Name: _______________________________________________________ DUE Date: ________

____ period Chapter 17: From Gene to Protein

Directions: Read the assigned chapter in the book and complete the directed reading guide. For your own benefit please do
not leave this assignment until the night before it its due. This is an individual assignment, as such, it is expected
that all work on this will be your own.
1. How did diseases involving metabolic pathways lead to hypotheses about the nature of genes?
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2. Identify some genetic diseases that occur along metabolic pathways.
a. _________________________________________ c. _________________________________________
b. _________________________________________
3. What was Beadle and Tatum’s hypothesis regarding enzymes?
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4. How has that hypothesis been modified?
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5. What occurs during transcription?
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6. What occurs during translation?
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7. How does the protein process differ in prokaryotes and eukaryotes?
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8. What is the genetic code?
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9. Why is the genetic code said to be universal?
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10. List several features about the genetic code.
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11. Give an example of what happens if reading frames are altered?
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12. List the highlights of the three stages of transcription.
a. Initiation
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b. Elongation
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c. Termination
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13. What happens to the transcript RNA before it leaves the nucleus?
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14. What is the advantage of the 5’ cap and poly A tail?
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15. Distinguish between exons and introns. In addition to your written explanation draw a diagram to help deepen your
understanding.
Explanation Diagram

Exon

Intron

16. Describe the mechanism for splicing RNA.

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17. What does alternative RNA processing do for cells?
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18. Identify the roles of the players of the translation process.
a. Transfer RNA
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b. Aminoacyl-tRNA synthetase
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c. Ribosomes
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19. Identify and briefly describe the steps of translation.
a. Initiation
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b. Elongation
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c. Termination
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20. What is the advantage of polyribosomes?
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 21. Give an example of how a polypeptide gets into the ER for additional processing.
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22. How does protein synthesis differ between prokaryotes and eukaryotes?
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23. Define point mutations.
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24. Define mutations that are:
a. Missense
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b. Nonsense
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c. Insertion
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d. Deletion
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25. Use the diagram to trace the flow of chemical information from the gene to the protein product.

Directed Reading Guide Rubric

Exceeds Standard Meets Standard Approaches Standard Does Not Meet Standard
The directed reading guide is
All questions in the directed All questions in the directed at least 75% complete.
The directed reading guide is
reading guide are completed reading guide completed. One or
less than 75% complete.
and correct. or two answers are incorrect. More than a few answers are
incorrect.