Release Date: 8/8/13

Product Name

8K28-27 ARCHITECT BNP Reagent Kit

00380740017484
8K28-35
00380740017491

Components:
8K28G ARCHITECT BNP Coated Microparticles
8K28H ARCHITECT BNP Conjugate
8K28J ARCHITECT BNP Specimen Diluent

Abbott Customers:
For additional information, please contact your Abbott Customer Support Center Representative by calling 1-800-527-1869,
1-800-323-9100, or 1-800-235-5396.

Abbott employees:
For additional information relative to the content of the MSDSs, please contact your local Safety Representative.
 Page 1/9

Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

* 1 Identification
· Product name: ARCHITECT BNP Coated Microparticles

· ADD List number: 8K28G

· Application of the substance / mixture: For In Vitro Diagnostic Use
· Manufacturer / Supplier:
Abbott Diagnostics
100 Abbott Park Road
Abbott Park, IL 60064-3500
· Department issuing SDS: Abbott Diagnostics Safety, Health and Environmental Assurance
· Emergency telephone number:
Contact the CHEMTREC® Emergency Call Center for assistance with transportation or hazardous materials
emergencies (24 hours/day, 7 days/week):
- Telephone (800) 424-9300 (toll-free) if you are calling from within the United States, Canada, Puerto Rico and the
Virgin Islands.
- Telephone +1 (703) 527-3887, the international and maritime number (collect calls accepted), if you are calling
from outside the United States or from a ship at sea.

* 2 Hazard(s) identification
· Classification of the substance or mixture
· Classification system:
The classification was made according to U.S. OSHA 29 CFR 1910.1200 and 1910.1030 and applicable
European regulations, and is expanded upon from company and/or literature data.
· Label elements
· Labelling according to EU guidelines:
· Code letter and hazard designation of product:

Xi Irritant

· Hazard-determining components of labeling:

2-Methyl-2H-isothiazol-3-one
· Risk phrases:
43 May cause sensitization by skin contact.
· Safety phrases:
24 Avoid contact with skin.
35 This material and its container must be disposed of in a safe way.
37 Wear suitable gloves.
46 If swallowed, seek medical advice immediately and show this container or label.
· Routes of Exposure: Skin
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Safety Data Sheet

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Product name: ARCHITECT BNP Coated Microparticles

· National Fire Protection Association (NFPA) ratings (scale 0-4)

Health = 0
Fire = 0
Reactivity = 0
· Hazard Overview
· Health: Sensitizer in contact with skin
· Fire: Noncombustible
· Reactivity: Minimal hazard - Stable, even in a fire. Not reactive with water. Not an oxidizer.
· Carcinogenicity information
· OSHA (Occupational Safety and Health Administration)
None of the ingredients is listed.
· Other hazards This product may cause skin sensitization (allergic reactions) in some people.

* 3 Composition/information on ingredients
· Chemical characterization: Mixture of chemical and/or biological substances for in vitro diagnostic use.
· Hazardous chemical ingredients per U.S. OSHA criteria (29 CFR 1910.1200 Hazard Communication):
2682-20-4 2-Methyl-2H-isothiazol-3-one 0.0094%

* 4 First-aid measures
· General information: Immediately remove any clothing soiled by the product.
· After inhalation: Remove from source of exposure. If irritation or signs of toxicity occur, seek medical attention.
· After skin contact:
Take off any clothing that the product touched.
Rinse skin with running water for 15 to 20 minutes. Seek medical attention if irritation or signs of toxicity occur.
· After eye contact:
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
If eye irritation persists, get medical advice/attention. Wash hands after handling.
· After swallowing: Rinse mouth with water. If irritation or signs of toxicity occur, seek medical attention.
· Information for Medical Personnel
· Most important symptoms and effects, both acute and delayed:
Allergic reactions
Possibly immune response
This product may cause skin sensitization reactions in some people. See Section 11 for additional information.
· Medical conditions aggravated by exposure:
Pre-existing skin ailments
Skin allergies
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Safety Data Sheet

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Product name: ARCHITECT BNP Coated Microparticles

* 5 Fire-fighting measures
· Suitable extinguishing agents
Dry chemical, carbon dioxide (CO2), water spray or regular foam.
- Caution: CO2 will displace air in confined spaces and may cause an oxygen-deficient atmosphere.
- For larger fires: There are no unique chemical or reactivity hazards that would impact firefighting decisions related
to this product. Use firefighting measures that suit the environment.
· Special hazards arising from the substance or mixture
There are no unique chemical or reactivity hazards that would impact firefighting decisions due to the chemicals in this
product.
· Protective equipment
For large fires, wear appropriate heat- and flame-resistant personal protective equipment and a NFPA/NIOSH
approved positive-pressure, self-contained breathing apparatus.

* 6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures
Minimize exposure by using appropriate personal protective equipment as listed in Section 8. Stop leak if possible.
Keep unprotected persons away.
· Environmental precautions
Prevent liquid and vapor from entering sewage system, storm drains, surface waters, and soil.
· Methods and material for containment and cleaning up
Blot up small volumes of spilled or spattered product with paper towels or similar materials.
- Contain larger spills by placing absorbants around the outside edges of the spill. Absorb with any material suitable
for water-based liquids - e.g. paper towels, universal sorbents, sand, diatomite, sawdust, etc.
Clean the affected area. Suitable cleaners are:
- warm water and detergent or similar cleansing agent
This product contains sodium azide, which is toxic and reactive. See Sections 10 and 13 for additional information
that could affect handling and disposal of contaminated spill materials.
NOTE FOR LARGE-VOLUME SPILL: This product contains sodium azide, which reacts with acid to liberate
hydrazoic acid, a very toxic gas. Select a disinfectant with the following properties if disinfection of materials used to
absorb a large volume of spilled product is required:
- Do not use any chemical or product with a pH below 6 to disinfect waste that contains sodium azide. Hydrazoic
acid, a toxic gas, will be released when the pH is lower than 6.
- Do not use any chemical or product that contains mercury or any other metal to disinfect waste that contains sodium
azide. This will create metal azide compounds, which can be highly explosive under pressure or shock (percussion).
- Select a disinfectant that does not bubble, effervesce or otherwise generate aerosols.
- Do not use excess disinfectant.
- Failure to follow manufacturer’s directions may lead to unexpected reactions with the waste.
- Do not use a disinfectant if you do not have the proper facility, equipment and other appropriate protective
measures available to work with it safely.
Dispose of spilled and contaminated material in accordance with Federal, State, and Local regulations. See Section
13 for information that may impact disposal of materials contaminated with this product.
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Safety Data Sheet

