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NON-HODGKIN Twec MA
DISORDERS > HODGKINS LYMPHOM
HODGKIN LYMPHOMA
More often localized to dsingle More frequent involvement of
axial araun of nod (cervical, multiple peripheral nodes
mediastinal) para-aortio
Orderly spre ad by contiguity Noncontiguous spread
Mesenteric no des and Waldeyer Waldeyer ring and mesenteric
ring rarely involved nodes commonly involved
Extranodal presentation rare Extranodal presentation common
Lj Sy
Figure 13-24 Feed-Stemberg oels and variants. A, Dlagnostic Reed-Sternberg cell, with two nuclear lobes, large inclusion-like nucleol, and abundant cyto
plasm, surounded by lmphocytes, macrophages, and an eosinophil. B, Reed-Stermberg cell, mononuclear variant. C, Reed-Sternberg cell, lacunar variant
his variant has afolded or mutiobated nucleus andlieswithin aopen space, whichisanartifactcreatedbydisruption ofthe cytoplasm during tissue sec-
tioning.D,Reed-Sternberg cl,present.
mphohistiocytic variant.Severalsuch variantswith mutipyintolded nuclear membranes,smallnucleoli,fine chromatin,and
(A, Courtesy Dr. Robert W. McKerna, Department of Pathology Unversity of Texas Southwesterm Medical School,
abundant pale
Dallas, TeK)
otoplasm are
Figure 13-25 Hodgkin lymphoma, nodular sclerosis type. A low-power view
shows wel-defined bands of pink, acellular collagen that subdivide the tumor
into nodules. (Courtesy Dr. Robert W. McKenna, Department of Pathology.
University of Texas Southwestern Medical School, Dallas, Tex.)
Figure 13-26 Hodgkin lymphoma, mixed-cellularity type. A diagnostic, binu-
cleate Reed-Sternberg cellis surounded by reactive cells,including eosino-
phils (bright red cytoplasm), lymphocytes, and histiocytes. (Courtesy
Dr. Robert W. McKenna, Department of Pathology,
University of Texas
Southwestern Medical School, Dallas, Tex.)
Figure 13-27 Hodgkin lymphoma, lymphocyte predominance type. Numer
ous mature-looking ymphocytes surround scattered, large, pale-staining
lymphohistiocytic variants (popcorn" cells). (Courtesy Dr. Robert W.
McKenna, Department of Pathology, University of Texas Southwestern
Medical School, Dallas, Tex.)
