ADVANCE PHARMACOLOGY -II

1. Which of the following is an anti-thyroid drug?

a. Prophythiouracil b. Warfarin c. Propranolol d. Phenytoin

2. Which of the following drug is alpha-glucosidase inhibitor?

a. Metformin b. Acarbose c. Bromocroptine d. Thiouracil

3. Which of the drugs is used for Emergency contraception

a. Levonorgestrel b. Mifepristone c. Ulipristal d. All of these

4. Etidronate is a:

a. Biphosphonate b. Corticosteroid c. Oral hypoglycemiuc d. All of these

5. The hormone secreted by lactotroph or mammotrph cells is:

a. Oxytocin b. Prolactin c. HCG d. All of these

6. A somatostatin analogue is:

a. Octreotide b. Acarbose c. Bromocroptine d. Thiouracil

7. Nafarelin is used as a nasal spray for:

a. Endometrosis b. Hyperthydoism c. Hypothyroidism d. All of these

8. Regular insulin has a duratioin of action of:

a. 2-4 hr b. 5-8hr c. 10-12 hr d. 24-36 hr

9. Pioglitazone is used for:

a. Hyperglycemia b. Hyperthydoism c. Hypothyroidism d. All of these

10. Stanozolol and Oxandrolone are:

a. Antidiabetic drugs b. Anti-thyroid drugs d c. Anabolic steroids

d. All of these
11. The drug that stimulates ovulation in female is:

a. Clomiphene citrate b. Prolactin c. Octreotide d. All of these

12. Which of the following is a hypocalcemic hormone:

a. Parathhormone b. Calcitonin c. Oxytocin d. Prolactin

13. A beta lactamase inhibitor is:

a. Clavulinic acid b. Sulbactam c. Tazobactam d. All of these

14. The first line agent for Tuberculosis is an aminoglycoside antibiotic, known as:

a. Streptomycin b. Azithromycin c. Neomycind. All of these

15. Isonicotinoyl radical ctive metabolite of:

a. Isoniazid b. Rifampin c. Chloramphenicol d. None of these

16. Zidovudine is a:

a. NRTI b. NNRTI c. Protease inhibitor d. All of these

17. Which of these drugs is prodrug of Ampicillin?

a. Talampicillin b. Pivampicil c. Bacampicillin d. All of these

18. The main limitations of Erythromycin is

a. Its spectrum is narrow b. Has low oral bioavailability c. Has significant GI

side effects d. All of these

19. Terbinfine is a:

a. Anti-viral drug b. Anti-fungal drug c. Anti-leprotic d. All of these

20. Polyene antibtiotic effective as an antifungal drug is:

a. Flucytosine b. Ketoconazole c. Nystatin d. All of these

21. A reversible inhibitor of renal dipeptidase that inhibits breakdown and inactivation
of imipenem is:

a. Cilastatinb. Aztreonam c. Mezcillin d. All of these

22. A steroidal antimicrobial drug that is exclusively used against Beta-lactamase
producing S. aureus is:

a. Polymixin-B b. Fusidic acid c. Tedizolid d. Clindamycin

23. Raltegravir is a:

a. Integrase inhibitor b. Mucolytic drug c. Bacteriocidal drug

d. None of these

24. Methotrexate is a:

a. Purine antagonist b. Pyrimidine antagonist c. Folate antagonist

d. None of these

25. Ipratropium bromide is used a:

a. bronchodialator b. mydriatic c. anti-viral drug d. anti-fungal drug

26. Cyclosporine and Tacrolimus are:

a. Calcineurin inhibitors b. Antimetabolites c. Antifungal drugs

d. Immunostimulants

27.Campothecin analogs such as Topotecan and Irinitecan are:

a. Topoisomerase I inhibitors b. Topoisomerase II inhibitors

c. Monoclonal antibodies d. All of these

28. The drug that inhibits activation of T-lymphocytes is

a. Sirolimus b. Rifampicin c. Ampicillin d.