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Product name: ARCHITECT BNP Coated Microparticles

· Reference to other sections

See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

* 7 Handling and storage

· Precautions for safe handling: Avoid contact with skin.
· Information about protection against explosions and fires: No special measures required.
· Requirements to be met by storerooms and receptacles:
Store only in the original container.
Refer to the package insert or product label for additional information on storage conditions for product quality.
· Information about storage in one common storage facility: Store in original packaging.
· Further information about storage conditions: Protect from heat and direct sunlight.

* 8 Exposure controls/personal protection

· Components with Occupational Exposure Limits
26628-22-8 Sodium azide (0.0711 %)
REL () STEL/C: C 0.3** mg/m³, C 0.1* ppm
*as HN3; **as NaN3; Skin
TLV () STEL/C: C 0.29** mg/m³, C 0.11* ppm
*as HN3 vapor **as NaN3
· General protective and hygienic measures:
Always maintain good housekeeping and follow general precautionary measures. Do not eat, drink or store food
and beverages in areas where chemicals or specimens are used. Wash hands before breaks, after handling
reagents and specimens, and at the end of the workshift.
Avoid contact with the skin.
Immediately remove all soiled and contaminated clothing.
· Breathing equipment:
Normal use and storage of product - respiratory protection is not necessary if room is well ventilated.

Small-volume spills (e.g. small enough to clean up with a paper towel or small sorbent pad) - respiratory protection
should not be necessary if room is well ventilated.

Other unusual conditions (e.g. volume spilled too big to clean up with materials in arm's reach) - Use appropriate
NIOSH-approved air-purifying respirator if airborne chemical concentrations may exceed the exposure limit (if any)
listed above.

Hazardous Materials Emergencies or Firefighting - use NIOSH/NFPA-approved respiratory protection.

· Hand protection:
Wear impervious gloves if hand contact with the material is anticipated. Dispose of contaminated gloves after use
in accordance with applicable laws and good laboratory practices.
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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Coated Microparticles

· Material of gloves and breakthrough time of the glove material:

The glove material must be suitable for use in a microbiological laboratory and have a measured breakthrough
time of at least 30 minutes, such as those with a Class 2 protection index per EN374 (or equivalent standard
applicable in your region). NOTE: This recommendation applies only to the product stated in this Safety Data
Sheet. When dissolving in or mixing with other substances, contact the supplier of approved gloves.
· Eye protection:
Wear safety glasses or other protective eyewear. If splash potential exists, wear full face shield or goggles.
· Body protection:
Normal use: protect personal clothing from spatters and small spills. Wear a laboratory coat (or other protective
clothing required by your institution).
Larger spills (e.g. that can saturate cloth): wear appropriate water-repellant covering over clothing.

* 9 Physical and chemical properties

· General Information
· Form: Liquid
· Color: Brown
· Odor: Odorless
· pH-value at 20 °C (68 °F) 8
· Melting point/Melting range: Not determined
· Boiling point/Boiling range: Not determined
· Flash point Not applicable
· Flammability (solid, gaseous) Not applicable
· Auto igniting Product is not self-igniting.
· Danger of explosion Product does not present an explosion hazard.
· Explosion limits
· Lower: Not determined
· Upper: Not determined
· Density at 20 °C (68 °F) 1.055 g/cm³ (8.804 lbs/gal)
· Evaporation rate: Not determined
· Solubility in / Miscibility with
· Water: Fully miscible
· Dynamic: Not determined.
· Water: 82.3 %

* 10 Stability and reactivity

· Thermal decomposition / conditions to be avoided
No decomposition if used and stored according to specifications.
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Safety Data Sheet

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Product name: ARCHITECT BNP Coated Microparticles

· Possibility of hazardous reactions:

This product contains sodium azide. Sodium azide solutions are reported to:
- react with acids to release hydrazoic acid, a very toxic gas. Higher quantities of hydrazoic acid are released as the
solution becomes more acidic (i.e., as the pH of the solution gets lower). Low quantities of hydrazoic acid can be
released from sodium azide in water.
- react with certain metals (copper, lead, silver, brass) to form explosive metal azide compounds. Violent explosions
have been reported during plumbing work on drain systems containing accumulations of azide on copper, lead, brass,
or solder.
· Conditions to avoid: No further relevant information available.
· Incompatible materials: No further relevant information available.
· Hazardous decomposition products: No dangerous decomposition products known.

