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Nobel Laureate Joseph Goldstein

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29 views9 pages

Nobel Laureate Joseph Goldstein

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peterhorscoff898
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© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
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Joseph L.

Goldstein
Joseph Leonard Goldstein ForMemRS (born April
18, 1940) is an American biochemist. He received the Joseph L. Goldstein
Nobel Prize in Physiology or Medicine in 1985, along
with fellow University of Texas Southwestern
researcher, Michael Brown, for their studies regarding
cholesterol.[2] They discovered that human cells have
low-density lipoprotein (LDL) receptors that remove
cholesterol from the blood and that when LDL
receptors are not present in sufficient numbers,
individuals develop hypercholesterolemia and become
at risk for cholesterol related diseases, notably
coronary heart disease.[3] Their studies led to the
Born Joseph Leonard Goldstein[1]
development of statin drugs.[2] April 18, 1940
Kingstree, South Carolina, U.S
Alma mater Washington and Lee University
Life and career
University of Texas Southwestern
Goldstein was born in Kingstree, South Carolina, the Medical Center
son of Fannie (Alpert) and Isadore E. Goldstein, who Known for cholesterol
owned a clothing store. His family is Jewish.[4]
Awards Heinrich Wieland Prize (1974)
Goldstein received his BSci from Washington and Lee
University in 1962, and his MD from the University of Richard Lounsbery Award (1979)
Texas Southwestern Medical School in 1966.[2] Upon Louisa Gross Horwitz Prize (1984)
completion of his residency, Goldstein moved to the Nobel Prize in Physiology or
National Institutes of Health (NIH) in Bethesda, Medicine (1985)
Maryland, where he worked in biochemical genetics.[5]
William Allan Award (1985)
In 1972, Goldstein relocated back to the Southwestern
National Medal of Science (1988)
Medical Center, accepting a post as the head of the
Division of Medical Genetics.[5] Scientific career
Fields biochemistry
At the Southwestern Medical Center Goldstein
collaborated extensively with Michael Brown, a fellow Institutions University of Texas Southwestern
researcher at the center who had also worked at the Medical Center

NIH.[5] From 1973 to 1985, Goldstein and Brown Website [Link]


together published over one hundred major papers.[6] /profile/12645/joseph-goldstein
They are both listed in Thomson Reuters’ index of .html ([Link]
highly cited authors.[7] Frequently mentioned as a [Link]/profile/12645/joseph-goldst
candidate for nationally prominent positions in [Link])
scientific administration, Goldstein, like his colleague
Michael Brown, chose to continue hands-on research.[8][9]
In 1993, their postdoctoral trainees, Wang Xiaodong and Michael Briggs ([Link]
[Link]/), purified the Sterol Regulatory Element-Binding Proteins (SREBPs), a family of membrane-
bound transcription factors. Since 1993, Goldstein, Brown, and their colleagues have described the
unexpectedly complex machinery that proteolytically releases the SREBPs from membranes, thus
allowing their migration to the nucleus where they activate all the genes involved in the synthesis of
cholesterol and fatty acids. The machinery for generating active SREBPs is tightly regulated by a
negative feedback mechanism, which explains how cells maintain the necessary levels of fats and
cholesterol in the face of varying environmental circumstances.[10][11][12]

Goldstein is chair, Molecular Genetics at University of Texas Southwestern Medical Center. Together,
Goldstein and Brown lead a research team that typically includes a dozen doctoral and postdoctoral
trainees. They have trained over 145 graduate students and postdoctoral fellows, and six of their former
postdoctoral fellows (Thomas C. Südhof, Wang Xiaodong, Helen H. Hobbs, David W. Russell, Monty
Krieger, and Russell DeBose-Boyd) have been elected to the U.S. National Academy of Sciences.[13]
Former postdoctoral fellow Thomas C. Südhof received the 2013 Nobel Prize in Medicine or
Physiology[14] and Helen H. Hobbs received the 2015 Breakthrough Prize in Life Sciences.[15][16]

