Agilent ICP-MS (7850/7800/7900)

MassHunter Workstation User Guide

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 Content

MassHunter Workstation Overview 5

Starting the MassHunter Workstation Software 7
Commands on the Ribbon 9
Commands on the Task Navigator 10
Checking the Hardware Settings 11
Preparations Before Analysis 15
Things to check before analysis 15
Preparing tuning solutions 16
Preparing calibration solution and samples 17
Plasma ON/Executing a Startup 18
Checking the Instrument Status 22
Instrument Status Indicator 22
Status Viewer dialog box 23
Instrument Status pane 23
Creating a Batch 27
Setting up an Acquisition Method 30
Setting up a Data Analysis Method 38
Setting up a Sample List 41
Checking the Method 42
Executing the Queue 43
Checking the Analysis Results 46
Quantitative Analysis 46
Commands on the Ribbon 47
Semiquantitative Analysis 50
Generating a Report 52
Generating the Sample report 52
Generating a Quick Batch Report 53

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 3

 Content

Saving the Analysis Results 54

Plasma OFF 54
Exiting the MassHunter Workstation 55
Appendix 56
Recommended Values for Tuning Parameters 56
Types of Preset Methods 59

4 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 MassHunter Workstation Overview

The following flowchart describes the main workflow of a basic analysis with
MassHunter Workstation. The steps are described further in this User Guide. For
additional details, advanced functions, and non-standard configurations, refer to
the online Help.

Refer to online Help for simplified workflows for non-standard configurations

NOTE (Organic Solvent, GC, etc.).

Start MassHunter Workstation Start the MassHunter Workstation software.

Configure and check the settings such as the presence of an

Check Hardware Settings
autosampler and the types of the nebulizer and lens.
Check the gas pressure and cooling water, and then set the
Prepare for Analysis tuning solution, standard solution, samples, internal standard
solution, and so on to the autosampler.

Turn Plasma ON/Execute Startup After plasma ignition, run Startup to optimize the instrument.

Check Instrument Status Check meter values to see the instrument status.

Create a batch, and configure the acquisition method, data

Create Batch analysis method, and sample list.

Execute Queue Add the created batch to the queue and start the acquisition.

Check Analysis Results The analysis results can be viewed on the panes in the ICP-MS
Data Analysis window.

Generate Reports Generate a sample report or quick batch report.

Save Analysis Results Save Analysis results.

Turn Plasma OFF Turn off the plasma.

Exit MassHunter Workstation Exit the MassHunter Workstation software.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 5

 MassHunter Workstation Overview

You can access online Help from MassHunter by:

NOTE
• Click on the title bar of the Window.
• Click the Help button in a dialog box.
• Click in a dialog box.
• Press the F1 key.

6 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Starting the MassHunter Workstation Software

Starting the MassHunter Workstation Software

This section explains how to start the Agilent ICP-MS software.

1 Start the Agilent ICP-MS software in one of the following ways:
• Click on Start on the Windows taskbar and select ICP-MS MassHunter
Workstation > ICP-MS Instrument Control.
• Double-click the shortcut icon on the Windows desktop.
The ICP-MS MassHunter Workstation dialog box appears.

2 Select the relevant button for the task you wish to start; refer to the following
table.
The behavior depends on the button you click. For example, to check the
hardware settings, click the Instrument Control button, then the Dashboard
pane is displayed in the ICP-MS MassHunter window. Click one of the menus
on the Task Navigator to display a different task pane.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 7

 Starting the MassHunter Workstation Software

Button Function

Instrument Control Button Click this button to open the Dashboard pane to configure and check
the hardware.

Process Data Button Click this button to do offline data analysis. The Batch pane and Offline
ICP-MS Data Analysis window are displayed.

Acquire New Data Button Click this button to do a new data acquisition. The New Batch Folder
dialog box is displayed, which lets you create a new batch folder.

Load Option This item is displayed when User Tune is selected on the Options
category in the Settings dialog box (see page 14). The first time to start
MassHunter Workstation, Load Option will be disabled (grayed out).
Standard Tune: Loads the factory default tuning parameters.
User Tune: Loads the User Tune. For more information, refer to the
online Help.

Close Button To close this dialog box and go to MassHunter Workstation. To hide
this dialog box at the next startup, mark the box for Do not display this
dialog again.

A pane is a section of a window.

NOTE

Tab
Ribbon
Group
Tool Bar

Instrument
Status
Indicator

Task Navigator

Status Bar

8 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Commands on the Ribbon

Commands on the Ribbon

The following table indicates the commands on each tab on the Ribbon.
For details on each function, refer to the online Help.

Ribbon Command

File tab New Batch Folder, Open Batch Folder, Import from Existing Batch, Save
Batch, Save Batch As, Save as Batch Template, Close, About, Exit commands

Home tab Sample Handling group Nebulizer Pump Speed command

Autosampler command

Startup group Plasma command

Configuration command
Skip Warming up command

Tune group Set as Global Tune command

Batch group New command

Open command
Create from Template command
Validation command
Save As command
Add to Queue command
Advanced Option command

Acquisition Queue group Resume command

Pause command
Stop command

View tab Show group Panes command

Toolbars command
Instrument Status Indicator command
Task Navigator command
Status Viewer command

Maximize group Maximize Pane command

Meter group Meters command

Report tab Hardware group Performance Report command

Tune Report command
Tune Report Settings command
Tune Check Criteria command

Batch group Print Batch Method command

Tune Report command
Tune Report Settings command
Tune Check Criteria command

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 9

 Commands on the Task Navigator

Ribbon Command

Tools tab Settings group Settings command

DA group Offline Data Analysis command

Script group Actions command

Add-Ins group Add-Ins command

Batch Archive group Archive command

Commands on the Task Navigator

The following table indicates the commands in the Task Navigator.

For details on each function, refer to the online Help.

Group Command

Hardware group Dashboard command

Startup group Startup Configuration command

User Tune Configuration command

Acquisition group Setup command

Tune Modes command
Element Selection command
Sample Introduction command
Monitor command
Analyte List command (only Isotope Dilution Analysis)
Calibration command
SemiQuant command
Isotope Ratio command
QC command
Worklist Action command

Sequence group Sample List command

Queue group Acquisition Queue command

Result group Online Data Analysis command

10 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Checking the Hardware Settings

Checking the Hardware Settings

Now configure and check the settings such as the presence of an autosampler
and the types of the nebulizer and lens.
Use the following procedure to check and configure the hardware settings.

If you have modified the ICP-MS configuration or changed the devices that are
NOTE connected to the ICP-MS, change the hardware settings accordingly.

1 Click Settings from the Settings group on the Tools tab.

The Settings dialog box appears.

2 During initial setup, click at the side of Hardware.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 11

 Checking the Hardware Settings

3 During initial setup, click Mainframe, and then click Edit from
"Communication".
The Set Communication dialog box is displayed.

4 (At initial setup) After checking all items, click OK.