Fusidic acid

29. Which of these drugs is a prodrug?

a. Azathioprine b. Thalidomide c. Penicillin G d. All of these

30. Ketotifen is a:

a. mast cell stabilizer b. leukotriene antagonist c. glucocorticoid

31. Mepolizumab and Reslizumab are monoclonal antibodies used for:

a. Peptic ulcer b. Candidiasis c. Bronchial asthma d. None of these

32. Ivermectin and Niclosamide are:

a. Antimalarial drugs b. Antihelmenthic drugs c. Anticancer

drugs

d. All of these

33. A common adverse effect associated with chronic use of aluminium containing
antacids is:

a. gastrointestinal bleeding b. flatulence c. diarrhea d. constipation

34. Dioctyl sodium sulfosuccinate is a:

a. lubricant b. stool softner c. antidiarrheal d. antiemetic

35. Which of the following is a gallstone dissolving drug:

a. Chenodiol b. Papain c. Diatase d. Granisetron

36. Atropine is added to Diphenoxylate in antidiarrheal preparations mainly to:

a. potentiate its anti-diarrheal action

b. to decrease gastric motility and enhance absorption

c. to discourage abuse of this opioid preparation

d. reduce systemic absorption of diphenoxylate and promote local action

37. The active constituents of Castor oil is:

a. Anthraquinone glycosides b. Ricinoleic acid c. Peppermint oil

d. Diphenoxylate

38. Which of the following drugs is a lipase inhibitor, used to suppress appetite:

a. Sibutramine b. Orlistat c. Phentermine d. Diethylpropion

39. Orexigenics refer to:

a. Appetite stimulants b. Appetite suppressants c. Mood stabilizers

d. Memory enhancers

40. Which of the following statements about Omeprazole is true:

a. Omeprazole is a prodrug

b. Omeprazole is preferably absorbed from stomach

c. Omeprazole is a H2 antagonist

d. Omeprazole stimulates metabolism of warfarin, phenytoin, diazepam and

cyclosporine

41. Sucralfate should not be coadministered with:

a. Aluminium hydroxide gel b. Sodium bicarbonate c. Ranitidined. All of

these

42. Which of drug is an angiogenesis inhibitor:

a. Bevacizumab b. Nystatin c. Bromocriptine d. Chlorambucil

43. Platinum complexes used for cancer include:

a. Cisplatin b. Carboplatin c. Aurofin d. Both Cisplatin and Carboplatin

44. Which of the following anti-hypertensive drugs is both an arteriolar and venous
vasodilator:

a. Hydralazine b. Minoxidil c. Diazoxided. Sodium nitroprusside

45. Cisapride has been withdrawn from markets of some countries, because:

a. Vestibular toxicity

b. Nephrotoxicity

c. Hepatotoxicity

d. Cardiac toxicity, serious cardiac arrhythmias and sudden death

46. The cholinesterase reactivator which crosses Blood brain barrier is:

a. Pralidoxime b. Diacetylmonooxime c. MINA d. Tacrine

47. Hypertrophy refers to:

a. an abnormal increase in number of cells in a tissue

b. an enlargement or overgrowth of an organ

c. excessive perspiration

d. excessive sensitivity of the skin

48. Contact dermatitis and rejection of transplanted tissue are examples of:

a. Type I allergic reaction

b. Type II allergic reaction

c. Type III allergic reaction

d. Type IV allergic reaction

49. Patients receiving Levodopa should avoid using vitamin supplements that contain:

a. folic acid b. pyridoxine c. ascorbic acid d. riboflavin

50 . Which of the following is mechanism of action of anti-parkinsonian drug Slegiline:

