrups ' Terbutaline
Glycerine
Liquorice Pot. citrate Bromhexine Antitussives
Pot. iodide Ambroxol (Cough centre
Guaiphenesin Acetyl cysteine suppressants)
Tolu balsam Carbocisteine
Vasaka !
Ammon. chloride

Codeine Noscapine
es)
Chlorpheniramine —
Ethylmorphine| Dextromethorphan Diphenhydramine Prenoxdiazine
Pholcodine Chlophedianol Promethazine
 Drugs for Bronchial Asthma [ 33 |

DRUGS FOR BRONCHIAL ASTHMA

1

Leukotriene
Corticosteroids Anti-lgE antibody
antagonists

eine Sod. cromoglycate | [ Omalizumab |

Zafirlukast Ketotifen - .
| Systemic inhalational
Hydrocortisone Beclomethasone
Prednisolone dipropionate
Other glucocorticoids | Budesonide
Fluticasone
[ | ] propionate
- ’ . Flunisolide
p, Sympathomimetics |Methylxanthines Anticholinergics Cidlesomide
Salbutamol Theophylline | Ipratropium Br.
Terbutaline Aminophylline Tiotropium Br.
Bambuterol Choline L
Salmeterol theophyllinate
Formoterol Hydroxyethyl
theophylline
Doxophylline
Hormones and Related Drugs
ANTERIOR PITUITARY HORMONES
1

Crowth hormone (GH) Thyroid stimulating hormone (TSH)

Prolactin Adrenocorticotropic hormone (ACTH
Follicle stimulating hormone (FSH)
Luteinizing hormone (LH)

DRUGS ALTERING ANTERIOR PITUITARY HORMONE SECRETION

|

Somatostatin
Octreotide Bromocriptine Chlorpromazine
Lanreotide Cabergoline (other neuroleptics)
Apomorphine Metoclopramide
Reserpine

(Initially enhance Gn release) Ganirelix

Nafarelin Goserelin Cetrorelix
Triptorelin Leuprolide
 Thyroid Hormone and Thyroid Inhibitors [ 39 |

10. Triptorelin: For endometriosis and carcinoma prostate: 3.75-7.5 mg of depot injection im. every 4 weeks;
For female infertility: 0.1 mg s.c. daily for 10 days starting on 2nd day of menstruation;
For precocious puberty: 50 ng/kg im. of depot injection every 4 weeks.
DECAPEPTYL DAILY 0.1 mg inj, DECAPEPTYL DEPOT 3.75 mg inj.
11. Leuprolide: For palliative treatment of advanced carcinoma prostate—1 mg s.c. OD or 3.75 mg im./s.c. once
a month of depot preparation; LUPRIDE 1 mg inj, 3.75 mg depot inj, PROGTASE 1 mg/ml inj.

Thyroxine (Ty)
Triiodothyronine (T,, Liothyronine)

THYROID INHIBITORS

| (Antithyroid drugs) (lonic inhibitors) Iodine | Radioactive

Propylthiouracil Thiocyanates (-<SCN)| lodides of Na, K iodine 1
Methimazole Perchlorates (-ClOy) Organic iodide
Carbimazole Nitrates (-NO,)
[ 40 | Hormones and Related Drugs

Preparations
L-Thyroxine sod: Adulthypothyroidism—start with 50 ug/ day, increase every 2-3 weeks by 25-50 ug to the optimum dose of
100-200 ng/day adjusted by the clinical response and serum TSH level. Cretinism—6-8 ng/kg/day;
ELTROXIN, 25, 50, 100 ug tabs, ROXIN 100 ug tab, THYRONORM, 12.5, 25, 50, 62.5, 75, 88, 100, 112, 125, 137, 150 pg
tabs, THYROX 25, 50, 75, 100 ug tabs.
1. Propylthiouracil: 50-150 mg TDS followed by 25-50 mg BD-TDS for maintenance. PTU 50 mg tab.
2. Methimazole: 5-10 mg TDS initially, maintenance dose 5-15 mg daily in 1-2 divided doses.
3. Carbimazole: 5-15 mg TDS initially, maintenance dose 2.5-10 mg daily in 1-2 divided doses;
NEO MERCAZOLE, THYROZOLE, ANTITHYROX 5 mg tab.
4. Lugol's solution (5% iodine in 10% Pot. iodide solution):
LUGOL'S SOLUTION, COLLOID IODINE 10%: 5-10 drops/day. COLLOSOL 8 mg iodine /5 ml liq.
5. lodide (Sod./Pot.): 5-10 mg/day prophylactic for endemic goiter; 100-300 mg/day before partial
thyroidectomy in Graves’ disease.
INSULINS

Rapid acting | Short acting Intermediate acting | Long acting |

(Insulin analogues) Regular (soluble) Insulin zinc suspension (Insulin analogues)
Insulin lispro insulin (Lente insulin) Insulin glargine
Insulin aspart Neutral protamine hagedorn Insulin detemir
Insulin glulisine (NPH) or Isophane insulin
[42 ] Hormones and Related Drugs

