Cream base
[Link] Items Qty %
1 Cetostearyl alcohol 8%
2 Cetomacrogol 2%
3 Paraffin wax 2.5 %
4 Microwax 1.5 %
5 Light liquid paraffin 10 %
6 Water 70 %
7 Propylene glycol 6%
INGREDIENTS SPECIFICATION QUANTITY in % Function
w/w
Betamethasone BP 0.105 Active drug
valerate
Chlorocresol BP 0.100 Preservative
Cetomacrogal BP 2.0 Emulsifier
Cetostearyl alcohol BP 8.0 Emulsifier
White soft paraffin BP 15.33 Oil phase
BP Emollient
Propylene glycol 5.86
BP
Purified water BP 68.60 Aqueous phase
Polyethylene glycol ointment
PEG 4000 40 G
PEG 400 60 G
Melt both items at 600c allow to cool,and stir until congealed.
For firmer preparation
PEG 4000 50 G
PEG 400 50 G
If 6 to 25% aqueous items to be incorporated
PEG 4000 35 G
PEG 400 60 G
Stearyl alcocol 5G