In 1988 Goldstein received a National Medal of Science in the field of molecular genetics,[17] and in
2003 Goldstein and Brown won the Albany Medical Center Prize in Medicine and Biomedical Research
in recognition for their further work in understanding cholesterol and also the discovery of an insulin-
sensitive regulator, which potentially could be used to develop treatments for diabetes mellitus.[18]
Goldstein is a member of the U.S. National Academy of Sciences[19] and the Institute of Medicine[20] and
he was elected a Foreign Member of the Royal Society (ForMemRS) in 1991.[21]

Goldstein was appointed as chairman of the Albert Lasker Medical Research Awards jury in 1995,[22] and
was a recipient of the award ten years earlier.[23] Since 2000, Goldstein has authored a series of essays on
the deep relationship between art and science that appear in the annual Nature Medicine supplement that
accompanies the Lasker Awards.[24]

Among his professional activities, Goldstein is a member of the Board of Trustees of The Howard
Hughes Medical Institute[25] and of The Rockefeller University, where he was elected as a Life Trustee in
2015.[26] He also serves as chairman of the Board of Scientific Counselors of the Broad Institute,[27] and
is a member of the Board of Directors of Regeneron Pharmaceuticals, Inc.[28] He previously served on
The Board of Scientific Governors of the Scripps Research Institute, a nonprofit institute that conducts
biomedical research.[29]

Awards
Joseph L. Goldstein has been awarded the following:

2011 – Stadtman Distinguished Scientist Award, American Society for Biochemistry and
Molecular Biology[30]
2007 – Builders of Science Award, Research!America[31]
2005 – Woodrow Wilson Awards for Public Service[32]
2005 – Herbert Tabor Award, American Society for Biochemistry and Molecular Biology[33]
2003 – Albany Medical Center Prize in Medicine and Biomedical Research[34]
2002 – Kober Medal, Association of American Physicians[35]
1999 – Warren Alpert Foundation Prize, Harvard Medical School[36]
1991 – Elected a Foreign Member of the Royal Society (ForMemRS)[21]
1988 – U.S. National Medal of Science[37]
1987 – Elected member of the American Philosophical Society[38]
1986 – Golden Plate Award of the American Academy of Achievement[39]
1985 – Nobel Prize in Physiology or Medicine[40]
1985 – Albert Lasker Award for Basic Medical Research[41]
1985 – William Allan Award, American Society of Human Genetics[42]
1984 – Louisa Gross Horwitz Prize, Columbia University[43]
1981 – Gairdner Foundation International Award[44]
1981 – Elected member of the American Academy of Arts and Sciences[45]
1980 – Elected member of the National Academy of Sciences[46]
1979 – Richard Lounsbery Award, U.S. National Academy of Sciences[47]
1978 – Passano Award, Johns Hopkins University[48]
1976 – Pfizer Award in Enzyme Chemistry, American Chemical Society[49]