ORAL ANTIDIABETIC DRUGS

|

Enhance insulin Overcome insulin Miscellaneous

secretion resistance drugs

Metformin Pioglitazone — Acarbose

Miglitol
| Voglibose

| Sitagliptin Pramlintide
Vildagliptin
| Saxagliptin
Tolbutamide Alogliptin
Glibenclamide Repagliide Linagliptin | Bromocriptine
£ pide Nateglinide
Gliclazide g
Glimepiride

| Da agliflozin
[44 ] Hormones and Related Drugs

CORTICOSTEROIDS
|

|Gluccooricade Mineralocorticoids
Desoxycorticosterone
acetate (DOCA)
Fludrocortisone
Hydrocortisone | Prednisolone Dexamethasone Aldosterone
(Cortisol) Methyl prednisolone Betamethasone
Triamcinolone
Deflazacort
TOPICAL STEROIDS
|
ET
— Beclomethasone dipropionate (0.025%) Fluocinolone acetonide (0.01%) Hydrocortisone
Betamethasone benzoate (0.025%) Fluocortolone (0.025%) acetate (0.1-1.0%)
Betamethasone valerate (0.12%) Clobetasol butyrate (0.05%) Hydrocortisone
Halcinonide (0.1%) Mometasone (0.1%) butyrate (0.001%)
Clobetasol propionate (0.05%) Fluticasone propionate (0.05%)
Fluocinolone acetonide (0.025%) Hydrocortisone acetate (2.5%)
Fluocortolone (0.5%)
Triamcinolone acetonide (0.1%)
Dexamethasone sod. phos. (0.1%)
 Androgens and Related Drugs

18. Hydrocortisone acetate 0.1-1.0% LYCORTIN 1% oint.,in CORTOQUINOL 1% with quiniodochlor, 4% cream,
GENTACYN-HC TOPICAL 1% with gentamicin 0.1%, CORTISON-KEMICETINE 0.5% with chloramphenicol 0.5%.
19. Hydrocortisone butyrate 0.001% LOCOID cream
ANDROGENS AND RELATED DRUGS

Androgens Anabolic steroids Antiandrogens

Methandienone Cyprolerone acetate

Nandrolone Flutamide
! phenylpropionate Bicalutamide
Testosterone Methyl testosterone Natdralona
Dihydrotestosterone | | Fluoxymesterone decanpate
Androsterone Mesterolone Oxymetholone Su-Reductase inhibitors
| Stanozolol
| Finasteride
Drugs for Erectile Dysfunction _uente_|
1

Testosterone | | Sildenafil apaverine phentolamine

(and others) Tadalafil Alprostadil (PGE)
Vardenafil
[ 50 | Hormones and Related Drugs

ESTROGENS AND RELATED DRUGS

Antiestrogen Selective estrogen Selective estrogen Aromatase

receptor down regulator receptor modulators inhibitors

‘Clomiphene Fulvestrant Tamoxifen citrate [ Letrozole

citrate Toremifene Anaslrozole
Raloxifene Exemestane

[Natural Synthetic
Estradiol |
Estrone IL - " 1
Estriol | | Steroidal Nonsteroidal
md | Ethinylestradiol Diethylstilbestrol
Mestranol Hexestrol
Tibolone Dienestrol
 Progestins [ 53 |

PROGISTING

Medroxy progesterone acetate

Megestrol acetate
Dydrogesterone
Hydroxy progesterone caproate| |
Nomegestrol acetate Norethindrone Levonorgestrel
(Norethisterone) Desogestrel
Lynestrenol Norgestimate
(Ethinylestrenol) Gestodene
Allylestrenol

Antiprogestin Selective progesterone

receptor modulator
Mifepristone | Ulipristal
 Hormonal Contraceptives [ 55 |

HORMONAL CONTRACEPTIVES

Injectable

* Depot medroxy-
mE progesterone
acetate (DMPA)
* Norgestrel (0.5 mg) + * Levonorgestrel * Levonorgestrel (1.5 mg)
* Norethindrone
Ethinylestradiol (50 pg) (50 pg —75 pg — 125 ug) * Levonorgestrel (0.5 mg)
enanthate
¢ Levonorgestrel + +
(0.1 -0.25 mg) + Ethinylestradiol Ethinylestradiol (100 pg)
Ethinylestradiol (30 pg —40 pg - 30 pg) x 2 doses
(20-50 pg) * Norethindrone
+ Desogestrel (0.15 mg) + (0.5 mg — 0.75 mg 1.0 mg)
Ethinylestradiol + * Norethindrone
Ethinylestradiol (35 pg) (0.35 mg)
(20-30 pg)
e Norgestrel (75 pg)
[58 | Hormones and Related Drugs

UTERINE STIMULANTS
(Oxytocics)
l

- Ergometrine PGE, (Dinoprostone) Ethacridine

24S do oh (Ergonovine) PGE,, (Dinoprost) Quinine
samino-oxytocm
¥: 7 :
| Methylergometrine 15-methyl PGF,
(Carboprost)
Misoprostol +
(Mifepristone)
UTERINE RELAXANTS
(Tocolytics)
1

Ritodrine | Nifedipine Atosiban Magnesium sulfate

Salbutamol (Other dihydro- Progesterone
Terbutaline pyridines) Nitrates
Isoxsuprine Halothane
Drugs Acting on Peripheral (somatic) Nervous System
SKELETAL MUSCLE RELAXANTS
1
Peripherally acting Centrally acting

Carisoprodol
Dantrolene sodium [— Chlorzoxazone
Quinine Chlormezanone
Methocarbamol

yn
Suceinyl choline Diazepam, etc.
(suxamethonium)
Decamethonium

|. Baclofen
Thiocolchicoside
d-Tubocurarine Vecuronium Mivacurium
Pancuronium Alracurium
Doxacurium Cisatracurium
Pipecuronium Rocuronium — Tizanidine
Rapacuronium
(62 | Drugs Acting on Peripheral (somatic) Nervous System

