Jean Fréchet

Jean M.J. Fréchet (born August 1944) is a French-

American chemist and professor emeritus at the Jean M.J. Fréchet
University of California, Berkeley. He is best known Born August 19, 1944
for his work on polymers including polymer-supported Burgundy, France
chemistry, chemically amplified photoresists, Known for Dendrimers
dendrimers, macroporous separation media, and Contributions in the fields of
polymers for therapeutics. Ranked among the top 10 polymer science,
chemists in 2021,[2] he has authored nearly 900 photolithography, molecular
scientific paper and 200 patents including 96 US self-assembly, microfluidics,
patents.[3] His research areas include organic synthesis and nanotechnology.
and polymer chemistry applied to nanoscience and Awards Dickson Prize (2007), Arthur C.
nanotechnology with emphasis on the design, Cope Award (2007), Japan
fundamental understanding, synthesis, and applications Prize (2013), King Faisal
of functional macromolecules. International Prize (2019)

Fréchet is an elected fellow of the American Scientific career

Association for the Advancement of Science, the Fields Chemistry
American Chemical Society, and the American Institutions King Abdullah University of
Academy of Arts and Sciences, and an elected member Science and Technology
of the US National Academy of Sciences, the US University of California,
National Academy of Engineering, and the Academy Berkeley
of Europe (Academia Europaea). Lawrence Berkeley National
Laboratory
Cornell University
Education and academic career University of Ottawa
Thesis Solid Phase Synthesis of
Fréchet received his first university degree at Oligosaccharides[1] (1972)
the Institut de Chimie et Physique Industrielles (now
Doctoral Shelley Claridge
CPE) in Lyon, France, before coming to the US for
students
studies in organic and polymer chemistry under
Conrad Schuerch at the State University of New York Other notable Craig Hawker
College of Environmental Science and Forestry, and students
at Syracuse University (Ph.D. 1971). He was on the Website chemistry.berkeley.edu/faculty
Chemistry Faculty at the University of Ottawa in /chem/emeriti/frechet (http://ch
Canada from 1973 to 1987, when he became the IBM emistry.berkeley.edu/faculty/ch
Professor of Polymer Chemistry at Cornell University. em/emeriti/frechet), www.kaust
In 1997 Fréchet joined Chemistry faculty at the .edu.sa/office-vp-research-
University of California, Berkeley and was named the jean-frechet.html (http://www.k
Henry Rapoport Chair of Organic Chemistry in 2003 aust.edu.sa/office-vp-research-
and Professor of Chemical and Biological Engineering jean-frechet.html)
in 2005. From 2010 to 2019 he served as the first Vice President for Research, then Senior Vice-President
for Research, Innovation, and Economic Development at the King Abdullah University of Science and
Technology.

Research
Fréchet’s early work focused on polymer-supported chemistry with the first approach to the solid-phase
synthesis of oligosaccharides [4] and pioneering work on polymeric reagents and polymer protecting
groups.[5] In 1979 Working with C.G. Willson at IBM during a sabbatical leave, he invented chemically
amplified photoresists [6][7] for micro and nanofabrication. This widely used patented technology [8]
which enables the extreme miniaturization of microelectronic devices is now ubiquitous for the
fabrication of the very powerful computing and communication equipment in worldwide use. The
addition of photogenerated bases [9] led to additional advances in chemically amplified resists. In 1990
working with Craig Hawker at Cornell, he developed the convergent synthesis of dendrimers [10] as well
as approaches to hyperbranched polymers.[11] In 1992, working with F. Svec at Cornell, he reported the
first preparation of macroporous polymer monoliths [12] that are now used in a variety of chemical
separations. Later work at Berkeley saw the development of polymers and dendrimers as carriers for
targeted therapeutics [13] and successful approaches to new organic materials for transistors and solar
cells.[14]