If you find anything wrong in the settings, correct the settings.
• ICP-MS
Make sure that the instrument is Online and also that the host name or IP
address of the instrument is correctly entered in Host Name or IP Address.
• Check Firmware Version
Make sure this check box is selected.

Online is the state in which MassHunter Workstation is connected to the

NOTE instrument. Offline is the state in which MassHunter Workstation is used alone
without being connected to the instrument.

12 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Checking the Hardware Settings

5 Check the settings for the peripheral equipment that are displayed in the
System category of the Settings dialog box.
Click to the side of Hardware to change the settings if necessary.
• Sample Introduction
When using an autosampler, select Use Autosampler, and then click Edit.
In the Configure Autosampler dialog box, set the autosampler, and then
click OK.
Sample Introduction: Displays the type of the sample introduction.
Nebulizer: Displays the nebulizer type. The nebulizer usually used is
MicroMist; Microflow (200) when using the s-lens configuration.
• Plasma
Ignition Mode: Set the type of the solution to be introduced at ignition.
Usually, select Aqueous Solution.
• Ion Lenses
Model: Select the lens configuration. Usually select x-Lens; select s-Lens if
you are using the s-Lens configuration.

The term "ALS" has been changed to "Autosampler" in MassHunter 4.5.

NOTE

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 13

 Checking the Hardware Settings

6 When using optional functions, check the settings for the optional functions in
the Options category of the Settings dialog box.
Click to the side of Selected Options to change the settings if necessary.
Refer to online Help.

14 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Preparations Before Analysis

Preparations Before Analysis

Things to check before analysis

Utilities
• Argon gas pressure: 500 to 700 kPa
• Cell gas (Helium): 90 to 130 kPa
• Cell gas (Hydrogen): 20 to 60 kPa (if using the H2 option)
• Exhaust duct
• Cooling water
• Drain and rinse tanks

Purging cell gases

• We recommend you flow the cell gas through the cell gas tube if you have
not used the cell gas for a long time. In Standby mode, click the illustration
of Collision/Reaction Cell on the Dashboard pane to display the menu, click
Maintenance in the menu, and then enter the maximum flow rate in the
output column of H2 Gas Flow Rate or He Gas Flow Rate. Then click the
icon to open the valve and purge the gas for more than 30
minutes.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 15

 Preparing tuning solutions

Preparing tuning solutions

You will need the following standards and solutions for ICP-MS operation:
• Tuning solution (Ex: 10,000 times dilution of P/N 5188-6564: 10 ppm Li, Co, Y,
Ce, Tl)
• Internal standard solution (Ex: 100 times dilution of P/N 5188-6525)
• For P/A factor tuning solutions, use one or more solutions with a
concentration of at least 100 ppb among the calibration standards. (Note that
the concentrations of the standards must be selected so that at least 560,000
cps signals can be obtained in P/A factor tuning). P/A factor is a factor used
to convert a measured value for analog mode into the one for pulse mode.
This is an important tuning for obtaining a calibration curve that is linear
across pulse mode to analog mode. Pulse mode is used to quantitate
relatively low concentrations (ppb). Analog mode is used to quantitate
relatively high concentrations (ppm).

16 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Preparing calibration solution and samples

Preparing calibration solution and samples

Quantitative Analysis
1 Prepare the calibration solution and samples. You can easily prepare the
calibration solution by diluting mixed standard solutions.

• To avoid adsorption in the container and to help stabilize concentrations,

NOTE prepare the samples so that all samples contain the same concentration of
nitric acid (approx. 1%).
• Prepare an on-line ISTD solution so that the concentration of each element is
about 1 ppm. Set the online ISTD tube.
• Use of nitric acid (about 1 to 5%) is recommended for the cleaning solution, as
it cleans the introduction system better than pure water. If pure water is used,
residual memory may be washed out when you run acidic samples, which
may affect quantitative measurements.

2 If you use the autosampler, set the bottle of each solution in the autosampler.

Semiquantitative Analysis
1 Prepare the standard solution for SemiQuant factor correction and samples.
Each solution should contain approximately 1% nitric acid.
• Sample
• For the standard solution for SemiQuant factor correction, you can use the
tuning solution.
• Cleaning solution (1 to 5% nitric acid)
2 If you use the autosampler, set the bottle of each solution in the autosampler.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 17

 Plasma ON/Executing a Startup

Plasma ON/Executing a Startup

Before starting analysis, do a Startup to optimize the basic performance of the

instrument.

The optimization performed in Startup is applied to the basic performance of the

NOTE instrument. The optimization specific to applications is performed by the preset
method and auto tune in each batch.

The user can execute startup and data acquisition with their own tuning
NOTE parameters easily. For more information, refer to Executing Startup with User Tune
in the online Help.

1 Make sure that the instrument is in Standby mode.

In Standby mode, "Standby" is displayed in the status bar, the indicator in the
Status Viewer dialog box, and the Instrument Status pane.
2 Click Startup Configuration from the Startup group in the Task Navigator.

To display the Startup group, click Configuration from the Startup group on the
NOTE Home tab.

The Startup pane is displayed.

18 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Plasma ON/Executing a Startup

3 Mark the check boxes for the items to be set in the hardware settings.
Usually, mark the check boxes for Torch Axis, EM, Plasma Correction, Standard
Lenses Tune, Resolution/Axis, and Performance Report. Although P/A Factor
can be tuned in Startup, we recommend you tune it in each batch. Here,
Standard Lenses Tune is a tuning that sets the instrument to the basic setting
state and is different from the auto tune that optimizes for the analysis used
in each batch.

Each Startup item works properly when a standard nebulizer is used. The
NOTE standard nebulizers are as follows.
• For x-lens: MicroMist and Mira Mist nebulizers
• For s-lens: MicroMist and Microflow (200) nebulizer
If you use another nebulizer, do not execute a Startup to adjust each item at this
stage, but after plasma ignition, do a custom tune to adjust the items in each
batch.

4 Set each item in the Standard Setting table.

• Vial#: Sets the location of the vial that contains a tuning solution when the
autosampler is used.
• Monitored Masses: Set the mass to be acquired.
• Set PeriPump/ISIS: Displays the PeriPump Setting dialog box, which lets
you configure detailed settings when you use a peripump or ISIS as the
sample introduction.

Resolution/Axis auto tune checks the peak position of the highest peak found in
NOTE a 3 u window around the reference mass. Make sure that the solution that you
introduce contains only the elements that are used for autotuning (i.e. Li(7),
Y(89), Tl(205) in most cases). If you use a different solution for autotuning, then
make sure to choose a mass that does not have a higher peak adjacent to it.
For example:
• Don’t select Li(7) if a high concentration of Li(6) is being introduced as an
on-line internal standard.
• Don’t select Y(89) when NIST Glass is being analyzed by laser ablation, as
Sr(88) will be a higher peak.

5 Set the tuning solution (in the autosampler).

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 19

 Plasma ON/Executing a Startup

6 Click Plasma from the Startup group on the Home tab.

A confirmation dialog box is displayed.

