R-422A

Safety Data Sheet

R-422A
1. CHEMICAL PRODUCT AND COMPANY IDENTIFICATION

PRODUCT NAME: R-422A

OTHER NAME: Pentafluoroethane, 1,1,1,2-Tetrafluoroethane, Isobutane
DISTRIBUTOR: National Refrigerants, Inc.
661 Kenyon Avenue
Bridgeton, New Jersey 08302

FOR MORE INFORMATION CALL: IN CASE OF EMERGENCY CALL:

(Monday-Friday, 8:00am-5:00pm) CHEMTREC: 1-800-424-9300
1-800-262-0012

2. HAZARDS IDENTIFICATION

CLASSIFICATION: Gases under pressure, Liquefied Gas

SIGNAL WORD: WARNING
HAZARD STATEMENT: Contains gas under pressure, may explode if heated
SYMBOL: Gas Cylinder
PRECAUTIONARY STATEMENT: STORAGE: Protect from sunlight, store in a well ventilated place

EMERGENCY OVERVIEW: Colorless, volatile liquid with ethereal and faint sweetish odor. Non-flammable material.
Overexposure may cause dizziness and loss of concentration. At higher levels, CNS depression and cardiac arrhythmia
may result from exposure. Vapors displace air and can cause asphyxiation in confined spaces. At higher temperatures,
(>250C), decomposition products may include Hydrochloric acid (HCI), Hydrofluoric Acid (HF) and carbonyl halides.

POTENTIAL HEALTH HAZARDS

SKIN: Irritation can result from a defatting action on tissue. Liquid contact may cause frostbite.

EYES: Liquid may cause frostbite. Mist may irritate.

INHALATION: Overexposure may cause dizziness and loss of concentration. At higher levels, central nervous system
depression and cardiac arrhythmia may result.

INGESTION: Unlikely route of exposure. Should it result, discomfort in the gastrointestinal tract would occur.

DELAYED EFFECTS: None Known

CHRONIC (CANCER) INFORMATION: None of the components are designated as carninogens by IARC, NTP, OSHA,
or ACHIH.

TERTATOLOGY (BIRTH DEFECT) INFORMATION: No hazard expected

Ingredients found on one of the OSHA designated carcinogen lists are listed below.
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INGREDIENT NAME NTP STATUS IARC STATUS OSHA LIST
No ingredients listed in this section

3. COMPOSITION / INFORMATION ON INGREDIENTS

INGREDIENT NAME CAS NUMBER WEIGHT %

Pentafluoroethane 354-33-6 85.1%
1,1,1,2-Tetrafluoroethane 811-97-2 11.5%
Isobutane 75-28-5 3.4%

COMMON NAMES and SYNONYMS

R-422A; HFC422A

There are no impurities or stabilizers that contribute to the classification of the material identified in Section 2

4. FIRST AID MEASURES

INHALATION: Immediately remove to fresh air. If breathing has stopped, give artificial respiration. Get medical attention
immediately.

SKIN: Promptly flush skin with lukewarm water. Do not use hot water. Immediately remove contaminated clothing or footwear. If
it sticks, do not pull it off. Cover the affected area with a sterile dressing. Get medical attention immediately.

EYES: Immediately flush eyes with large amounts of water for at least 15 minutes keeping the eyes wide open. Consult an eye
specialist immediately.

INGESTION: Not specifically applicable (gas).

ADVICE TO PHYSICIAN: Avoid administering adrenaline or any other similar products.

5. FIRE FIGHTING MEASURES

FLAMMABLE PROPERTIES

FLASH POINT: None

FLASH POINT METHOD: Not Applicable
AUTOIGNITION TEMPERATURE: >550˚C (1022˚F)
UPPER FLAME LIMIT (volume % in air): None*
LOWER FLAME LIMIT (volume % in air): None*
*Based on ASHRAE Standard 34 with match ignition
FLAME PROPAGATION RATE (solids): Not applicable
OSHA FLAMMABILITY CLASS: Not applicable

EXTINGUISHING MEDIA:
All suitable extinguishing agents can be used.

UNUSUAL FIRE AND EXPLOSION HAZARDS:

Pressurized container. On heating there is a risk of bursting due to internal pressure build-up. NOT flammable. However, it
may present a risk in the event of a fire. Toxic vapours (halogen compounds) are released.
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SPECIAL FIRE FIGHTING PRECAUTIONS INSTRUCTIONS:
Stay upwind. Evacuate all personnel away from the fumes. Cool down the containers/equipment exposed to heat with a
water spray. Fire-fighters must use self-contained breathing apparatus.

6. ACCIDENTAL RELEASE MEASURES

SAFEGUARDS (Personnel):
Avoid contact with skin and eyes. Do not breathe gas. No naked flames. Do not smoke. For further information refer to
section 8 “Exposure controls/personal protection.” Heavy vapours. Shut off low-level openings in the vicinity (ventilation
shafts, drains. . .) . Prevent the product from entering cellars, basements or pits. Stop the leak. Ventilate spillage area.
Ventilate basements.

ENVIRONMENTAL PRECAUTIONS:
Prevent the product from spreading into the environment. Contain the spilled material by bunding.