15. Baclofen: 10 mg BD-25 mg TDS oral; LIORESAL, LIOFEN 10, 25 mg tabs.

16. Thiocolchicoside: 4 mg TDS-QID; NUCOXIA-MR: thiocolchicoside 4 mg + etoricoxib 60 mg tabs.
17. Tizanidine: 2 mg TDS; max 24 mg/day; SIRDALUD 2, 4, 6 mg tab; TIZAN 2, 4 mg tab; BRUFEN-MR, TIZAFEN
2 mg + ibuprofen 400 mg tab; TIZANAC 2 mg + diclofenac 50 mg tab., PROXYVON-MR 2 mg + nimesulide 100 mg cap.

LOCAL ANAESTHETICS
|
Injectable anaesthetic Surison mastic]

f
Low potency,
T—
Intermediate potency
1 _
High potency,
‘short duration and duration long duration
Procaine Lidocaine (Lignocaine} Tetracaine
Chloroprocaine Prilocaine Bupivacaine
Ropivacaine
Dibucaine

Soluble [ Insoluble
Cocaine Benzocaine
Lidocaine Butylamino-
Tetracaine benzoate
Proparacaine Oxethazaine
6 | Drugs Acting on Central Nervous System

=m
GENERAL ANAESTHETICS
1
Inhalational

Nitrous oxide Ether | Thiopentone sod.

Halothane Methohexitone sod.
Isoflurane |Propofol
Desflurane | Etomidate
Sevoflurane Diazepam Fentanyl
Lorazepam
Midazolam

Ketamine
[66 | Drugs Acting on Central Nervous System

PREANAESTHETIC MEDICATION DRUGS

= Morphine - Chlorpromazine Metoclopramide

| Diazepam Pethidine Atropine Triflupromazine Domperidone
{Lorazepam Hyoscine Haloperidol Ondansetron
| Promethazine Glycopyrrolate

Ranitidine
Famotidine
Omeprazole
Pantoprazole

Preanaesthetic Medication Drugs

Note: See Index for preparations

 Sedative-Hypnotic Drugs

SEDATIVE-HYPNOTIC DRUGS

Benzodiazepines Non-benzodiazepines j§ Other CNS

| Zopiclone | depressants
| Eszopiclone Chloral hydrate
| Zolpidem Triclophos
| Zaleplon Paraldehyde
Diazepam Diazepam | Diazepam Glutethimide
Flurazepam Chlordiazepoxide | | Lorazepam Methaqualone
Nitrazepam Oxazepam Clonazepam Meprobamate
Alprazolam Lorazepam Clobazam Promethazine
Temazepam Alprazolam Chlorpromazine

Morphin
Triazolam Amitriptyline

| Phenobarbitone Butobarbitone Thiopentone

Pentobarbitone Methohexitone
 Antiepileptic Drugs [ 69 |

ANTIEPILEPTIC DRUGS

|Phenobarbitone Phenytoin Ethosuximide ic lonazepam

—_—
Topiramate
[Fosphenytoin | Diazepam Zonisamide
| Lorazepam Levetiracetam
|Clobazam Vigabatrin
Tiagabine
Lacosamide

Primidone Carbamazepine
| Oxcarbazepine Valproate sod
({Valproic acid)
Tempteiging Gabapentin
Divalproex Pregabalin
 Drugs Acting on Central Nervous System

ANTIPARKINSONIAN DRUGS

Drugs affecting brain Drugs affecting brain

dopaminergic system cholinergic system

Levodopa Bromocriptine Entacapone Trihexyphenidyl Orphenadrine

Ropinirole Tolcapone Procyclidine Promethazine
~ Pramipexole Biperiden

Selegiline Amantadine
Carbidopa Rasagiline
| Benserazide
 Antipsychotic Drugs

ANTIPSYCHOTIC DRUGS
(Neuroleptic drugs)

Flupenthixol
Clozapine
Risperidone
Olanzapine
Quetiapine
| Chlorpromazine Thioridazine | Trifluoperazine Pimozide Aripiprazole
Triflupromazine Fluphenazine Loxapine Ziprasidone
Amisulpiride
Zotepine
Haloperidol
Trifluperidol
Penfluridol
 Drugs for Mania and Bipolar Disorder

DRUGS FOR MANIA AND BIPOLAR DISORDER

[
Lithium
carbonate Sodium valproate
Carbamazepine
Olanzapine
: :
Lamotrigine Risperidone
Quetiapine
Aripiprazole
HALLUCINOGENS
(Psychotomimetics, Psychedelics, Psychodysleptics)

Lysergic acid . Mescaline Tetrahydro-

diethylamide (LSD) Ecstasy Phencyclidine cannabinol (*A THC)
Lysergic acid amide (Methyline dioxy-
Psilocybin methamphetamine)
Harmine YABA
Dimethyl tryptamine (Methamphetamine
+ methylhexanamine)
 Antidepressants

