HeartTrends® Test Report
Subject Name: Gourav Chandel Health Factors
Subject ID: 317916 Diabetes Family history
Belt ID: H10A7831 Ischemic Disease Renal failure
Date (YMD): 2024-08-04 Pacemaker Hypertension
Test Time: 12:41 Myocarditis Smoking
Test Duration: 23 minutes Alcohol Cardiac Surgery
Gender: Male Beta Blocker Dyslipidemia
Age: 25 Atrial Fibrillation Heart Failure
Weight (kg): 68 Medications Other
Heart Rate (BPM): 73 + 9
Other notes:
HeartTrends Score (MPW): 3.31
HeartTrends® Test Report Explained
Description: HeartTrends is a diagnostic test for early detection of myocardial ischemia in
individuals without known coronary artery disease. This clinically proven test analyzes
20 minutes of heart rate data without any stressful maneuvers or heart strain. It is intended for
screening patients without known coronary artery disease (CAD) who present with CAD risk
factors or with atypical chest pain, offering an independent, new cardiac risk factor for enhanced
patient diagnosis. Scores above 2.6 indicate a very low likelihood for the presence of significant
cardiac ischemia with a very high negative predictive value (NPV) of 97%. Scores below 2.0
indicate an increased likelihood for the presence of cardiac ischemia. Be sure to rule out
arrhythmias and other exclusionary conditions.
HeartTrends Guidelines for Ischemia Detection and Risk Assessment
Scores displayed as ([Link]*) mean the test duration was too short and the results may be inconclusive
Pathophysiology: Low heart rate variability (HRV) is associated with sympathetic and parasympathetic
imbalance. Prior studies have shown that low HRV identifies subjects with increased risk for all-cause
mortality, and cardiac events. The HeartTrends test uses a unique Multipole Parameter Weight (MPW)
algorithm that enables identification of active myocardial ischemia based on the fact that there is also an
imbalance between sympathetic and parasympathetic activity among subjects with significant coronary
artery disease.
Clinical evidence: HeartTrends has been shown to be at least as reliable as exercise testing for the
detection of cardiac ischemia in individuals without known disease (American J. Cardiology, 2015;
115:1518) and to provide incremental diagnostic data for ischemia to conventional CAD risk factors.
Sensitivity on these 450 subjects was 77% and NPV was 98%. Exercise testing in a large prospective,
multicenter, international study with the Mayo Clinic & Sheba Hospital (J. American Heart Assoc. 2019;
8:e014540) providing an important risk assessment and re-stratification tool (see graph below). Sensitivity
on those 1,043 subjects was 71% and NPV was 97%.
Clinical exclusion criteria: Because the accuracy of HeartTrends relies on analysis of a normal heart rate
unaffected by arrhythmias, good clinical practice recommends not applying the test on the following
subjects: presence of a cardiac pacemaker or arrhythmias, established CAD, atrial fibrillation or flutter,
diagnosis of an acute coronary syndrome or typical angina, clinical diagnosis of heart failure, moderate
or severe pulmonary disease, acute myocarditis or any presence of cardiomyopathy, previous cardiac
surgery, clinical depression, caffeine (e.g., Red Bull), known drug or alcohol dependence, presence of left
bundle branch block, significant intra-ventricular conduction delay or significant (>1mm) ST deviations
at baseline. Athletes should use a treadmill to attain true target heart rate measurements.
Professor Ilan Goldenberg, MD
Professor of Medicine (Cardiology)
Director, Clinical Cardiovascular Research Center
University of Rochester Medical Center
Diagnosing Physician (optional): _____________________
*HeartTrends has CE certification in Europe & FDA-cleared algorithm [Link]
