David Botstein

David Botstein (born September 8, 1942) is an

American biologist who is the chief scientific officer of David Botstein
Calico. He was the director of the Lewis-Sigler
Institute for Integrative Genomics at Princeton
University[4][5][6][7] from 2003 to 2013, where he
remains an Anthony B. Evnin Professor of Genomics.

Education
Botstein graduated from the Bronx High School of
Science in 1959, and Harvard University in 1963. He Born September 8, 1942 (age 82)
started his Ph.D. work under Maurice Sanford Fox at Zurich, Switzerland
the Massachusetts Institute of Technology, then moved
Alma mater Harvard University
and received a Ph.D. from the University of Michigan
University of Michigan
in 1967 for work on P22 phage.[8]
Known for Genetic linkage map using
restriction fragment length
polymorphisms
Career
Relatives Leon Botstein (brother)
Botstein taught at the Massachusetts Institute of Awards Eli Lilly and Company Award
Technology, where he became a professor of genetics. in Microbiology (1978)
Botstein joined Genentech, Inc. in 1987 as vice Genetics Society of America
president – science. In 1990, he became chairman of Medal (1988)[1]
the Department of Genetics at Stanford University. Allan Award of the American
Botstein was elected to the U.S. National Academy of Society of Human Genetics
Sciences in 1981 and to the Institute of Medicine in (1989)
1993. Rosenstiel Award (1991)
Novartis-Drew Award (2003)
Botstein is the director of the Integrated Science Gruber Prize in Genetics
Program at Princeton University.[9] (2003)
Albany Medical Center Prize
In 1980, Botstein and his colleagues Ray White, Mark
(2010)
Skolnick, and Ronald W. Davis proposed a method[10]
Breakthrough Prize in Life
for constructing a genetic linkage map using restriction
Sciences (2013)
fragment length polymorphisms that was used in
Warren Alpert Foundation
subsequent years to identify several human disease
Prize (2013)
genes including Huntington's and BRCA1. Variations
Double Helix Medal (2015)[2]
of this method were used in the mapping efforts that Thomas Hunt Morgan Medal
predated and enabled the sequencing phase of the (2020)
Human Genome Project.
Scientific career
In 1998, Botstein and his postdoctoral fellow Michael Fields Genetics
Eisen, together with graduate student Paul Spellman Institutions MIT
and colleague Patrick Brown, developed a statistical Stanford University
method and graphical interface that is widely used to Genentech
interpret genomic data including microarray data.[11] Princeton University
This approach was refined and applied for diverse
Thesis The Synthesis and Maturation
applications, including for a molecular classification of
of Phage-P22 DNA (http://sea
heterogenous tumors using gene expression. These
rch.proquest.com/docview/30
efforts included work on discovery of tumor subtypes
2261666) (1967)
with Lou Staudt, Ash Alizadeh and Ronald Levy,
Doctoral Olga Troyanskaya[3]
yielding a refined classification of diffuse large B cell
students Fred Winston
lymphomas, and in painting the molecular portraits for
Douglas Koshland
refined classification of breast cancers with Anne-Lise
Tim Stearns
Børresen-Dale and Charles Perou. He has subsequently
worked on the creation of the influential Gene Other notable Michael Eisen (postdoc)
Ontology[12] with Michael Ashburner and Suzanna students
Lewis. He is one of the founding editors of the journal Website www.princeton.edu/genomics
Molecular Biology of the Cell, along with Erkki /botstein (http://www.princeto
Ruoslahti and Keith Yamamoto.[13] n.edu/genomics/botstein)
molbio.princeton.edu/faculty
In 2013, Botstein was named chief scientific officer of /molbio-faculty/96-botstein (ht
Google's anti-aging health startup Calico. tp://molbio.princeton.edu/facul
ty/molbio-faculty/96-botstein)

Awards
Botstein has won the Eli Lilly and Company Award in Microbiology (1978), the Genetics Society of
America Medal (1988, with Ira Herskowitz),[1] the Allan Award of the American Society of Human
Genetics (1989, with Ray White), the Gruber Prize in Genetics (2003), the Albany Medical Center Prize
(2010, with Eric Lander and Francis Collins) and the Dan David Prize in 2012. In 2013 he was awarded
the $3 million Breakthrough Prize in Life Sciences for his work and in 2020 the Thomas Hunt Morgan
Medal of the Genetics Society of America.[14] In 2016, Semantic Scholar AI program included Botstein
on its list of most top ten most influential biomedical researchers.[15]

Personal
Botstein is an alumnus of Camp Rising Sun. He is the brother of the conductor Leon Botstein. Both of
Botstein's parents were physicians.