ATIRRFREaRANTS

Trazodone
Moclobemide Fluoxetine
Mianserin
Clorgyline Fluvoxamine
Mirtazapine
Paroxetine
Bupropion
Sertraline
Citalopram Tianeptine
Escitalopram Amineptine
Atomoxetine
Dapoxetine

iiss 1689 |
Venlafaxine
Duloxetine

Imipramine Desipramine
Amitriptyline Nortriptyline
Trimipramine Amoxapine
Doxepin Reboxetine
Dothiepin
Clomipramine
 Antianxiety Drugs [81 |

18. Trazodone: 50-200 mg/day; TRAZODAC 25, 50 mg tab, TRAZONIL, TRAZALON 25, 50, 100 mg tabs.
19. Mianserin: 30-100 mg/day; TETRADEP 10, 20, 30 mg tab, SERIDAC 10, 30 mg tab.
20. Bupropion: 150-300 mg/day; SMOQUIT-SR, BUPRON-SR 150 mg tab.
21. Mirtazapine: 15-45 mg/day; MIRT 15, 30, 45 mg tabs, MIRTAZ 15, 30 mg tab.
22. Venlafaxine: 75-150 mg/day; VENLOR 25, 37.5, 75 mg tabs, VENIZ-XR 37.5, 75, 150 mg ER caps.
28. Tianeptine: 12.5 mg BD-TDS; STABLON 12.5 mg tab.
24. Amineptine: 100 mg BD at breakfast and lunch; SURVECTOR 100 mg tab.
25. Duloxetine: 30-80 mg/day; DELOK, DULANE, DUZAC 20, 30, 40 mg caps.

ANTIANXIETY DRUGS

Benzodiazepines | Azapirones | Sedative- [-adrenergic |

Diazepam Buspirone | antihistamin blocker
Oxazepam Gepirone Hydroxyzine Propranolol
Lorazepam Ispapirone
Chlordiazepoxide
Alprazolam
 Opioid Analgesics and Antagonists [ 83 |

OPIOID ANALGESICS AND ANTAGONISTS

Opioid pu receptor agonists Complex action opioids Pure opioid

antagonists

Naloxone
Naltrexone
Morphine Diacetylmorphine Pethidine Nalorphine Nalmefene
Codeine (Heroin) (Meperidine) Pentazocine
: Pholcodine Methadone Butorphanol
Ethylmerphine Fentanyl
Dextro-
propoxyphene
Tramadol
Buprenorphine

Preparations
Opioid Analgesics
1. Morphine: 10-50 mg oral, 10-15 mg im. or s.c., 2-6 mg i.v.; 2-3 mg epidural/intrathecal; children 0.1-0.2 mg/
kg im. or s.c. MORPHINE SULPHATE 10 mg/ml inj; MORCONTIN 10, 30, 60, 100 mg continuous release tabs;
30-100 mg BD; RILIMORF 10, 20 mg tabs, 60 mg SR tab.
 CNS Stimulants and Cognition Enhancers [ 85 |

CNS STIMULANTS

Strychnine Doxapram Amphetamines Armodafinil

Picrotoxin Methyl phenidate Pemoline
Bicuculline Atomoxetine Cocaine
Pentylenetetrazole Modafinil Caffeine

COGNITION ENHANCERS
(Cerebroactive drugs)

5 made Piracetam Citicoline

Rivastigmine Memantine Pyritinol Piribedil
he (Pyrithioxine) Ginkgo biloba
alantamine
Dihydroergotoxine
Tacrine (Codergocrine)
 Cardiovascular Drugs
ANTIHYPERTENSIVE DRUGS (1)

Renin-angiotensin Sympathetic
system inhibitors inhibitors

Hydrochlorothiazide | | Furosemide Spironolactone

Chlorthalidone (others) Eplerenone Propranolol
Indapamide Amiloride Metoprolol Labetalol
Atenolol Carvedilol
(others)

Captopril
Enalapril Losartan Aliskiren
Lisinopril Candesartan Prazosin Clonidine
Perindopril Valsartan Terazosin Methyldopa
Ramipril Telmisartan Doxazosin
Fosinopril Irbesartan Phentolamine
Quinapril Olmesartan Phenoxybenzamine Contd...
Trandolapril
 Antihypertensive Drugs [ 89 |

ANTIHYPERTENSIVE DRUGS (2)

Calcium channel blockers Vasodilators

Diltiazem Nifedipine Hydralazine

Verapamil Felodipine Minoxidil Nitroprusside
Amlodipine Diazoxide sod.
Nitrendipine
Lacidipine
Lercanidipine
Benidipine
 Antianginal Drugs [ 93 |

ANTIANGINAL DRUGS

B-blockers Calcium channel Pot. channel Other

blockers opener antianginal
drugs

| Short acting [Long acting Propranolol Verapamil Nicorandil | Trimetazidine

Glyceryl trinitrate Isosorbide Metoprolol Diltiazem Ranolazine
Isosorbide dinitrate Atenolol Amlodipine Ivabradine
dinitrate (oral) | (others) Nitrendipine Oxyphedrine
(sublingual) Isosorbide (others) Dipyridamole
E mononitrate
Erythritol
tetranitrate
Pentaerythritol
tetranitrate
 Drugs for Peripheral Vascular Diseases [ 95 |

DRUGS FOR PERIPHERAL VASCULAR DISEASES

Vitamin E
Pentoxiphylline || | Cilostazol Aspirin
(Oxpentifylline) Clopidogrel
i Ticlopidine

Cyclandelate
Xanthinol Isoxsuprine Prazosin Nifedipine Prostacyclin
nicotinate | Phenoxybenzamine Nitrendipine (PCL)
 Drugs for Congestive Heart Failure

