National Hospital & Medical Center

(A PROJECT OF SPECIALISTS CARE HOSPITAL (PVT) LTD.)

32/3. L-Block, Near Sports Stadium DHA, Lahore Cantt.
U.A.N. 111-17-18-19, Fax: 042-35728761, E-mail: [email protected]

DRUGS USED IN ANESTHESIA

Drugs Doses Trade Names
Induction Agents
Propofol Induction: 1-2.5 mg/kg Propofol 200 mg/20 ml
Infusion: 1.5-4.5 mg/kg/hr
Ketamine Induction: 1-2 mg/kg Ketarol 500 mg/10 ml
Infusion: 1-3 mg/kg/hr
Analgesia: 0.25-0.5 mg/kg
Thiopental Induction: 3-6 mg/kg Pentothal 500 mg pwd.
Etomidate Induction: 0.2-0.5 mg/kg Etomidate 20 mg/10 ml
Sedative hypnotics & Tranquilizers
Dexmeditomidine Loading: 1µg/kg (10 mins) Precidex 200 µg/2 ml
Infusion: 0.2-1.4µg/kg/h
Midazolam Pre-med: 0.07-0.15mg/kg Dormicum 5 mg/5 ml
Induction: 0.1-0.4mg/kg
Infusion: 0.01-0.1mg/kg/hr
Diazepam Pre-med: 0.2-0.5mg/kg oral Valium 10 mg/2 ml
Sedation: 0.04-0.2mg/kg
(max. 30mg/8 hours)
Flumezanil 200 µg, then 100 µg at 1 min Anexate 1 mg/10 ml
intervals, upto 1 mg in adult
Haloperidol Sedation: 2–10 mg, max 18 Serenace 5 mg/1 ml
mg/d Anti-emesis: 1.25 mg
Valproic Acid Bolus: 10-15 mg/kg/day IV Epival 500mg/5ml
divided q12hr
Infusion: Max dose
60mg/kg/day
Levetiracetam 500 mg IV/PO q12hr Lerace 500mg/5ml
Relaxants & Reversals
Atracurium Loading: 0.5 mg/kg Acuron 30 mg/3 ml
Maintenance: 5–10 µg/kg/m
Cisatracurium Loading: 0.2 mg/kg Cis-curon 10 mg/5 ml
Maintenance: 1–2 µg/kg/m
Rocuronium Rapid Sequence Induction: Esmeron 50mg/5ml
0.6-1.2 mg/kg Rescuron 500mg/5ml
Intubation: 0.45-0.6 mg/kg
Infusion: 0.01-0.012
mg/kg/min
Succinylcholine Loading: 1–1.5 mg/kg S-Choline 100 mg/2 ml
Maintenance: 0.5–10 mg/m
Neostigmine 0.04–0.08 mg/kg Neopyrolate 2.5mg/1ml (+0.5
mg Glycopyrolate)
Sugammadex 4–8 mg/kg Bridion 200 mg/2 ml
Anti-Emetics & GI Meds.
Ondansetron 0.1 mg/kg
Metoclopramide 0.25 mg/kg
Dimenhydrinate 0.5–1.5 mg/kg
Omeprazole 0.5 mg/kg
Opioid Analgesics
Nalbuphine 0.2 mg/kg Kinz 10 mg/1 ml
Tramadol Upto 400 mg/day Campex 100 mg/2 ml
Fentanyl Intra-op analgesia: 2–50 Fentra 0.25 mg/5 ml
µg/kg Post-op analgesia: 0.5–
1.5 µg/kg Infusion: 2–4
µg/kg/h Epidural: 50–100 µg
Spinal: 5-20 µg
Morphine Analgesia: 0.03–0.15 mg/kg Morphine 15 mg/1 ml
Infusion: 1-3.5 mg/h
Epidural: 2–5 mg, Spinal: 0.1–
1 mg
Meperidine Analgesia: 25–50 mg Pethidine 100 mg/2 ml
Shivering: 10–25 mg
Naloxone Bolus: 5–10 µg/kg Infusion: Nalaxone 0.4 mg/1 ml
5–20 µg/kg/h
Other Analgesics
Ketorolac 0.5–0.75 mg/kg BD (max 90 Toradol 30 mg/1 ml
mg/d)
Ibuprofen 800 milligrams per dose or Xaleve 400mg/4ml
3200 mg per day (4
maximum doses)
Diclofenac 1 mg/kg TDS (PO/PR/IM) max Voren 75 mg/3 ml
150 mg/d
Paracetamol 7.5–15 mg/kg QDS Provas 1000 mg/100 ml
Anti-Muscarinic Agents
Atropine 0.01–0.02 mg/kg Elitopine 1 mg/1 ml
Glycopyrolate 5–10 µg/kg Pyrolate 0.2 mg/1 ml

