• 1)What is probable diagnosis
• ALL
• 2)Mention 2 test for diagnosis
• Immunopheno typing and bone marrow examination
• 3)Two lymphoreticular organs involved in this case
Liver, Spleen, lymph node
• 4)Mension types
• B cell ALL
• T cell ALL
• 5)Morphology of cells in peripheral smear
• Hand mirror cells
• 1)Diagnose the case
• CLL
• 2)What is evans syndrome
• Evans syndrome is an autoimmune condition that present with two or more cytopenias which commonly include autoimmune
hemolytic anaemia and immune thrombocytopenia with or without immune neutropeia
• 3)Name the condition where there is malignant transformation in the above setting
• Ritchers syndrome cll may transform into DLBCL
• 4)Mension two markers for diagnosis of above case-CD19,CD 5,CD20,CD23,CD200
• Menstion significance of rai and binet classification
• Staging of CLL and predicting the outcome of patient
• 1)What is your disgnosis
• ITP
• 2)Identify arrow marked cell
• Giant pleatlet
• 3)What will be the bone marrow finding in this case
• Normal or increased number of megakaryocyte
• In some patient hypolobulation of megakaryocyte
• 4)What is evans syndrome
• Evans syndrome is an autoimmune condition that present with two or more cytopenias which commonly
include autoimmune hemolytic anaemia and immune thrombocytopenia with or without immune
neutropeia
• 1)What is the diagnosis
• Thalassemia
• 2)Identify the cell with arrow
• Target cell
• 3)What is the specific test to diagnose the case
• HPLC
• 4)Write peripheral smear finding in this case
• Microcytic hypochromic cells, anisopoikilocytosis, target cells tear drop cells, pencil cells,
nRBCs
• 1)Diagnose the case
• CML
• 2)What are the phases seen in this condition
• Chronic phase
• Accelerated phase
• Blast phase
• 3)defining criteria for this phases
• -Chronic phase
• Leucocytosis usually 12-1000x 10 9 /L
• Less than 2% blast in blood and less than 5% blast in bone marrow
• -Accerlerated phase
• ≥ 1 of the following criteria
• Persistent or increasing WBC > 10x10 9 /L
• Persistent platelet count > 1000x10 9 /L unresponsive to therapy
• Persistent platelet count < 100x10 9 /L unrelated to therapy
• ≥20% basophils in the blood
• Persistent or increased splenmegaly unresponsive to therapy
• -Blast phase
• ≥20% blast in marrow or blood or the presence of an extramedullary
proliferation of blast
• 1)Write down your provisional diagnosis
• Apastic anemia
• 2)Write down etiological factors of above condition
Infectious agents Heatitis A,B,C viruses
Other viruses –HIV,EBV,CMV,Parvovirus
Toxins –Benzen solvent, insecticides
Drugs-allopurinol,chloroquine, penicillamine
Autoimmune diseases-SLE,RA
• 3)Describe the peripheral smear
• Severe cytopenia no overt dysplastic features
• Sometime megaloblastic changes
• 1)What is your diagnosis
• DIC
• 2)What happens to the FDP levels elevated
• 3)Which poikilocytes will be seen in peripheral smear
• 4)Enumerate some causes of this condition
• 5)Which coagulation factor will initiate the pathogenic cascade
• 1)Descibe the peripheral smear and give our diagnosis
• Hypochromia, pencil cells and hypersegmented neutrophils
• 2)Mention two causes of this blood picture
• Folic acid and Vit B12 deficiency
• 3) Which are the bone marrow finding in this condition
• Erythroid hyperplasia with reversal of M: E ratio
• Megaloblastosis – Megaloblast have Large , immature nucleus with open sieve like
chromatin macronormoblast
• Myeloid lineage abnormality
• Giant band form
• 1) What is your diagnosis
• VWD
• 2)Which is the cause of platelet function defect and prolonged aPTT
• Reduced plasma level of vWD
• 3)Which are various types of this diseases
• Type 1, 2,3
• 1)Describe the peripheral smear and give your diagnosis
• Hypochromic cells, sickle shaped cells, target cells
• Sickle cell anemia
• 2)Enumerate test performed for confirmstion
• HPLC
• 3)Enumertae types of crisis associated with this anemia
• Vaso occulusive crisis
• Aplastic crisis
• 1)What is your diagnosis
• Haemophili A
• 2)What is the mode of inheritance
• X linked recessive
• 3)Treatment to be given
• Factor VIII
• 1)Interpret the peripheral smear finding
• Microcytosis, hypochromia, anisopoikilocytosis, pencil cells, spherocytes
• 2)Which is your provisional diagnosis
• Heridetaray speherocytosis
• 3)What is defect involved in pathogesis of this disorder
• Defect in RBC skeleton due to mutation of spectrin, band 3, ankyrin and
band 4.2
• 1)Describe peripheral smear finding and give provisional diagnosis
• Autoimmune hemolytic anemia
• Red cell agglutination, spherocytes seen
• 2)Name laboratory test which support diagnosis
• DAT(Direct antiglobulin test
• 3)Enumearte causes of such disorder
• Infections-Hep C,HIV,EBV,CMV
• Medications – Penicillin, cephalosporin
• Autoimmune - SLE,RA
• CLL
• 1)Diagnose the case
• Pancytopenia with Macrocytic anemia
• 2)Mention for causes of macrocytic anemia
• Folic acid and vit B12 deficiency,Hypothyroidism,Alcoholism,Liver disesase
• 3)What is Arneth index and its significance
• Classification system for neutrophils based on number of lobes in their nucleus
• AS it reveals the production of neutrophils it indirectly reflects activity of bone
marrow
• Shift to left means younger neutrophils – Prognosis of infectious diseases
• 1)What is probable diagnosis
• Multiple myeloma
• 2)Mention to investigation to confirm the diagnosis
• Immunophenotyping CD 138 positive
• 3)Identify cells marked arrow in the pic
• Russel bodies
• What is POEMS syndrome
• Polyneuropathy,organomegaly,endocrinopathy,monoclonal plasma cell
disorder, skin changes
• What is probable diagnosis
• ALL
• 2)Mentio two test for diagnosis
• Immunophenotyping,cytochemistry and bone marrow examination
• 3)Mention two reticular organ involved in this case
• Liver and lymphnode
• 4)Mention types
• 5)Describe morphology of labelled cells in above picture
• What is your diagnosis
• SCC cervix
• Write the Caustive agent
• HPV 6 and 11
• What is VIA and VILI
• Visual inspection with acetic acid
• Visual inspection with lugals iodine
• What is your interpretation
• Normal
• Enumerate other such test used screening diagnosis and ruling out
cancer
• Mammography for breast cancer
• FNAC and biopsy of breast , thyroid and lymphnode
• What is the diagnosis
• Mild dyplasia
• What is nature of disease
• Precancerous condition
• Give other example of similar condition
• DCIS
• Barrets esophagus
• Lichen Planus
