PAPER I have following Subject :

1. Anatomy
2. Physiology, pharmacology,and Biochemistry
3. Pathology & Microbiology
4. Research and Biostatistics, Epidemiology
5. Behavioural Science, Medical Ethics

PAPER II have following subject :

1. Anatomy, Histology, and Embryology

2. Physiology, and Biochemistry
3. Pathology, Microbiology & Immunology
4. Pharmacology
5.

Paper I

FCPS part 1 : PAPER I

1. ANATOMY

1. Gross Anatomy

1. Muscles
2. Joints
3. Major Blood Vessels

2. Embryology (General aspects)

3. Histology (General)

1. Types of tissues
2. Epithelia
3. Muscles
 4. Nerve
5. Blood Vessels
6. Fibro fatty tissue
7. Lymph Nodes

4. Brain and Spinal Cord (Central Nervous System) Gross

Structure,Spinal Nerves (Origin and distribution, Action, and
Function), Cranial Nerves, Peripheral Nerves.
5. Head and Neck (General Aspects)
6. Viscera(Soft ogan): Gross Structure

1. Heart
2. Lung
3. Kidney

7. Anatomical Outline-Bronchial Tree

8. Endocrine Glands – Anatomical Structure of-

1. Pituitary,
2. Thyroid,
3. Parathyroid and
4. Adrenal Glands etc

2. PHYSIOLOGY, PHARMACOLOGY & BIOCHEMISTRY

2.1. General Physiology

1. Components of cell & cytoplasm with their functions (in

general) & transport across the cell membranes.
2. Nerves & Muscle Contraction
3. Classification & properties of nerve fibers,
4. Receptors (types, properties & functions)
 5. Function of motor & sensory areas of Brain.
6. CSF/Cerebrospinal Fluid, it’s formation, functions, drainage,
lumbar puncture.
7. Autonomic nervous system(Sympathetic & parasympathetic)
– (outflow and responses of affected organs)
8. General properties and composition of blood.
9. Normal counts and functions of Erythrocyte/RBCs,
Leucocyte/WBCs, Platelets
10. Mechanism of homeostatic coagulation factors and their
actions.
11. Blood groups (types, antigens, antibodies, phenotypes,
genotypes and significance)
12. Conducting tissues of heart (generation and propagation
of cardiac impulse).
13. Cardiac cycle (pressure, volumes, valvular changes),
14. Blood pressure and its regulation (general)
15. Respiratory and non-respiratory functions of respiratory
tract
16. Body fluids, compartments and regulations of Osmotic
equilibrium & acid base balance.
17. Regulation of extra cellular fluid(ECF) and blood volume
18. General functions of kidney
19. Regulations of body temperature

2.2. Pharmacology

1. General principles of rational drug therapy

2. Clinical pharmacokinetics
3. Adverse reactions of common drugs

2.3. Biochemistry
 1. Requisites of a balanced diet
2. General principles of electrolyte balance
3. Role and function of endocrine hormones
4. Metabolism of carbohydrates, protein, fats and vitamins

3. PATHOLOGY INCLUDING MICROBIOLOGY

1. Effects of injury on cell by physical, chemical and biological

agents
2. Inflammation (Acute & Chronic Including granulomatous)
3. Regeneration and repair
4. Metabolic response to trauma
5. Disturbance of homeostatic mechanism (hemorrhage and
shock and Oedema)
6. Thrombosis and embolism, infarction and gangrene
7. Disorders of growth (adaptation, atrophy, hypertrophy,
hyperplasia)
8. Carcinogens and pre-malignant lesions
9. Neoplasia: General classification and its spread
10. General aspects of tumor markers
11. General characteristics of bacteria, viruses, chlamydia,
recketsia, parasites and fungi
12. Immunology and Immune system: General principles
13. Medical genetics – basic concepts
14. Interpretation of routine biochemical tests e.g liver function
test, glucose, urea and creatinine.
15. Nutritional diseases: deficiency of vitamins and
minerals,PEM.

