Arvid Carlsson

Arvid Carlsson (25 January 1923 – 29 June

2018)[2][3][4] was a Swedish neuropharmacologist who Arvid Carlsson
is best known for his work with the neurotransmitter
dopamine and its effects in Parkinson's disease. For his
work on dopamine, Carlsson was awarded the Nobel
Prize in Physiology or Medicine in 2000, together with
Eric Kandel and Paul Greengard.[5][6]

Early life and education

Carlsson was born on 25 January 1923 in Uppsala,
Sweden, one of four siblings. His family moved to
Lund after his father became a history professor at
Lund University. Although his two older siblings
followed their father's career path, he instead chose to
Carlsson in 2011
study medicine at Lund, beginning in 1941.[4][7]
Born 25 January 1923
In 1944, he participated in the task of examining Uppsala, Sweden
prisoners of Nazi concentration camps, whom Swedish Died 29 June 2018 (aged 95)
aristocrat Folke Bernadotte had managed to bring to Göteborg, Sweden
Sweden, which was neutral during World War II.[4][7]
Alma mater Lund University
He received his MD and PhD in pharmacology in
1951.[4] Known for Dopamine
Awards Wolf Prize in Medicine (1979)
Japan Prize (1994)[1]
Career Feltrinelli International Award
(1999)
In 1951, Carlsson became an associate professor at Nobel Prize in Physiology or
Lund University. He spent five months as a research Medicine (2000)
fellow for the pharmacologist Bernard Beryl Brodie at
Scientific career
the National Heart Institute in Bethesda, Maryland,
United States, and the change in his research focus to Institutions University of Gothenburg
psychopharmacology eventually led to his Nobel
Prize.[4] In 1959 he became a professor at the University of Gothenburg.[4][7]

In 1957 Katharine Montagu demonstrated the presence of dopamine in the human brain; later that same
year Carlsson also demonstrated that dopamine was a neurotransmitter in the brain and not just a
precursor for norepinephrine.[8][9] Carlsson went on to develop a method for measuring the amount of
dopamine in brain tissues. He found that dopamine levels in the basal ganglia, a brain area important for
movement, were particularly high. He then showed that giving animals the drug reserpine caused a
decrease in dopamine levels and a loss of movement control. These effects were similar to the symptoms
of Parkinson's disease. By administering to these animals L-Dopa, which is the precursor of dopamine, he
could alleviate the symptoms. These findings led other doctors to try using L-Dopa in patients with
Parkinson's disease, and it was found to alleviate some of the symptoms in the early stages of the disease.
L-Dopa is still the basis for most commonly used means of treating Parkinson's disease.[5]

Carlson collaborated with the drug company Astra AB (now AstraZeneca) during the 1970s and the
1980s.[10] He and his colleagues were able to derive the first marketed selective serotonin reuptake
inhibitor (SSRI), zimelidine, from brompheniramine.[5] Zimelidine was later withdrawn from the market
due to rare cases of Guillain–Barré syndrome,[11] but Carlson's research paved the way for fluoxetine
(Prozac), one of the most widely used prescription medicines in the world.[7]

Carlsson was still an active researcher and speaker when he was over 90 years old and, together with his
daughter Lena, he worked[12] on OSU6162, a dopamine stabilizer which alleviates symptoms of post-
stroke fatigue.[13]

Honours and awards

Carlsson's research on the brain's chemical signals and the resulting treatment for Parkinson's disease
earned him the 2000 Nobel Prize in Physiology or Medicine, which he shared with Paul Greengard and
Eric R. Kandel.[4][7] He won many other awards including Israel's Wolf Prize in Medicine (1979), the
Japan Prize (1994),[7] and Italy's Feltrinelli Prize (1999).[14] He was elected as a member of the Royal
Swedish Academy of Sciences in 1975.[4] He was awarded an honorary Doctor of Science from the
University of Southern California in 2007.[15]

Personal life
Carlsson married Ulla-Lisa Christoffersson in 1945 and they had three sons and two daughters. His
daughter Maria was his lab manager[4][7] and his daughter Lena was one of his collaborators.[12]

He opposed the fluoridation of drinking water in Sweden.[16][17][18] He was a vocal opponent of

homeopathy and worked to prevent homeopathic preparations from being classified as medication in
Sweden.[2]

Carlsson died on 29 June 2018, at the age of 95.[4][7]