* 11 Toxicological information
· Acute toxicity
· LD50/LC50 values for hazardous ingredients per OSHA criteria:
· Ingredients (100% pure substance/s):
2682-20-4 2-Methyl-2H-isothiazol-3-one
Oral LD50 60 mg/kg (mouse)
By analogy to methylchloroisothiazolinone.
53 mg/kg (rat)
By analogy to methylchloroisothiazolinone.
· Primary toxicological effects of the final product:
· Skin irritation: No irritant effect.
· Eye irritation: No irritant effect.
· Sensitization:
Skin sensitization is possible with prolonged exposure, based on the reported properties of methylisothiazolones.
· Additional toxicological information: None
· Carcinogenic categories
· IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
· NTP (National Toxicology Program)
None of the ingredients is listed.
· Target organs/systems:
Skin
Immune system

* 12 Ecological information
· Aquatic toxicity: No further relevant information available.
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Product name: ARCHITECT BNP Coated Microparticles

· Additional ecological information

· General notes:
Do not allow undiluted product or large quantities of it to reach ground water, water course, or sewage system.
· Results of PBT and vPvB assessment
· PBT: Not applicable
· vPvB: Not applicable

* 13 Disposal considerations
· Recommendation for disposal of unused product:
Dispose in accordance with federal, state and local regulations and institutional requirements. Waste containing
this product may be considered hazardous per U.S. EPA, state or local regulations. The following may be
particularly important when identifying appropriate disposal:
- Contains sodium azide. See Section 10 when considering how to appropriately dispose of unused product. For
drain systems with pipes or solder containing copper, lead, brass and/or silver, flush drains thoroughly with
copious amounts of water to prevent the formation of potentially explosive metal azides in plumbing. Detailed
information about azides in drains is available from the U.S. NIOSH Current Intelligence Bulletin No. 13 (August
16, 1976).
· Recommendation for disposal of packaging:
Non-contaminated packaging may be used for recycling. Refer to applicable local regulations and institutional
policies.
For disposal of contaminated packaging, refer to applicable local regulations and institutional policies.
· Recommended cleansing agent: Water with cleansing agents, if necessary.

* 14 Transport information
· DOT, ADN, IMDG, IATA none
· UN proper shipping name
· DOT, ADR, ADN, IMDG, IATA none
· Transport hazard class(es)
· DOT, ADR, ADN, IMDG, IATA
· Class none
· DOT, IMDG, IATA none
· Environmental hazards
· Marine pollutant: No
· Additional information
· DOT
· Remarks: Not restricted for transportation.
· ADR
· Remarks: Not restricted for transportation.
· IMDG
· Remarks: Not restricted for transportation.

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Safety Data Sheet

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Product name: ARCHITECT BNP Coated Microparticles

· IATA
· Remarks: Not restricted for transportation.

* 15 Regulatory information
· SARA (Superfund Amendments and Reauthorization Act of 1986 - USA):
· Section 302/304 (40CFR355.30 / 40CFR355.40):
26628-22-8 Sodium azide
· Section 313 (40CFR372.65):
26628-22-8 Sodium azide
· California Proposition 65 (USA):
· Chemicals known to cause cancer:
The product does not contain listed substances.
· Chemicals known to cause female reproductive toxicity:
None of the ingredients is listed.
· Chemicals known to cause male reproductive toxicity:
None of the ingredients is listed.
· Chemicals known to cause developmental reproductive toxicity:
None of the ingredients is listed.

* 16 Other information
The information and recommendations contained herein are based upon information or tests believed to be reliable.
Abbott Laboratories does not guarantee the accuracy or completeness of this information or recommendations
contained herein, NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER
EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOODS, THE MERCHANTABILITY OF THE GOODS,
OR THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE.

This information is not a substitute for the advice of a health care professional, nor is it a recommendation for any
particular course of treatment. It is not intended to supplement, modify or supersede any information (e.g. labeling
and package inserts) provided with respect to the medical use of the product. Abbott Laboratories assumes no
responsibility for results obtained or for incidental or consequential damages, including lost profits, arising from the
use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied.
· Department issuing MSDS
- Abbott Diagnostics Safety, Health and Environmental Assurance
Department 0571
· Contact

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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Coated Microparticles

- General information about this product:

Abbott Diagnostics
Technical Support
100 Abbott Park Road
Abbott Park, IL 60064-3500

Phone: 1-877-4 ABBOTT

· * Sections marked with an asterisk (*) have been altered since the previous version.
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Safety Data Sheet

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* 1 Identification
· Product name: ARCHITECT BNP Conjugate

· ADD List number: 8K28H

· Application of the substance / mixture: For In Vitro Diagnostic Use
· Manufacturer / Supplier:
Abbott Diagnostics
100 Abbott Park Road
Abbott Park, IL 60064-3500
· Department issuing SDS: Abbott Diagnostics Safety, Health and Environmental Assurance
· Emergency telephone number:
Contact the CHEMTREC® Emergency Call Center for assistance with transportation or hazardous materials
emergencies (24 hours/day, 7 days/week):
- Telephone (800) 424-9300 (toll-free) if you are calling from within the United States, Canada, Puerto Rico and the
Virgin Islands.
- Telephone +1 (703) 527-3887, the international and maritime number (collect calls accepted), if you are calling
from outside the United States or from a ship at sea.

* 2 Hazard(s) identification
· Classification of the substance or mixture
· Classification system:
The classification was made according to U.S. OSHA 29 CFR 1910.1200 and 1910.1030 and applicable
European regulations, and is expanded upon from company and/or literature data.
· Label elements
· Labelling according to EU guidelines:
· Code letter and hazard designation of product:

Xi Irritant

· Hazard-determining components of labeling:

Reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-2H -isothiazol-3-one
[EC no. 220-239-6] (3:1);
reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-4-isothiazolin-3-one
[EC no. 220-239-6] (3:1)
· Risk phrases:
43 May cause sensitization by skin contact.
· Safety phrases:
24 Avoid contact with skin.
35 This material and its container must be disposed of in a safe way.
37 Wear suitable gloves.
46 If swallowed, seek medical advice immediately and show this container or label.
· Routes of Exposure: Skin
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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Conjugate

· National Fire Protection Association (NFPA) ratings (scale 0-4)

Health = 0
Fire = 0
Reactivity = 0
· Hazard Overview
· Health: Sensitizer in contact with skin
· Fire: Noncombustible
· Reactivity: Minimal hazard - Stable, even in a fire. Not reactive with water. Not an oxidizer.
· Carcinogenicity information
· OSHA (Occupational Safety and Health Administration)
None of the ingredients is listed.
· Other hazards This product may cause skin sensitization (allergic reactions) in some people.