DRUGS FOR CONGESTIVE HEART FAILURE

Inotropic drugs Diuretics Aldosterone

antagonists

I 1] | Spironolactone
; : Furosemide 'Hydrochloro- Eplerenone
Tn
Digoxin Dobutamine Inamrinone Putibtinide thiszide
Ouabain Dopamine Milrinone Metolazone rv T—

Xipamide blockers
Renin-angiotensin inhibitors
Vasodilators Metoprolol
Bisoprolol
Nebivolol
Carvedilol
Enalapril Glyceryl-
| Ramipril Losartan trinitrate Sod.
| (others) Candesartan Tsosorbide- nitroprusside
| (others) dinitrate i

PDE: Phosphodiesterase; ACE: Angiotensin converting enzyme Hydralazine

 Antiarrhythmic Drugs [ 99 |

ANTIARRHYTHMIC DRUGS

Class | Class IV
Membrane stabilizing agents Calcium channel
blockers

.| | I
- v erapami il
(A) (8) (©)
Moderately decrease | | Little decreasein | | Marked decreasein | Diltiazem
:
dv/dt of 0 phase dvi/di of 0 phase dv/dt of 0 phase Class Ill
Quinidine Lidocaine Propafenone Agents widening
Procainamide Mexiletine Flecainide action potential
Disopyramide

Class ll Amiodarone
Antiadrenergic Dronedarone
rr agents Dofetilide
PSVT : — Ibutilide
- Propranolol
EET Sotalol (class III
Lgoxin property as well)

PSVT: Paroxysmal supraventricular tachycardia | Bemiol

8 | Drugs Acting on Kidney
DIURETICS

High ceiling Medium efficacy Weak/adjunctive

(Inhibitors of Na'-K"-2CI” (Inhibitors of Na'-Cl diuretics
cotransport) symport)

Furosemide
(Frusemide)
Bumetanide Hydrochlorothiazide Chlorthalidone
Torasemide Hydroflumethiazide Metolazone Mannitol
Benzthiazide Xipamide Acetazolamide Isosorbide
Indapamide Glycerol
ANTIDIURETICS Clopamide

5 Thiazides Carbamazepine
Vasopressin Amiloride Chlorpropamide
Desmopressin Indomethacin
Lypressin Spironolactone | | Amiloride
Terlipressin Eplerenone Triamterene
9 | Drugs Affecting Blood
HAEMATINICS

Vitamin By,:
Cyanocobalamin Copper
Hydroxocobalamin Pyridoxine
Methylcobalamin Riboflavin
Ferrous sulfate Iron-dextran
Folic acid:
Ferrous fumarate Iron-sorbitol-
Folinie acid
Ferrous gluconate citric acid
(leucovorin,
Ferrous succinate Ferrous sucrose,
citrovorum factor)
Ferrous aminoate Ferric carboxy-
Ferric ammonium maltose
citrate
Ferric hydroxy
polymaltose
Carbonyl iron
Iron-cal. complex
 Coagulants [109 |

4. Folinic acid: 1-3 mg iv; CALCIUM LEUCOVORIN 3 mg/ml inj, FASTOVORIN 3 mg and 15 mg amps,
50 mg vial; RECOVORIN 15 mg tab, 15 mg and 30 mg vial for inj.

Erythropoietic factor
Recombinant human erythropoietin (Epoetin a, B): 25-100 IU/kg s.c./iv. 3 times a week (max 600 IU/
kg/week);
HEMAX 2000 IU/ml and 4000 IU/ml vials; EPREX 2000 IU, 4000 IU and 10,000 IU in 1 ml prefilled syringes;
ZYROP (epoetin $) 2000 IU and 4000 IU vials.

COAGULANTS

| vitamin K | Miscellaneous
K;: Phytonadione Fibrinogen (human)
(Phylloquinone) Antihaemophilic factor,
K;: Menadione Desmopressin
Acetomenaphthone Adrenochrome mono-
Menadione sod. semicarbazone
bisulfite Ethamsylate
Menadione sod. Rutin
diphosphate
 Anticoagulants

ANTICOAGULANTS
]
Parenteral anticoagulants Oral anticoagulants

Heparin (unfractionated) Bishydroxycoumarin Rivaroxaban Dabigatran-

Low molecular weight Lepirudin (dicumarol) etexilate
heparins Bivalirudin Warfarin sod.
(Enoxaparin, Reviparin, Argatroban Acenocoumarol
Nadroparin, Dalteparin, (Nicoumalone)
Heparin
Parnaparin, Ardeparin) Ethyl-biscoum-
Sod. edetate
Fondaparinux acetate
Sod. citrate
Danaparoid
Sod. oxalate
 Fibrinolytics/ Antifibrinolytics/Antiplatelet Drugs [113 |

Acenocoumarol (Nicoumalone): 8-12 mg followed by 2-8 mg/day; ACITROM, NISTROM 1, 2, 4 mg tabs.

Ethylbiscoum acetate: 900 mg followed by 300-600 mg/day.
Sodium citrate: 1.65 g for 350 ml of blood (for transfusion); ANTICOAGULANT ACID CITRATE DEXTROSE
SOLUTION 2.2 g/100 ml (75 ml is used for 1 unit of blood).
Sodium oxalate: 10 mg for 1 ml blood (for blood counts etc).
. Sodium edetate: 2 mg for 1 ml blood (for investigations).