Research papers
Brown MS, Goldstein JL (June 2012). "Reflections – Scientific side trips: six excursions from
the beaten path" ([Link] J. Biol. Chem.
287 (27): 22418–22435. doi:10.1074/jbc.X112.381681 ([Link]
381681). PMC 3391146 ([Link]
PMID 22584575 ([Link]
Brown MS, Goldstein JL (May 2011). "Richard G.W. Anderson (1940–2011) and the birth of
receptor-mediated endocytosis" ([Link]
J. Cell Biol. 193 (4): 601–603. doi:10.1083/jcb.201104136 ([Link]
1104136). PMC 3166872 ([Link]
PMID 21576388 ([Link]
Goldstein JL, Brown MS (April 2009). "History of Discovery: The LDL Receptor" ([Link]
[Link]/pmc/articles/PMC2740366). Arterioscler. Thromb. Vasc. Biol. 29 (4):
431–438. doi:10.1161/ATVBAHA.108.179564 ([Link]
9564). PMC 2740366 ([Link]
PMID 19299327 ([Link]
Brown MS, Goldstein JL (April 2009). "Cholesterol feedback: from Schoenheimer's bottle to
Scap's MELADL" ([Link] J. Lipid Res. 50
(Supplement): S15–S27. doi:10.1194/jlr.R800054-JLR200 ([Link]
00054-JLR200). PMC 2674699 ([Link]
PMID 18974038 ([Link]
Brown MS, Goldstein JL (October 2004). "A tribute to Akira Endo, discoverer of a "penicillin"
for cholesterol". Atherosclerosis Supplements. 5 (3): 13–16.
doi:10.1016/[Link].2004.08.007 ([Link]
up.2004.08.007).
Brown MS, Goldstein JL (April 1986). "A receptor-mediated pathway for cholesterol
homeostasis". Science. 232 (4746): 34–47. Bibcode:1986Sci...232...34B ([Link]
[Link]/abs/1986Sci...232...34B). doi:10.1126/science.3513311 ([Link]
6%2Fscience.3513311). PMID 3513311 ([Link]
Brown MS, Goldstein JL (March 1974). "Familial hypercholesterolemia: defective binding of
lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-
methylglutaryl coenzyme A reductase activity" ([Link]
C388099). Proceedings of the National Academy of Sciences of the United States of
America. 71 (3): 788–792. Bibcode:1974PNAS...71..788B ([Link]
s/1974PNAS...71..788B). doi:10.1073/pnas.71.3.788 ([Link]
788). PMC 388099 ([Link] PMID 4362634
([Link]
Goldstein JL, Brown MS (October 1973). "Familial hypercholesterolemia: identification of a
defect in the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity
associated with overproduction of cholesterol" ([Link]
MC427113). Proceedings of the National Academy of Sciences of the United States of
America. 70 (10): 2804–2808. Bibcode:1973PNAS...70.2804G ([Link]
u/abs/1973PNAS...70.2804G). doi:10.1073/pnas.70.10.2804 ([Link]
as.70.10.2804). PMC 427113 ([Link]
PMID 4355366 ([Link]

Essays on "The Art of Science"


Since 2000, Goldstein has authored a series of essays considering science as a creative pursuit, and
explores the links between art and science. The essays have appeared in the journals Nature Medicine,
Cell, and most recently, PNAS. They coincide with the annual announcement of the Lasker Awards, with
which Goldstein is affiliated in the capacity of jury chairman. A collection of Goldstein's essays titled The
Art of Science was published in 2023.