* 3 Composition/information on ingredients
· Chemical characterization: Mixture of chemical and/or biological substances for in vitro diagnostic use.
· Hazardous chemical ingredients per U.S. OSHA criteria (29 CFR 1910.1200 Hazard Communication):
9002-93-1 Polyethylene glycol octylphenyl ether 0.9524%
55965-84-9 Reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl- 0.0034%
2H -isothiazol-3-one [EC no. 220-239-6] (3:1);
reaction mass of: 5-chloro-2-methyl-4-isothiazolin-3-one [EC no. 247-500-7] and 2-methyl-4-
isothiazolin-3-one [EC no. 220-239-6] (3:1)

* 4 First-aid measures
· General information: Immediately remove any clothing soiled by the product.
· After inhalation: Remove from source of exposure. If irritation or signs of toxicity occur, seek medical attention.
· After skin contact:
Take off any clothing that the product touched.
Rinse skin with running water for 15 to 20 minutes. Seek medical attention if irritation or signs of toxicity occur.
· After eye contact:
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
If eye irritation persists, get medical advice/attention. Wash hands after handling.
· After swallowing: Rinse mouth with water. If irritation or signs of toxicity occur, seek medical attention.
· Information for Medical Personnel
· Most important symptoms and effects, both acute and delayed:
Allergic reactions
Possibly immune response
This product may cause skin sensitization reactions in some people. See Section 11 for additional information.
· Medical conditions aggravated by exposure:
Pre-existing skin ailments
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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Conjugate

Skin allergies

* 5 Fire-fighting measures
· Suitable extinguishing agents
Dry chemical, carbon dioxide (CO2), water spray or regular foam.
- Caution: CO2 will displace air in confined spaces and may cause an oxygen-deficient atmosphere.
- For larger fires: There are no unique chemical or reactivity hazards that would impact firefighting decisions related
to this product. Use firefighting measures that suit the environment.
· Special hazards arising from the substance or mixture
There are no unique chemical or reactivity hazards that would impact firefighting decisions due to the chemicals in this
product.
· Protective equipment
For large fires, wear appropriate heat- and flame-resistant personal protective equipment and a NFPA/NIOSH
approved positive-pressure, self-contained breathing apparatus.

* 6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures
Minimize exposure by using appropriate personal protective equipment as listed in Section 8. Stop leak if possible.
Keep unprotected persons away.
· Environmental precautions
Prevent liquid and vapor from entering sewage system, storm drains, surface waters, and soil.
· Methods and material for containment and cleaning up
Blot up small volumes of spilled or spattered product with paper towels or similar materials.
- Contain larger spills by placing absorbants around the outside edges of the spill. Absorb with any material suitable
for water-based liquids - e.g. paper towels, universal sorbents, sand, diatomite, sawdust, etc.
Clean the affected area. Suitable cleaners are:
- warm water and detergent or similar cleansing agent
This product contains sodium azide, which is toxic and reactive. See Sections 10 and 13 for additional information
that could affect handling and disposal of contaminated spill materials.
NOTE FOR LARGE-VOLUME SPILL: This product contains sodium azide, which reacts with acid to liberate
hydrazoic acid, a very toxic gas. Select a disinfectant with the following properties if disinfection of materials used to
absorb a large volume of spilled product is required:
- Do not use any chemical or product with a pH below 6 to disinfect waste that contains sodium azide. Hydrazoic
acid, a toxic gas, will be released when the pH is lower than 6.
- Do not use any chemical or product that contains mercury or any other metal to disinfect waste that contains sodium
azide. This will create metal azide compounds, which can be highly explosive under pressure or shock (percussion).
- Select a disinfectant that does not bubble, effervesce or otherwise generate aerosols.
- Do not use excess disinfectant.
- Failure to follow manufacturer’s directions may lead to unexpected reactions with the waste.
- Do not use a disinfectant if you do not have the proper facility, equipment and other appropriate protective
measures available to work with it safely.
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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Conjugate

Dispose of spilled and contaminated material in accordance with Federal, State, and Local regulations. See Section
13 for information that may impact disposal of materials contaminated with this product.
· Reference to other sections
See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

* 7 Handling and storage

· Precautions for safe handling: Avoid contact with skin.
· Information about protection against explosions and fires: No special measures required.
· Requirements to be met by storerooms and receptacles:
Store only in the original container.
Refer to the package insert or product label for additional information on storage conditions for product quality.
· Information about storage in one common storage facility: Store in original packaging.
· Further information about storage conditions: Protect from heat and direct sunlight.

* 8 Exposure controls/personal protection

· Components with Occupational Exposure Limits
26628-22-8 Sodium azide (0.0714 %)
REL () STEL/C: C 0.3** mg/m³, C 0.1* ppm
*as HN3; **as NaN3; Skin
TLV () STEL/C: C 0.29** mg/m³, C 0.11* ppm
*as HN3 vapor **as NaN3
· General protective and hygienic measures:
Always maintain good housekeeping and follow general precautionary measures. Do not eat, drink or store food
and beverages in areas where chemicals or specimens are used. Wash hands before breaks, after handling
reagents and specimens, and at the end of the workshift.
Avoid contact with the skin.
Immediately remove all soiled and contaminated clothing.
· Breathing equipment:
Normal use and storage of product - respiratory protection is not necessary if room is well ventilated.