Fibrinolytics Antifibrinolytics
(Thrombolytics) (Antithrombaolytics)
Streptokinase Epsilon amino-caproic acid
Urokinase (EA CA)
Alteplase (rt-PA) Tranexamic acid
Reteplase
Tenecteplase

ANTIPLATELET DRUGS
(Antithrombotic drugs)

| | |
Platelet P2V,, receptor GP II,/lll,
cAMP - blockers ‘antagonists
enhancer Ticlopidine Abciximab
Aspirin | |Dipyridamole | | Clopidogrel Eptifibatide
a Prasugrel Tirofiban
 HYPOLIPIDAEMIC DRUGS

| Lovastatin Ezetimibe
Simvastatin Clofibrate
Pravastatin Gemfibrozil
Atorvastatin Bezafibrate
Rosuvastatin Fenofibrate
| Pitavastatin

[ Cholestyramine
Colestipol | Nicotinic acid

Preparations
Lovastatin: 10-40 mg/day; ROVACOR, AZTATIN, LOVAMEG 10, 20 mg tabs.
akrwh

Simvastatin: 5-20 mg/day (max 80 mg); SIMVOTIN, SIMCARD, ZOSTA 5, 10, 20 mg tabs.
Pravastatin: 10-40 mg/day; PRAVATOR 10, 20 mg tabs.
Atorvastatin: 10-40 mg/day (max 80 mg); AZTOR, ATORVA, ATORLIP 5, 10, 20 mg tabs.
Rosuvastatin: 5-20 mg/day (max. 40 mg/day); ROSUVAS, ROSYN 5, 10, 20 mg tab.
 Gastrointestinal Drugs

DRUGS FOR PEPTIC ULCER

Gastric acid secretion inhibitors Gastric acid neutralizers Anti H. pylori

(Antacids) drugs
Amoxicillin
‘Proton pump Prostaglandin Ulcer protectives Clarithromycin
Metronidazole
Cimetidine inhibitors analogue Sucralfate Tinidazole
Ranitidine Omeprazole Misoprostol Colloidal bismuth
Tetracycline
Famotidine Esomeprazole subeitrate (CBS)
CBS
Roxatidine Pantoprazole
Lansoprazole — HE
Rabeprazole [ Systemic Nonsystemic

Anticholinergics| Dexrabeprazole | | Sod. bicarbonate Mag. hydroxide

Sod. citrate Mag, trisilicate
|
| Pirenzepine Alumin. hydroxide
| Propantheline Magaldrate
| Oxyphenanium Cal. carbonate
 ANTIEMETICS

| Hyoscine | Metoclopramide
Dicyclomine Chlorpromazine Domperidone Aprepitant
. Triflupromazine Cisapride, Fosaprepitant
Prochlorperazine Mosapride
(others) Itopride

| Promethazine Ondansetron
Diphenhydramine Granisetron Dexamethasone
Dimenhydrinate Palonosetron Benzodiazepines
Doxylamine Ramosetron Dronabinol
Meclozine (Meclizine) Nabilone
 Laxatives [125 |

LAXATIVES
(Purgatives, Cathartics)

Dietary fibre: bran Docusates (DOSS) Mag. sulfate

Psyllium (plantago) Liquid paraffin Mag. hydroxide
Ispaghula Sod. sulfate
Methyl cellulose Sod. phosphate
Sod. pot. tartrate
Lactulose

Phenolphthalein Prucalopride Castor oil

Bisacodyl Senna
Sod. picosulfate Cascara sagrada
(128 Gastrointestinal Drugs

DRUGS FOR DIARRHOEA

Antimicrobial Drugs for inflammatory

drugs Lactobacillus sp. bowel disease

Norfloxacin Bifidobacterium
Ciprofloxacin bifidum
Rifaximin Strep. faecalis
Cotrimoxazole Enterococcus sp.
Ampicillin Bacillus clausit ‘ :
Tetracycline Saccharontyces Sulfasalazine Prednisolone
Erythromycin boulardii Mesalazine Hydrocortisone
Metronidazole Balsalazide (enema)
Olsalazine

Nonspecific
antidiarrhoeal drugs
Azathioprine
Methotrexate
Cyclosporine
Infliximab
Ispaghula Rasecadotril Codeine
Methylcellulose Bismuth subsalicylate Diphenoxylate
Kaolin Anticholinergics Loperamide
Pectin Octreotide
 Antibacterial Drugs

ANTIBACTERIAL DRUGS
|

Penicillins Tetracyclines Rifampin

Cephalosporins Chloramphenicol Aminoglycosides: L
Carbapenems Erythromycin (Streptomycin,
Monobactams (other macrolides) Contain Z
Vancomycin Clindamycin others) ’
Cycloserine Linezolid L
Bacitracin Sulfonamides
3 Sulfones
Trimethoprim
Pyrimethamine
; Ciprofloxacin Para amino-
Polymyxin (Other fluoro- salicylic acid
Colistin quinolones) Metronidazole
Bacitracin
Amphotericin B
 Sulfonamides/Quinolone Antimicrobials

SULFONAMIDES

Sulfadiazine Sulfamethoxazole Sulfadoxine Sulfacetamide sod.

