MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)
MODEL ANSWER
SUMMER– 19 EXAMINATION
Subject Title: PHARMACEUTICS-l Subject Code: 0805
__________________________________________________________________________________________________
Important Instructions to examiners:
1) The answers should be examined by key words and not as word-to-word as given in the model answer
scheme.
2) The model answer and the answer written by candidate may vary but the examiner may try to assess the
understanding level of the candidate.
3) The language errors such as grammatical, spelling errors should not be given more Importance (Not
applicable for subject English and Communication Skills.
4) While assessing figures, examiner may give credit for principal components indicated in the figure. The
figures drawn by candidate and model answer may vary. The examiner may give credit for anyequivalent
figure drawn.
5) Credits may be given step wise for numerical problems. In some cases, the assumed constant values may
vary and there may be some difference in the candidate’s answers and model answer.
6) In case of some questions credit may be given by judgement on part of examiner of relevant answer based
on candidate’s understanding.
7) For programming language papers, credit may be given to any other program based on equivalent concept.
Page 1/34
MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)
MODEL ANSWER
SUMMER– 19 EXAMINATION
Subject Title: PHARMACEUTICS-l Subject Code: 0805
__________________________________________________________________________________________________
Q. Sub Answer Marking
No. Q. Scheme
N.
1 Answer any Eight of the followings: 16M
1 a) Give any four reasons for film coating. 2M
•To mask the disagreeable odour, colour or taste of the drug/tablet. (0.5x4)
• To offer a physical and/or chemical protection to the drug.
• To protect drug from the deterioration effect of external environment.
• Increasing the mechanical strength of the dosage form.
• To improve the appearance of tablets
1 b) Explain any four factors affecting size reduction 2M
Factor affecting size reduction are: (0.5x4)
1.Hardness: Soft material easy break than hard.
2.Toughness: Drug with fibrous nature or those having high moisture content are tough
and hard to reduce in size.
3.Stickiness: Material adheres to the grinding surface or sieve surface of the mill. It is
very difficult to powder a drug of having gummy or resinous material.
4.Material structure: Material with some special structure cause problem during size
reduction e.g. Vegetable drug with cellular structure produce long fibrous particle on size
reduction, similarly a mineral substance having lines of weakness, produce flake like
particle on its size reduction.
5.Moisture content: The presence of moisture in the material influences a number of its
properties such as hardness, toughness or stickiness. The material having 5% moisture in
case of dry grinding and 50% in case of wet grinding is permissible.
6.Temperature: Waxy material such as stearic acid or drug containing oils or fat,
become softened during the size reduction, due to heat. This can be avoided by cooling
the mill.
7.Purity: In some mills during size reduction there is chances of addition of impurities. If
Page 2/34
MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)
MODEL ANSWER
SUMMER– 19 EXAMINATION
Subject Title: PHARMACEUTICS-l Subject Code: 0805
__________________________________________________________________________________________________
high degree of purity is required avoid such mills or Mills should be cleaned thoroughly.
8.Physiological effect: Some drugs are very potent. During their size reduction in mill,
dust is produced which may have effect on operator.
9.Ratio of feed size to product size: To get a fine powder in a mill, it is required that a
fairly small feed size should be used. Hence to carry out size reduction in various stages
e.g. preliminary crushing followed by coarse powder and then fine grinding.
10.Bulk density: The output of the size reduction of the material in a machine depends
upon the bulk density of the substance.
1 c) Define 2M
(i) Drug- A chemical agent intended for use in the diagnosis, mitigation, treatment, cure (1 X2 =
or prevention of disease in man or in other animals. 2M
(ii) Dosage forms- Dosage form is a transformation of a pure chemical compound into a
predetermined form by admixing drug components with non- drug components.
1 d) Give Significance of drying.
1) In pharmaceutical industry it is used as a unit process in the manufacture of granules
which can be dispensed in bulk or converted into tablets or capsules. 2M
2) Drying can also be used to reduce the bulk and weight of the material, thereby (0.5 X 4)
lowering the cost of transportation and storage.
3) It helps in the preservation of crude drugs of plant from mould growth, which occurs
due to presence of moisture.
4) It helps in the size reduction of crude drugs. The presence of moisture in the crude
drug does not allow it to get powdered easily.
5) Drying is also used in the processing of materialseg. the preparation of dried
aluminium hydroxide, the spray drying of lactose and in the preparation of solid extract.
6) Improves solubility of product, when powder is dried it gets solubilised fast.
7) Drying ensures free flowing of powders.
Page 3/34
MAHARASHTRA STATE BOARD OF TECHNICAL EDUCATION
(Autonomous)
(ISO/IEC - 27001 - 2005 Certified)
MODEL ANSWER
SUMMER– 19 EXAMINATION
Subject Title: PHARMACEUTICS-l Subject Code: 0805
__________________________________________________________________________________________________
1 e) Write difference between Hard and Soft gelatin capsules 2M
Sr. No. Hard gelatin capsules Soft gelatin capsules (0.5×4)
1 The hard gelatin capsule shell consists The soft gelatin capsule
of two parts: Body and cap shell becomes a single unit.
2 They are cylindrical in shape They are available in
round, oval and tube-like
shapes.
3 The contents usually consist of The contents usually
medicaments in the form of powder, consist of liquids or
beads or granules semisolids.
4 These are prepared from gelatin, These are prepared from
titanium dioxide, colouring agent and gelatin, more amount
plasticizer of plasticizer (sorbitol or
glycerin) and preservative.
5 Filling and sealing takes place in Filling and sealing are
different steps. done in a combined
operation of machines
6 Shell is perfectly dry Shell is not perfectly dry
7 These capsules can be adulterated These capsules cannot be
adulterated
8 Eg: Amoxycillin Capsule Eg: Pudin Hara Capsule
1 f) Find out the proportion of procaine HCL which will yield solution iso-osmotic with 2M
0
blood plasma (FP 1% procaine HCL = -0.122 C )
Formula: %w/v of adjusting sub needed=0.52-a/b
Calculation : % w/v procaine HCLrequired = 0.52 – 000/ 0.122
= 4.26% w/v
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