Pathway spread of cancer
Direct or local Perineural spread Trans-celamic spread Hematogenous spread
Lymphatic spread
spread
A) Direct or local spread:
tumor spread to surrounding tissue
B) Lymphatic spread :
Tumor spread through lymph node
the first regional lymph node involved in the
metastasis is called sentinel lymph node
C) Perineural spread :
Spread through nerve fibers
D) trans-celamic spread :
Through serous membranes
E) Hematogenous spread
Spread through blood vessels to
systemic organs
Most affected sites of metastasis
2L: lung , liver
skeletal muscle even
they rich in capillaries
but it is rare to see
tumor metastasis in
themskeletal muscle even
they are rich in capillaries
but it is rare to see tumor
2B : brain , bone metastasis in them