Small-volume spills (e.g. small enough to clean up with a paper towel or small sorbent pad) - respiratory protection
should not be necessary if room is well ventilated.

Other unusual conditions (e.g. volume spilled too big to clean up with materials in arm's reach) - Use appropriate
NIOSH-approved air-purifying respirator if airborne chemical concentrations may exceed the exposure limit (if any)
listed above.

Hazardous Materials Emergencies or Firefighting - use NIOSH/NFPA-approved respiratory protection.

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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Conjugate

· Hand protection:
Wear impervious gloves if hand contact with the material is anticipated. Dispose of contaminated gloves after use
in accordance with applicable laws and good laboratory practices.
· Material of gloves and breakthrough time of the glove material:
The glove material must be suitable for use in a microbiological laboratory and have a measured breakthrough
time of at least 30 minutes, such as those with a Class 2 protection index per EN374 (or equivalent standard
applicable in your region). NOTE: This recommendation applies only to the product stated in this Safety Data
Sheet. When dissolving in or mixing with other substances, contact the supplier of approved gloves.
· Eye protection:
Wear safety glasses or other protective eyewear. If splash potential exists, wear full face shield or goggles.
· Body protection:
Normal use: protect personal clothing from spatters and small spills. Wear a laboratory coat (or other protective
clothing required by your institution).
Larger spills (e.g. that can saturate cloth): wear appropriate water-repellant covering over clothing.

* 9 Physical and chemical properties

· General Information
· Form: Liquid
· Color: Colorless
· Odor: Odorless
· pH-value at 20 °C (68 °F) 6.2
· Melting point/Melting range: Not determined
· Boiling point/Boiling range: Not determined
· Flash point Not applicable
· Flammability (solid, gaseous) Not applicable
· Auto igniting Product is not self-igniting.
· Danger of explosion Product does not present an explosion hazard.
· Explosion limits
· Lower: Not determined
· Upper: Not determined
· Density at 20 °C (68 °F) 1.05 g/cm³ (8.762 lbs/gal)
· Evaporation rate: Not determined
· Solubility in / Miscibility with
· Water: Fully miscible
· Dynamic: Not determined.
· Water: 81.0 %
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Product name: ARCHITECT BNP Conjugate

* 10 Stability and reactivity

· Thermal decomposition / conditions to be avoided
No decomposition if used and stored according to specifications.
· Possibility of hazardous reactions:
This product contains sodium azide. Sodium azide solutions are reported to:
- react with acids to release hydrazoic acid, a very toxic gas. Higher quantities of hydrazoic acid are released as the
solution becomes more acidic (i.e., as the pH of the solution gets lower). Low quantities of hydrazoic acid can be
released from sodium azide in water.
- react with certain metals (copper, lead, silver, brass) to form explosive metal azide compounds. Violent explosions
have been reported during plumbing work on drain systems containing accumulations of azide on copper, lead, brass,
or solder.
· Conditions to avoid: No further relevant information available.
· Incompatible materials: No further relevant information available.
· Hazardous decomposition products: No dangerous decomposition products known.

* 11 Toxicological information
· Acute toxicity
· LD50/LC50 values for hazardous ingredients per OSHA criteria:
· Ingredients (100% pure substance/s):
9002-93-1 Polyethylene glycol octylphenyl ether
Oral LD50 1800 mg/kg (rat)
· Primary toxicological effects of the final product:
· Skin irritation: No irritant effect.
· Eye irritation: No irritant effect.
· Sensitization:
Skin sensitization is possible with prolonged exposure, based on the reported properties of methylisothiazolones.
· Additional toxicological information: None
· Carcinogenic categories
· IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
· NTP (National Toxicology Program)
None of the ingredients is listed.
· Target organs/systems:
Skin
Immune system
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* 12 Ecological information
· Aquatic toxicity: No further relevant information available.
· Additional ecological information
· General notes:
Do not allow undiluted product or large quantities of it to reach ground water, water course, or sewage system.
· Results of PBT and vPvB assessment
· PBT: Not applicable
· vPvB: Not applicable

* 13 Disposal considerations
· Recommendation for disposal of unused product:
Dispose in accordance with federal, state and local regulations and institutional requirements. Waste containing
this product may be considered hazardous per U.S. EPA, state or local regulations. The following may be
particularly important when identifying appropriate disposal:
- Contains sodium azide. See Section 10 when considering how to appropriately dispose of unused product. For
drain systems with pipes or solder containing copper, lead, brass and/or silver, flush drains thoroughly with
copious amounts of water to prevent the formation of potentially explosive metal azides in plumbing. Detailed
information about azides in drains is available from the U.S. NIOSH Current Intelligence Bulletin No. 13 (August
16, 1976).
· Recommendation for disposal of packaging:
Non-contaminated packaging may be used for recycling. Refer to applicable local regulations and institutional
policies.
For disposal of contaminated packaging, refer to applicable local regulations and institutional policies.
· Recommended cleansing agent: Water with cleansing agents, if necessary.

* 14 Transport information
· DOT, ADN, IMDG, IATA none
· UN proper shipping name
· DOT, ADR, ADN, IMDG, IATA none
· Transport hazard class(es)
· DOT, ADR, ADN, IMDG, IATA
· Class none
· DOT, IMDG, IATA none
· Environmental hazards
· Marine pollutant: No
· Additional information
· DOT
· Remarks: Not restricted for transportation.