When the Instrument Status pane or Status Viewer dialog box is displayed, you
NOTE can turn on the plasma by double-clicking the status indicator on which "Standby"
is displayed.

7 Click Yes.
The instrument goes to analysis mode and starts the hardware setting
automatically.
If you click No, even if the plasma is ignited and the instrument goes to
analysis mode, nothing is done.

If you use a nebulizer other than standard nebulizers, select No. Then after
NOTE plasma ignition, do a custom tune in each batch to adjust the items.

8 Click Acquisition Queue from the Queue group in the Task Navigator.
The Acquisition Queue pane appears and displays the progress of the
hardware setting.

When the plasma is ignited, each item is executed after waiting for the warm-up
NOTE time specified in advance. In this case, the remaining warm-up time value is
displayed on the status bar. If you want to skip the warm-up time, select "Skip
Warm-up" on the tool bar.

20 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Plasma ON/Executing a Startup

9 After completing all “Startup” items, check the performance.

Click Performance Report from the Hardware group on the Report tab.
You can review performance information, tuning status, and meter values
from each tab in the Performance Report pane.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 21

 Checking the Instrument Status

Checking the Instrument Status

The Instrument Status Indicator, the Status Viewer dialog box and the Instrument
Status pane in the ICP-MS MassHunter window gives a real-time display that lets
you check the current status of the instrument.

Instrument Status Indicator

The Instrument Status Indicator uses a color bar to indicate the status of the
instrument. It also indicates error messages.

If the Instrument Status Indicator is not displayed, click Instrument Status Indicator
NOTE from the Show group on the View tab.

22 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Status Viewer dialog box

Status Viewer dialog box

If the Status Viewer dialog box is not displayed, click Status Viewer from the Show
NOTE group on the View tab.

Instrument Status pane

To display the Instrument Status pane, select Panes > Instrument Status from the
NOTE Show group on the View tab.

The Instrument Status pane can display the values of five meters at the same
time. To change which meters are displayed in the Instrument Status pane, do the
following steps:

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 23

 Instrument Status pane

1 Click Meter from the Meters group on the View tab.

The Select Meter dialog box appears.

2 Mark the check boxes of the meters you want to display.

Up to 5 meters can be selected.
3 Click OK.
The values of the selected meters are displayed on the Instrument Status
pane.

The term "Carrier Gas" has been changed to "Nebulizer Gas" in MassHunter 4.4.
NOTE

24 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Instrument Status pane

7900 Meter Control Panel Values

Meter Typical Ranges Units

Shutdown Mode Standby Mode Analysis Mode

IF/BK Press --- 2 to 8 150 to 300 (when the foreline pump is Pa

used)

Analyzer Press --- 1x10-5 to 5x10-4 7x10-5 to 1x10-3 Pa

TMP Revolution 0 95 to 100 95 to 100 %

Water RF/WC/IF 0.0 0.0 1 to 2 L/min

Water Temp 15 to 25 15 to 25 15 to 40 °C

Inlet Temp Room Temp. Room Temp. 15 to 35 °C

Internal Temp Room Temp. Room Temp. --- °C

Forward Power 0 0 700 to 1600 W

Reflected Power 0 0 < 20 W

Plasma Freq. --- --- 26.0 to 28.0 MHz

Nebulizer Gas (BP) 0 0 200 to 500 kPa

OP Gas Tank Press 0 0 kPa

Ar Gas Tank Press 500 to 700 500 to 700 500 to 700 kPa

Nebulizer Gas 0 0 0.7 to 1.2 L/min

MU./Dil. Gas 0 0 0 to 1.0 L/min

Optional Gas 0 0 0 to 40 %

Plasma Gas 0 0 15 L/min

Aux Gas 0 0 0.8 to 1.0 L/min

H2 Gas 0 0 3 to 5 mL/min

He Gas 0 0 4 to 6 mL/min

3rd Cell Gas 0 0 10 to 50 %

S/C Temp (L) Room Temp. Room Temp. 2 °C

ISIS 3 Pump Speed 0 0 0 to 100 %

Valve Position Load/Inject Load/Inject Load/Inject ---

Tune/ISTD Valve Tune/ISTD Tune/ISTD Tune/ISTD ---

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 25

 Instrument Status pane

7850/7800 Meter Control Panel Values

Meter Typical Ranges Units

Shutdown Mode Standby Mode Analysis Mode

IF/BK Press --- 0.3 to 5 220 to 490 (when the foreline pump is Pa
used)

Analyzer Press --- 1x10-5 to 5x10-4 7x10-5 to 1x10-3 Pa

TMP Revolution 0 95 to 100 95 to 100 %

Water RF/WC/IF 0.0 0.0 1 to 2 L/min

Water Temp 15 to 25 15 to 25 15 to 40 °C

Inlet Temp Room Temp. Room Temp. 15 to 35 °C

Internal Temp Room Temp. Room Temp. --- °C

Forward Power 0 0 700 to 1600 W

Reflected Power 0 0 < 20 W

Plasma Freq. --- --- 26.0 to 28.0 MHz

Nebulizer Gas (BP) 0 0 200 to 500 kPa

OP Gas Tank Press 0 0 kPa

Ar Gas Tank Press 500 to 700 500 to 700 500 to 700 kPa

Nebulizer Gas 0 0 0.7 to 1.2 L/min

MU./Dil. Gas 0 0 0 to 1.0 L/min

Optional Gas 0 0 0 to 40 %

Plasma Gas 0 0 15 L/min

Aux Gas 0 0 0.8 to 1.0 L/min

H2 Gas 0 0 3 to 5 mL/min

He Gas 0 0 4 to 6 mL/min

3rd Cell Gas 0 0 10 to 50 %

S/C Temp (L) Room Temp. Room Temp. 2 °C

ISIS 3 Pump Speed 0 0 0 to 100 %

Valve Position Load/Inject Load/Inject Load/Inject ---

Tune/ISTD Valve Tune/ISTD Tune/ISTD Tune/ISTD ---

26 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Creating a Batch

Creating a Batch

The acquisition method (including tuning), data analysis method, and sample list
for a batch are stored in a single batch folder. Create a new batch before
performing an acquisition.
To create a batch, do the following steps.
1 Click New from the Batch group on the Home tab.
The New Batch Folder dialog box is displayed.

2 Select Preset Method, Existing Batch, Blank Template, or Method Wizard from
the Create from list.
• Preset Method
Loads a preset method to create a new batch.
• Existing Batch
Copies the contents from an existing batch to create a new batch.
• Blank Template
Lets you create a new batch from a blank template.
• Method Wizard
Follow the on-screen instructions to create a suitably configured batch to
match your device's configuration.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 27

 Creating a Batch

We recommend you usually create using the Method Wizard, from a batch from a
NOTE preset method or from an existing batch that was created from a preset method.
The auto tune cannot be used for a batch that is created from a blank template or
created from an existing batch that was created from a blank template.

