THE TAMIL NADU DR. M.G.R.
MEDICAL UNIVERSITY
[MBBS 0322] MARCH 2022 Sub. Code :6066
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2019-2020 Batch onwards)
SECOND YEAR
PAPER III – MICROBIOLOGY – II
Q.P. Code: 526066
Time: Three hours Maximum : 100 Marks (80 Theory + 20MCQs)
Answer all the Questions
I. Essay: (2 x 15 = 30)
1. A 45 years old female has attended the Gynac op with c/o Mucopurulent
vaginal discharge for the past one week. In gram’s staining of cervical swab,
kidney shaped Gram negative cocci are seen. Answer the following questions
a) Which organism causes this symptoms and list out the other possible
organism that cause Sexually Transmitted Infection.
b) Explain the pathogenesis and clinical feature of the organism
c) What are the diagnostic methods and management
2. A 55 years old male patient was admitted in ICU were with fever, cough with
expectoration, fatigue and sore throat. There is H/O loss of smell and taste.
The contact history with fever patient before 5 days is also elucidated
a) What is the cause of the above condition and list out other organism that
causes interstitial pneumonia?
b) Explain the structure of the organism
c) How will you diagnose this condition .Add a note on its vaccine
II. Write Short notes on: (10 x 5 = 50)
1. Write about the lab diagnosis of Hepatitis B virus.
2. Explain various properties of enterotoxin produced by Escherichia coli.
3. Write the lab diagnosis of systemic mycosis.
4. Write short notes on carriers in typhoid infections.
5. Explain Weil-Felix Test and its application.
6. Write short notes on Brugian Filariasis.
7. Short notes on Granulomatous Amoebic Encephalitis.
8. Discuss the vaccine against Poliomyelits.
9. Write the clinical feature and lab diagnosis of Melioidosis.
10. Write the clinical feature and lab diagnosis of Plague.
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THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[MBBS 0822] AUGUST 2022 Sub. Code :6066
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2019-2020)
SECOND YEAR (SUPPLEMENTARY (CBME)
PAPER III – MICROBIOLOGY – II
Q.P. Code: 526066
Time: Three hours Maximum : 100 Marks (80 Theory + 20MCQs)
Answer all the Questions
I. Essay: (2 x 15 = 30)
1. A 65 year old male patient admitted in the hospital with history of fever, sore
throat, head ache, body pain and loss of taste and smell. Symptomatic treatment
was given. After 2 days, he developed difficulty in breathing, his oxygen
saturation was <90 %. Blood investigations like CRP, D-dimer and IL-6 were
elevated. CT Chest shows ground glass opacities. Patient was treated with high
flow oxygen, steroid, antibiotics and antiviral agents.
a) What is the clinical condition?
b) Describe in detail about transmission, pathogenesis and clinical manifestations
of this condition?
c) Write in detail about microbiological and non-microbiological investigations of
this conditions?
d) Add note on prevention and control of this clinical condition?
2. A 17-year-old boy presented with bloody diarrhea with mucus and pus cells,
colicky abdominal pain, fever, and prostration. The wet mount examination of the
stool sample was performed which showed trophozoites of 5–20 μm, actively
motile, with fingerlike pseudopodia. Inside the trophozoites, the ingested RBCs
present?
a. What is the etiological diagnosis?
b. Describe the pathogenesis and clinical manifestations produced?
c. What are the various diagnostic modalities?
d. How will you treat this condition?
II. Write Short notes on: (10 x 5 = 50)
1. An 18-year old female presented with high-grade fever which rises every third
day with chills and rigor. Her blood sample was subjected to a rapid diagnostic test
which revealed positive for Plasmodium vivax. Discuss the laboratory diagnosis
and treatment for the same?
2. A 40-year-old male presented with history of loss of appetite, malaise and
jaundice of 2 months duration. On examination, there was icterus, hepatomegaly
and tenderness in the right hypochondriac region. He gave a history of blood
transfusion in the past. On laboratory examination, he was found to be positive for
HBsAg.
… 2 …
… 2 …
a. What is the most probable etiological diagnosis?
b. Discuss in detail about the various viral markers, their laboratory diagnosis and
prophylaxis of this condition.
3. A 25-year-old male with history of multiple sex partners is admitted with
complaints of unexplained fever, progressive loss of weight, persistent diarrhea and
generalized lymphadenopathy for the past 6 months.
a. What is the most probable diagnosis?
b. Discuss the pathogenesis and laboratory diagnosis of the above condition.
4. Rajesh, a 28-year-old male, was admitted to the hospital with complaints of
evening rise of temperature, night sweat, loss of weight, loss of appetite and
chronic cough with expectoration for the past 6 months. Sputum examination
revealed long, slender and beaded acid-fast bacilli.
a. What is your provisional diagnosis?
b. Describe the laboratory diagnosis and drug resistance that occur in the
etiological agent.
5. A 35 year old male with c/o hard painless penile ulcer attends STD OP. Blood
sample drawn and sent for VDRL test. The laboratory reports VDRL test as
Reactive. How will you counsel & what advice you will give to the patient.