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· ADR
· Remarks: Not restricted for transportation.
· IMDG
· Remarks: Not restricted for transportation.
· IATA
· Remarks: Not restricted for transportation.

* 15 Regulatory information
· SARA (Superfund Amendments and Reauthorization Act of 1986 - USA):
· Section 302/304 (40CFR355.30 / 40CFR355.40):
26628-22-8 Sodium azide
· Section 313 (40CFR372.65):
26628-22-8 Sodium azide
· California Proposition 65 (USA):
· Chemicals known to cause cancer:
The product does not contain listed substances.
· Chemicals known to cause female reproductive toxicity:
None of the ingredients is listed.
· Chemicals known to cause male reproductive toxicity:
None of the ingredients is listed.
· Chemicals known to cause developmental reproductive toxicity:
None of the ingredients is listed.

* 16 Other information
The information and recommendations contained herein are based upon information or tests believed to be reliable.
Abbott Laboratories does not guarantee the accuracy or completeness of this information or recommendations
contained herein, NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER
EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOODS, THE MERCHANTABILITY OF THE GOODS,
OR THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE.

This information is not a substitute for the advice of a health care professional, nor is it a recommendation for any
particular course of treatment. It is not intended to supplement, modify or supersede any information (e.g. labeling
and package inserts) provided with respect to the medical use of the product. Abbott Laboratories assumes no
responsibility for results obtained or for incidental or consequential damages, including lost profits, arising from the
use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied.
· Department issuing MSDS
- Abbott Diagnostics Safety, Health and Environmental Assurance
Department 0571
· Contact
- General information about this product:
Abbott Diagnostics
Technical Support
USA

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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Conjugate

100 Abbott Park Road

Abbott Park, IL 60064-3500

Phone: 1-877-4 ABBOTT

· * Sections marked with an asterisk (*) have been altered since the previous version.
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* 1 Identification
· Product name: ARCHITECT BNP Specimen Diluent

· ADD List number: 8K28J

· Application of the substance / mixture: For In Vitro Diagnostic Use
· Manufacturer / Supplier:
Abbott Diagnostics
100 Abbott Park Road
Abbott Park, IL 60064-3500
· Department issuing SDS: Abbott Diagnostics Safety, Health and Environmental Assurance
· Emergency telephone number:
Contact the CHEMTREC® Emergency Call Center for assistance with transportation or hazardous materials
emergencies (24 hours/day, 7 days/week):
- Telephone (800) 424-9300 (toll-free) if you are calling from within the United States, Canada, Puerto Rico and the
Virgin Islands.
- Telephone +1 (703) 527-3887, the international and maritime number (collect calls accepted), if you are calling
from outside the United States or from a ship at sea.

* 2 Hazard(s) identification
· Classification of the substance or mixture
· Classification system:
The classification was made according to U.S. OSHA 29 CFR 1910.1200 and 1910.1030 and applicable
European regulations, and is expanded upon from company and/or literature data.
· Label elements
· Labelling according to EU guidelines:
· Code letter and hazard designation of product:

Xi Irritant

· Hazard-determining components of labeling:

2-Methyl-2H-isothiazol-3-one
· Risk phrases:
43 May cause sensitization by skin contact.
· Safety phrases:
24 Avoid contact with skin.
35 This material and its container must be disposed of in a safe way.
37 Wear suitable gloves.
46 If swallowed, seek medical advice immediately and show this container or label.
· Routes of Exposure: Skin
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Product name: ARCHITECT BNP Specimen Diluent

· National Fire Protection Association (NFPA) ratings (scale 0-4)

Health = 0
Fire = 0
Reactivity = 0
· Hazard Overview
· Health: Sensitizer in contact with skin
· Fire: Noncombustible
· Reactivity: Minimal hazard - Stable, even in a fire. Not reactive with water. Not an oxidizer.
· Carcinogenicity information
· OSHA (Occupational Safety and Health Administration)
None of the ingredients is listed.
· Other hazards This product may cause skin sensitization (allergic reactions) in some people.

* 3 Composition/information on ingredients
· Chemical characterization: Mixture of chemical and/or biological substances for in vitro diagnostic use.
· Hazardous chemical ingredients per U.S. OSHA criteria (29 CFR 1910.1200 Hazard Communication):
2682-20-4 2-Methyl-2H-isothiazol-3-one 0.0094%

* 4 First-aid measures
· General information: Immediately remove any clothing soiled by the product.
· After inhalation: Remove from source of exposure. If irritation or signs of toxicity occur, seek medical attention.
· After skin contact:
Take off any clothing that the product touched.
Rinse skin with running water for 15 to 20 minutes. Seek medical attention if irritation or signs of toxicity occur.
· After eye contact:
Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
If eye irritation persists, get medical advice/attention. Wash hands after handling.
· After swallowing: Rinse mouth with water. If irritation or signs of toxicity occur, seek medical attention.
· Information for Medical Personnel
· Most important symptoms and effects, both acute and delayed:
Allergic reactions
Possibly immune response
This product may cause skin sensitization reactions in some people. See Section 11 for additional information.
· Medical conditions aggravated by exposure:
Pre-existing skin ailments
Skin allergies
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Product name: ARCHITECT BNP Specimen Diluent

* 5 Fire-fighting measures
· Suitable extinguishing agents
Dry chemical, carbon dioxide (CO2), water spray or regular foam.
- Caution: CO2 will displace air in confined spaces and may cause an oxygen-deficient atmosphere.
- For larger fires: There are no unique chemical or reactivity hazards that would impact firefighting decisions related
to this product. Use firefighting measures that suit the environment.
· Special hazards arising from the substance or mixture
There are no unique chemical or reactivity hazards that would impact firefighting decisions due to the chemicals in this
product.
· Protective equipment
For large fires, wear appropriate heat- and flame-resistant personal protective equipment and a NFPA/NIOSH
approved positive-pressure, self-contained breathing apparatus.