Drugs
1. Preclamol
2. FLA-57
3. Rotigotine
4. HW-165
5. UH-232
6. Nomelidine
 7. Zimelidine
8. 8-OH-DPAT
9. 7-OH-DPAT
10. DS-121

References
1. Laureates of the Japan Prize (http://www.japanprize.jp/en/laureates_by_year1990.html).
Japan Prize
2. "Nobelpristagaren Arvid Carlsson död" (https://web.archive.org/web/20180701030617/http://
unt.se/nyheter/omvarld/nobelpristagaren-arvid-carlsson-dod-5019874.aspx). Upsala Nya
Tidning. 30 June 2018. Archived from the original (http://unt.se/nyheter/omvarld/nobelpristag
aren-arvid-carlsson-dod-5019874.aspx) on 1 July 2018. Retrieved 30 June 2018.
3. "In memory of Arvid Carlsson (1923-2018)" (https://web.archive.org/web/20180701030548/h
ttps://sahlgrenska.gu.se/english/research/researchers/arvid-carlsson). Sahlgrenska
Academy. Archived from the original (https://sahlgrenska.gu.se/english/research/researcher
s/arvid-carlsson) on 1 July 2018. Retrieved 30 June 2018.
4. Gellene, Denise (1 July 2018). "Arvid Carlsson, Who Discovered a Treatment for
Parkinson's, Dies at 95" (https://mobile.nytimes.com/2018/07/01/obituaries/arvid-carlsson-w
ho-discovered-a-treatment-for-parkinsons-dies-at-95.html). The New York Times. Retrieved
3 July 2018.
5. Barondes, Samuel H. (2003). Better Than Prozac (https://archive.org/details/betterthanproz
ac00baro/page/21). New York: Oxford University Press. pp. 21–22, 39–40 (https://archive.or
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6. Les Prix Nobel. 2001. The Nobel Prizes 2000, Editor Tore Frängsmyr, Nobel Foundation:
Stockholm.
7. Smith, Harrison (2 July 2018). "Arvid Carlsson, Nobel laureate who uncovered a treatment
for Parkinson's, dies at 95" (https://www.washingtonpost.com/local/obituaries/arvid-carlsson-
nobel-laureate-who-uncovered-a-treatment-for-parkinsons-dies-at-95/2018/07/02/c13d9aee-
7e00-11e8-b660-4d0f9f0351f1_story.html). Washington Post. Retrieved 3 July 2018.
8. Carlsson, Arvid; Lindqvist, Margit; Magnusson, Tor (November 1957). "3,4-
Dihydroxyphenylalanine and 5-hydroxytryptophan as reserpine antagonists" (https://doi.org/
10.1038%2F1801200a0). Nature. 180 (4596): 1200. Bibcode:1957Natur.180.1200C (https://
ui.adsabs.harvard.edu/abs/1957Natur.180.1200C). doi:10.1038/1801200a0 (https://doi.org/1
0.1038%2F1801200a0). PMID 13483658 (https://pubmed.ncbi.nlm.nih.gov/13483658).
S2CID 28141709 (https://api.semanticscholar.org/CorpusID:28141709).
9. Abbott A (2007). "Neuroscience: the molecular wake-up call". Nature. 447 (7143): 368–70.
Bibcode:2007Natur.447..368A (https://ui.adsabs.harvard.edu/abs/2007Natur.447..368A).
doi:10.1038/447368a (https://doi.org/10.1038%2F447368a). PMID 17522649 (https://pubme
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60604/msgs/654587.html). www.dr-bob.org. Retrieved 22 June 2016.
12. "Publications card" (https://web.archive.org/web/20160808101106/http://www.gu.se/english/
research/publication/?publicationId=165289). University of Gothenburg. 25 November 2010.
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14. "Accademia Nazionale dei Lincei - Premi e borse di studio - Premi "Antonio Feltrinelli" finora
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15. "Past Recipients – Honorary Degrees" (https://honorarydegrees.usc.edu/past-recipients/).
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16. Fluoride in drinking water can cause cancer, Svenska Dagbladet (in Swedish) (http://www.sv
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g/details/fluoridedeceptio00brys). ISBN 1583225269.

External links
Arvid Carlsson (https://www.nobelprize.org/laureate/722) on Nobelprize.org including the
Nobel Lecture 8 December 2000 A Half-Century of Neurotransmitter Research: Impact on
Neurology and Psychiatry
The Sahlgrenska Academy at the University of Gothenburg (http://www.sahlgrenska.gu.se/e
nglish/)

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