Worksheet
Medicinal Chemistry - II
1. Give the synthesis of Cimetidine.
2. State the mechanism of action and uses of Methotrexate.
3. What are anti-anginal drugs? Outline the structure of Nitroglycerin.
4. Give the synthesis and uses of Furosemide.
5. Namne and give structures of any two drugs used in Congestive Heart
Failure.
6. State the importance of anticoagulants.
7. Write the structure and uses of Testosterone.
8. Discuss mechanism of action and uses of Sildenafil.
9. Outline the synthesis of benzocaine.
[Link] the mechanism of action and uses of metformin
[Link] any two structures of antimetabolites used as antineoplastic agents.
[Link] synthesis of isosorbide dinitrate.
[Link] are oral contraceptives. Give examples.
[Link] the mechanism of action and uses of acetazolamide.
[Link] structure and mechanism of action of any one antihyperlipidemic
agent.
[Link] calcium channel blockers along with their uses.
[Link] the role of digoxin in treatment of congestive heart failure.
[Link] oral anticoagulants with examples.
[Link] the synthesis of benzocaine.
20. Write down the structure, mechanism of action and uses of rabeprazole
[Link] structure and write uses of diphenhydramine hydrochloride.
[Link] mechanism of action of methotrexate.
[Link] structure and write mechanism of action of verapamil.
[Link] the structure and uses of loop diuretics drugs.
[Link] mechanism of action and uses of lovastatin.
26. Write ashort note on digitoxin.
27. Write mechanism of action and draw structure of sildenafil.
[Link] the advantages of amide local anesthetics over ester local
anesthetics.
[Link] a short note on thiazolidinediones.
[Link] about metabolic pathway of insulin
[Link] the SAR and mechanism of action of H2 receptor antagonists.
32. Write the synthesis and MOA of Acetazolamide.
[Link] antianginal drug. Give the synthesis and SAR of isosorbjde
dinitrite
[Link] diuretics. Explain SAR of thiazides diuretics along with
synthesis of chlorothiazide.
[Link] and classify antihistaminic agents. Explain in detail about
structures and uses of first generation Hlantihistaminic agents.
[Link] are antidiabetic agents. Classify oral hypoglycemic agents and
describe in detail about SAR and mechanism of action of sulfonylureas
along with synthesis of tolbutamide
[Link] anti-neoplastic agents in detail. Give the synthesis of
Mechlorethamine.
[Link] SAR of local anaesthetics.
[Link] are antihypertensive agents? Classify them and give mode of action
and uses of methyldopate hydrochloride.
[Link] the SAR and synthesis of disopyramide phosphate.
[Link] anticoagulants. Write the SAR and synthesis of warfarin.
[Link] antithyroid drugs and write a detailed note on propylthiouracil.
[Link] sulphonyl ureas and biguanides derivative. Write SAR of
tolbutamide.
[Link] the structural classification of local anesthetics, write the
mechanism of benzocaine.
45. Write the SAR and mechanism of action of meclorethamine.
46. Write the structural classification of oral contraceptives.
[Link] local anesthetics with examples and explain in detail about
various benzoic acid derivatives.
[Link] antihypertensive drugs. xplain in detail about structures and
mechanism of action of angiotensin converting enzyme inhibitors.
[Link] antineoplastic agents. Discuss in detail about structure and
mechanism of action of alkylating agents.
[Link] thyroid and antithyroid drugs with structures and uses.
[Link] classification of antianginal drugs. Discuss in detail structure,
mechanism of action and uses of nitrates.
[Link] in detail about different corticosteroids. Give structures of
cortisone and prednisolone.
[Link] antiarrhythmic drugs. Describe in detail about structures and
mechanism of action of drugs belonging to class I
[Link] SAR of Thiazide Diuretics. Outline the synthesis of
Chlorthiazide.
[Link] about histamine receptors and their distribution in human body.
Detail about H2-antagonists.
Disopyramide
discuss give
and
and Sulfonylureas
agents (i)
inhibitors.
steroids. two:
antihyperlipidemic drugs
any
of antithyroid
reductase
of SAR of
stereochemistry
synthesis
Discuss Dibucaine
HMG-CoA of
of and classification
agents. (iii)
classification
and Tolbutamide.
ofsynthesis
action
of nomenclatureWarfarin
action antidiabetic
of detail
mode
mechanism (ii)
theof
phosphate
in
56.1llustrate
[Link]
[Link] [Link]
[Link]
