Role of Chemical Potential in Thermodynamics
A SEMINAR REPORT ON
Role of Chemical Potential in Thermodynamics
Submitted to the University of Pune, Pune
in Partial Fulfilment of the Requirements
for the Award of the Degree of
BACHELOR OF ENGINEERING
In
CHEMICAL ENGINEERING
Of
SAVITRIBAI PHULE UNIVERSITY
BY
Somnath Ghadge
(Prn. No. 12210121)
Vedant Rane
(Prn. No. 12210122)
Sanika Virnodkar
(Prn. No. 12210076)
Abhay Yadav
(Prn. No. 12210627)
Snehal Kamble
(Prn. No.12320069)
Under the guidance of
Prof. Tanushree Bhattacharjee
Department of Chemical Engineering
BRACT’S Vishwakarma Institute of Technology,
666, Upper Indiranagar, Bibwewadi, Pune – 411 037
October 2024
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Role of Chemical Potential in Thermodynamics
Bansilal Ramnath Agarwal Charitable Trust’s
VISHWAKARMA INSTITUTE OF TECHNOLOGY
(An Autonomous Institute Affiliated to University of Pune)
666, Upper Indiranagar, Bibwewadi, Pune – 411 037
October 2024
CERTIFICATE
It is certified that the project work entitled.
Role of Chemical Potential in Thermodynamics
Submitted by
Somnath Ghadge Prn-12211570 Roll No - 53
Vedant Rane Prn-12210122 Roll No - 55
Sanika Virnodkar Prn-12210076 Roll No.- 56
Abhay Yadav Prn-12210627 Roll No - 57
Snehal Kamble Prn-12320069 Roll No - 73
is a bonafide work carried out under the supervision of Prof. Tanushree
Bhattacharjee for the partial fulfilment of Bachelor of Technology in Chemical
Engineering of Savitribai Phule Pune University. This work has not been submitted
elsewhere for any degree.
Prof. Dr. Tanushree Prof. Manik Desosarkar
Bhattacharjee Head of Department
Guide
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Role of Chemical Potential in Thermodynamics
DECLARATION
We declare that this written submission represents our ideas in our own words and
where others’ ideas have been included; We have adequately cited and referenced the
sources. We also declare that We have adhered to all principles of academic honesty
and integrity and have not misrepresented or fabricated or falsified any
idea/data/fact/source in my submission. We understand that any violation of the above
will be cause for disciplinary action by the Institute and can also evoke penal action
from the sources that have thus not been properly cited or from whom proper
permission has not been taken when needed.
Somnath Ghadge
Vedant Rane
Sanika Virnodkar
Abhay Yadav
Snehal Kamble
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Role of Chemical Potential in Thermodynamics
ACKNOWLEDGMENTS
We hereby acknowledge all the help and guidance we received throughout the
preparation of this Course Project from various quarters. We cannot overstate the
importance of the guidance received from our guide Prof. (Dr.) Tanushree
Bhattacharjee & Head of the Chemical Engineering Department Prof. (Dr.) M. P.
Deosarkar. Not only did they guide us in the choice of the topic but also went out of
their way to provide the background study material for the same. For all this and
more, we thank them.
Our sincere gratitude goes also to Prof. (Dr.) R.M. Jalnekar, Director, Vishwakarma
Institute of Technology, for the support and encouragement he provided to everyone
in this department. A word of thanks also for all the staff, teaching and non-teaching,
because whether it be a seminar or any other student activity, there’s always a
contribution from them.
Lastly, we would like to thank all our classmates for their support during this seminar.
