Variable portion of an immunoglobulin

Amino terminal
Carboxy terminal
Acid terminal
Amoxy terminal
Hinge region
A

Vaccination is based on the principle of

Agglutination
Phagocytosis
Immunological memory
Clonal detection
leukocytes
B

Antibody diversity is due to

Gene rearrangement
Gene translocation
Antigenic variation
CD40 molecules
CD30 molecules
A

Which of the following statements is true about isotypic variation?

These result due to subtle amino acid changes resulting from allelic differences
These result due to changes in amino acid in heavy and light chain at variable region
Changes in heavy and light chain in constant region is responsible for class and subclass of
immunoglobulins
These are areas in antigen that bind specifically to antibody
Specific antibody producing cells are integrated with myeloma cells
C

All of the following statements about hybridoma technology are true except
Specific antibody producing cells are integrated with myeloma cells
Myeloma cells with mutation in salvage pathway grows well in HAT medium
Aminopterin, a folate antagonist, inhibits denovo pathway
HGPRT ase and thymidylate synthetase are required for salvage pathway
Different chains of same immunoglobulins are coded by different chromosomes
B
Antigen binding site on antibody is:
Hinge region
Constant region
Variable region
Hyper variable region
Genotype region
D

In which of the following(s), the two allele are inherited together:

Idiotype
Genotype
Phenotype
Allotype
Lysotype
D

Which of the following statements is true regarding kappa, lambda and heavy chain immunoglobulins?
Coded in the same site of a chromosome
Coded in different sites of same chromosome
The chains are formed by genetic rearrangement after maturation
Different chains of same immunoglobulins are coded by different chromosomes
Coded sites of same chromosome
C

When Papain cleaves IgG antibody, it produces:

2 Fab and 1 Fc
2 Fab and 2 Fc
1 Fab and 1 Fc
1 Fab and 2 Fc
5Fab and 3 Fc
A

True about an immunoglobulin:

IgG has max conc. in serum
IgM has max conc. in serum
IgA has max conc. in serum
IgE has max conc. in serum
IgD has max conc. in serum
A

Ig that helps in Opsonization:

IgA
IgG
IgD
IgE
IgM
B

The serum concentration of which of the following human IgG subclass is maximum
IgG 1
IgG 2
IgG3
IgG4
IgG5
A

Which of the following immunoglobulins can cross placenta?

IgA
IgM
IgG
IgD
IgE
C
True about antibody:
IgM is produced in primary response
IgD protects mucosa
IgE is main antibody in secondary response
IgG is main antibody in secondary response
IgM protects mucosa
A

Which antibody deficiency causes recurrent infection by organisms with polysaccharide capsule?
IgA
IgG1
IgG2
IgM
IgE
B

True of the following is /are:

IgA crosses placenta
Half life of IgG is 23days
IgD is heat stable
IgE has highest carbohydrate content
IgG crosses placenta
B

Activator of classical pathway of complement?

IgA
IgG
IgM
IgE
IgD
C

Pentameric antibody with a J chain is?

IgA
IgG
IgM
IgE
IgD
C

Which immunoglobulin acts as receptor on B cell?

Ig G
Ig A
Ig M
Ig E
IgD
C

In-utero infection leads to raise of which immunoglobulin first?

IgG
IgA
IgG
IgD
IgM
E

Rheumatoid arthritis is best diagnosed by:

Anticitrulline antibody
Ig G antibody
Ig A antibody
Ig M antibody
Ig E antibody
A

The most avidly complement fixing antibody is:

IgA
IgG
IgM
IgE
IgD
С

Which antibody is elevated in primary immune response?

IgA
IgM
IgG
IgD
IgE
B

Which is the first antibody is elevated in fetal life?

IgA
IgM
IgG
IgD
IgE
B

Synthesis of an immunoglobulin in membrane bound or secretory form is determined by:

One turn to two turn joining rule
Class switching
Differential RNA processing
Allelic exclusion
Differential DNA processing
C

Immunoglobulin in peyer’s patch is:

IgM
IgG
IgA
IgD
IgE
C
Immunoglobulin present in local secretions is:
IgG
IgA
IgM
IgD
IgE
B

The secretory component of immunoglobulin molecule is:

Formed by epithelial cells of lining mucosa
Formed by plasma cell
Formed by epithelial cell and plasma cell
Secreted by bone marrow
Formed by WBC cell
A

Immunoglobulin that is inactive by heating is?