Joseph L. Goldstein (September 26, 2023). "The secret to a successful career in science--
according to Magritte" ([Link] PNAS.
120 (39). doi:10.1073/pnas.2304819120 ([Link]
PMC 10523505 ([Link]
PMID 37732754 ([Link]
Joseph L. Goldstein (September 2022). "The art and science of building castles in the sky
and houses of cards that don't collapse" ([Link]
Cell. 185 (21): 3839–3843. doi:10.1016/[Link].2022.08.027 ([Link]
2022.08.027). PMID 36174577 ([Link]
Joseph L. Goldstein (September 2021). "The surprise element: A hallmark of creativity in
scientists, artists, and comedians" ([Link] Cell. 184
(21): 5261–5265. doi:10.1016/[Link].2021.08.007 ([Link]
07). PMID 34562364 ([Link]
Joseph L. Goldstein (September 2020). "The Spanish 1918 Flu and the COVID-19 Disease:
The Art of Remembering and Foreshadowing Pandemics" ([Link]
c/articles/PMC7560262). Cell. 183 (2): 285–289. doi:10.1016/[Link].2020.09.030 ([Link]
rg/10.1016%[Link].2020.09.030). PMC 7560262 ([Link]
s/PMC7560262). PMID 33064981 ([Link]
Joseph L. Goldstein (September 2019). "Seurat's Dots: A Shot Heard 'Round the Art World
—Fired by an Artist, Inspired by a Scientist" ([Link]
Cell. 179 (1): 46–50. doi:10.1016/[Link].2019.07.051 ([Link]
7.051). PMID 31519312 ([Link]
Joseph L. Goldstein (September 2018). "What Makes a Piece of Art or Science a
Masterpiece?" ([Link] Cell. 175 (1): 1–5.
doi:10.1016/[Link].2018.08.026 ([Link]
PMID 30217357 ([Link]
Joseph L. Goldstein (September 2017). "Artists Create Puzzles, Scientists Solve Them" (htt
ps://[Link]/10.1016%[Link].2017.08.022). Cell. 171 (1): 5–9.
doi:10.1016/[Link].2017.08.022 ([Link]
PMID 28888326 ([Link]
Joseph L. Goldstein (September 2016). "The Rule of Three for Prizes in Science and the
Bold Triptychs of Francis Bacon" ([Link] Cell. 167
(1): 5–8. doi:10.1016/[Link].2016.08.040 ([Link]
PMID 27634320 ([Link]
Joseph L. Goldstein (September 2015). "A Well-Hung Horse: Sired by Knowledge and
Imagination" ([Link] Cell. 162 (6): 1179–1182.
doi:10.1016/[Link].2015.08.039 ([Link]
PMID 26359973 ([Link]
Joseph L. Goldstein (October 2014). "Balzac's Unknown Masterpiece: spotting the next big
thing in art and science". Nature Medicine. 20 (10): 1106–1111. doi:10.1038/nm.3676 (http
s://[Link]/10.1038%2Fnm.3676). PMID 25295945 ([Link]
45). S2CID 3558056 ([Link]
Joseph L. Goldstein (October 2013). "Juxtapositions in Trafalgar Square: tip-offs to creativity
in art and science". Nature Medicine. 19 (10): 1222–1226. doi:10.1038/nm.3329 ([Link]
org/10.1038%2Fnm.3329). PMID 24100991 ([Link]
S2CID 22189523 ([Link]
Joseph L. Goldstein (October 2012). "Paradigm shifts in science: insights from the arts".
Nature Medicine. 18 (10): 1473–1477. doi:10.1038/nm.2923 ([Link]
2923). PMID 23042355 ([Link] S2CID 27954297 (http
s://[Link]/CorpusID:27954297).
Joseph L. Goldstein (October 2011). "The card players of Caravaggio, Cézanne and Mark
Twain: tips for getting lucky in high-stakes research". Nature Medicine. 17 (10): 1201–1205.
doi:10.1038/nm.2465 ([Link] PMID 21989010 ([Link]
[Link]/21989010). S2CID 26830785 ([Link]
6830785).
Joseph L. Goldstein (October 2010). "How to win a Lasker? Take a close look at Bathers
and Bulls". Nature Medicine. 16 (10): 1091–1096. doi:10.1038/nm1010-1091 ([Link]
10.1038%2Fnm1010-1091). PMID 20930751 ([Link]
S2CID 31919299 ([Link]
Joseph L. Goldstein (October 2009). "Lasker Awards and papal portraiture: turning fields
upside down". Nature Medicine. 15 (10): 1137–1140. doi:10.1038/nm1009-1137 ([Link]
org/10.1038%2Fnm1009-1137). PMID 19812573 ([Link]
3). S2CID 26946901 ([Link]
Joseph L. Goldstein (October 2008). "Exuberant unpredictability: sine qua non for priceless
and prizeworthy biomedical research". Nature Medicine. 14 (10): 1029–1032.
doi:10.1038/nm1008-1029 ([Link] PMID 18841142 (htt
ps://[Link]/18841142). S2CID 36086102 ([Link]
CorpusID:36086102).
Joseph L. Goldstein (October 2007). "Creation and revelation: two different routes to
advancement in the biomedical sciences". Nature Medicine. 13 (10): 1151–1154.
doi:10.1038/nm1642 ([Link] PMID 17917663 ([Link]
[Link]/17917663). S2CID 29403975 ([Link]
9403975).
Joseph L. Goldstein (October 2006). "Venture science: climbing the ladder to telomerase,
cognitive therapy and in situ hybridization". Nature Medicine. 12 (10): 1129–1132.
doi:10.1038/nm1006-1129 ([Link] PMID 17024207 (htt
ps://[Link]/17024207). S2CID 5938083 ([Link]
CorpusID:5938083).
Joseph L. Goldstein (October 2005). "60 years of winged victories for biomedical research".
Nature Medicine. 11 (10): 1023–1025. doi:10.1038/nm1005-1023 ([Link]
Fnm1005-1023). PMID 16211026 ([Link]
S2CID 33375813 ([Link]
Joseph L. Goldstein (October 2004). "Towering science: an ounce of creativity is worth a ton
of impact". Nature Medicine. 10 (10): 1015–1017. doi:10.1038/nm1004-1015 ([Link]
10.1038%2Fnm1004-1015). PMID 15459692 ([Link]
S2CID 35721266 ([Link]
Joseph L. Goldstein (October 2003). "It's a grand year for celebrating science". Nature
Medicine. 9 (10): 1237–1238. doi:10.1038/nm937 ([Link]
PMID 14520362 ([Link] S2CID 5661980 ([Link]
[Link]/CorpusID:5661980).
Joseph L. Goldstein (October 2002). "Synergy and symbiosis à la Matisse-Picasso". Nature
Medicine. 8 (10): 1053–1054. doi:10.1038/nm768 ([Link]
PMID 12357230 ([Link] S2CID 30056843 ([Link]
[Link]/CorpusID:30056843).
Joseph L. Goldstein (October 2001). "Knockout mice and test-tube babies". Nature
Medicine. 7 (10): 1079–1080. doi:10.1038/nm1001-1079 ([Link]
1-1079). PMID 11590416 ([Link] S2CID 2396219 (htt
ps://[Link]/CorpusID:2396219).