4. RESEARCH AND BIOSTATISTICS – BASIC CONCEPTS EPIDEMIOLOGY

An introduction to epidemiology and its role in understanding
distribution and determinants of disease.
Measure of disease occurrence
Screening
Biostatistics:

1. Introduction to biostatistics
2. Data and its kinds
3. Summarization of data
4. Normal distribution
5. Point and interval estimation and probability
6. Hypothesis testing, significance level and power

5. BEHAVIORAL SCIENCE AND MEDICAL ETHICS – GENERAL PRINCIPLES

1. Medical Ethics
2. Communication skills including doctor patient relationship
and counseling
3. Psycho social aspects of general healthcare

Read more:

Paper II

FCPS part 1 (PAPER II) : Medicine & Allied

1. ANATOMY, HISTOLOGY, and EMBRYOLOGY
1. Embryology: Development of heart, Brain, Kidney Common
developmental defects.
2. Histology
Liver
Pancreas
Spleen
Kidney
Brain
GIT

3. Regional Anatomy:
Structure and General disposition
4. Upper Limb:
Pectoral girdle and axilla
Breast
Arm
Forearm
Wrist
Hand
Innervation of muscles
Osteology
5. Lower Limb:
Gluteal region and hip joint
Thigh
Popliteal fossa and knee joint, leg
Ankle and Foot
Innervation of muscles
Osteology

[Link]:
Thoracic wall and diaphragm
Heart
Mediastinum
Pleura
Lungs
7. Abdomen:
Anterior abdominal wall
Peritoneum
Gastro Intestinal tract
Liver and biliary tract
Pancreas
Spleen
Kidney
Ureters
Suprarenal gland
8. Pelvis:
Pelvic cavity
Urinary bladder
Male genital organs and urethra
Female genital organs
Pelvic vessels
Nerves
Pelvic joint and ligaments
Lumber and sacral plexuses
9. Head, Neck, Spine:
Cranial cavity and meninges
Vertebral column and vertebral canal
Scalp
Face
Parotid glands
Nose and sinuses
Oral cavity
Pharynx

10. Central Nervous System:

Cereberum – Internal structure
Cortical areas
Cerebellum
Brain stem
Descending and Ascending tracts
Special senses – Anatomical pathway
O Visual
O Tastes
o Olfactory
Autonomic Nervous System

2. PHYSIOLOGY & BIOCHEMISTRY

1. Kidney:
Functions of kidney
Glomerular filtration – determinants
Tubular reabsorption and secretion
Regulation of Sodium. Potassium,
Calcium, Phosphate and Magnesium
concentration
Micturition

2. The Heart:
Physiology of cardiac muscle
Cardiac cycle
Relationship of the heart sound to heart
pumping, cardiac output
Electrical Activity of the Heart
Electro cardiogram – characteristics
Vectorial analysis of E.C.G.- Abnormalities
Cardiac Arrhythmias
3. The Circulation:
Capillary fluid exchange
Interstitial fluid and lymph flow
Nervous Regulation of the circulation
Control of blood pressure
Humoral control of circulation
Circulation through special regions –
Cerebral, Coronary, Pulmonary & splanchnic
Cardiovascular changes in exercise