IgG
IgA
IgM
IgE
IgD
D

Immunoglobulin that is elevated in helminthic infection?

IgG
IgA
IgM
IgE
IgD
D

IgE is secreted by:

Mast cell
Basophil
Eosinophils
Plasma cells
Red blood cells
D

Which immunoglobulin is scarce in human serum:

IgA
IgG
IgM
IgE
IgD
D

Which precipitates at 50 to 60°C but re dissolve on heating :

Bence jones proteins
Heavy chain
Both light and heavy chains
None
Protein
A

Naegler reaction is example of:

Precipitation
CFT
Agglutination
Neutralization
Coombs
D
Coombs test is example of:
Coombs
Agglutination
Neutralization
CFT
Widal test
B

Paul Bunnel test is example of:

Agglutination
Precipitation
Neutralization
CFT
Coombs
A

Which are example of agglutination test:

Widal test
VDRL test
Kahn test
○ Ascoli’s test
Coombs test
A

Which of the following acts as an opsonin?

C3a
C3b
C5a
LTB4
LTB2
B

Immunoglobulins bound to the surface of bacteria mediates phagocytosis by- (Phagocytosis causes
complement activation by:
C3b and Fc
Receptor mediated endocytosis
Lysozomal burst
Oxidase action
C3a
A
Heterophile agglutination is/are used in all test except:
Widal test
Weil-Felix reaction
Paul -Bunnel test
ELISA
Ascoli’s test
A

Prozone phenomenon is due to:

Excess antigen
Excess antibody
Hyperimmune reaction
Disproportionate antigen – antibody levels
Formed elements
B

Prozone phenomenon is a feature is:

Tularemia
Legionnaire’s disease
Plague
Brucellosis
Anthrax
D

Antigen antibody reaction is seen maximum in?

Excess antibody
Excess antigen
Antigen & antibody are equal
Antigen & antibody are low
Immunoglobulins
C

Complements act by:

They activate Adeny l cyclase
Inhibits elongation factor
Destruction of cell wall
Increased permeability of cell membrane
Excess antibody factor
D

Powerful Activator of classical complement pathway:

IgA
IgG
IgM
IgD
IgE
C

Complement formed in liver

C2, C4
C3, C6, C9
C5, C8
C1
C2
B

C-3 convertase in alternate complement pathway:

C4b2a
C3b
C3bBb
C3a
C2b
C
Central component of complement system is?
C3a
C3b
C4
C5
C3
B

Which of the following acts as a chemoattractant?

C3a
C3b
C5b
LTB4
C4b
A

Snake venom acts by?

Classical pathway
Alternate pathway
Both
None
pathway
B

Recurrent facial/oropharyngeal /laryngeal edema in a patient has low C4 & C3 and normal factor B. The
pathogenesis is most likely due to:
Immune complex disease
C1 esterase inhibitors deficiency
Hereditary deficiency of C2
Classical pathway activation by IgM
Hereditary deficiency of C4
B

Which of the following best denotes classical complement pathway activation in immuno inflammatory
condition:
C2, C4, C3 decreased
C3 normal and C2 C4 decreased
C2 and C4 normal, C3 is decreased
C2, C4, C3 all are elevated
C2, C3, C1 all are elevated
A
C3 convertase acts on:
C4b2b
C4b2B3a
C4b
C3
C5 and C3
D

Lymphoreticular system includes:

T-cells
B-cells
Platelets
Macrophages
Red blood cells
A

All are peripheral lymphoid organ except

LN
Spleen
MALT
Thymus
Pancreas
D

T cell dependent region in lymphnode:

Cortex
Medulla
Paracortical area
Mantle layer
MALT
C

Neonatal thymectomy leads to:

Decreased size of germinal center
Decreased size of paracortical areas
Increased antibody production by B cells
Increased bone marrow production of lymphocytes
Increased antibody production by T cells
B

Which of the following features is not shared between ‘T cells’ and ‘B cells’?
Positive selection during development
Class I MHC expression
Antigen specific receptors
All of the above
Class 2 MHC expression
A