Somnath Ghadge
Vedant Rane
Sanika Virnodkar
Abhay Yadav
Snehal Kamble
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Role of Chemical Potential in Thermodynamics
TABLE OF CONTENTS
Certificate
Declaration
Acknowledgement
Table of Contents
List of Tables
List of Figures
Abstract
Chapter 1 INTRODUCTION
1.1 Background
1.2 Relevance
1.3 Project Undertaken
1.4 Objective
Chapter 2 LITERATURE SURVEY
2.1 History
2.2 Properties
2.3 Market Analysis
Chapter 3 MANUFACTURING
3.1 Introduction
3.2 Manufacturing Process
Chapter 4 RESULT AND DISCUSSION
Chapter 5 CONCLUSION
REFERENCES
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ABSTRACT
Chemical potential is a key thermodynamic quantity that governs the behaviour of
systems in both chemical and physical processes. It determines the direction of
chemical reactions, phase transitions, diffusion, and transport phenomena by driving
substances toward equilibrium. This report examines the fundamental role of
chemical potential in phase equilibria, where it balances the coexistence of different
phases, and in chemical reactions, where it dictates the forward or reverse direction
based on Gibbs free energy. The concept of fugacity is also explored as a corrective
measure to account for non-ideal system behaviours, particularly in gases and real-
world applications such as industrial processes.
The report further investigates the importance of chemical potential in phase
transitions like melting and vaporization, where changes in chemical potential govern
the shift between phases. In addition, the role of chemical potential gradients in
driving diffusion and mass transport is analyzed, with applications in membrane
separation and biological systems. By understanding how chemical potential
influences molecular movement, engineers can optimize transport processes and
design more efficient systems in areas such as water treatment, drug delivery, and
energy production.
Through a combination of mathematical modelling and real-world examples, the
report provides insights into the behaviour of chemical potential across different
phases—solid, liquid, and gas. The study also highlights the practical applications of
chemical potential in industrial operations, particularly in optimizing reaction
conditions, separation processes, and energy storage. Understanding and applying the
principles of chemical potential is crucial for improving efficiency and sustainability
in chemical engineering and related industries.
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Chapter 1
INTRODUCTION
Chemical potential is a fundamental concept in thermodynamics, representing the
potential energy per particle in a system, which drives various physical and chemical
processes. It plays a critical role in determining the equilibrium conditions in phase
transitions, chemical reactions, and mass transfer. In engineering applications,
understanding chemical potential is essential for optimizing processes such as
distillation, reactor design, and transport phenomena. This report explores the
significance of chemical potential across these areas, examining its influence on phase
equilibria, reaction dynamics, diffusion, and real-world industrial applications.
1.1 Background
Chemical potential is a fundamental concept in thermodynamics that
quantifies the change in a system's Gibbs free energy when an additional
amount of a substance is introduced.
It plays a critical role in determining the direction of chemical reactions, phase
transitions, and transport processes like diffusion.
It helps in understanding systems at equilibrium, where the chemical potential
of each component is uniform across phases.
1.2 Relevance
Chemical potential is key to understanding a wide range of natural and
industrial processes, including:
Phase equilibria (liquid-vapor, solid-liquid)
Diffusion in gases and liquids
Osmosis and membrane transport
Reactions in chemical engineering processes
It is also essential for designing and optimizing reactors, separation units, and
energy systems in engineering applications.
1.3 Project Undertaken
This report focuses on the chemical potential concept and its application in
various thermodynamic systems. We will examine its role in equilibrium,
transport processes, and energy conversion, supported by mathematical
modelling and real-world case studies.
1.4 Objective
To investigate the role of chemical potential in thermodynamics, focusing on
its application in phase equilibria, reaction equilibria, and transport processes.
To simulate and model systems driven by chemical potential using
mathematical tools to understand real-world industrial applications.
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Chapter 2
Literature Survey
2.1History
The concept of chemical potential was first introduced by Josiah Willard
Gibbs in the 19th century as part of his work on thermodynamics and
statistical mechanics.
It has since become central to thermodynamic analysis, particularly in
understanding multiphase systems and reaction kinetics.
2.2 Properties
Chemical potential (μ) is defined as:
Where,
G is the Gibbs free energy,
n is the number of moles,
T is temperature, and
P is pressure.