Sulfamethopyrazine Sulfasalazine
Silver sulfadiazine
| Mafenide
QUINOLONE ANTIMICROBIALS

Nonfluorinated Fluoroquinolones
quinolone
Nalidixic acid

Norfloxacin Levofloxacin
Ciprofloxacin Moxifloxacin
Ofloxacin Gemifloxacin
Pefloxacin Prulifloxacin
) Lomefloxacin
Sparfloxacin
134 Antibacterial Drugs

PENICILLINS

Natural penicillin Semisynthetic penicillins p-lactamase

inhibitors
Benzyl penicillin
(Penicillin G) Clavulanic acid
Sulbactam
| Tazobactam

Phenoxymethyl Methicillin
penicillin Cloxacillin
(Penicillin V) Dicloxacillin
Ampicillin Piperacillin
Bacampicillin Mezlocillin
Amoxicillin

Carbenicillin
 Cephalosporins 137
CEPHALOSPORINS

First generation Third generation Fourth generation

Cephalexin | Cefixime Cefotaxime Cefepime

Cefadroxil Cefpodoxime Ceftriaxone Cefpirome
Second generation proxetil Ceftizoxime
Cefdinir Ceftazidime
Ceftibuten Cefoperazone
Ceftamet pivoxil

Cefaclor
Cefuroxime
axetil
Cefprozil
 Antitubercular Drugs [145 |

ANTITUBERCULAR DRUGS

First line drugs Second line drugs

Isoniazid
Rifampin
Pyrazinamide
Ethambutol Ofloxacin | Ethionamide Kanamycin
Streptomycin Levofloxacin | Prothionamide Amikacin
Moxifloxacin Cycloserine Capreomycin
Ciprofloxacin | Terizidone
Paraamino-
salicylic acid (PAS)
| Rifabutin
| Thiacetazone
 Antitubercular/Antileprotic Drugs | 11:7/

ALTERNATIVE CLASSIFICATION
ANTITUBERCULAR DRUGS

Isoniazid Streptomycin Ofloxacin

Rifampin Kanamycin Levofloxacin Ethionamide Thiacetazone
Pyrazinamide Amikacin Monxifloxacin Prothionamide Clarithromycin
Ethambutol Capreomycin Ciprofloxacin Cycloserine Clofazimine
Terizidone Linezolid
Para amino-
salicylic acid

ANTILEPROTIC DRUGS

Dapsone
L Clofazi—mine |
Rifampini Chloe
Moxifloxacin
Ethionamide Minocycline
Clarithromycin
 Antifungal, Antiviral, Antiprotozoal and Anthelmintic Drugs

ANTIFUNGAL DRUGS

Antimetabolite Topical agents

| Flucytosine Terbinafine Tolnaftate

Undecylenic acid
Benzoic acid
Ciclopirox olamine
Butenafine
Amphotericin B Quiniodochlor
Nystatin Griseofulvin Sod. thiosulfate
Hamycin Fluconazole
Itraconazole
Voriconazole
Caspofungin Posaconazole
Micafungin =r dq Ek
Anidulafungin Clotrimazole Ketoconazole
Econazole
Miconazole
Oxiconazole
 Antiviral Drugs (Non-retroviral) 153 |

ANTIVIRAL DRUGS (Non-retroviral)

Anti-herpes Anti-influenza Anti-hepatitis virus/

virus drugs virus drugs Nonselective antiviral
| Idoxuridine Amantadine drugs
Trifluridine Rimantadine
Acyclovir Oseltamivir
Valacyclovir Zanamivir
Famciclovir For hepatitis B ‘For hepatitis C
Ganciclovir ET TEE
Valganciclovir Lamivudine Ebi
Cidofovir Adefovir dipivoxil Interferon
Foscarnet Tenofovir
Fomivirsen
(154) Antifungal, Antiviral, Antiprotozoal and Anthelmintic Drugs

ANTIRETROVIRUS DRUGS

Ritonavir
Zidovudine Nevirapine Atazanavir
Didanosine Efa virenz Indinavir
Stavudine Delavirdine Nelfinavir
Lamivudine Saquinavir
Abacavir } Amprenavir
Emtricitabine
Lopinavir
Tenofovir | P

| Enfuvirtide Maraviroc Raltegravir

(158) Antifungal, Antiviral, Antiprotozoal and Anthelmintic Drugs

ANTIMALARIAL DRUGS

Chloroquine Proguanil ‘Halofantrine

Amodiaguine |{Chloroguanide) Sulfadoxine Lumefantrine
Piperaquine Sulfametho-
pyrazine
Dapsone

Mefloquine Pyrimethamine Doxycycline Atovaquone

Clindamycin

[Quinine | Primaquine Artesunate | Pyronaridine

Quinidine | Tafenoquine | Artemether |

Arteether
Arterolane
(162) Antifungal, Antiviral, Antiprotozoal and Anthelmintic Drugs

ANTIAMOEBIC DRUGS

Tissue amoebicides Luminal amoebicides

Diloxanide furoate Tetracycline

Nitazoxanide Paromomycin
Chloroquine

Quiniodochlor
- - (lodochlorehydroxyquin)
Metronidazole Emetine Diiodohydroxvquin
Tinidazole Dehydroemetine (lodoquinol)
Secnidazole |
Ornidazole
Satranidazole
(166 Antifungal, Antiviral, Antiprotozoal and Anthelmintic Drugs

Combinations
1. Liposomal amphotericin B (5 mg/kg iv. infusion single dose) + Miltefosine (100 mg/day oral for 7 days)
2. Liposomal amphotericin B (5 mg/kg iv. infusion single dose) + Paromomycin (15 mg/kg im. daily for 10 days)
3. Miltefosine (100 mg/day oral for 10 days) + Paromomycin (15 mg/kg im. daily for 10 days).

