1.

Heparin mechanism of action asked -> binds to antithromin 3

2. Paclitaxel MOA , A case was given of patient taking treatment for cancer develops neuropathic
symptoms -> inhibitis the disruption of tubulin
3. A person had pain while climbing which muscle ? gluteus maximus
4. A patient had an intertrochanteric fracture and leg was laterally rotated asked due to which
muscle it is laterally rotated? Piriformis
5. There were 4-5 questions about MOA and adv of protein synthesis inhibitors
6. Defence mechanism : counter transference: patient came to doctor , doctor felt she looks like
her ex girlfriend and wanted to tell her about it.
7. Altruism : a cancer patient suddenly gives charity to cancer hospitals
8. A woman come to doctor and tells him that you are treating me wrong and she has a paper in
her hand which she claims is evidence : what ll be your response? Lets together go through it
and reach the reality.
9. Fungi tinea questions ( corporis and rubrum)
10. Praziquantal MOA.
11. 1 question on Kaplan meler curve , asked about potency and efficacy.
12. ECG was given and in description skipped beat. Option: v tach , premature ventricular excitation,
atrial fib, torsades pointes , myocardial ischemia ?
13. Aortic stenosis case , syncope angina symptoms and heart sound ws also given ( media question
but description also given) right upper sternal border
14. One more murmur on mitral regurgitation
15. Pleural effusion : red on gross examination: cause was asked? Hemothorax due to malignancy?
Not confirm do check
16. A man 25 year age went europe asia had sex with multiple partners present with severe knee
pain , pustules and tendosynovitis : characteristic of organism was asked : organism inside the
neutrophils. Not confirm , do check ( this option is according to Neisseria)
17. KRAS question: anti EGF antibody given but did not show any improvement why? Mutation in
wild type kras
18. An old man came with oral lesion and blisters which rupture (flaccid bullae) pemphigus vulgaris
case: immunofluorescence was asked: IgG against desmosomes in keratinocytes
19. Case on facial nerve palsay lower motor neuron type : a picture was given and options were
placed on cranial nerve 6 7 8 , had to choose from that picture. ( 6 is medial most then facial
then vestibulocochlear at pontomedullary junction)
20. A case on stroke: uvula deviates on left : again picture was given had to choose. Uvula deviates
to left means lesion in right vagus nerve as uvula deviates Away. Right medulla was right option.
21. A case on pneumocystis jiroveci : silver stain was given. HIV was positive
22. A pictue was given . it was probably of rhabdomyosarcoma. Google the picture .in description
marker was given actin +ve. Two confusing options : rhabdomyosarcoma or lipomyosarcoma
23. Pelvic ischemia one pq
24. Women taking Ca tablets , preparation action pq
25. Progestrone graph spiral artery coiled gland pq
26. One question was given on a women taking anti epileptic. Asked the nutrient which is deficient
in her ( antiepileptic cause folate deficiency) ll do what? Methylation
27. Vit a deficiency : dry skin corneal bitot spots
28. Flip the coin question . pq
29. Cancer in sigmoid colon : a. KRAS b.mismatch. Sigmoid is on left so APC KRAS P53 SEQUENCE
more proll.
30. 1 question on attributable risk reduction
31. Question on replication, diagram given, asked about which molecule ll save from degradation of
strand ? SSBPs
32. A virus given and drug given . association asked between drug and virus? Plausabilty temporalty
(Bradford hill criteria)
33. P value < 0.05 and r -0.5 -> strong study, weak co relation. (corelation when approaches 1
signifies strong correlation.
34. A medical student has to submit research by tomorrow. He took 300 different literatures. From
it he concluded 150 took drug and 150 didn’t. from 150 who took drug , 100 were treated and
from 150 who did not take drug , 60 treated. Which bias? Options were given: selection bias,
literature bias , information bias?