3 Perform the following operations suitable for the selected source data.
• When Preset Method is selected:
Click the Select button.
The Select Preset Method dialog box is displayed. Select a preset method
on the dialog box and click OK.
Enter a batch name in New Batch Name and click the Create button.
The preset method is loaded and displayed in the Setup pane.
• When Existing Batch is selected:
Click the Select button.
Select an existing batch to be used as a source for a new batch, and click
the Open button. Then, the Select Batch Contents dialog box appears.
Check the check boxes for the items to be copied, and click OK.
Enter a batch name in New Batch Name and click the Create button.
The contents of the existing batch are copied and displayed in the Setup
pane.
• When Blank Template is selected:
Enter a batch name in New Batch Name and click the Create button.
A blank batch is displayed in the Setup pane.
• When Method Wizard is selected:
Enter a batch name in New Batch Name and click the Create button.
Start the Method Wizard.
Follow the on-screen instructions, and then click Finish.
The created method is displayed in the Setup pane.

Configure an acquisition method, data analysis method, and sample list in

the displayed batch. For more information on how to configure the
settings, refer to the following sections.

28 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Creating a Batch

The sample uptake time and rinse time are affected by the internal diameter and
NOTE length of the tubes that are used. The values for the pre-run and post-run in the
preset method are for the following configuration.
• Probe tube for the autosampler (SPS 4 or ASX-500 Series)
Inner diameter: 0.5 mm (blue band)
Length: 1.4 to 1.6 m
• Peristaltic pump tube (for samples)
Inner diameter: 1.02 mm
Length: 130 to 140 mm (Use as two stopper tubes by cutting it at the positions
of 20 to 25 mm from both ends of the stopper)

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 29

 Setting up an Acquisition Method

Setting up an Acquisition Method

To set up an acquisition method, click each menu from the Acquisition group on
the Task Navigator. Set the acquisition method on the panes displayed.
• Setup: Setup pane
• Tune Modes: Tune Modes pane
• Element Selection: Element Selection pane
• Sample Introduction: Sample Introduction pane

Setup Pane
This pane is used to set the acquisition mode, analysis type, analysis mode,
interference correction, report template, and so on.

30 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Setting up an Acquisition Method

1 Set the following items.

Item Description

Acq Mode For general quantitative or semiquantitative analyses, select

Spectrum. For analyses that use a GC or LC, select TRA (Time
Resolved Analysis) to process the chromatograms (Option).

Spectrum Mode Options Peak Pattern: Select 1 point or 3 points for quantitative analysis or 6
points for semiquantitative analysis.
Replicates: For normal quantitative analyses, enter about 3 times.

Sweeps/Replicate: Set the sweeps count (an integer between 1 and

1000) per acquisition in replicated acquisitions. Usually, set it to "100"
for spectrum analysis.
Set it to "1000" when precision of isotopic information (including
isotopic ratio and isotope dilution) is required (such as radioactive
isotope analysis for determining age).

Acq Option Auto/Semi Auto Tune before Batch: Automatically executes

autotuning or custom tuning before a batch is executed in the queue.
Print Tune Report: Select to print the tune report.
P/A Factor Adjustment: Select to automatically adjust the P/A factor
while the batch is running.
Advanced Configuration: Click this link to display the Configure Batch
Acquisition dialog box where you can make detailed settings for the
batch acquisition.

Total Acq Time Displays the estimated acquisition time under the specified conditions.

Set Batch Comment When the user clicks Set Batch Comment, the comment can be
edited. When the user moves away from the text box, edit mode is
canceled.

Data Analysis Method Select FullQuant Analysis to perform a quantitative analysis.

Select SemiQuant Analysis to perform a semiquantitative analysis.
Analysis Mode: Select Spectrum normally.

Sample Template Select a sample template to use for the analysis report output. In an
automatic analysis, the template that you select here is used to
generate the report.

Batch Template Select a batch template to use for the analysis report output. Usually
this item is not specified because of the time that is required to
generate the report.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 31

 Setting up an Acquisition Method

Tune Modes Pane

This pane is used to set up a tuning that will optimize the instrument for analysis
with this batch.

1 Click the icon on the toolbar.

The Configure Tune Way dialog box is displayed.

32 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Setting up an Acquisition Method

Item Description

Auto Tune Usually, select Auto Tune. When the auto tune is completed
successfully, the result is saved in the batch.
Doing a Startup optimizes the hardware setting parameters, which are
the basic setting performance of the instrument. In addition, doing an
auto tune for each batch optimizes the parameters for the relevant
acquisition.
For a batch that was created from a blank template, Auto Tune
cannot be selected.

Custom Tune Select each lens parameter to tune and then do the auto tune. Also,
you can adjust each tuning parameter manually by operating the slider
or changing the value while you monitor the signal. The result of the
manual tuning is saved in the batch.

Signal Monitor Select this item to monitor the signal. While each tuning parameter
can be changed here, updated values cannot be saved in the batch.

Show Hardware Settings When Signal Monitor and this check box are selected, all hardware
setting values are displayed and can be changed.

2 Usually, select Auto Tune, then click OK.

3 Click in Tune toolbar.
The Start Auto Tune dialog box appears.

4 Select All Tune Modes, then click OK.

The auto tune starts.
When the auto tune is completed, the result is saved in the batch.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 33

 Setting up an Acquisition Method

To tune automatically in a batch acquisition:

NOTE
To tune automatically, select Auto/Semi Auto Tune before Batch from Acq Option
on the Setup Pane.
This auto tune uses the vial position and peristaltic pump program that is applied
to Startup and the Performance Report of the hardware settings.
When a batch is set in the queue, the auto/semi auto tune is performed
automatically before starting the batch, so you do not need to perform tuning
manually in advance.

Element Selection Pane

This pane is used to set the tune mode and mass numbers.

34 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Setting up an Acquisition Method

1 Set the following items.

Item Description

Quick Scan To quickly acquire the full spectra across all masses (Quick Scan),
select a tune mode (normally He mode) used in the acquisition. The
Quick Scan data is useful for doing an analysis when an error occurs in
the quantitation values or for semiquantitative analyses.

Stabilization Time Set a time (usually 10 to 30 seconds) to let the signal stabilize when
the tune conditions change, before acquiring data.

Monitored Masses Table Set the elements to be acquired. For details on how to configure the
settings, refer to step 2 and later.

2 Click to start setting the elements to acquire.

The Select Elements on Periodic Table dialog box appears.
The elements already set are displayed in the table on the right.

Periodic Table

Mass Table

3 From the Tune Mode list, select a tune mode to use for the selected elements.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 35

 Setting up an Acquisition Method

4 To add an element to acquire, click to select the element on the periodic table
and mark the check boxes for the masses to acquire in the Mass table.
To delete a mass, right-click the mass to delete.
For ISTD, check the ISTD columns.

• Elements in orange:
NOTE Indicate that the elements are selected in the current tune mode.
• Elements in light blue:
Indicate that the elements are selected in another tune mode.