ANTHELMINTIC DRUGS

Praziquantel
Niclosamide Albendazole
Albendazole Albendazole Albendazole Mebendazole
Mebendazole Mebendazole
Pyrantel pamoate
Piperazine
Levamisole

Ivermectin Diethylcarbamazine
Albendazole Ivermectin
| Albendazole
Anticancer Drugs (Antineoplastic Drugs)
ANTICANCER DRUGS (1)

Cytotoxic drugs (1)

Cisplatin
Carboplatin
Oxaliplatin
Methotrexate 6-Mercaptopurine 5-Fluorouracil
Pemetrexed | 6-Thioguanine Capecitabine
Azathioprine Cytarabine
Fludarabine

| Thiotepa Carmustine Procarbazine

| Mechlorethamine Lomustine
| Cyclophosphamide
| Ifosphamide
| Chlorambucil
| Melphalan Busulfan Dacarbazine
Temozolomide Contd.....
 Anticancer Drugs (Antineoplastic Drugs)

ANTICANCER DRUGS (2)

Cytotoxic drugs (2)

| Actinomycin D | Hydroxyurea
Etoposide Topotecan Doxorubicin L-Asparaginase
Irinotecan Daunorubicin Tretinoin
Epirubicin Arsenic trioxide
Mitoxantrone
Bleomycins
| Mitomycin C
Vincristine Paclitaxel
Estramustine
(oncovin) Docetaxel
Vinblastine
Vinorelbine
Contd...
 Anticancer Drugs | {7(
ANTICANCER DRUGS (3)
|
Targeted drugs Hormonal drugs

Imatinib Gefitinib Sunitinib Bortezomib Rituximab

Nilotinib Erlotinib Bevacizumab
Cetuximab

Prednisolone Tamoxifen Ebro

(others) Toremifene Letrozole Finasteride 2 A
Anastrozole Dutasteride 4 p= te (others)
Exemestane

Ethinyl estradiol Flutamide Nafarelin

Fosfestrol Fulvestrant Bicalutamide Leuprorelin
Triptorelin
Miscellaneous Drugs

IMMUNOSUPPRESSANT DRUGS
|

Prednisolone
Cyclosporine Sirolimus Azathioprine (others)
(Ciclosporin) Everolimus Methotrexate
Tacrolimus Cyclophosphamide
Chlorambucil
Mycophenolate mofetil

Etanercept Anakinra Daclizumab Muromonab CD3 Antithymocyte

Infliximab Basiliximab antibody (ATG)
Adalimumab Rho(D) immune
globulin
(184) Miscellaneous Drugs

DRUGS FOR ACNE VULGARIS

Topical drugs

Antimicrobials | | Retinoids Azelaicacid | | Antibiotics | | Retinoid |

Benzoylperoxide Tretinoin Doxycycline Isotretinoin
Erythromycin (all trans- Minocycline (13-cis retinoic
Clindamycin retinoic acid) Erythromycin acid)
Nadifloxacin Adapalene
Tazarotene

Preparations

1. Benzoyl peroxide: 25-10% topical application;

PERSOL, PERNOX, BENZAC-AC 2.5% and 5% gel, in PERSOL FORTE 10% cream with sulfur ppt. 5%.
2. Tretinoin (Retinoic acid, all trans vitamin A acid): 0.025%-0.05% topical application;
EUDYNA 0.05% cream, RETINO-A 0.025% and 0.05% cream.
3. Adapalene: 0.1% topical application once daily at bed time; ADAFERIN, ADAPEN, ACLENE 0.1% gel.
Azelaic acid: 10-20% topical application; AZIDERM 10%, 20% cream.
as

Eryth romycin: 2-4% topical application; ACNEDERM 2% lotion and oint; ERYTOP 3% lotion and cream;
EROMED 2% lotion, 4% gel, ACNELAC-Z 4% lotion and gel with zinc acetate 2%.
 Vaccines 189 |

VACCINES

Killed (inactivated) vaccines

CrTL R—
Typhoid - paratyphoid (TAB) Poliomyelitis inactivated Bacillus Poliomyelitis oral
Vi Typhoid polysaccharide (IPV; Salk vaccine) Calmette- vaccine (OPV, Sabin)
Cholera Rabies (Neural tissue) Guerin (BCG) Mumps (Live atte.)
Whooping cough (Pertussis) Rabies (chick embryo cell; Typhoid Ty 21a Measles (Live atte.)
Meningococcal PCEV) (oral) Rubella (Live atte.)
Haemophilus influenzae Rabies (Human diploid Varicella (Live atte.)
type B cell; HDCV)
Plague Rabies (Vero cell; PVRV)
Influenza OC —
Hepatitis B
Hepatitis A Tetanus (fluid /adsorbed)
Diphtheria (adsorbed)

Double antigen: Diphtheria toxoid + tetanus toxoid (DT-DA)

Triple antigen: Diphtheria toxoid + tetanus toxoid + pertussis vaccine (DPT)
Pentavalent vaccine: DPT + Hepatitis B + H. influenzae type B vaccines
Measles + mumps + rubella vaccine (MMR)