35. One q on hydronephrosis. Picture was given of kidney. Parenchymal atrophic and dilated.
36. Alcohol withdrwal question which receptors are upregulated? NMDA (glutamate)
37. A patient with htn , we gave ace inhibitor , what ll be effect on efficacy potency? Km increase or
decrease? Graph was given
38. One question on lineweaver burk plot. Non competitive. (non competitive doesnot cross)
39. Phophotidyl serine apoptosis pq
40. One question on shock . TLR interact with lps pq
41. Scabies question nursing homes pq
42. One question on contact dermatitis. Linear streaks
43. Pipecollinic acid peroxisome pq
44. One question on vitamin D . a patient has hypocalcemia we have given vit D what ll it do?
Increased ca absorption from gut
45. Secondary hyperparathyroidism graph pq
46. Camping giardiasis pq
47. Diencephalon kallman pq
48. VHL question. 10 year ago diagnosed with hemangiblastoma, now which can cancer may
develop? RCC
49. One question on telephone interpretator , Spanish one pq
50. Double cortex radial migration pq
51. Paint spilled stratum corneum pq
52. Appendicitis case. Doing appendectomy. Which artery supply this region? SMA
53. SSRI what are your concerns question . pq
54. Experimental question on hydroxyproline in collagen. Which organelle ? Rough endoplasmic
reticulum
55. One brain picture was given . from recent may paper. Ischemia on lateral sulcus tempora lobe
involved. Asked which nucleus of thalamus injured ? confused. Options : anterior medial lateral
venteromedial
56. One case on dementia: one women sexual worker. Taken to police station. Police called her
daughter. Woman started crying, and said she doesn’t remember anyting kay she was having
 sex. Her daughter came and told the police she forgets things, dx. Alzhemir? But age was 50. Do
confirm this
57. One picture on brain. Arrow on pons . what option is correct regarding it? One option on facial
nerve symptoms. Ipsilateral symptoms. Cranial nerve nuceli gives ipsilateral symtoms
58. One question on Central retinal artery occlusion. Fundoscopy given. Cherry red spot. What is the
cause? A fib
59. Papillary muscle rupture picture
60. Pneumonia case given, pneumonia infection happened and subsided. What ll we find in lungs 3
months after infection? Normal or fibrosis? Do confirm.
61. One question on cell cycle. One molecule added ,rapidly dividing cell uptakes this molecule
which phase? S phase?
62. Problem in G1 which is next checkpoint? S or G2?
63. One question on infectious mononucleosis
64. African American microcytic anmemia? Decreased heme synthesis. (thalaesemia)
65. One question on ancylostoma duodenale . iron deficiency anemia and surpingeous rash on foot.
66. Osler nodes picture given. Endocarditis
67. Case on benzocaine adv effect asked. A patient given anesthesia during to endoscopy. Adv
effect? Decreased oxygenation of heme ie methemoglobinemia.
68. KRAS mutation one more. Non small cell carcinoma of lung.
69. Subpleural plaques -> asbestos
70. diabetic ketoacidosis , a patient with hx of diabetes after exercise found unconciouss, hormone
asked ? Increase cortisol ?
71. TNF alpha inhibitor : a patient presenting with lupus like symptoms after taking tnf inhibitor.
Ans: antihistone antibodies.(drug induced lupus)
72. Question on aging. Resting energy expenditure last year was 1200 kcal. After 1 year resting
energy expenditure (bmr) is 1500 , why? A.increased TSH b. Dec TSH. Inc fat free mass. D.
decreased fat free mass
73. Cyanosis with increased intensity of S2 in age 2 years child -> subpulmonic stenosis with right
ventricular hypertrophy (TOF)
74. Patent foramen ovale. DVT kay baad stroke why? Ans was patent foramen ovale
75. Shock. Shock after MI-> Cardiogenic shock.
76. Exercise effect on SVR-> decrease
77. Woman came for well child examination , she was reluctant for vaccine administration of her
child . her brother had autism, what ll be physician s response?
I am giving your broucher go home and read it and after then come in next appointment?
78. A man has to quit smoking and alcohol but wants to quit smoking first, what ll be response?
Only one option to smoking , first address smoking. Lets first talk about somking and once you
are done with quitting it then we ll talk about alchol
79. One question on decision making capacity.
80. Substance abuse question. A man found on road is agitated, is talking irrelevantly and saying I
want to kill everyone how ll you treat. Antagonism of dopamine . pq
81. One question on hypercholesterolemia experimental. Antibody binds to LDL-receptor clathrin
antibody pq
82. Myotonic dystrophy case given can/t relax fist pedigree-> autosomal dominant
83. One case on hashimoto thyroiditis, what causes it? Autoimmune.
84. One case on amylydosis . patient of old age had tinel sign positive and long case on systemic
amylydosis.
85. One question on diabetes. A patient taking metformin now given another oral agent where it ll
act? K channel pq diagram one
86. Cell membrane swelling blebing , Mitochondrial swelling moderate chromatin condensation?
Apoptosis.
87. Polycythemia case hct 60, itching after bath? Tyrosine kinase jak2 (activating mutation of
JAK/stat)
88. Anemia cases . TMP-SMX for infection -.G6PD
89. Another question on adverse effect of Trimethorpim-> hyperkalemia
90. A wasted boy with protruded abdomen-> fat deposition in liver pq
91. Hypoketotic hypoglycemia case, defect in what? Fatty acid oxidation defect.
92. One question on McCardles. Muscle cramp and red urine after exercise which enzyme?
Myophosphorylase.