a. Non-selective MAO inhibitor

b. Selective irreversible inhibitor of MAO-B

c. Dopamine agonist at D2 receptors, and antagonist at D1 receptors

d. Irreversible inhibitor or GABA transaminase

 ADVANCE PHARMACOLOGY-II

1. What are disorders due to excess of Growth hormone? Explain mechanism of action
and Adverse effects of Octreotide.

2. What is hyperprolactinemia? Name the drugs used for hyperprolactinaemia.

3. What are the therapeutic indications and adverse effects of Levothyronine?

4. Write a short note on oral contraceptives.

5. How is corticosteroid therapy utilized for the treatment of Bronchial asthma?

6. What is the physiological role of Calcitonin and Parathormone?

7. How is insulin production regulated in humans? What are Diabetes mellitus and its
complications? Write a short note on Metformin.

8. a. Write a short note on Finasteride.

b. Write a short note on Clomiphene citrate

c. Write a short note on Tamoxifen Citrate

9. How is thyroid hormone production regulated? What are the disorders of thyroid
hormone production? Write a short note on Anti-thyroid drugs.

10. What are the various Insulin preparation available? What is the role of Calcium in
body and is calcium homeostatis regulated? Write a short note on anabolic steroids.

11. a. Write a short note on sex hormones.

b. What are the physiological effects of corticosteroids in humans.

12. a. Write a short note on incretinmimetics.

b. What are the therapeutic uses and adverse effects of Radioactive iodine?

13. Classify Penicillins.

14. Classify Anti-viral drugs

15. Write a note on adverse effects of Aminoglycoside antibiotics.

16. Explain antimicrobial Drug resistance and its Remedy.

17. Explain DOTS therapy as recommended by WHO.

18. Classify Cephalosporins based on their generation. Write a note on Beta Lactamase
inhibitors. What are the Therapeutic indications of Quinolone antibiotics?

19. Classify anti-fungal drugs. What therapeutic options are available for HIV? Explain
the mechanism of action of NRTI and NNRTI as anti-viral drugs.

20. a. Write a note on first line antitubercular drugs.

b. What is the mechanism of action, therapeutic uses and adverse effects of

Macrolide antibiotics.

21. a. What is the mechanism of action, therapeutic uses and adverse effects of
Aminoglycoside antibiotics.

b. What is the mechanism of action, therapeutic uses and adverse effects of

Penicillins.

22. a. Write a note on Carbopenems.

b. What is the mechanism of action, therapeutic uses and adverse effects of

Ketoconazole.

23. Classify the drugs used for Malaria.

24. What is inflammation? Explain the role of various inflammatory mediators.

25. What are immunostimulants? What are their therapeutic indications?

26. What is cancer? Classify anti-cancer drugs. Explain the mechanism of action of
Cyclophosphamide.

27. What is bronchial asthma? Explain its Pathophysiology. Classify the drugs used for
bronchial asthma.

28. What are immunosuppressants? What are the therapeutic indications of

immunosuppressants? Explain the mechanism of action of Cyclosporine.

29. What is irritable bowel syndrome? What drugs are used for the disorder?

30. What are anti-emetic drugs and their therapeutic indications?

31. Classify the drugs used for constipation.

32. What is Peptic ulcer? Classify the drugs used for ulcer? Write the mechanism of
action, therapeutic indications and adverse effects of Ranitidine.

33. What is chronopharmacology? What is the application of chronotherapy in the

treatment of various cardiovascular diseases?

34. Explain he biological and circadian rythms in human system. What is the application
of chronotherapy in the treatment of bronchial asthma?

35. How are free radicals generated in human body? How do they harm human body?

36. Classify anti-oxidants.

37. Explain the Pathophysiology of Parkinson’s disease as a neurodegenerative disease.

38. What is the Pathophysiology of Alzheimer’s disease? What are the recent advances
in the treatment of Alzheimer’s.

39. What is the Pathophysiology of Diabetes? What are the recent advances in the
treatment of Diabetes.

40. What is the role of free radicals in the Pathophysiology of Cancer? What are the
recent advances in the treatment of Cancer.