It can also be expressed as:
Chemical potential drives processes like diffusion, osmosis, and
phase transitions by pushing systems toward equilibrium.
2.3 Market Analysis
The concept of chemical potential is crucial in industries such as:
Petrochemicals: Governs reactions in refineries and separation units.
Pharmaceuticals: Key in drug delivery and membrane transport mechanisms.
Energy Sector: Essential in battery technology and fuel cells.
Growing demand for optimizing energy-efficient processes and green
chemistry is increasing the relevance of chemical potential in industrial
applications.
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Fig. Literature Review.
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Role of Chemical Potential in Thermodynamics
Chapter 3:
Manufacturing
3.1 Introduction
Chemical potential is critical in manufacturing processes involving reaction
kinetics, phase transitions, and mass transfer operations.
Understanding the behaviour of chemical potential helps improve yield,
efficiency, and sustainability in manufacturing plants.
3.2 Manufacturing Process
In the production of chemicals (e.g., ammonia synthesis, polymerization), controlling
the chemical potential of reactants ensures optimal reaction conditions.
Distillation: A common industrial process where chemical potential differences drive
the separation of components based on their volatilities.
Membrane Separation: Chemical potential gradients are utilized to selectively transfer
molecules across membranes in processes like reverse osmosis and dialysis.
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Chapter 4
RESULT AND DISCUSSION
In this report, the role of chemical potential in various thermodynamic processes was
explored, with a focus on phase equilibria, chemical reactions, phase transitions,
diffusion, and transport phenomena. The findings demonstrate how chemical potential
serves as a universal driving force that dictates the behavior of systems at equilibrium
and during mass and energy transfers. Through mathematical modeling and literature
analysis, key observations were made across different processes.
Phase Equilibria
The analysis revealed that chemical potential plays a crucial role in maintaining
equilibrium between phases. The equality of chemical potential across phases ensures
that no net transfer of mass occurs, thus maintaining a stable equilibrium. For
instance, in liquid-vapor systems, the chemical potential of a substance is equal in
both phases at equilibrium, a concept integral to processes like distillation and liquid-
liquid extraction. The introduction of **fugacity** as a correction factor for non-ideal
systems provided a more accurate representation of chemical potential in real-world
applications, particularly for gases at high pressures or non-ideal liquid mixtures.
Discussion: The use of fugacity instead of pressure or concentration in real systems
proved effective for calculating chemical potential more accurately. In industrial
distillation, for example, accounting for deviations from ideal behavior through
fugacity leads to better process control and optimization. This correction is critical in
high-pressure systems or systems involving complex mixtures, ensuring more precise
predictions of phase behavior and separation efficiency.
Chemical Reactions
Chemical potential also dictates the direction of chemical reactions, as demonstrated
by the relationship between Gibbs free energy and reaction equilibrium. The findings
indicated that reactions proceed in the direction that minimizes the system's free
energy, with equilibrium achieved when the chemical potentials of reactants and
products are equal. The report also showed how the equilibrium constant is linked to
the difference in chemical potentials of the species involved.
Discussion: Understanding the role of chemical potential in chemical reactions
provides significant benefits in reaction engineering, particularly in optimizing
conditions for maximum yield. In processes like the Haber-Bosch method for
ammonia synthesis, the balance of chemical potential between nitrogen, hydrogen,
and ammonia is essential for determining reaction efficiency. This insight enables
engineers to fine-tune pressure, temperature, and catalyst conditions to shift the
equilibrium in favor of the desired product, leading to increased efficiency and
reduced energy consumption.
Phase Transitions
In phase transitions such as melting, vaporization, and sublimation, the report
highlighted that chemical potential governs the temperature and pressure conditions
under which these transformations occur. The condition for phase equilibrium—
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where the chemical potential of a substance is equal in both phases—was validated
through the study of phase diagrams and transition points. Additionally, the analysis
showed that changes in Gibbs free energy during phase transitions are directly related
to the chemical potential difference between phases.