4. Gastro Intestinal System:

Motility and propulsion. Nervous Control
Secretory function
Digestion and absorption – Malabsroption
syndrome
Functions of liver – Metabolic functions
Bilirullin formation and excretion – types
of jaundice
Energy Metabolism – Energy requirement
Defecation
Vomiting
5. Respiratory System:
Pulmonary Ventilation: Ventilation – Perfusion ratio
Principles of gas cxchango – diffusion of gases
Pulmonary Capillary dynamics
Regulation of respiration, Lung function tests
Respiratory insufficiency – Hypoxia
Cyanosis
Oxygen therapy
Hypocopnia, Hypercapnia
Respiratory changes in exercise
6. Central Nervous System:
Cortical and brain stem control of motor
functions.
Cerebellum – Functions in overall motor
control
Basal ganglia – Functions in executing pattern
of motor activity
Role in cognitive control of sequence of
motor control:
Integration of total motor control systems
o Control of posture and movement
7. Cerebral cortex – higher functions of the Nervous system:
+ Conditioned reflexes
Learning and Memory
+ Function of Neocortex
The limbic system and the hypothalamus:
Behavioural and Motivational Mechanism
Physiology of sleep and electric activity of
the brain – E.E.G.
Somatic sensations – pain, headache,
thermal sensation.
Speech mechanism.
8. Physiology of special senses:
Smell
Taste
Hearing
Vision
9. Physiology of Endocrine:
Mechanism of action of Hormones
Pituitary Hormones – Hypothalamic
control growth hormone, ADH, oxytocin
Adrenal glands – Adrenocortical
hormones-functions and control of
secretion
Adrenal Medullary Hormones
Thyroid Metabolic Hormones – Functions
and control of secretion
Parathyroid Hormone – Calcium and
Phosphate Regulation
Vit. D for development of bone and teeth.
Insulin, glucagon.
Reproductive System.
Male reproduction.
Fomalo Hormones, Hypothalamic-pituitary
and ovarian control of reproduction.
Pregnancy and lactation.
Neonatal physiology.

III. PATHOLOGY, MICROBIOLOGY and IMMUNOLOGY

1. Mechanism of immune mediated injury:

Types of hyper-sensitivity reactions
[Link] of auto-immune diseases:
Immunologic tolerance
Genetic factors in auto-immunity
Major abnormalities of immune function in AIDS
[Link]-deficiency Diseases:
Primary immuno-deficiencies
Suvere combined immuno-deficiency
Genetic deficiencies of complement components
Secondary immune-deficiencies
4. Neoplasia:
Epidemiology
Etiological factors
Tumor Immunity Host defense against tumour
Effects of tumour on Host
Para neoplastic syndrome
Grading and staging of malignancy
Laboratory diagnosis of cancer
5. Genetic Diseases:
Transmission Pattem of single gene disorders
Disorders of multi-factorial inheritance
Cytogenetic disorders involving autosome and sex chromosome
Single gene disorders with atypical pattern
of inheritance Diagnosis of genetic disease
Factors responsible for common
environmental diseases
Pathogenesis of Atherosclerosis and
Ischaemic Heart Disease – Risk factors

6. Disorders of Haemopoietic and lymphoid

systems:
Non-neoplastic disorders of W.B.C.
Bleeding disorders. causes.
7. Pathophysiology of Jaundice
8. Myco-bacteria:
Tuberculosis
Leprosy
9. Viruses:
Pathogenesis and diagnosis of viral diseases
Hepatitis A,B,C,D,E
HIV / AIDS
Rabies
Herpes
Influenza
10 Parasitology:
Haemo-parasites – Malaria, Leishmania, filariasis Intestinal –
Giardia, entamoeba, nematodes, cestodes Hydatid disease

IV. PHARMACOLOGY

1. Antibiotics, Antifungal and Anti-Viral Drugs: Anti-tubercular

drugs
Anti-Malarial
Anti-Amebic
Anti-helmintic
2. Drugs used in peptic ulcer:
Anti-emetics
Purgatives
Gastric anti-acid
Drugs used in diarrhea

3. Analgesics – NSAIDs:
Anti-rheumatic and anti-gout drugs
Opioid analgesics
Drugs used in Parkinsonism
Drugs used in epilepsy
Anxiolytics and hypnotics
Anti-depressants
Anti-histamines (H. Blockers)
Anti-hypertensive drugs
Anti-anginal drugs
Drugs used in congestive heart failure and
arrhythmias
Drugs used in hyper-lipidemia
Drugs used in anemias
Drugs used in coagulation disorders
4. Insulins and oral anti-diabetics
5. Thyroid and anti-thyroid drugs
6. Autonomic drugs
7. Vaccine and immuno-globulins

Medicine Paper III topics

The FCPS Medicine Part 1 Paper III has seven topics :e.g. below
following :

1. Immunology
2. Respiratory Medicine
3. Infectious diseases and Tropical Medicine
4. Nephrology
5. Disturbances in Water, Electrolyte and Acid-Base balance
6. Rheumatology
7. Principles of Geriatric Medicine

