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The document covers essential topics in medicinal chemistry, including the physiochemical properties of drug molecules, bioisosterism, and the influence of stereochemistry on biological activity. It details various drug classes acting on the autonomic and central nervous systems, including sympathomimetic agents, cholinergic agents, antipsychotic agents, and analgesics, along with their structure-activity relationships (SAR) and synthesis of specific drugs. Additionally, it discusses anesthetics, NSAIDs, and the classification of sedatives and hypnotics.

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25 views2 pages

Questions (PMC1)

The document covers essential topics in medicinal chemistry, including the physiochemical properties of drug molecules, bioisosterism, and the influence of stereochemistry on biological activity. It details various drug classes acting on the autonomic and central nervous systems, including sympathomimetic agents, cholinergic agents, antipsychotic agents, and analgesics, along with their structure-activity relationships (SAR) and synthesis of specific drugs. Additionally, it discusses anesthetics, NSAIDs, and the classification of sedatives and hypnotics.

Uploaded by

Shree Noob
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

IMPORTANT QUESTION OF MEDICINAL CHEMISTRY I( 402TP)

Introduction of medicinal chemistry


Enlist Physiochemical Properties of Drug Molecules that influencing Biological activity &
Describe hydrogen bonding, Partition Coefficient, Solubility, Complexation & Protein Binding,

Define Bioisostrerism. Discuss classification & application with example

Justify stereochemistry of Drug Molecule influence the biological activity.

Drug acting Autonomic nervous system

Detail note on Sympathomimetic agents & SAR of Sympathomimetic agents


Detail note on Adrenergic Antagonists and synthesis of propranolol
Detail note on SAR of beta blockers

Synthesis of following drugs......Phenylephrine , Salbutamol, Tolazoline, Propranolol


Cholinergic neurotransmitters
Define and classify cholinergic agents. What are cholinesterase inhibitors? SAR of B-
phenylethanolamine or SAR of cholinolytic agents
What are Parasympathomimetics? Classify them with suitable examples.

Synthesis of following drugs......Carbachol, Neostigmine, Ipratropium bromide, Dicyclomine


hydrochloride , Procyclidine hydrochloride

Drug acting on central nervous system(sedative & hypnotic, antipyscotic, anticonvoulsant)


Explain in detail SAR of barbiturate
Synthesis of following drugs :Diazepam, Barbital, Chlorpromazine hydrochloride, Phenytoin,
Ethosuximide

What are antipsychotic agents? Classify them with examples. Discuss the SAR of phenothiazines
Define sedatives and hypnotics. Classify with examples.

Explain in detail SAR of Anticonvoulsants

What is Psychoses? Explain SAR of Phenothiazines

Explain in detail SAR of Benzodiazepines


Drug acting on central nervous system (general anasthetics, narcotic and non narcotic
analgegics, narcotic antagonist, anti inflammatory agents)
Synthesis of following drugs : Halothane, Methohexital sodium, Ketamine hydrochloride,
Fentanyl citrate, Methadone hydrochloride, Mefenamic acid, Ibuprofen

Explain stages of anesthesia with classification of Inhalation anesthetics.


Write note on general anaesthetics.

What are NSAIDs? Classify them with two examples of each class. Write the synthesis of
Ibuprofen.
Difference between Opiod and Non-Opioid analgesics.
Write synthesis of one non steroidal NSAID having one chiral center
What are Analgesics? Write SAR and mode of action of morphine

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