Discussion: The application of chemical potential in understanding phase transitions
is critical for designing efficient thermal systems, such as refrigeration,
crystallization, and material processing. By predicting the conditions for phase
changes, engineers can control cooling and heating processes, ensuring optimal
energy use. This understanding also extends to the development of new materials,
where precise control of phase transitions can influence properties like hardness,
conductivity, and stability.
Diffusion and Transport Phenomena
The role of chemical potential gradients in driving diffusion and transport was
thoroughly examined. The study confirmed that particles move from regions of higher
to lower chemical potential, a principle that governs mass transport in both natural
and industrial systems. The application of Fick's law, modified to incorporate
chemical potential gradients, provided a more fundamental understanding of diffusion
in non-ideal systems, as opposed to using simple concentration gradients.
Discussion: In practical applications like membrane filtration, osmosis, and gas
separation, the chemical potential gradient is a more accurate predictor of diffusion
rates, especially in non-ideal systems or when multiple components are involved. This
understanding leads to improvements in process design for efficient separation of
gases, liquids, and solids, enhancing performance in industries like water treatment,
air purification, and biochemical manufacturing.
Comparison Across Phases
Finally, the comparison of chemical potential across different states (solid, liquid, gas)
demonstrated how it varies due to differences in molecular interactions and entropy.
The study confirmed that solids have the lowest chemical potential due to strong
intermolecular forces and low entropy, while gases have the highest chemical
potential due to weak forces and high entropy. This comparison provided insights into
phase stability and transitions under varying temperature and pressure conditions.
Discussion: The variation in chemical potential across phases has direct implications
for material processing and phase-change technologies. For instance, in the
manufacturing of metals and alloys, controlling the chemical potential during
solidification ensures the formation of desired microstructures and properties.
Similarly, in chemical processes involving gas absorption or desorption,
understanding the high chemical potential of gases aids in designing more effective
equipment for mass transfer operations.
The results of this study underscore the central role of chemical potential in
understanding and optimizing a wide range of thermodynamic processes. By applying
this concept to real-world systems, engineers can better control phase transitions,
chemical reactions, and transport phenomena, leading to more efficient and
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sustainable industrial processes. The inclusion of corrections for non-ideal behaviour,
such as fugacity, enhances the accuracy of predictions and improves process
optimization in complex systems.
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Chapter 5
CONCLUSION
Chemical potential is a fundamental thermodynamic property that plays a pivotal role
in governing various physical and chemical processes. From phase equilibria and
chemical reactions to phase transitions and diffusion, chemical potential provides the
driving force that determines the direction and extent of these processes. Through this
study, it has been demonstrated that chemical potential is not only essential for
understanding equilibrium conditions in both ideal and non-ideal systems, but also
critical for optimizing industrial applications such as distillation, reaction engineering,
and mass transport. By utilizing chemical potential, engineers can predict the behavior
of materials under different conditions, allowing for more efficient process design and
enhanced control over phase behaviour and reaction dynamics.
Importance of Chemical Potential
Chemical potential is important because it allows us to quantify the energy changes
associated with the addition or removal of particles in a system. It helps explain why
substances move, react, or change phases. In phase equilibria, chemical potential
ensures that no net mass transfer occurs between phases at equilibrium, which is
critical for processes like distillation and crystallization. In chemical reactions, it
provides insight into reaction spontaneity and equilibrium, making it a key tool for
predicting whether a reaction will occur and under what conditions. In diffusion and
transport phenomena, chemical potential gradients are responsible for driving the
movement of molecules, which is vital in systems like membrane filtration and gas
separation.