6. Enlist the opportunistic fungal infection. Write in detail about the pathogenesis,
clinical features and laboratory diagnosis of aspergillosis?
7. A 28-year-old female was admitted with high grade fever, vomiting, flank pain
with increased frequency of micturition for the past 3 days. What is your clinical
diagnosis, etiological agents and laboratory diagnosis?
8. A 25-year-old Australian visited his local doctor complaining of difficulty in
swallowing liquids, loss of appetite and restlessness. He had a travel history to
India one month back and did mention being bitten by a street dog.
a. What is the most probable etiological diagnosis?
b. Discuss the laboratory diagnosis and the vaccines available for human use.
9. List the bacterial organism causing pyogenic meningitis. Write in detail about
clinical manifestations. laboratory diagnosis and treatment of pyogenic
meningitis?
10. A 29-year-old female came to casualty with complaints of high-grade fever, severe
joint pain, back pain and myalgia. Gradually, she developed petechial rashes over
the body. On examination, she was found to have jaundice, hepatomegaly and a
low platelet count (30,000/cm), Raised hematocrit (packed cell volume) by 20%.
A tourniquet test done over the cubital fossa demonstrated 25 petechial
spots/square inch area. On inquiry, she told that she has been bitten by the
mosquitoes.
a. What is the clinical diagnosis and how is this disease transmitted?
b. How will you confirm the diagnosis in the laboratory?
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[MBBS 0822]
THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[MBBS 0223] FEBRUARY 2023 Sub. Code :6066
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2019-2020)
SECOND YEAR – (CBME)
PAPER III – MICROBIOLOGY – II
Q.P. Code: 526066
Time: Three hours Maximum : 100 Marks (80 Theory + 20MCQs)
Answer all the Questions
I. Essay: (2 x 15 = 30)
1. A 5 year old male child admitted in ICU with c/o fever, headache and chills. His
mother complained that child is not able to stand 5 days after the onset of fever.
O/E there is flaccid paralysis of lower limbs and tripod sign is elucidated. On CSF
analysis glucose level and protein level is normal. Microscopic examination of CSF
show 25-40 lymphocytes per microlitre and no bacteria seen. Ziehl – Neelsen staining of
CSF is negative for Acid Fast bacilli.
a) Mention the organism causing the disease. Enumerate the other organisms
causes myelitis.
b) Write in detail about the clinical manifestation, Lab diagnosis of disease.
c) Describe prophylaxis of the causative organism.
2. A 45 year old male patient attend O.P. with H/O fever with chills, headache
abdominal pain with vomiting. History was elicited, that he went to Andaman and
has taken drinking water from a lake. On examination there is jaundice with
Hepato splenomegaly. On dark ground microscopic examination of blood shows
spirally coiled bacilli.
a) What is the causative bacteria and write its pathogenesis.
b) Describe the lab diagnosis and management of the disease.
c) Write the preventive measures of it.
II. Write Short notes on: (10 x 5 = 50)
1. Explain blood culture method for detection of Infective Endocarditis.
2. Write the current definition and etiology of fever of unknown origin.
3. Write short notes on drug resistance in Typhoidal Salmonella.
4. Short note on Scrub typhus.
5. Explain the pathogenesis and the diagnosis of dengue fever.
6. Write the lab diagnosis of diarrhoea caused by coccidian parasite.
7. How will you diagnose Respiratory tract Infection caused by Aspergillus.
8. Describe the structure of SARS CoV -2.
9. Describe the life cycle of Echinococcus granulosus.
10. Write the prophylaxis of whooping cough.
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THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[MBBS 0723] JULY 2023 Sub. Code :6066
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2019-2020)
SECOND YEAR – (CBME)
PAPER VI – MICROBIOLOGY – II
Q.P. Code: 526066
Time: Three hours Maximum : 100 Marks (80 Theory + 20MCQs)
Answer all the Questions
I. Essay: (2 x 15 = 30)
1. A 70 year old man was hospitalized with fever, weakness in lower limbs.
Echocardiogram showed vascular vegetations on the mitral value. He also had
elevated CRP and ESR.
a) What is the most probable diagnosis?
b) Write about the etiological agents.
c) Describe the diagnostic criteria used for this condition.
d) How will you collect specimen for this clinical condition and enumerate
the other laboratory investigation needed?
2. A 40 year old woman working in a paddy field developed fever, headache with
conjunctival suffusion. Examination revealed hepato splenomegaly, elevated
liver functions, Oliguria and Uremia.
a) What is the etiological agent and how is this disease transmitted?
b) What is the typical clinical presentation and pathogenesis of this condition?
c) Write briefly about lab diagnosis.
d) How will you manage this clinical condition?
II. Write Short notes on: (10 x 5 = 50)
1. Discuss briefly about Viral Gastroenteritis?
2. Write short notes on Mycotoxicoses?
3. A 5 year old child had high grade fever, pain in the throat with difficulty in
swallowing. On examination the child was toxic, white patch was found on the
fauces which bleeds on touch. Immunization status not known.
a) What is your probable diagnosis and the etiological agent?
b) Write briefly about the pathogenesis and lab diagnosis of this condition.
