Vamsi Mootha
Vamsi K. Mootha is an Indian-born American
physician–scientist and computational biologist. He is Vamsi K. Mootha
an Investigator of the Howard Hughes Medical Born Kakinada, Andhra Pradesh, India
Institute, Professor of Systems Biology and Medicine Citizenship United States
at Harvard Medical School, Investigator in the Education M.D.
Department of Molecular Biology at Massachusetts
Alma mater Stanford University
General Hospital. He is also an Institute Member of the
Harvard–MIT Division of Health
Broad Institute.[1]
Sciences and Technology
Mootha and his research group have made major Occupation Professor
contributions to mitochondrial biology and genomics. Employer(s) Howard Hughes Medical Institute
His group characterized the mammalian mitochondrial Massachusetts General Hospital
proteome and has produced a widely utilized reference Harvard Medical School
protein atlas called MitoCarta.[2] He and his clinical
collaborators pioneered the use of targeted next-generation sequencing of these proteins to identify the
Mendelian genetic basis of a very large number of mitochondrial disorders. His team used “integrative
genomics” to identify all of the molecular components of the mitochondrial calcium uniporter, a key
channel of communication between the organelle and the rest of the cell. His team used genomics to
make the unexpected discovery that in animal models, low oxygen can alleviate mitochondrial disease.
As a postdoctoral fellow he developed Gene Set Enrichment Analysis, an algorithm that is widely used in
genomics and has been implemented into a popular software tool.
Mootha graduated from Kelly High School in Beaumont, Texas. As a high school student he won first
place in the mathematics category of the International Science and Engineering Fair. He received his BS
in Mathematical and Computational Science from Stanford University and his M.D. from Harvard
University in the Harvard–MIT Division of Health Sciences and Technology. He completed his internship
and residency in internal medicine at Brigham and Women's Hospital in Boston, and then pursued
postdoctoral training with Eric Lander at the Whitehead Institute/MIT Center for Genome Research.[3]
He is a 2004 recipient of the Macarthur Foundation "genius award" for developing computational
methods for integrative genomics. He received the 2008 Daland Prize from the American Philosophical
Society, the 2014 Keilin Medal from the Biochemical Society, and a 2014 Padma Shri Award from the
Republic of India, the fourth highest civilian award given by the Indian government.[4][5][6][7] He was
elected to the United States National Academy of Sciences in 2014 and the National Academy of
Medicine in 2021. In 2023 he was awarded the Lurie Prize in Biomedical Sciences.[8]
References
1. http://mootha.med.harvard.edu/members_vm.html Mootha's biography
2. "MitoCarta3.0: An Inventory of Mammalian Mitochondrial Proteins and Pathways" (https://w
ww.broadinstitute.org/mitocarta/mitocarta30-inventory-mammalian-mitochondrial-proteins-an
d-pathways). 14 September 2020.
3. Mootha Laboratory (http://mootha.med.harvard.edu/)
4. Padma awards for 7 persons under NRI, PIO, foreign category - The Hindu (http://www.thehi
ndu.com/news/national/padma-awards-for-7-persons-under-nri-pio-foreign-category/article5
618199.ece)
5. "Five eminent personalities from the US get Padma awards, 3 of them Indian Americans" (ht
tp://www.americanbazaaronline.com/2014/01/27/five-eminent-personalities-us-get-padma-a
wards-3-indian-americans/). 27 January 2014.
6. Vamsi Mootha | Broad Institute of MIT and Harvard (http://www.broad.mit.edu/about/bios/bio
-mootha.html)
7. Vamsi Mootha: Taking an inventory of mitochondria (http://jem.rupress.org/cgi/content/full/20
5/6/1248)
8. Lurie Prize in Biomedical Sciences 2023 (https://fnih.org/our-programs/powering-science/the
-lurie-prize-in-biomedical-sciences/)
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