To select masses in a batch, for example, in a semiquantitative analysis, do as

follows.
a Click the Go to Mass Scale button on the Select Elements on Periodic Table
dialog box.
The Select Masses on Mass Scale dialog box appears.
b After selecting a tune mode, click the Clear All button, and then double-click
on the top, middle, and bottom rows to select all mass numbers.

c To return to the Select Elements on Periodic Table dialog box, click the Go to
Periodic Table button.

36 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Setting up an Acquisition Method

5 After you select elements to acquire, click OK on the Select Elements on

Periodic Table or the Select Masses on Mass Scale dialog box.
The specified elements and masses to monitor are displayed in the Monitored
Masses table on the Element Selection pane.

Sample Introduction Pane

This pane is used for setting the peristaltic pump/ISIS.

Set the following items.

Any columns in gray use the default values and do not need to be specified.
NOTE

Item Description

Sample Introduction Select a sample introduction to use from the list. When ISIS 3 is not used, only
General can be selected.

Tune Vial This vial is used for Auto Tune (including Semi-Auto Tune) and Generate Tune
Report. The PeriPump program and the ISIS program (PreRun and PostRun) in
PeriPump/ISIS are also used for Auto Tune and Generate Tune Report.

PreRun Set the program to run before acquisition. Set the sample uptake time, the
increased speed of the nebulizer pump during uptake, and the stabilization time
needed for the speed of the nebulizer pump to return to its original speed.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 37

 Setting up a Data Analysis Method

Item Description

Acquisition This item shows the settings for the acquisition in progress (for display only).

PostRun This is the program to run after acquisition, mainly to rinse the sample line. After
the rinse at the rinse port, it is possible to do multiple rinses from Rinse 1 to Rinse
3, as necessary.
Enter enough time to make the sample line clean in the "Time" column. When you
are using an auto sampler, click the "Vial#" column to set the vial position for the
cleaning bin.

Intelligent Rinse If this item is marked, the setup table for the Intelligent Rinse is displayed.

Preemptive Rinse If this item is marked, the setup table for the Preemptive Rinse is displayed. To
reduce the total analysis time, enter the time when the rinse is started before the
end of acquisition.

Setting up a Data Analysis Method

To set up a data analysis method, click each menu from the Acquisition group in
the Task Navigator. Set the analysis method on the panes displayed.
• Calibration: Calibration pane
• SemiQuant: SemiQuant pane

The data analysis settings can be configured also after data acquisition.
NOTE

38 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Setting up a Data Analysis Method

Calibration Pane
This pane is used to set the calibration curve parameters for quantitative
analysis.

Set the calibration curve parameters in the table.

• Calibration method (External Calibration/Standard Addition)
• Curve fit type (Linear/Quadratic/Excluded/Average Response Factor)
• Handling of the origin (Ignore/Force/Blank offset)
• ISTD elements used for correction
• Unit for concentration
• Concentration of each calibration curve level

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 39

 Setting up a Data Analysis Method

Semi Quant Pane

This pane is used to set each item for semiquantitative analysis.

Mainly set the following items.

Item Description

Data Usually, select Quick Scan data. When the IntelliQuant check box is
selected, semiquantitation is automatically performed using Quick
Scan Data. If all masses have been selected in the acquisition
method setting, select Main data. Here, also specify the tune mode.

Standard for SQ Factor Correction Select the concentrations of the standard sample elements to use
for SemiQuant factor correction. Click to add an element, then
specify the concentration and unit.

40 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Setting up a Sample List

Setting up a Sample List

Click Sample List from the Sequence group in the Task Navigator to display the
Sample List pane. Enter the order of the sample acquisitions and vial positions in
the Sample List pane. The samples are acquired in the order that they appear in
the sample list.

Even if you do not use an autosampler, set up the sample list here.
NOTE

Sample List Pane

Mainly set and check the following items.

Item Description

Block List Table Set the sample blocks.

For more information, refer to the online Help.

Estimated Time for Batch Displays the estimated time for batch acquisition. This does not
Acquisition include the time that is required to move to the vial position. Actual
acquisition time is longer than this value.

Sample List Table Each line corresponds to an acquired sample, and the acquisitions
start from the first line sample and are performed sequentially. Set the
sample type and vial number for each sample.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 41

 Checking the Method

Main setting items on the sample list table

Item Description

Skip Select the lines you want to ignore.

Sample Type Set a sample type.

• For quantitative analysis:
Set CalBlk for the calibration blank solution.
Set CalStd for the calibration standard.
Set Sample for unknown samples.
• For semiquantitative analysis:
Set SQStd for the solution of SQ Factor Correction.
Set SQBlk for the blank (nitric acid and so on).
Set Sample for unknown samples.

Sample Name Enter a sample name if necessary.

Comment Enter a comment if necessary.

Vial# Set this item always when an autosampler is used.

Click on the right end of the cell, and set a vial position.

File Name Enter the data file name as necessary. If the field is left blank, a file
name will be automatically generated.

Level Select a calibration curve level from the list as follows.

Calibration blank solution (CalBlk): Select Level 1.
Calibration standard (CalStd): Select Level 2, Level 3, and so on, in
ascending order of concentration.

Checking the Method

After you set up the acquisition method, data analysis method, and sample list,
check whether the settings of the methods are correct or not.
When you have made the settings on all panes, click Validation from the Batch
group on the Home tab.
If one or more errors are found in the method, the error information is displayed
in the Method Error List pane. Double-click the error message to view the line in
the Method Table pane that contains the error.

You must fix the error in the method before you can start acquisition.
NOTE

42 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Executing the Queue

Executing the Queue

This section describes how to start the acquisition after you create a batch. To
start the acquisition, add a batch to the queue and execute it.
1 Click Add to Queue from the Batch group on the Home tab.
The configured batch is added to the queue. The acquisition starts
automatically if no other task is currently running.
When the acquisition starts, the ICP-MS Data Analysis window is opens
automatically.

For a batch that is added to the queue or that was previously executed in a queue,
NOTE the data analysis method cannot be changed in the batch.
In such a case, you can change the data analysis method in the ICP-MS Data
Analysis window, and then reprocess the batch.

2 To check the progress status of the automatic acquisition, click Acquisition

Queue from the Queue group in the Task Navigator.
The Acquisition Queue pane is displayed.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 43

 Executing the Queue

The current progress status is displayed in the status bar in the lower right area
NOTE of the screen.

To specify the items to display in the status bar, right-click on the status bar to
open the Configure Acquisition Status Bar dialog box, which lets you the items.

The Acquisition Queue pane displays the details and results of each task. To
suspend or cancel a task, do as follows.
• Suspending a task
If you click Pause from the Acquisition Queue group on the Home tab, and
then click OK in the message displayed, the queue is suspended after the
current sample acquisition is complete. To resume the suspended task,
click Resume from the Acquisition Queue group on the Home tab.
• Deleting a task
To delete a task, select a task to delete, then click the icon on the
toolbar. The task is deleted from the Acquisition Queue pane. Note that a
task being run cannot be removed.
• Immediate Stop
Click Stop from the Acquisition Queue group on the Home tab.