Honors and awards

2020 National Academy of Engineering Charles Stark Draper Prize in Engineering [15]
2019 King Faisal International Prize in Chemistry [16]
2013 Japan Prize for the "Development of chemically amplified resist polymer materials for
innovative semiconductor manufacturing process"[17][18]
2010 Grand Prix de la Maison de la Chimie (Paris) [19]
2010 Erasmus Medal of the Academia Europaea [20]
2010 Society of Polymer Science of Japan, International Award for the "Development of
functional polymers from fundamentals to application"
2010 University of California Department of Chemistry Teaching Award
2010 Fellow of the American Chemical Society
2009 Elected to the Academy of Europe (Academia Europaea)
2009 Nagoya Gold Medal[21]
2009 Arun Guthikonda Memorial Award, Columbia University.
2009 Society of Polymer Science of Japan, International Award for the "Development of
functional polymers from fundamentals to applications".
2009 Carothers Award for "Outstanding contributions and advances in industrial applications
of chemistry".
2009 Herman Mark Award, American Chemical Society.
2008 D.Sc. (Honoris Causa), University of Liverpool, UK
2007 Dickson Prize in Science, Carnegie Mellon University
2007 Arthur C. Cope Award (American Chemical Society award for outstanding achievement
in the field of Organic Chemistry)
 2006 Macro Group UK Medal (joint Royal Society for Chemistry and Society of Chemical
Industry) for Outstanding Achievement in the field of Macromolecular Chemistry
2005 Esselen Award for Chemistry in the Service of the Public
2005 Chemical Communications 40th Anniversary Award
2004 Docteur de L'Université, Université d'Ottawa, Canada
2003 Henry Rapoport Chair of Organic Chemistry, University of California, Berkeley
2002 Docteur (Honoris Causa), Université de Lyon I, France
2001 American Chemical Society, Salute to Excellence Award
2001 American Chemical Society, A.C. Cope Scholar Award
2000 Elected Fellow of the American Academy of Arts and Sciences
2000 Elected Member of the US National Academy of Engineering
2000 Elected Fellow of the PMSE Division of the American Chemical Society
2000 Elected Fellow of the American Association for the Advancement of Science
2000 Elected Member of the US National Academy of Sciences
2000 American Chemical Society, ACS Award in Polymer Chemistry
2000 Myron L. Bender & Muriel S. Bender Distinguished Summer Lectureship
1999 Society of Imaging Science and Technology, Kosar Memorial Award
1996 American Chemical Society, ACS Award in Applied Polymer Science
1995 Peter J. Debye Chair of Chemistry, Cornell University, NY
1994 American Chemical Society, Cooperative Research Award in Polymer Science
1987 IBM Professor of Polymer Chemistry
1986 American Chemical Society, Doolittle Award in Polymer Materials Science &
Engineering
1986 Polymer Society of Japan Lecture Award
1983 IUPAC Canadian National Committee Award