93. Von geirke scenario. Which enzyme? Glucose-6-phosphatase
94. Histo picture of neiman pick (foamy macrophage one given ) asked about which enzyme
deficient? Sphingomyelinase
95. Metachromatic leukodystrophy case, enzyme asked? Aryl sulfatase A.
96. B1 case .
97. Experimental q. NADPH is decreased. What ll be state of glutathione? Oxidized glutathione.
98. Linoleic and linelonic acid can’t be absorbed , what? Pancreatic insufficiency pq
99. A patient is injured, clear fluid oozing out? Fluid coming out due to chemotaxis or vasodilation?
100. HHV 6 scenario. Fever followed by rash . DNA double stranded enveloped virus.
101. Influenza virus strain changing yearly why? Due to mutation in hemagglutinin.
102. Hepatitis questions , IgM hep A positive , long scenario diagnosis asked. Hep A
103. Hep B core positive IgG and HbS IgG positive. Ans: recovered from infection and
immunized.
104. Another question on Hep Vaccination, which antibody ll be positive? HbSAg IgG.
105. Candida infection scenario vulvovaginitis hx of ocps. Treatment MOA asked? Inhibit
ergosterol synthesis (azoles)
106. One question on Cryptococcus neoforms drug MOA asked? Pore in membrane
(amphotericin is first line, for maintenance give flucanozole)
107. Case was given , it was told kay trypnosoma cruzi infection, transmission? Reduvidaee
bugs (triatomine bug/kissing bug)
108. Infectious mono question after kissing present with tender heoatisplenomegaly,
oropharynx pink? Dx asked? Infectious mono
109. Another question on infectious mono which drug shouldn’t be given?
Penicillin/amoxicillin
110. Patient presenting with Hoarseness, dysphagia , history of infectious mono and
childhood , hx of alchol and smoking , had ear ache too , which of the following risk factor
involved in presentation? Smoking or previous ebv?
111. Another question was given. A women came with gerd and endoscopy of esophagus
showed normal mucosa. Normal esophagus was right option
112. Hydrops fetalis case . Rh incompatabilty was option.
113. Ganciclovir resistant cmv -> foscarnet.
114. another cmv scenario on retinitis. Treatment given but in effective why? Mutation in
thymdine kinase. Pq
115. one question on lipodystrophy. Case was given and fat redistribution explained like thin
arms and legs but fat deposition in abdomen and over neck. Drugs were asked -> protease
inhibitor (cause cushing like syndrome)
116. one question on Baloxavir. MOA asked? inhibit 5 cap snatching activity of influenza
endonuclease.
117. One question on Rett syndrome. A girl with classic swinging movements of hands and
regression. Diagnosis was asked.
118. Marfan syndrome history given, asked where ll find the murmur> cardiac apex
119. Another murmur of MVP given and in hx scoliosis given, diagnosis was asked. Marfan
120. Diabetes patient has heartfailure , has overt symptoms of dyspnea edema, which
diuretic ll be given. Na K 2Cl option. (thiazide/NaCl also there but in diabetes can’t be given due
to hyperglycemia and loop has better edema resolving or diuretic effect than thiazide).
121. Tdt and CD3+ ->immature thymocytes.
122. CD4+ CD8+ -> thymocyte pq
123. Which receptor involved in shock? TLR4 pq
124. Normal saline infusion , what ll rise? Tnf alpha /cytokine. Pq
125. An experimental ques. Injection of growth hormone , which cell ll have inc activity?
Osteoblast or cartilage? Most prolly cartilage b/c growth hormone inc linear growth?
126. Parkinson case, defect where? Section of midbrain substania nigra given.
127. Subdural hemorrhage given , why it doesnot cross midline? Falx cerebri
128. Patient with frequency and urgency, asked palpation ll illicit pain where? Suprapubic
tenderness or flank? Dermatome level given. T12-L1 or L1-L3
129. Pancreatitis case, we should avoid giving what in nutrition? Fatty acid
130. Papillary muscle rupture questions , 5-6 related to heart failure
131. skewed question. Graph was given characterstic asked. Ans was negative skewed
132. Adrenal insufficiency case, hypotensive and rash and meningitis: waterhousefreidrich
syndrome. N meningitis. Acute adrenal insffuciency was option (why hypotensive was asked)
133. Another question about Neisseria , what increase risk. Terminal hypocomplementemia
(decreased C7 was option)
134. Another question. A women presents with cough and says she feels heaviness in neck
and has pain in hands , -> increased bradykinin (hereditary angioedema)
135. A question on giant cell arteritis why ESR is raised? Acute phase reactants.
136. Zero order kinetics curve given. No effect of loading dose on plasma conc? Do confirm
137. Leprosy case . few hypoesthetic and hypopigmented areas on hand . hx of travel from
india. -> TH1 mediated option.
138. One question on precision. A new test was developed and susbsequently reproduced
same results what could be concluded ? good precision.
139. Surfactant function asked? Decrease surface tension relative to water.
140. Malaria case given, ring in erythrocytes -> malaria related option given.
141. Case on riverblindness onchocera , treatment was asked? Ivermectin
142. Interferon given in HBV case, what ll it do? Decrease nucleic acid synthesis , ns3b no
change? Do confirm
143. A case on ulcer , risk factor asked? Smoking or obesity?