* 6 Accidental release measures

· Personal precautions, protective equipment and emergency procedures
Minimize exposure by using appropriate personal protective equipment as listed in Section 8. Stop leak if possible.
Keep unprotected persons away.
· Environmental precautions
Prevent liquid and vapor from entering sewage system, storm drains, surface waters, and soil.
· Methods and material for containment and cleaning up
Blot up small volumes of spilled or spattered product with paper towels or similar materials.
- Contain larger spills by placing absorbants around the outside edges of the spill. Absorb with any material suitable
for water-based liquids - e.g. paper towels, universal sorbents, sand, diatomite, sawdust, etc.
Clean the affected area. Suitable cleaners are:
- warm water and detergent or similar cleansing agent
This product contains sodium azide, which is toxic and reactive. See Sections 10 and 13 for additional information
that could affect handling and disposal of contaminated spill materials.
NOTE FOR LARGE-VOLUME SPILL: This product contains sodium azide, which reacts with acid to liberate
hydrazoic acid, a very toxic gas. Select a disinfectant with the following properties if disinfection of materials used to
absorb a large volume of spilled product is required:
- Do not use any chemical or product with a pH below 6 to disinfect waste that contains sodium azide. Hydrazoic
acid, a toxic gas, will be released when the pH is lower than 6.
- Do not use any chemical or product that contains mercury or any other metal to disinfect waste that contains sodium
azide. This will create metal azide compounds, which can be highly explosive under pressure or shock (percussion).
- Select a disinfectant that does not bubble, effervesce or otherwise generate aerosols.
- Do not use excess disinfectant.
- Failure to follow manufacturer’s directions may lead to unexpected reactions with the waste.
- Do not use a disinfectant if you do not have the proper facility, equipment and other appropriate protective
measures available to work with it safely.
Dispose of spilled and contaminated material in accordance with Federal, State, and Local regulations. See Section
13 for information that may impact disposal of materials contaminated with this product.
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Product name: ARCHITECT BNP Specimen Diluent

· Reference to other sections

See Section 7 for information on safe handling
See Section 8 for information on personal protection equipment.
See Section 13 for disposal information.

* 7 Handling and storage

· Precautions for safe handling: Avoid contact with skin.
· Information about protection against explosions and fires: No special measures required.
· Requirements to be met by storerooms and receptacles:
Store only in the original container.
Refer to the package insert or product label for additional information on storage conditions for product quality.
· Information about storage in one common storage facility: Store in original packaging.
· Further information about storage conditions: Protect from heat and direct sunlight.

* 8 Exposure controls/personal protection

· Components with Occupational Exposure Limits
26628-22-8 Sodium azide (0.0711 %)
REL () STEL/C: C 0.3** mg/m³, C 0.1* ppm
*as HN3; **as NaN3; Skin
TLV () STEL/C: C 0.29** mg/m³, C 0.11* ppm
*as HN3 vapor **as NaN3
· General protective and hygienic measures:
Always maintain good housekeeping and follow general precautionary measures. Do not eat, drink or store food
and beverages in areas where chemicals or specimens are used. Wash hands before breaks, after handling
reagents and specimens, and at the end of the workshift.
Avoid contact with the skin.
Immediately remove all soiled and contaminated clothing.
· Breathing equipment:
Normal use and storage of product - respiratory protection is not necessary if room is well ventilated.

Small-volume spills (e.g. small enough to clean up with a paper towel or small sorbent pad) - respiratory protection
should not be necessary if room is well ventilated.

Other unusual conditions (e.g. volume spilled too big to clean up with materials in arm's reach) - Use appropriate
NIOSH-approved air-purifying respirator if airborne chemical concentrations may exceed the exposure limit (if any)
listed above.

Hazardous Materials Emergencies or Firefighting - use NIOSH/NFPA-approved respiratory protection.

· Hand protection:
Wear impervious gloves if hand contact with the material is anticipated. Dispose of contaminated gloves after use
in accordance with applicable laws and good laboratory practices.
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· Material of gloves and breakthrough time of the glove material:

The glove material must be suitable for use in a microbiological laboratory and have a measured breakthrough
time of at least 30 minutes, such as those with a Class 2 protection index per EN374 (or equivalent standard
applicable in your region). NOTE: This recommendation applies only to the product stated in this Safety Data
Sheet. When dissolving in or mixing with other substances, contact the supplier of approved gloves.
· Eye protection:
Wear safety glasses or other protective eyewear. If splash potential exists, wear full face shield or goggles.
· Body protection:
Normal use: protect personal clothing from spatters and small spills. Wear a laboratory coat (or other protective
clothing required by your institution).
Larger spills (e.g. that can saturate cloth): wear appropriate water-repellant covering over clothing.

* 9 Physical and chemical properties

· General Information
· Form: Liquid
· Color: Colorless
· Odor: Odorless
· pH-value at 20 °C (68 °F) 8
· Melting point/Melting range: Not determined
· Boiling point/Boiling range: Not determined
· Flash point Not applicable
· Flammability (solid, gaseous) Not applicable
· Auto igniting Product is not self-igniting.
· Danger of explosion Product does not present an explosion hazard.
· Explosion limits
· Lower: Not determined
· Upper: Not determined
· Density at 20 °C (68 °F) 1.055 g/cm³ (8.804 lbs/gal)
· Evaporation rate: Not determined
· Solubility in / Miscibility with
· Water: Fully miscible
· Dynamic: Not determined.
· Water: 81.5 %

* 10 Stability and reactivity

· Thermal decomposition / conditions to be avoided
No decomposition if used and stored according to specifications.
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Product name: ARCHITECT BNP Specimen Diluent

· Possibility of hazardous reactions:

This product contains sodium azide. Sodium azide solutions are reported to:
- react with acids to release hydrazoic acid, a very toxic gas. Higher quantities of hydrazoic acid are released as the
solution becomes more acidic (i.e., as the pH of the solution gets lower). Low quantities of hydrazoic acid can be
released from sodium azide in water.
- react with certain metals (copper, lead, silver, brass) to form explosive metal azide compounds. Violent explosions
have been reported during plumbing work on drain systems containing accumulations of azide on copper, lead, brass,
or solder.
· Conditions to avoid: No further relevant information available.
· Incompatible materials: No further relevant information available.
· Hazardous decomposition products: No dangerous decomposition products known.