Editing the Batch that is currently running

NOTE
• To modify the batch that is currently running in the queue, click
on the toolbar on the Batch pane to change the batch. To add a queue, click
.
• To add or delete a sample from the Sample list, click on the
toolbar on the Acquisition Queue pane. To resume, click .

44 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Executing the Queue

If Plasma Off at the End on the toolbar in the Acquisition Queue pane is set to On,
NOTE the plasma is turned off automatically after all tasks in the queue are done, and
the instrument is put in Standby mode.

If you click on the toolbar in the Acquisition Queue pane to

NOTE enable this function, each sample acquisition in a batch acquisition does not
start automatically after pre-run. To start the acquisition, click on
the toolbar in the Real-Time Display pane.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 45

 Checking the Analysis Results

Checking the Analysis Results

The analysis results can be checked on each pane in the ICP-MS Data Analysis
window.

Quantitative Analysis

The ICP-MS Data Analysis window displays information such the sample list, data
analysis results, mass spectra, and calibration curves.

Ribbon Batch Table

Tab

Group
Tool bar

Status Bar
Spectrum Pane Calibration Curve Pane IntelliQuant Pane

46 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Commands on the Ribbon

Commands on the Ribbon

The following table indicates the commands on each tab on the Ribbon.
For details on each function, refer to the online Help.

Ribbon Command

File tab New Batch Folder, Open Batch Results, Save Batch Results, Save Batch Result As,
Close, Save Annotation in Data, About, Exit commands

Home tab Batch group Open command

Save command
Import Samples command

Batch Option group Process Batch command

Process Order command
Clear Results command

Method group Edit command

New command
Correction Equation command
Import DA Method command

View tab Show group Pane command

Toolbars command
Load/Save command

Maximize group Maximize Pane command

Batch Table group Arrange Elements command

Group By Calibration command
Batch Table Layout command
Lock Sample Columns command

Columns group Add/Remove command

Auto Fit command
Load/Save command
Reset command

Auto Review group Samples command

Elements command

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 47

 Commands on the Ribbon

Ribbon Command

Report tab Batch group Quick Batch Report command

Samples group Generate command

Calibration group Print command

Export Summary command

Instrument group Show Tune Report command

Show P/A Factor Report command
Acquisition Method command
Instrument Configuration command

LIMS group Export command

USP<232>/<233> and ICH Q3D group Spike Recovery% Report command

Elemental Impurities command

Tools tab Settings group Settings command

Data group Display Report for Data command

Convert Data command

Script group Actions command

Add-Ins group Add-Ins command

48 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Commands on the Ribbon

Batch Table Check the concentration and count for each element in the samples.
Pane • The concentrations and counts for the data specified as outliers are
displayed with a different background color for each outlier type.
• How data is displayed can be modified, for example, by sorting the
elements in a column or doing other customizations.
Spectrum Pane Displays mass spectra. To zoom in on a spectrum, right-click on the spectrum
and drag the mouse cursor around the desired mass number. Here, you can do
the following operations:
• Change between log scale and linear scale
• Change the horizontal scale (1 row or 3 rows)
• Add a comment
• Identify unknown spectra against an element database
• Subtract background spectra
• Overlay multiple spectra
• Tabulate the spectral information
Calibration Check the calibration curves for each element in the samples.
Curve Pane • Problematic calibration curves (outliers) are displayed with a pink
background.
• On this pane, you can ignore a calibration curve level, change the
concentration of the calibration curve level, change the calibration curve
type, change how the origin is handled, or change the weighting of
calibration curve, and so on.
ISTD Stability Check the recovery (%) of each ISTD element.
Graph Pane

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 49

 Semiquantitative Analysis

Semiquantitative Analysis

The ICP-MS Data Analysis window displays information such as the sample list,
data analysis results, mass spectra, and SemiQuant Factor.

The semiquantitative analysis is done for a single tune mode. For data that is
NOTE acquired with multiple tune modes, perform the semiquantitative analysis for
each tune mode.

Ribbon Batch Table

Tab

Group
Tool Bar

Status Bar
Spectrum Pane SemiQuant Factor Pane IntelliQuant pane

50 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Semiquantitative Analysis

Batch Table Check the concentration and count for each element in the samples.
Pane
Spectrum Pane Check mass spectra. To zoom in on the spectrum to identify each element,
right-click on the spectrum and drag the mouse cursor around the desired mass
number.
SemiQuant Check the SemiQuant factor graph for each sample. Put the cursor near a point
Factor Pane on the graph to display element names, SemiQuant factor correction details, and
so on.
ISTD Stability Check the recovery (%) of each ISTD element.
Graph Pane
IntelliQuant You can check each element’s concentration and outliers calculated by
pane IntelliQuant in the periodic table.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 51

 Generating a Report

Generating a Report

There are two types of analysis reports: sample report, which is a report for each
sample, and quick batch report, which is a report for the batch table.

Generating the Sample report

1 Click the Generate from the Samples group in the Report tab on the ICP-MS
Data Analysis window.
The Generate Report dialog box is displayed.
2 Set the report options.

3 Click Generate.
The sample report prints.

52 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Generating a Quick Batch Report

Generating a Quick Batch Report

1 Click Quick Batch Report from the Batch group on the Report tab in the ICP-MS
Data Analysis window.
2 Click Print.
The Quick Batch Report prints.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 53

 Saving the Analysis Results

Saving the Analysis Results

If you changed the data analysis method after acquisition, be sure to save the
analysis results in one of the following ways.

Overwriting the existing result file with the same name:

• Click Save from the Batch group on the Home tab.
• Click Save Batch Results on the File tab.

Saving as a new file:

• Click Save - Save As from the Batch group on the Home tab.
• Click Save Batch Results As on the File tab.

Plasma OFF

To turn off the plasma:

1 Click the Plasma from the Startup group in the Home tab.
A confirmation dialog box is displayed.
2 Click Yes.
The Plasma icon indicates that the plasma is off.

54 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Exiting the MassHunter Workstation

Exiting the MassHunter Workstation

Use any one of the following methods to exit MassHunter Workstation. Be sure
to save any changes before you exit the program.
• Double-click the Control Box Menu in the upper left corner of the ICP-MS
MassHunter window, or click the Control Box Menu and then click Close in the
pop-up menu that appears.
• Click on the button in the upper right corner of the ICP-MS MassHunter
window.
• Click Exit on the File tab in the ICP-MS MassHunter window.
A message appears that says "Save changes you made to batch?". Click Yes to
save changes and exit MassHunter Workstation. Click No to exit the program
without saving changes. Click Cancel to return to the program.