References
1. Mahowald, A. (1988). "Genetics society of america records, proceedings and reports" (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203430). Genetics. 119 (2): s1–s15.
doi:10.1093/genetics/119.2.s1 (https://doi.org/10.1093%2Fgenetics%2F119.2.s1).
PMC 1203430 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1203430). PMID 17246435
(https://pubmed.ncbi.nlm.nih.gov/17246435).
 2. "2015 Double Helix Medal recipient Dr. David Botstein" (https://www.cshl.edu/videos/2015-d
ouble-helix-medal-recipient-dr-david-botstein/). Cold Spring Harbor Laboratory. November
12, 2015. Retrieved October 13, 2022.
3. Mullins, J.; Morrison Mckay, B. (2011). "International Society for Computational Biology
Honors Michael Ashburner and Olga Troyanskaya with Top Bioinformatics/Computational
Biology Awards for 2011" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3107244). PLOS
Computational Biology. 7 (6): e1002081. Bibcode:2011PLSCB...7E2081M (https://ui.adsab
s.harvard.edu/abs/2011PLSCB...7E2081M). doi:10.1371/journal.pcbi.1002081 (https://doi.or
g/10.1371%2Fjournal.pcbi.1002081). PMC 3107244 (https://www.ncbi.nlm.nih.gov/pmc/artic
les/PMC3107244).
4. "Princeton University - Department of Molecular Biology - David Botstein" (https://web.archiv
e.org/web/20061127033459/http://www.molbio2.princeton.edu/index.php?option=content&ta
sk=view&id=201). Archived from the original (http://www.molbio2.princeton.edu/index.php?o
ption=content&task=view&id=201) on November 27, 2006. Retrieved November 8, 2006.
David Botstein at Princeton Department of Molecular Biology
5. https://www.princeton.edu/genomics/botstein/ Botstein Laboratory Princeton
6. Gitschier, J. (2006). "Willing to Do the Math: An Interview with David Botstein" (https://www.n
cbi.nlm.nih.gov/pmc/articles/PMC1464829). PLOS Genetics. 2 (5): e79.
doi:10.1371/journal.pgen.0020079 (https://doi.org/10.1371%2Fjournal.pgen.0020079).
PMC 1464829 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1464829). PMID 16733551
(https://pubmed.ncbi.nlm.nih.gov/16733551).
7. "The Daily Princetonian - Mapping the path of genetics" (https://web.archive.org/web/20061
020012122/http://www.dailyprincetonian.com/archives/2005/10/18/news/13503.shtml).
Archived from the original (http://www.dailyprincetonian.com/archives/2005/10/18/news/135
03.shtml) on October 20, 2006. Retrieved October 19, 2006. The Daily Princetonian –
Mapping the path of genetics
8. Botstein, David (1967). The Synthesis and Maturation of Phage-P22 DNA (PhD thesis).
University of Michigan. ProQuest 302261666 (https://search.proquest.com/docview/302261
666).
9. Thean, Tara. "Integrated Science Pays Off for Graduates" (https://web.archive.org/web/2011
0830154320/http://www.dailyprincetonian.com/2009/10/12/24100/). The Daily Princetonian.
Princeton University Press. Archived from the original (http://www.dailyprincetonian.com/200
9/10/12/24100/) on August 30, 2011. Retrieved October 23, 2011.
10. Botstein, D.; White, R.; Skolnick, M.; Davis, R. (1980). "Construction of a genetic linkage
map in man using restriction fragment length polymorphisms" (https://www.ncbi.nlm.nih.gov/
pmc/articles/PMC1686077). American Journal of Human Genetics. 32 (3): 314–331.
PMC 1686077 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1686077). PMID 6247908 (ht
tps://pubmed.ncbi.nlm.nih.gov/6247908).
11. Eisen, M.; Spellman, P.; Brown, P.; Botstein, D. (1998). "Cluster analysis and display of
genome-wide expression patterns" (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24541).
Proceedings of the National Academy of Sciences of the United States of America. 95 (25):
14863–14868. Bibcode:1998PNAS...9514863E (https://ui.adsabs.harvard.edu/abs/1998PN
AS...9514863E). doi:10.1073/pnas.95.25.14863 (https://doi.org/10.1073%2Fpnas.95.25.148
63). PMC 24541 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC24541). PMID 9843981 (htt
ps://pubmed.ncbi.nlm.nih.gov/9843981).
12. Botstein, D.; Cherry, J. M.; Ashburner, M.; Ball, C. A.; Blake, J. A.; Butler, H.; Davis, A. P.;
Dolinski, K.; Dwight, S. S.; Eppig, J. T.; Harris, M. A.; Hill, D. P.; Issel-Tarver, L.; Kasarskis,
A.; Lewis, S.; Matese, J. C.; Richardson, J. E.; Ringwald, M.; Rubin, G. M.; Sherlock, G.
(2000). "Gene ontology: Tool for the unification of biology. The Gene Ontology Consortium"
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3037419). Nature Genetics. 25 (1): 25–29.
doi:10.1038/75556 (https://doi.org/10.1038%2F75556). PMC 3037419 (https://www.ncbi.nl
m.nih.gov/pmc/articles/PMC3037419). PMID 10802651 (https://pubmed.ncbi.nlm.nih.gov/10
802651).
13. "MBC Editorial Board" (http://www.molbiolcell.org/site/misc/edboard.xhtml).
14. "Congratulations to the recipients of the 2020 GSA Awards!" (http://genestogenomes.org/co
ngratulations-to-the-recipients-of-the-2020-gsa-awards/). Genetics Sooiety of America.
January 29, 2020. Retrieved February 5, 2020.
15. Singh, Dalmeet (October 17, 2017). "Who's the most influential biomedical scientist?
Computer program guided by artificial intelligence says it knows" (https://www.science.org/c
ontent/article/who-s-most-influential-biomedical-scientist-computer-program-guided-artificia
l). Science | AAAS. Retrieved September 22, 2020.

External links
David Botstein's Talk: "An Integrated Science Curriculum" (https://www.ibiology.org/science-
and-society/integrated-science-curriculum-princeton/)
David Botstein iBiology Seminar: "Fruits of the Genome Sequence" (https://www.ibiology.or
g/genetics-and-gene-regulation/fruits-genome-sequences/)
David Botstein personal archives (https://archivesspace.mit.edu/repositories/2/resources/79
0), MC-0227. Massachusetts Institute of Technology, Department of Distinctive Collections,
Cambridge, Massachusetts.

Retrieved from "https://en.wikipedia.org/w/index.php?title=David_Botstein&oldid=1255455155"