1.
As per BCS classification a drug is considered to be highly permeable
(A) the extent of absorption in human is excepted to be>90% of the administered dose
(B)the extent of absorption in human is excepted to be <90% of the administered dose
(C) the extent of absorption in human is excepted to be >50% of the administered dose
(D) the extent of absorption in human is excepted to be <50% of the administered dose
2. As per BCS classification a drug is considered highly soluble when the highest dose strength is soluble
in
(A) 250ml or less of aqueous medium over the pH range of 1-8
(B)500ml or more of aqueous medium over the pH range of 1-8
(C)250ml or more of aqueous medium over the pH range of 1-8
(D)500ml or less of aqueous medium over the pH range of 1-8
3. Cyclodextrins are used in pharmaceutical applications for improving the bioavailability of drugs
belongs to which class, according to the BCS classification
(A)class I
(B)class II
(C)class III
(D)class IV
[Link] to BCS classification , the drugs having low solubility and high permeability are classified in
a. Class I
b. Class II
c. Class III
d. Class IV
5. According BCS , the drugs have low solubility and low permeability belongs to
a. Class I
b. Class II
c. Class III
d. Class IV
6. According to the BCS classification, which class of drugs often considered as poor drug candidates for
oral administration
(A)class I
(B)class II
(C)class III
(D)class IV
7. Choose the right sentence.
(A) Picking means tablet material adhered to the wall of die cavity.
(B) Sticking means tablet material adhered to the wall of die cavity.
(C) Sticking means small amount of tablet powder adhered to punch face after
compression.
(D) Sticking means particles stick to each other and forms a segregated mass.
8. Adhesion of tablet material to die wall is called
a) Mottling
b) Sticking
c) Picking
d) Capping
9. Poorly mfged Tablets have small pinholes on the surface known as
(A) Mottling
(B) Picking
(C) Cracking
(D) Leaching
10. Unequal distribution of color on the surface of tablet is called
a. Weight Variation
b. Capping
c. Mottling
d. Picking
11. …….. is a defect in which film of a tablet become dull or hazed after a prolonged period of storage
a. Chipping
b. Blooming
c. Blushing
d. Blistering
12. Too rapid evaporation of the solvent from tablet coat may result
(A)bloom
(B)dull film
(C)blistering
(D)hazing
13. The segregation of tablet into two or more layers is termed as
a. Capping
b. Lamination
c. Chipping
d. Cracking
[Link] of the following defect is due to highly viscous coating solution?
(A) Lamination
(B) Orange peel
(C) Cracking
(D) Blooming
15. The friability test for tablets determines the
(A)durability of a tablet to withstand handling
(B)time taken for a tablet to disintegrate
(C) rate at which drug release occurs
(D)none of the above
16. Granules for compression into tablets may be lubricated with
(A)magnesium stearate
(B)magnesium sulphate
(C)magnesium phosphate
(D)magnesium carbonate
17. The acceptable weight loss in case of conventional tablets after friability test is about
(A)less than 0.5 to 1%
(B)more than 0.5 to 1%
(C)less than 2 to 4%
(D)more than 2 to 4%
18. Which one of the following test is performed to assure uniform potency for tablets of low dose drugs
(A)friability test
(B)hardness test
(C)content uniformity test
(D)disintegration test
19. To assess the resistant of tablet to abrasion, the test performed is known as
a) Hardness test
b) Disintegration test
c) Friability test
d) None of the above
20. Apparatus use for the evaluation of tablet friability
a. Monsanto tester
b. Roche friabilator
c. Disintegration apparatus
d. Rotary tablet press
21. Durability of tablet to combined effect of shock and abrasion is evaluated by using
(A) Hardness tester
(B) Disintegration test apparatus
(C) Friabilator
22. Water for injection differs from sterile water for injection because it is free from
(A) Carbon dioxide
(B) Pyrogen
(C) Preservative
(D) Anti-Oxidant
23. When the term “sterile dosage form” is used,it refers to a product
(A)free from particular matter
(B)free from dissolved gases
(C)free from living microorganisms
(D)free from pyrogens
24. Which animal is used in pyrogen test?
a. Mice
b. Rabbit
c. Cat
d. Rat
25. Pyrogen can be completely destroyed from parenteral container by:
(A) Heating at 650˚F for 60 sec.
(B) Heating at 650˚C for 60 sec.