See also
List of Jewish Nobel laureates

References
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ates/1985/[Link]). [Link] (1940-04-18). Retrieved on 2013-10-08.
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Lederberg (1958) is set to retire as president of Rockefeller University in January... Things
might not have grown so tense had the man who apparently was at the top of the list said
"Yes." But Nobel laureate Joseph Goldstein (1985), who is still very active in the laboratory
at the University of Texas at Dallas, was not ready to give up his work on the molecular
genetics of blood lipids."
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bel-prize-winners-robert-lefkowitz-joseph-goldstein-and-michael-brown/30529) Archived (htt
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u/Academic/AlbanyPrize/Recipients/recipients_previous/[Link]) Albany Medical College
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[Link]/articles/view/120039/files/pdf) The Journal of Clinical Investigation
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Archived ([Link]
2012-04-10 at the Wayback Machine Warren Alpert Foundation
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cip_details.cfm?recip_id=142) National Science Foundation
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ml#allan) Archived ([Link]
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43. The Louisa Gross Horwitz Prize for Biology or Biochemistry ([Link]
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t/joseph-l-goldstein) Gairdner Foundation
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-goldstein) at the Wayback Machine
46. "Joseph Goldstein" ([Link]
[Link]. Retrieved 23 March 2018.
47. Richard Lounsbery Award ([Link]
[Link]) National Academy of Sciences
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30) The Passano Foundation
49. The Pfizer Award ([Link] Archived ([Link]
[Link]/web/20210731165454/[Link]
2021-07-31 at the Wayback Machine ACS Division of Biological Chemistry

External links
Joseph L. Goldstein ([Link] on [Link]
Journal of Clinical Investigation Interview ([Link]
p://[Link]/movie/interview-with-nobel-prize-winners-robert-lefkowitz-joseph-gol
dstein-and-michael-brown/30529).
Joseph Goldstein ([Link] Nobel Luminaries
Project, The Museum of the Jewish People at Beit Hatfutsot

Retrieved from "[Link]

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