Adrenergics / Inotropes
Phynylephrine 0.5–1 µg/kg Synephrine 10 mg/1 ml
Adrenaline 0.03–0.3 µg/kg/m Adenyph 1 mg/1 m
Noradrenaline 0.03–0.3 µg/kg/m Norepine 4 mg/4 ml
Dopamine 1–20 µg/kg/m Dopamine 200 mg/5 ml
Dobutamine 2–20 µg/kg/m Buta 250 mg/5 ml
Vasopressin 1–4U/h (septic shock) 20U Vasopressin 20U/1 ml
over 15min (variceal bleed)
IM 5–20U/4h (diabetes
insipidus)
Milrinone Lactate 50 mcg/kg loading dose by IV Milron
over 10 minutes, then 0.375-
0.75 mcg/kg/min
Maintenance: 1.13
mg/kg/day
Local Anesthetics
Lidocaine 4.5 mg/kg Xylocaine 2% (200mg/10ml)
1 mg/kg, then 1–4 mg/min 2
+ Adrenaline 7 mg/kg + 1:200,000 (50mcg/10ml)
Ropivacaine 3 mg/kg R Ropicain 0.5% (50mg/10ml)
Bupivacaine 3 mg/kg Bupicain 0.5% (50mg/10ml)
(Bupivacaine SP 0.5%) Sensocain-SP 0.5%
Sensocaine 0.75%) (20mg/4ml) + Glucose
(320mg/4ml)
Miscellaneous
Aminophyline 5 mg/kg over 20 min, then Aminophylline 250 mg/10 ml
0.5 mg/kg/h infusion
Dexamethasone Anti-emesis: 0.1 mg/kg Decadron 4 mg/1 ml
Hydrocortisone 100 mg TDS from day of Solucortef 100 mg or 250 mg
surgery (4 mg/kg then 2–4 pwd
mg/kg TDS)
Methyl prednisolone Solumedrol, Hy-solone
Oxytocin Post-partum slow IV 5u, Synto 5IU/ml
followed by inf. 10u/hr.
Tranexamic acid 10–15 mg/kg TDS Transamin 500 mg/5 ml
Mannitol 20% 0.25–2 g/kg (typically 0.5 20% Mannitol 500 ml
g/kg)
Furosemide Lasix 20mg/2ml
Protamine Sulfate Slow 1 mg per 100u Heparin Protamine 50 mg/5 ml
to be reversed
25% D/W 10-25 g (ie, 20-50 mL 50% 25% D/W 25 ml
solution or 40-100 mL of
25%)
Potassium Chloride 2.5-3.5 mEq/L: 10 mEq/hr KCL 20MEq/20ML
maximum infusion rate; 40
mEq/L max
<2.5 mEq/L: 40 mEq/hr
maximum infusion rate

Sodium Bicarbonate Cardiac arrest: 1mEq/kg/dose Sodium Bicarbonate

 IVx1 20mEq/20ml
Hyperkalemia: 50mEq IV
over5 mins
Mild metabolic Acidosis: 2-5
mEq/kg inf. over 4-8 hrs
Severe: 90-180 mEq/L
Magnesium Sulphate Asthma / Arrhythmias: 2g 500mg/ml in 10ml amp
over 10 mins & repeat once if
necessary
Eclampsia: 4g over 10 mins.,
then 1g/hr. for 24 hrs.
Vasodilators & Anti-Arrhythmics
Adesosine 6 mg fast IV bolus, then 12 Adenocor 6 mg/2 ml
mg at 1-2 m intervals if
necessary Paeds: 0.1 mg/kg
initial dose then 0.2 mg/kg
repeat dose
Amiodarone 5 mg/kg over 20–120 min, Cordarone 150 mg/3 ml
then infusion, maximum 1.2g
in 24 h. 300 mg slow for
defib-resistant VF/VT
Calcium Gluconate 6–15 ml of 10% sol. (30 Calcium Gluconate 10%
mg/kg) solution (1 g/10 ml)
Digoxin 250–500 µg over 30 min, Lanoxin 0.5 mg/2 m
maximum 1 mg/24h
Glyceryl Trinitrate 0.5–10 mg/h Nitronal 10 mg/10 ml
Hydralazine 5mg increments upto 20mg Hydralazine 20 mg/1 ml
Labetalol 5mg increments upto 100mg Labetalol 50 mg/10 ml
Metoprolol 1–5mg increments upto Lopressor 5 mg/5 ml
15mg
Nimodipine 1mg/h, can ↑ to 2mg/h after Nimotop 10 mg/50 ml
2h, PO 60mg every 4h upto
360mg/d
Papaverine 30-65 mg (up to 120 mg) ParaTime SR
Verapamil Afib, AF, SVT: 2.5-5 mg IV, 5- Isoptin
10 mg dose may be repeated
every 15-30 mins.
Alternatively 0.075-0.15
mg/kg (not to exceed 10 mg)
IV over 2 minutes