Please always turn off the plasma prior to exiting the program. If you exit
NOTE MassHunter Workstation while the plasma is ignited, the plasma will remain
ignited.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 55

 Appendix

Appendix

Recommended Values for Tuning Parameters

7900 x-Lens Configuration

Table 1. Recommended Values (When Using a MicroMist Nebulizer)

Parameter No Gas Mode Cell Gas Mode (High Energy) Collision Mode *1

Value Range Value Range Value Range

RF Power [W] 1550 Fixed 1550 Fixed 1550 Fixed

Smpl Depth [mm] 8.0 Fixed 8.0 Fixed 8.0 Fixed

Nebulizer Gas [L/min] 1.05 1.01 to 1.11 1.05 1.01 to 1.11 1.05 1.01 to 1.11

Makeup Gas [L/min] 0 0 to 0.50 0 0 to 0.50 0 0 to 0.50

Dilution Gas [L/min] 0 Fixed 0 Fixed 0 Fixed

Neb Pump [rps] 0.1 Fixed 0.1 Fixed 0.1 Fixed

S/C Temp [degC] 2 Fixed 2 Fixed 2 Fixed

He or H2 gas [ml/min] 0 Fixed 4.3 (He) 4.0 to 5.5 (He) 10 (He) 8 to 11 (He)
6.0 (H2) 5.0 to 7.0 (H2)

Extract 1 [V] 0 Fixed 0 Fixed 0 Fixed

Extract 2 [V] -180 -250 to -160 -180 -250 to -160 -180 -250 to -160

Omega Bias [V] -80 -110 to -70 -80 -110 to -70 -80 -110 to -70

Omega Lens [V] 10 7 to 12 10 7 to 12 10 7 to 12

Cell Entrance [V] -30 -40 to -30 -40 -40 to -30 -130 -150 to -110

Cell Exit [V] -50 -60 to -40 -60 -60 to -40 -150 Fixed

Deflect [V] 10 8 to 15 0 -5 to 4 -80 -90 to -70

Plate Bias [V] -35 -50 to -30 -60 Fixed -150 Fixed

OctP RF [V] 180 150 to 200 180 150 to 200 190 180 to 200

OctP Bias [V] -8 -10 to -6 -18 Fixed -100 Fixed

Energy Discrimination [V] 5 2 to 6 5 3 to 6 7 6 to 9

*1 These settings reduce interferences in Helium mode. However, since they also reduce low-mass
sensitivity, use these settings if they are appropriate for your particular analysis.

56 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Recommended Values for Tuning Parameters

7900 s-Lens Configuration

Table 2. Recommended Values (When Using a MicroFlow Nebulizer)

Parameter High Sensitivity Cell Gas Mode (High Energy) Collision Cool Plasma
Mode*1

Value Range Value Range Value Range Value Range

RF Power [W] 1500 fixed 1500 fixed 1500 fixed 600 fixed

Smpl Depth [mm] 8 7 to 10 8 7 to 10 8 7 to 10 18 fixed

Nebulizer Gas [L/min] 0.7 fixed 0.7 fixed 0.7 fixed 0.7 fixed

Makeup Gas [L/min] 0.5 0.3 to 0.7 0.5 0.3 to 0.7 0.5 0.3 to 0.7 0.75 0.6 to 1.2

Dilution Gas [L/min] 0 fixed 0 fixed 0 fixed 0 fixed

Neb Pump [rps] 0.1 fixed 0.1 fixed 0.1 fixed 0.1 fixed

S/C Temp [degC] 2 fixed 2 fixed 2 fixed 2 fixed

He or H2 gas [ml/min] 0 fixed 5.0 (He) 4.0 to 6.0(He) 9 (He) 8 to 11 (He) 0 fixed
6.0 (H2) 5.0 to 7.0(H2)

Extract 1 [V] 4.5 3 to 7 4.5 3 to 7 4.5 3 to 7 -120 -200 to -40

Extract 2 [V] -130 -170 to -60 -130 -170 to -60 -130 -170 to -60 -5 -30 to 5

Omega Bias [V] -70 -100 to -30 -70 -100 to -30 -70 -100 to -30 -70 -120 to -30

Omega Lens [V] 11 5 to 15 11 5 to 15 11 5 to 15 6 3 to 10

Cell Entrance [V] -30 -40 to -30 -40 -40 to -30 -130 -150 to -110 -30 -40 to -30

Cell Exit [V] -50 -60 to -40 -60 -60 to -40 -150 fixed -60 fixed

Deflect [V] 12 8 to 15 0 -5 to 4 -80 -90 to -70 9 5 to 13

Plate Bias [V] -30 -50 to -30 -60 fixed -150 fixed -60 fixed

OctP RF [V] 180 150 to 200 180 150 to 200 190 180 to 200 150 100 to 200

OctP Bias [V] -8 -12 to -6 -18 fixed -100 fixed -20 fixed

Energy Discrimination [V] 5 2 to 6 3 3 to 6 5 5 to 9 15 15 to 17

*1 These settings reduce interferences in Helium mode. However, since they also reduce low-mass
sensitivity, use these settings if they are appropriate for your particular analysis.

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 57

 Recommended Values for Tuning Parameters

7850/7800 Configuration
Table 3. Recommended Values (When Using a MicroMist Nebulizer) (x-Lens)

Parameter No Gas Mode Cell Gas Mode High Energy Collision Mode *1

Value Range Value Range Value Range

RF Power [W] 1550 Fixed 1550 Fixed 1550 Fixed

Smpl Depth [mm] 8.0 Fixed 8.0 Fixed 8.0 Fixed

Nebulizer Gas [L/min] 1.05 1.01 to 1.11 1.05 1.01 to 1.11 1.05 1.01 to 1.11

Makeup Gas [L/min] 0 0 to 0.50 0 0 to 0.50 0 0 to 0.50

Dilution Gas [L/min] 0 Fixed 0 Fixed 0 Fixed

Neb Pump [rps] 0.1 Fixed 0.1 Fixed 0.1 Fixed

S/C Temp [degC] 2 Fixed 2 Fixed 2 Fixed

He or H2 gas [ml/min] 0 Fixed 4.3 (He) 4.0 to 5.5 (He) 10 (He) 8 to 11 (He)
6.0 (H2) 5.0 to 7.0 (H2)

Extract 1 [V] 0 Fixed 0 Fixed 0 Fixed

Extract 2 [V] -180 -200 to -160 -180 -200 to -160 -180 -200 to -160

Omega Bias [V] -90 -120 to -70 -80 -120 to -70 -80 -120 to -70

Omega Lens [V] 10 7 to 13 10 7 to 13 10 7 to 13

Cell Entrance [V] -30 -40 to -30 -40 -40 to -30 -130 -150 to -110

Cell Exit [V] -50 -60 to -40 -60 -60 to -40 -150 Fixed

Deflect [V] 10 8 to 15 0 -5 to 4 -80 -90 to-70

Plate Bias [V] -35 -50 to -30 -60 Fixed -150 Fixed

OctP RF [V] 180 150 to 200 180 150 to 200 190 180 to 200

OctP Bias [V] -8 -10 to -6 -18 Fixed -100 Fixed

Energy Discrimination [V] 5 2 to 6 3 3 to 6 7 6 to 9

*1 These settings reduce interferences in Helium mode. However, since they also reduce low-mass
sensitivity, use these settings if they are appropriate for your particular analysis.

