Seat No.: _____ Enrolment No.
_____________
GUJARAT TECHNOLOGICAL UNIVERSITY
B.PHARM - SEMESTER– 6 EXAMINATION – SUMMER-2024
Subject Code:BP601TP Date: 30/04/2024
Subject Name: Medicinal Chemistry III
Time: 10.30 a.m. to 1.30 p.m. Total Marks: 80
Instructions:
1. Attempt any five questions.
2. Make suitable assumptions wherever necessary.
3. Figures to the right indicate full marks.
Q.1 (a) Write about etiology of malaria. Discuss classification of anti-malarial agents. 06
(b) Write SAR of Sulphonamides. 05
(c) Write down synthesis, mode of action and uses of Dapsone. 05
Q.2 (a) Define combinatorial chemistry. Discuss concept and applications of 06
combinatorial chemistry
(b) Explain classification of Anthelmintic agents. 05
(c) Give the synthesis of Chloroquine & Pamaquine. 05
Q.3 (a) What is QSAR? Write about Hansch analysis in QSAR. 06
(b) Write a note on antiviral agents. 05
(c) Discuss SAR of Tetracycline. 05
Q.4 (a) Discuss basic concepts and application of Prodrugs design. 06
(b) Write SAR of Cephalosporins. 05
(c) Write uses and synthesis of Metronidazole and Mebendazole. 05
Q.5 (a) Explain Classification of Anti-tubercular agents. 06
(b) Write about mode of action, therapeutic uses and synthesis of 05
Chloramphenicol.
(c) Write a note on Aminoglycosides. 05
Q. 6 (a) Classify antifungal agents. Write down mode of action and therapeutic use of 06
azole class of antifungal agents.
(b) Write a note on anti-protozoal agents. 05
(c) Write uses and synthesis of Ciprofloxacin and Acyclovir. 05
Q.7 (a) Write a brief note on Quinolones. 06
(b) Write about mode of action, therapeutic uses and synthesis of 05
Sulphamethoxazole.
(c) Write the chemical degradation of penicillin with structures. 05
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