The concept is also crucial in phase transitions, where changes in chemical potential
govern the shifts between solid, liquid, and gaseous phases. Additionally, the
introduction of fugacity as a correction for non-ideal systems enhances the practical
application of chemical potential, especially in high-pressure systems or those with
significant deviations from ideal behaviour.
Advantages
1. Optimization of Industrial Processes: By understanding and applying chemical
potential, engineers can optimize processes such as distillation, crystallization, and
gas-liquid separations. For example, in multi-component distillation, the chemical
potential difference between components helps in determining the optimal
temperature and pressure for separation, leading to energy-efficient designs.
2. Control of Chemical Reactions: Chemical potential allows for better control over
chemical reactions. It helps in predicting reaction outcomes and adjusting conditions
(such as temperature, pressure, and concentration) to shift the equilibrium in favor of
the desired product. In processes like ammonia synthesis (Haber-Bosch process),
understanding the balance of chemical potentials between reactants and products is
essential for improving yield.
3. Enhanced Transport Processes: Chemical potential gradients are essential in
understanding diffusion and transport phenomena. Systems like reverse osmosis, gas
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Role of Chemical Potential in Thermodynamics
absorption, and molecular separation rely on chemical potential differences to drive
material flow, making it an indispensable tool for designing efficient transport
systems in industries such as water treatment and biopharmaceuticals.
4. Accurate Prediction in Non-Ideal Systems: The introduction of fugacity improves
the accuracy of chemical potential predictions in non-ideal systems. This is
particularly important in industries dealing with gases under high pressure or complex
liquid mixtures, where deviations from ideal behaviour are common. Using fugacity
ensures more reliable predictions, leading to better system design and process control.
Why Chemical Potential is Important
Chemical potential is integral to thermodynamic calculations and essential for both
academic and industrial applications. It provides a universal framework to analyze a
wide variety of processes, from phase changes and chemical equilibria to diffusion
and transport. Its ability to capture the energetic dynamics of systems with varying
compositions makes it an indispensable tool for chemical engineers.
Moreover, the application of chemical potential to non-ideal systems (through
concepts like fugacity) enables engineers to tackle real-world challenges where ideal
behavior cannot be assumed. Understanding chemical potential allows for the design
of systems that are more efficient, cost-effective, and sustainable, providing economic
and environmental benefits across industries such as energy production,
petrochemicals, pharmaceuticals, and environmental engineering.
In conclusion, chemical potential is not just a theoretical concept but a practical tool
that enables engineers to harness the laws of thermodynamics to optimize processes,
control reactions, and design systems that are more efficient and effective. By
mastering the applications of chemical potential, we can drive innovation and
sustainability in the chemical and process industries.
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References
[1] Visser, Manus R. "Holographic thermodynamics requires a chemical potential for color." Physical
Review D 105.10 (2022): 106014.
[2] Dong, W. "Nanoscale thermodynamics needs the concept of a disjoining chemical
potential." Nature Communications 14.1 (2023): 1824.
[3] Ipp, Andreas, and Anton Rebhan. "Thermodynamics of large-Nf QCD at finite chemical
potential." Journal of High Energy Physics 2003.06 (2003): 032.
[4] Allton, C. R., et al. "Thermodynamics of two flavor QCD to sixth order in quark chemical
potential." Physical Review D—Particles, Fields, Gravitation, and Cosmology 71.5 (2005): 054508.
[5] Bennethum, Lynn Schreyer, Márcio A. Murad, and John H. Cushman. "Macroscale
thermodynamics and the chemical potential for swelling porous media." Transport in Porous
Media 39.2 (2000): 187-225.
[6] D’Elia, Massimo, and Francesco Sanfilippo. "Thermodynamics of two flavor QCD from imaginary
chemical potentials." Physical Review D—Particles, Fields, Gravitation, and Cosmology 80.1 (2009):
014502.
[7] D’Elia, Massimo, and Francesco Sanfilippo. "Thermodynamics of two flavor QCD from imaginary
chemical potentials." Physical Review D—Particles, Fields, Gravitation, and Cosmology 80.1 (2009):
014502.