METHODS FOR CLEANING UP

Recover: Recover as much of the product as possible.
Cleaning/Decontamination: Allow residual product to evaporate.
Disposal: For disposal of contaminated materials refer to section 13: “Disposal Considerations”

7. HANDLING AND STORAGE

HANDLING (Personnel):
Avoid breathing vapors and liquid contact with eyes, skin or clothing. Use with sufficient ventilation to keep employee
exposure below recommended limits. Avoid contact with hot surfaces. Avoid high temperatures. Smoking is forbidden.

STORAGE RECOMMENDATIONS:
Storage facilities should be equipped with ventilation at low level. Take all necessary precautions to avoid the accidental
release of the product outside, due to the rupture of containers or transfer system. Keep the container tightly closed and dry
in a cool, well-ventilated area. Keep at temperatures not exceeding 45 and away from any source of heat or ignition.

INCOMPATIBILITIES:
Refer to the detailed list of incompatible materials (section 10 “Stability/Reactivity). Incompatible with magnesium and its
alloys, zinc and its alloys, and aluminum alloys containing more than 2% magnesium

8. EXPOSURE CONTROLS / PERSONAL PROTECTION

ENGINEERING CONTROLS:
Ensure good ventilation of the work station.

PERSONAL PROTECTIVE EQUIPMENT

SKIN PROTECTION:
Skin contact with refrigerant may cause frostbite. General work clothing and gloves (leather) should provide
adequate protection. If prolonged contact with liquid or gas is anticipated, insulated gloves constructed of PVA,
neoprene or butyl rubber should be used. Any contaminated clothing should be promptly removed and washed
before reuse.

EYE PROTECTION:

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For normal conditions, wear safety glasses. Where there is reasonable probability of liquid contact, wear chemical
safety goggles.

RESPIRATORY PROTECTION:
None generally required for adequately ventilated work situations. For accidental release or non-ventilated
situations, or release into confined space, where the concentration may be above the PEL of 1,000 ppm, use a self-
contained, NIOSH approved breathing apparatus or supplied air respirator. For escape: use the former or a NIOSH
approved gas mask with organic vapor canister.

ADDITIONAL RECOMMENDATIONS:
Where contact with liquid is likely, such as in a spill or leak, impervious boots and clothing should be worn. High
dose-level warning signs are recommended for areas of principle exposure. Provide eyewash stations and quick-
drench shower facilities at convenient locations. For tank cleaning operations, see OSHA regulations, 29 CFR
1910.132 and 29 CFR 1910.133.

EXPOSURE GUIDELINES
INGREDIENT NAME ACGIH TLV OSHA PEL OTHER LIMIT
1,1,1,2,2-Pentabluoroethane(R-125) None None *1000 ppm TWA (8 hr)
1,1,1,2-Tetrafluoroethane (R-134a) None None *1000 ppm TWA (8 hr)
Isobutane 1000 ppm TWA (8 hr) None **800 ppm TWA (10 hr)

* = Workplace Environmental Exposure Level (AIHA)

** = National Institute of Occupational Safety & Health (NIOSH)

OTHER EXPOSURE LIMITS FOR POTENTIAL DECOMPOSITION PRODUCTS:

Impervious gloves, chemical splash goggles, and impermeable clothing should be worn when handling refrigerant. Under
normal conditions, no respiratory protection is required when using this product. Self-contained breathing apparatus
(SCBA) is required in the event of insufficient ventilation. Do not drink, eat or smoke in the workplace.

9. PHYSICAL AND CHEMICAL PROPERTIES

APPEARANCE: Colorless
PHYSICAL STATE: Compressed liquefied gas
MOLECULAR WEIGHT: 113.6
CHEMICAL FORMULA: CF3CHF2,CF3CH2F,C4H10
ODOR: Slight ethereal
SPECIFIC GRAVITY: 1.157 @25˚C
pH: Not applicable
BOILING POINT: -46.2C to –41.5C
FREEZING POINT: Soluble in common solvents
VAPOR PRESSURE: 1220 kPa, @ 25C
VAPOR DENSITY (air =1.0): 3.93
EVAPORATION RATE: >1 (CC14+1)
% VOLATILES: 100%
ODOR THRESHHOLD: Not established
FLAMMABILTIY: Not applicable
LEL/UEL: None/None
RELATIVE DENSITY: 1.157 g/cm3 @ 25˚C
PARTITION COEFF (n-octanol/water) Not applicable
AUTO IGNITION TEMP: Not determined
DECOMPOSITION TEMPERATURE: >250˚C

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VISCOSITY: Not applicable
FLASH POINT: Not applicable
(Flash point method and additional flammability data are found in Section 5)
10. STABILITY AND REACTIVITY

NORMALLY STABLE (CONDITIONS TO AVOID):

The product is stable. However, avoid open flames and high temperatures.

INCOMPATIBILITIES:
Incompatible with alkali or alkaline earth metals, powdered metals, magnesium.

HAZARDOUS DECOMPOSITION PRODUCTS:

Decomposition products are hazardous. This material can be decomposed by high temperatures (open flames, glowing
metal surfaces, etc.) forming hydrofluoric acid and possibly carbonyl fluoride.