4. Write short notes on pulmonary anthrax.
5. Enumerate the causes of Vulvovaginitis. Write short notes on Trichomoniasis.
6. Explain shortly about the clinical manifestations and lab diagnosis
of Toxoplamosis.
7. A 7 year old girl admitted with fever, headache, vomiting and neck rigidity.
CSF showed elevated CSF pressure, Leukocytes predominantly neutrophils.
Glucose < 40 mg/dl and protein > 45 mg/dl.
a) What is your clinical interpretation?
b) Enumerate the probable causative agents.
c) Add a note on pneumococcal vaccine.
… 2 …
… 2 …
8. A 25 year old male visited the clinic of a local doctor with a history of dog bite.
Write about the prophylactic measures used against dog bite?
9. An 18 year old female presented to the casualty with complaints of high grade
fever, headache, joint pain, petechiae and low platelet count? What is your
clinical diagnosis and write briefly about the pathogenesis and lab diagnosis of
this condition?
10. What is Neurocysticercosis? Write briefly about the clinical manifestation and
lab diagnosis of Neurocysticercosis.
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[MBBS 0723]
THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[MBBS 0224] FEBRUARY 2024 Sub. Code :6066
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2019-2020)
SECOND PROFESSIONAL YEAR – (CBME)
PAPER II – MICROBIOLOGY
Q.P. Code: 526066
Time: Three hours Maximum : 100 Marks (80 Theory + 20MCQs)
Answer all the Questions
I. Essay: (2 x 15 = 30)
1. A 30 year old man presented with complaints of pain right side of abdomen. He gave
a history of having a pet dog. Ultrasonogram revealed a single space occupying
cystic lesion in the right lobe of liver.
a) Identify the disease and the causative agent?
b) Write briefly about the life cycle of the above clinical condition.
c) Write shortly on the lab diagnosis and management.
2. A middle aged man presented with fever for more than 3 weeks. He was
hospitalized for more than 5 days without identifying the definitive cause.
a) What is your probable diagnosis?
b) Classify the clinical condition and list the ethological agents involved.
c) What are the laboratory investigations required in this case?
II. Write Short notes on: (10 x 5 = 50)
1. Write about the pathogenesis and lab diagnosis of Shigellosis.
2. Describe the mechanism of action of tetanus toxin and the role of tetanus toxoid
vaccine.
3. Enumerate the causes of meningitis. Explain briefly about clinical features and lab
diagnosis of viral meningitis.
4. Write short note on Fasciolopsiasis.
5. Enumerate the common causes of urinary tract infection. Write briefly about the
lab diagnosis of urinary tract infection.
6. A 50 year old diabetic male developed blackish discoloration around the eye with
head ache and one sided facial swelling. He had recovered from Covid-19 two
weeks back. What is your probable diagnosis and Explain briefly about the clinical
manifestation of this condition?
7. Write the clinical feature and lab diagnosis of Lyme disease.
8. Enumerate Halophilic Vibrios. Write briefly about the clinical manifestation and
lab diagnosis.
9. Write about the lab diagnosis of Brucellosis.
10. Write short note on lab diagnosis and prophylactic measures against Pertussis.
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THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY
[MBBS 0524] MAY 2024 Sub. Code :6066
M.B.B.S. DEGREE EXAMINATION
(For the candidates admitted from the Academic Year 2019-2020)
SECOND PROFESSIONAL – SUPPLEMENTARY (CBME)
PAPER II – MICROBIOLOGY
Q.P. Code: 526066
Time: Three hours Maximum : 100 Marks (80 Theory + 20MCQs)
Answer all the Questions
I. Essay: (2 x 15 = 30)
1. A 3 year old boy was admitted to the hospital with complaints of high-grade
fever, headache, vomiting, altered mental status, seizure and neck rigidity.
CSF sample was collected by lumbar puncture in a sterile container and sent to
the laboratory for biochemical analysis, direct microscopic test, culture and
sensitivity testing
a) What is the probable clinical diagnosis?
b) What are the etiological agents, pathogenesis and clinical manifestations of
this disease?
c) Describe the laboratory diagnosis in detail.
d) What are the treatment modalities according to the etiological agents?
2. A 32-year-old male with history of multiple sex partners is admitted with
complaints of unexplained fever, progressive loss of weight, persistent
diarrhoea and generalized lymphadenopathy for the past 6 months.
a) What is the most probable diagnosis?
b) Discuss the pathogenesis, clinical manifestation and laboratory diagnosis of
the above condition.
II. Write Short notes on: (10 x 5 = 50)
1. Bioterrorism.
2. Opportunistic mycosis.
3. African sleeping sickness.
4. Typhoid Carriers.
5. Chancroid.
6. Campylobacter Jejuni.
7. Prions disease.
8. Diarrheagenic E.Coli.
9. Halophilic Vibrios
10. Laboratory diagnosis of Scrub typhus.
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