[8] Qian, Hong, et al. "Entropy production in mesoscopic stochastic thermodynamics: nonequilibrium
kinetic cycles driven by chemical potentials, temperatures, and mechanical forces." Journal of Physics:
Condensed Matter 28.15 (2016): 153004.
[9] Guenther, Jana N., et al. "Lattice thermodynamics at finite chemical potential from analytical
Continuation." Journal of Physics: Conference Series. Vol. 1070. No. 1. IOP Publishing, 2018.
Ichikawa, K., S. M. Granstaff, and J. C. Thompson. "Chemical potentials and related thermodynamics
of liquid Na–Cs alloys." The Journal of Chemical Physics 61.10 (1974): 4059-4062.
[10] Gardim, F. G., and F. M. Steffens. "Thermodynamics of quasi-particles at finite chemical
potential." Nuclear Physics A 825.3-4 (2009): 222-244.
[11] Van der Ven, A., and G. Ceder. "The thermodynamics of decohesion." Acta Materialia 52.5
(2004): 1223-1235.
[12] Megias, Eugenio, Débora P. Menezes, and Airton Deppman. "Non extensive thermodynamics for
hadronic matter with finite chemical potentials." Physica A: Statistical Mechanics and its
Applications 421 (2015): 15-24.
[13] Mukherjee, Swagato, Munshi G. Mustafa, and Rajarshi Ray. "Thermodynamics of the Polyakov-
Nambu-Jona-Lasinio model with nonzero baryon<? format?> and isospin chemical
potentials." Physical Review D—Particles, Fields, Gravitation, and Cosmology 75.9 (2007): 094015.
[14] Alberty, Robert A. "Use of Legendre transforms in chemical thermodynamics (IUPAC Technical
Report)." Pure and Applied Chemistry 73.8 (2001): 1349-1380.
[15] Li, J. C. M., R. A. Oriani, and L. S. Darken. "The thermodynamics of stressed solids." Zeitschrift
für Physikalische Chemie 49.3_5 (1966): 271-290.
[16] Job, G., and F. Herrmann. "Chemical potential—a quantity in search of recognition." European
journal of physics 27.2 (2006): 353.
[17] Job, G., and F. Herrmann. "Chemical potential—a quantity in search of recognition." European
journal of physics 27.2 (2006): 353.
[18] Domenicali, Charles A. "Irreversible thermodynamics of thermoelectricity." Reviews of modern
Physics 26.2 (1954): 237.
[19] Biot, Maurice A. "New fundamental concepts and results in thermodynamics' namics with
chemical applications." Chemical Physics 22.2 (1977): 183-198.
[20] Avanzini, Francesco, Gianmaria Falasco, and Massimiliano Esposito. "Thermodynamics of
chemical waves." The Journal of Chemical Physics 151.23 (2019).
[21] Smith, E. Brian. Basic chemical thermodynamics. World Scientific Publishing Company, 2013.
xvi
VIT [Link]. (Chemical)
Role of Chemical Potential in Thermodynamics
Biot, Maurice Anthony. "New chemical thermodynamics of open systems. Thermobaric potential, a
new concept." Bulletins de l'Académie Royale de Belgique 62.1 (1976): 239-258.
[22] Sughiyama, Yuki, et al. "Chemical thermodynamics for growing systems." Physical Review
Research 4.3 (2022): 033191.
[23] Koretsky, Milo D. Engineering and chemical thermodynamics. John Wiley & Sons, 2012.
[24]Shchekin, Alexander K., Tatiana S. Lebedeva, and Dmitry V. Tatyanenko. "Dependence of the
condensate chemical potential on droplet size in thermodynamics of heterogeneous nucleation within
the gradient DFT." Fluid Phase Equilibria 424 (2016): 162-172.
xvii
VIT [Link]. (Chemical)