HAZARDOUS POLYMERIZATION:
Will not occur.

11. TOXICOLOGICAL INFORMATION

IMMEDIATE (ACUTE) EFFECTS:

HFC-125: LC50 : 4 hr. (rat) - > 800,000 ppm

Cardiac Sensitization threshold (dog) 75,000 ppm.
HFC-134a: LC50 : 4 hr. (rat) - > 500,000 ppm
Cardiac Sensitization threshold (dog) 80,000 ppm.
R-600a: LC50 : 15 min. (rat) - 570,000 ppm

DELAYED (SUBCHRONIC AND CHRONIC) EFFECTS:

HFC-125: Teratogenic NOEL (rat and rabbit) – 50,000 ppm

Subchronic inhalation (rat) NOEL - >50,000 ppm
Chronic NOEL – 10,000 ppm
HFC-134a: Teratogenic NOEL (rat and rabbit) – 40,000 ppm
Subchronic inhalation (rat) NOEL - 50,000 ppm
Chronic NOEL – 10,000 ppm
R-600a: Subchronic inhalation (rat) NOAEL - 4,489 ppm

OTHER DATA:

HFC–125, HFC–134a: Not active in four genetic studies

R-600a: Negative Ames test with and without activation

POTENTIAL HEALTH HAZARDS

SKIN: Irritation can result from a defatting action on tissue. Liquid contact may cause frostbite.

EYES: Liquid may cause frostbite. Mist may irritate.

INHALATION: Overexposure may cause dizziness and loss of concentration. At higher levels, central nervous system
depression and cardiac arrhythmia may result.
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INGESTION: Unlikely route of exposure. Should it result, discomfort in the gastrointestinal tract would occur.

DELAYED EFFECTS: None Known

CHRONIC (CANCER) INFORMATION: None of the components are designated as carninogens by IARC, NTP, OSHA,
or ACHIH.

TERTATOLOGY (BIRTH DEFECT) INFORMATION: No hazard expected

Ingredients found on one of the OSHA designated carcinogen lists are listed below.

INGREDIENT NAME NTP STATUS IARC STATUS OSHA LIST

No ingredients listed in this section

12. ECOLOGICAL INFORMATION

MOBILITY
Volatility: Product is volatile when in aqueous solution.

Expected behavior of the product:

BIODEGRADABILITY
Ultimate aerobic biodegradability: Not readily biodegradable. (evaluation by structure-activity relationship)

BIOACCUMULATION
Bioconcentration factor: No information available.

ECOTOXICITY
--Effects on the aquatic environment: No information available.

13. DISPOSAL CONSIDERATIONS

WASTE DISPOSAL:
Do not allow product to be released into the environment. Disposal must comply with federal, state, and local disposal or
discharge laws. Consult the manufacturer or supplier for information regarding recovery and recycling of the product. If
recovery is not possible, incinerate at a licensed installation.

CONTAMINATED PACKAGING
Decontamination/Cleaning: De-gas
Destruction/Disposal: Re-usable containers: Return to the supplier
Disposable containers: Dispose of at an authorized landfill site.

NOTE: The user’s attention is drawn to the possible existence of local regulations regarding
disposal.

14. TRANSPORT INFORMATION

US DOT ID NUMBER: UN3163

US DOT PROPER SHIPPING NAME: Liquefied Gas, n.o.s (Pentafluoroethane, 1,1,1,2-Tetrafluoroethane)
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US DOT HAZARD CLASS: 2.2
US DOT PACKAGING GROUP: N/A

NOTE: The above regulatory prescriptions are those valid on the date of publication of this sheet.
Given the possible evolution of transport regulations for hazardous materials, it would be advisable to
check their validity with your sales office.

15. REGULATORY INFORMATION

LABELLING
EC REGULATIONS: Mandatory labeling (self-classification) of hazardous preparations: Not applicable

-R phrases No R phrases
-S phrases No S phrases

NOTE: The regulatory information given above only indicates the principal regulations specifically applicable to the
product described in the Material Safety Data Sheet. The user’s attention is drawn to the possible existence of
additional provisions which complete these regulations. Refer to all applicable national, international and local
regulations or provisions.

16. OTHER INFORMATION

CURRENT ISSUE DATE: January 04, 2021

PREVIOUS ISSUE DATE: May 2018

DISCLAIMER:

National Refrigerants, Inc. believes that the information and recommendations contained herein (including data and statements) are
accurate as of the date hereof. NO WARRANTY OF FITNESS FOR ANY PARTICULAR PURPOSE, WARRANTY OF
MERCHANTABILITY, OR ANY OTHER WARRANTY, EXPRESSED OR IMPLIED, IS MADE CONCERNING THE
INFORMATION PROVIDED HEREIN. The information provided herein relates only to the specific product designated and may not
be valid where such product is used in combination with any other methods or use of the product and of the information referred to
herein are beyond the control of National Refrigerants. National Refrigerants expressly disclaims any and all liability as to any results
obtained or arising from any use of the product or reliance on such information.

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