* 11 Toxicological information
· Acute toxicity
· LD50/LC50 values for hazardous ingredients per OSHA criteria:
· Ingredients (100% pure substance/s):
2682-20-4 2-Methyl-2H-isothiazol-3-one
Oral LD50 60 mg/kg (mouse)
By analogy to methylchloroisothiazolinone.
53 mg/kg (rat)
By analogy to methylchloroisothiazolinone.
· Primary toxicological effects of the final product:
· Skin irritation: No irritant effect.
· Eye irritation: No irritant effect.
· Sensitization:
Skin sensitization is possible with prolonged exposure, based on the reported properties of methylisothiazolones.
· Additional toxicological information: None
· Carcinogenic categories
· IARC (International Agency for Research on Cancer)
None of the ingredients is listed.
· NTP (National Toxicology Program)
None of the ingredients is listed.
· Target organs/systems:
Skin
Immune system

* 12 Ecological information
· Aquatic toxicity: No further relevant information available.
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Safety Data Sheet

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· Additional ecological information

· General notes:
Do not allow undiluted product or large quantities of it to reach ground water, water course, or sewage system.
· Results of PBT and vPvB assessment
· PBT: Not applicable
· vPvB: Not applicable

* 13 Disposal considerations
· Recommendation for disposal of unused product:
Dispose in accordance with federal, state and local regulations and institutional requirements. Waste containing
this product may be considered hazardous per U.S. EPA, state or local regulations. The following may be
particularly important when identifying appropriate disposal:
- Contains sodium azide. See Section 10 when considering how to appropriately dispose of unused product. For
drain systems with pipes or solder containing copper, lead, brass and/or silver, flush drains thoroughly with
copious amounts of water to prevent the formation of potentially explosive metal azides in plumbing. Detailed
information about azides in drains is available from the U.S. NIOSH Current Intelligence Bulletin No. 13 (August
16, 1976).
· Recommendation for disposal of packaging:
Non-contaminated packaging may be used for recycling. Refer to applicable local regulations and institutional
policies.
For disposal of contaminated packaging, refer to applicable local regulations and institutional policies.
· Recommended cleansing agent: Water with cleansing agents, if necessary.

* 14 Transport information
· DOT, ADN, IMDG, IATA none
· UN proper shipping name
· DOT, ADR, ADN, IMDG, IATA none
· Transport hazard class(es)
· DOT, ADR, ADN, IMDG, IATA
· Class none
· DOT, IMDG, IATA none
· Environmental hazards
· Marine pollutant: No
· Additional information
· DOT
· Remarks: Not restricted for transportation.
· ADR
· Remarks: Not restricted for transportation.
· IMDG
· Remarks: Not restricted for transportation.

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· IATA
· Remarks: Not restricted for transportation.

* 15 Regulatory information
· SARA (Superfund Amendments and Reauthorization Act of 1986 - USA):
· Section 302/304 (40CFR355.30 / 40CFR355.40):
26628-22-8 Sodium azide
· Section 313 (40CFR372.65):
26628-22-8 Sodium azide
· California Proposition 65 (USA):
· Chemicals known to cause cancer:
The product does not contain listed substances.
· Chemicals known to cause female reproductive toxicity:
None of the ingredients is listed.
· Chemicals known to cause male reproductive toxicity:
None of the ingredients is listed.
· Chemicals known to cause developmental reproductive toxicity:
None of the ingredients is listed.

* 16 Other information
The information and recommendations contained herein are based upon information or tests believed to be reliable.
Abbott Laboratories does not guarantee the accuracy or completeness of this information or recommendations
contained herein, NOR SHALL ANY OF THIS INFORMATION CONSTITUTE A WARRANTY, WHETHER
EXPRESSED OR IMPLIED, AS TO THE SAFETY OF THE GOODS, THE MERCHANTABILITY OF THE GOODS,
OR THE FITNESS OF THE GOODS FOR A PARTICULAR PURPOSE.

This information is not a substitute for the advice of a health care professional, nor is it a recommendation for any
particular course of treatment. It is not intended to supplement, modify or supersede any information (e.g. labeling
and package inserts) provided with respect to the medical use of the product. Abbott Laboratories assumes no
responsibility for results obtained or for incidental or consequential damages, including lost profits, arising from the
use of these data. No warranty against infringement of any patent, copyright or trademark is made or implied.
· Department issuing MSDS
- Abbott Diagnostics Safety, Health and Environmental Assurance
Department 0571
· Contact

USA

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Safety Data Sheet

© Abbott Laboratories Release date 08/08/2013 Last alteration on 08/08/2013

Product name: ARCHITECT BNP Specimen Diluent

- General information about this product:

Abbott Diagnostics
Technical Support
100 Abbott Park Road
Abbott Park, IL 60064-3500

Phone: 1-877-4 ABBOTT

· * Sections marked with an asterisk (*) have been altered since the previous version.
USA

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