58 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Types of Preset Methods

Types of Preset Methods

The following types of preset methods are available. Select the suitable one for
the sample to be analyzed.

Application Method

ChP
Item Description

Summary 7850/7900/7800 Application Method for Elemental Impurities in Pharma, using China
Pharmacopoeia.

Compatible Sample Types Simple aqueous matrices and acid digested samples up to 0.4% dissolved solids.

Pre-Defined Analytes Cu, As, Cd, Hg, Pb

Comment Method uses General Purpose plasma conditions and He mode only. The selection of an
appropriate internal standard should consider the analyte and the sample matrix.

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

USP<232>/ICH Q3D
Item Description

Summary 7850/7900/7800 Application Method for Elemental Impurities in Pharma, using USP<232>/ICH
Q3D

Compatible Sample Types Simple aqueous matrices and acid digested samples up to 0.4% dissolved solids

Pre-Defined Analytes Li, V, Cr, Co, Ni, Cu, As, Se, Mo, Ru, Rh, Pd, Ag, Cd, Sn, Sb, Ba, Os, Ir, Pt, Au, Hg, Tl, Pb

Comment Method uses General Purpose plasma conditions and He mode only, but requires the
7850/7900/7800. User Access Control option software is required for regulated pharma analysis.
The selection of an appropriate internal standard should consider the analyte and the sample
matrix.

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 59

 Types of Preset Methods

EPA 200.8
Item Description

Summary 7850/7900/7800 Application Method for EPA200.8 (No minerals, without ORSs)

Compatible Sample Types Application method for low matrix aqueous or acidic samples (up to 0.1% Total Dissolved Solids),
including drinking water, tap water, industrial water, riverine water, lake water, pond water and
surface water except seawater. Also suitable for closed-vessel acid digested or extracted
samples, after dilution to <0.1% Total Dissolved Solids.

Pre-Defined Analytes Li, Be, Al, V, Cr, Mn, Co, Ni, Cu, Zn, As, Se, Mo, Ru, Rh, Pd, Cd, Ag, Sn, Sb, Ba, Ho, Hg, Tl, Pb, Th, U

Comment Uses Low Matrix plasma conditions, and no gas mode only.

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

EPA 6020
Item Description

Summary 7850/7900/7800 Application Method for EPA6020

Compatible Sample Types Application method for low or medium matrix samples (up to 0.3% Total Dissolved Solids),
including diluted seawater, groundwater and mineral water, acid digested or extracted soil,
sediment, sludge and industrial waste samples.

Pre-Defined Analytes Li, Be, Na, Mg, Al, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Se, Rh, Ag, Cd, Sn, Sb, Ba, Ho, Hg, Tl, Pb

Comment Method is suitable only for the 7850/7900/7800, due to the short pre-defined cell gas stabilization
time. Uses General Purpose plasma conditions, and no gas, and He cell modes.

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

Drinking water (with He)

Item Description

Summary 7850/7900/7800 Application Method for Drinking Water (with ORS)

Compatible Sample Types Application method for low matrix aqueous or acidic samples (up to 0.1% Total Dissolved Solids),
including drinking water, tap water, industrial water, except seawater. Also suitable for
closed-vessel acid digested or extracted samples, after dilution to <0.1% Total Dissolved Solids.

Pre-Defined Analytes Na, Mg, Al, K, Ca, V, Cr, Mn, Fe, Co, Ni, Cu, Zn, As, Sr, Mo, Rh, Ag, Cd, Sn, Ba, Hg, Tl, Pb, Th, U

Comment Method is suitable only for the 7850/7900/7800, due to the short pre-defined cell gas stabilization
time. Uses Low Matrix plasma conditions, and no gas, and He cell modes

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

60 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

 Types of Preset Methods

Ultra-Pure Water
Item Description

Summary 7900 Application Method for Ultra-Pure Water

Compatible Sample Types Ultra-Pure Water

Pre-Defined Analytes Li, Be, B, Na, Mg, Al, Si, P, S, K, Ca, Sc, Ti, V, Cr, Mn, Fe, Ni, Co, Cu, Zn, Ga, Ge, As, Se, Br, Rb, Sr, Y, Zr,
Nb, Mo, Ru, Rh, Pd, Ag, Cd, In, Sn, Sb, Te, I, Cs, Ba, La, Ce, Pr, Nd, Sm, Eu, Gd, Tb, Dy, Ho, Er, Tm, Yb,
Lu, Hf, W, Ta, Re, Os, Ir, Pt, Au, Hg, Tl, Pb, Bi, Th, U

Comment Method is suitable only for the 7900, due to the use of cool plasma conditions for some analytes.

Required Hardware 7900, s-Lens, 2.5mm injector torch, quartz spray chamber (G3280-80008), quartz connector tube
(straight), MicroFlow Nebulizer, Pt sampling cone, Pt skimmer cone, Brass skimmer base

Generic Method

High Matrix
Item Description

Summary 7850/7900/7800 Generic Method for high matrix samples

Compatible Sample Types Generic method for high matrix aqueous or acid digested samples, and where exceptionally high
matrix tolerance is essential.

Pre-Defined Analytes None specified

Comment Method is suitable only for the 7850/7900/7800, due to the use of HMI aerosol dilution and the
short pre-defined cell gas stabilization time.

Required Hardware 7850/7900/7800, HMI, x-Lens, Micro Mist Nebulizer

Low Matrix
Item Description

Summary 7850/7900/7800 Generic Method for low matrix samples

Compatible Sample Types Generic method for low matrix aqueous or acid digested samples (<0.1% Total Dissolved Solids),
and where high sensitivity is required.

Pre-Defined Analytes None specified

Comment Method is suitable only for the 7850/7900/7800, due to the short pre-defined cell gas stabilization
time.

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

ICP-MS (7850/7800/7900) MassHunter Workstation User Guide 61

 Types of Preset Methods

General Purpose
Item Description

Summary 7850/7900/7800 Generic Method for medium matrix samples

Compatible Sample Types Generic method for typical aqueous or acid digested samples (up to 0.2% Total Dissolved Solids),
and where matrix tolerance is more important than high sensitivity.

Pre-Defined Analytes None specified

Comment Method is suitable only for the 7850/7900/7800, due to the short pre-defined cell gas stabilization
time.

Required Hardware 7850/7900/7800, x-Lens, Micro Mist Nebulizer

High Sensitivity
Item Description

Summary 7900 Generic Method with high sensitivity for low matrix samples

Compatible Sample Types Generic method for low matrix aqueous samples (e.g. 1%nitric acid solution), and where high
sensitivity is required.

Pre-Defined Analytes None specified

Comment Method is suitable only for the 7900, due to the use of H2 cell mode and cool plasma conditions
for some analytes.

Required Hardware 7900, s-Lens, Micro Flow Nebulizer

62 ICP-MS (7850/7800/7900) MassHunter Workstation User Guide

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*G7201-90407*
Part Number: G7201-90407
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August 2022 Document Revision: A.00