References
1. WorldCat. (https://www.worldcat.org/oclc/18433314) Accessed: January 31, 2013.
2. "World's Best Chemistry Scientists: H-Index Chemistry Science Ranking" (https://research.c
om/scientists-rankings/chemistry).
3. "Jean M. J. Frechet Inventions, Patents and Patent Applications – Justia Patents Search" (ht
tps://patents.justia.com/inventor/jean-m-j-frechet).
4. Fréchet, J.M.J.; Schuerch, C. Solid-Phase Synthesis of Oligosaccharides. III. Preparation of
Some Derivatives of di- and tri- saccharides via a simple Alcoholysis Reaction. Carbohyd.
Res., 1972, 22, 399–412
5. Fréchet, J.M.J. Synthesis and Applications of Organic Polymers as Supports and Protecting
Groups. Tetrahedron, 1981, 37, 663–83
6. Fréchet, J.M.J.; Ito, H.; Willson, C.G. Sensitive Deep UV Resist Incorporating Chemical
Amplification. Proceedings Microcircuit Engineering 1982, Grenoble, 260–261
7. "Patterning the World: The Rise of Chemically Amplified Photoresists" (https://www.scienceh
istory.org/distillations/patterning-the-world-the-rise-of-chemically-amplified-photoresists). 2
October 2007.
8. Ito, H., Willson. C.G., Fréchet, J.M.J Positive and Negative Working Resist Compositions
with Acid-Generating Photoinitiator and Polymer with Acid-Labile Groups Pendant From
Polymer Backbone. US Patent No. 4,491,628 issued January 1, 1985
9. Frechet, J.M.J. Pure & Appl. Chem., 1992, 64, 1239–1248
10. Hawker, C.J.; Fréchet, J.M.J. Preparation of Polymers with Controlled Molecular
Architecture: A New Convergent Approach to Dendritic Macromolecules. J. Am. Chem. Soc.
1990, 112, 7638–47
11. Tomalia, D. A.; Fréchet, J.M. J. Discovery of dendrimers and dendritic polymers: a brief
historical perspective. 2002, Journal of Polymer Science, Part A: Polymer Chemistry 40,
2719–2728
12. Svec, F.; Fréchet, J.M.J. Novel continuous rods of macroporous polymer as High-
Performance Liquid Chromatography Separation Media. Analytical Chemistry 1992, 64,
820–822
13. Fox, M.E.; Szoka, F.C.; Fréchet, J.M.J.; Soluble polymer carriers for the treatment of cancer:
the importance of molecular architecture. Accounts Chem Res. 2009. 42, 1141–1151
14. Beaujuge, P.M.; Frechet, J.M.J. Molecular Design and Ordering Effects in pi-Functional
Materials for Transistor and Solar Cell Applications – A Perspective. J. Am. Chem. Soc.
2011, 133, 20009-20029
15. "2020 Charles Stark Draper Prize for Engineering Recipients" (https://www.nae.edu/221023/
2020Draper).
16. King Faisal International Prize 2019 (https://kingfaisalprize.org/)
17. Tobin, Dave. (2013, January 30). "SUNY ESF alumnus Jean Fréchet wins Japan Prize," (htt
p://www.syracuse.com/news/index.ssf/2013/01/suny_esf_alumnus_jean_frchet_w.html#inca
rt_river_default) Archived (https://web.archive.org/web/20190110140619/http://www.syracus
e.com/news/index.ssf/2013/01/suny_esf_alumnus_jean_frchet_w.html#incart_river_default)
2019-01-10 at the Wayback Machine Syracuse.com. Accessed: January 31, 2013.
18. "Laureates of the Japan Prize The 2013 (29th) Japan Prize" (http://www.japanprize.jp/en/pri
ze_past_2013_prize01.html). Japan Prize Foundation. Retrieved 2013-02-13.
19. "Les anciens lauréats" (https://actions.maisondelachimie.com/les-prix-de-la-fondation/grand-
prix-de-la-fondation/les-anciens-laureats/).
20. "Academy of Europe: Erasmus Medal 2010" (https://www2.ae-info.org/ae/Acad_Main/Activiti
es/Awards_and_Prizes/Erasmus_Medal/Erasmus_Award/Erasmus_Medal_2010).
21. "The Nagoya Medal of Organic Chemistry" (https://www.itbm.nagoya-u.ac.jp/en/news/Nagoy
aMedal.pdf) (PDF). www.itbm.nagoya-u.ac.jp. Nagoya University. Archived (https://web.archi
ve.org/web/20220718015001/https://www.itbm.nagoya-u.ac.jp/en/news/NagoyaMedal.pdf)
(PDF) from the original on 18 July 2022. Retrieved 27 July 2022.

External links
Berkeley College of Chemistry, Emeriti Faculty, Jean M. J. Fréchet (http://chemistry.berkele
y.edu/faculty/chem/emeriti/frechet)

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