(C) Heating at 650˚C for 60 min
(D) Heating at 210 ˚C for 60 min
26. Standard temp. for autoclaving is
A. 120°C for 1hr/650°C for 1min.
B. 100°C for 1hr/ 630°C for 1min.
C. 140°C for 5hr/610°C for 1min.
D. 120°C for 5hr/660°C for 1min.
27. Which of the following is commonly used as a preservative in eye drops?
(A) Propyl paraben
(B) Butylated hydroxy Toluene
(C) Phenol
(D) Benzalkonium chloride
28. The direction “To be used within 30 days after first opening.” is given for ______
a) Suppositories
b) Mixture
c) Paste
d) Eye drops
29. Which of the following is used as vehicle in ophthalmic drops
a) Ethanol
b) Methanol
c) Isopropyl alcohol
d) Boric acid
30. Ingredient used to increase the viscosity of eye drops
a. Buffers
b. Preservative
c. Thickening agent
d. None of the above
31. The container used to protect the product from contamination and as well as from loss of contents
during use are called
a) Well-closed containers
b) Air tight containers
c) Light-resistance containers
d) Multiple dose containers
32. Non parental type of glass consists of which of the following type
(A) Type -I
(B) Type -II
(C) Type -III
(D) Type -IV
33. Which of the following is used as Vulcanizing agent in manufacture of rubber closure?
a) Sulphur
b) Activated carbon black
c) Talc
d) Stearic acid
34. The package composed of base layer having cavities which hold the pharmaceutical product and a lid
is called
a) Strip Package
b) Child resistant package
c) Blister Package
d) Well closed package
35. ……… is also known as hermetic container
a. Multi-dose Container
b. Air-tight Container
c. Well-closed container
d. Aerosol container
36. Which type of glass container is not generally used for parenteral preparation?
(A) Type 1
(B) Type 2
(C) Type 3
(D) Type 4
37. Type 2 glass is also known as….
(A) Highly resistant borosilicate glass
(B) Treated soda lime glass
(C) Soda lime glass
(D) General purpose soda lime glass
38. Leaker Test is carried out for
(A) Vials
(B) Ampoules
(C) Bottles
(D) All of Above
39. Type II glass is prepared from Type III glass by surface treatment with;
(A) Lime
(B) Oxygen
(C) Sulfur dioxide
(D) Silicon
40. The water resistance of glass container is tested by measuring;
(A) Amount of acid released into water
(B) Amount of alkali leached into water
(C) Determination of Silicon Level
(D) After Autoclaving turbidity of an aqueous solution
41. Aspirin USP tablets should be packed and stored in:
(A) Well closed container
(B) Tightly closed container
(C) Light resistant container
(D) Both B&C
[Link] of pharmaceutical product will…….
(A) Protect the drug from light and other environmental factors
(B) Helps in identifying the drug products
(C) Protect from damage occurring during the transportation
(D) All of above
43. It is also called as surface treated soda lime glass.
(A) USP type I
(B) USP type II
(C) USP type III
(D) USP type IV
44. The following type of Glass is used for packaging of food products
(A) USP type I
(B) USP type II
(C) USP type III
(D) USP NP type
45. The following type of Glass is used for packaging of topical products
(A) USP type I
(B) USP type II
(C) USP type III
(D) USP NP type
46. If the product containing high amount of alcohol, ethers or organic acids then we should avoid use
of………………….. For packaging of these products.
(A) Metal
(B) Glass
(C) Plastic
(D) Any of the above can be used
47. Hermetically sealed container
(A) Protect loss of product during handling
(B) Is Impervious to air
(C) Is Light resistant
(D) Prevent loss of product from effectiveness
48. Hermetic container are used for;
(A) Oral solution
(B) Powder
(C) Injectable
(D) None
49. Soda lime glass not suitable for parenteral solution because.
(A) Mechanically weak
(B) Release Alkali
(C) Losses brilliancy
(D) None
50. Ferrous or manganese oxide is added during the manufacture of glass container to make
(A) Alkali resistant
(B) Eory mould able
(C) Colored glass
(D) None
51. Plastic container is not suitable because
(A) Permeable to gases
(B) Additives leach out from plastic
(C) Adsorb ingredient from product
(D) All of above
Which one of this material is commonly used for closures?
(A) Rubber
(B) Metal
(C) Glass
(D) Plastic