The prototype of type -II hypersensitivity reaction is :

Arthus reaction
SLE
Auto immune hemolytic anemia
Contact dermatitis
Osteomyelitis
C

Delayed hypersensitivity involves :

Neutrophils
Monocyts
Eosinophils
Lymphocytes
Basophils
D

Which is an example of type-III hypersenstivity :

Contact dermatitis
Hemolytic anemia
Serum sickness
Good pasture
Tonsillitis
C

All of the following are immune complex disease except :

Serum sickness
Farmer
SLE
Graft rejection
Good pasture
D

Delayed tuberculin test response is due to :

B lymphocytes
T lymphocytes
Monocytes
Histocytes
Leukocytes
B

Variable protion of antibody molecule is :

C-terminal
N-terminal
Intermediate region
Carbohydrate moiety
M-terminal
B

Phagocytic cells elaborate :

Prostaglandins
Thromboxane
Leukocytes
All of the above
Thrombocytes
A
Runt disease is :
Graft rejection
Graft versus host treaction
Deficient T cell function
Complement dificiency
Carbohydrate moiety
C

The immunoglobin that can cross the placenta :

IgG
IgM
IgE
IgA
IgD
A

Structure of antibodies is composed of :

Single peptide chain
Two peptide chain
Non sulphur amino acid
2 long and 2 short peptide chain
Five peptide chain
D

All the following types of hypersensitivity reactions can be demonstrated by skin test except :
Type I
Type II
Type III
Type IV
All types
B

Isoantigens are
Found in some but all members of species
Found in some but not all members of species
Occurs in different biological species, class and kingdoms
All individuals in a particular species
all members of species
B

Antibodies are most responsive to :

Recipients tissue
Donor tissue
Isografts
Allograft
Recipients and donor tissue
B

First immunoglobin to appear following infections:

IgG
IgM
IgA
IgE
IgD
B

Phagocytic function is assessed by

Proliferative response to mitogen
Reduction of NBT (Nitroblue tetrazolium test)
Serum Immunoglobulin assay
Skin test with purified protein derivative
Immune reaspons
B
Which of the following cells is knows as large grnaular lymphocyte ?
Plasma cells
NK cells
K cells
T cells
B cells
B

Which of the following is a flocculation test :

Widal test
Weil-felix test
VDRL
Paul-Bunnell test
Weil-Felix reaction
C

Transplantation of the hosts own tissue is known as :

Isograft
Allograft
Xenograft
Autograft
Isograft and Allograft
D

Pro-inflammatory cytokines include all except :

Interlukin 1
Interleukin 2
Interleutkin 6
TNF-alfa
TNF-betta
B

Delayed hypersensitivity reaction is mediated b the following

B lymphocytes
NK cells
Mast cells
T lymphocytes
leukocytes
D

The following constitutes approximately 75% of total immunogobulin in humans :

IgG
IgM
IgE
IgA
IgD
A

Which immunoglobulin is least important in human beings:

IgE
IgD
IgG
IgA
IgM
B

Chemoattractant is :
C5a
C1
C3
C5
C2
A

Complement C5-C9 predispose to which infection

Menigococi
Pneumococcal
Pseudomonas
Brucella
All
A

Opsonization occurs due to :

Endotoxin
Complement
IgM
IgG
IgD
B

Primary immune response is mediated by :

IgG
IgM
IgD
IgA
IgE
B

Which is not pyrogenic IL :

IL
TNF
IL
○ IL
LI
B

First antibody response is mediated by :

IgG
IgM
IgE
IgA
TgM
E
Tuberculin test is reaction of :
Anaphyxis mediated
Cell mediated
Antibody mediated
Immuno complex mediated
All
C

True about anaphylaxis:

Type – I reaction
Large amount of histamine released
Cytokines like IL4 ,IL5 and GMCSF are released
Mediated through allergen specific IgE
All
A

Type 1 hypersensitivity includes all of the following except:

Autoimmune hemolytic anemia
Anaphylaxis
Extrinsic asthma
Hay fever
All
A
Anaphylaxis is mediated by:
5-hydroxytryptamine
Heparin
Prostaglandin
Anaphylotoxins from complement activation

complement activation
A