1. Immunology
You have need to understand following topics:
• Humoral and cell-mediated immunity
• Immunodeficiency syndromes
• Phagocytic dysfunction diseases
• Complement deficiencies
• Hypersensitivities including allergies and autoimmune diseases

Immunology and immunological tests:

● Common immunological laboratory tests

● Evaluation of patients with immune disease
● Intercellular communication and signal transduction
● Lymphocyte and phagocytic cell biology
● Antigen presentation
● Humoral, cellular and mucosal immunity including TH1 and
TH2 responses
● Inflammation
● Complement system and cytokines
● Hypersensitivity and autoimmunity
Clinical conditions:

● Mechanisms of immunodeficiency
● Antibody immunodeficiency disorders
● T-cell immunodeficiency disorders
● Combined antibody and cellular immunodeficiency disorders
● Phagocytic dysfunction diseases
● Complement deficiencies

immediate management of acute allergic emergencies:

● Anaphylaxis
● Angio-oedema
● Urticaria

immunology as applied to other medical diseases:

● Rheumatic disease (connective tissue diseases)

● Endocrine diseases (thyroid autoimmune diseases, diabetes
mellitus, Addison’s disease)
● Haematological diseases (pernicious anaemia, autoimmune
● haemolytic anaemia, idiopathic thrombocytopenic purpura)
● Gastroentestinal diseases (Coeliac disease, inflammatory
bowel disease, hepatobiliary disease)
● Renal diseases (Goodpasture’s syndrome, immune-complex
glomerulonephritis)
● Dermatological diseases (discoid lupus, pemphigus,
pemphigoid)
● Neurological diseases (demyelinating diseases, myasthenic
syndromes)

Management
 ● Principles of immunosuppressive therapy with indications
and side effects.
● Immunosuppressive drug therapy (corticosteroids, cytotoxic
agents, and cyclosporin)
● Intravenous immunoglobulin
● Monoclonal antibodies
● Bone marrow transplantation
● You should know about the principles of immunisation and
be familiar with vaccines currently in use

Read more:

2. RESPIRATORY MEDICINE
Anatomy of Lungs

● upper and lower respiratory tract

● thorax
● radiological anatomy.

Physiology of Lungs

● How respiration is controlled

● Principles of gas exchange and oxygen transport
● Ventilation -perfusion relationship
● Lung volumes and transfer factor
● Respiratory aspects of sleep and exercise physiology

You have to understand following topics:

● Physical, humoral and cellular aspects of respiratory defence

mechanisms
 ● Physiology of the proteinase inhibitors and pulmonary
surfactant
● The pulmonary and bronchial circulations and gas exchange
● Adaptations to chronic hypoxemia
● Pleural fluid production and reabsorption

Pathophysiology and Pathology

● Asthma
● COPD
● Pneumonia
● Tuberculosis
● microbiology of acute and chronic respiratory infections
should be known.

Cell Biology and Genetics

● Lung inflammation and repair

● Vasculitis
● Cystic fibrosis
● Anti-protease deficiency

Clinical Pharmacology

● indications of drugs used in respiratory disease.

● mechanisms of action of drugs used in respiratory disease
● Interactions and side effects of drugs used in respiratory
disease.
● Important respiratory complications of other drugs, e.g.,
NSAIDs and beta blockers should also be understood.

Clinical conditions

● Pleural effusion
 ● Lung cancer
● Chest pain
● Haemoptysis
● Breathlessness
● Systemic disease associated with lungs:
● Vasculitis
● Neuromuscular diseases
● HIV infection

You should have understand to following topics:

● assess respiratory malignant conditions and

● understand the general principles of oncological
management including the indications for surgery.
● The indications for specialized investigations, including
bronchoscopy, CT scanning, lung biopsy, lung volumes and
exercise testing should be known.
● control of Mycobacterium tuberculosis infection.

3. Infectious Diseases and Tropical Medicine

You should understand the basic microbiology. Major Bacteria,
Virus and tungus and all important protozoa and helminths should
be known to all.

● Aerobic or anaerobic bacteria

● Gram-staining characteristics of bacteria

Immunology of infectious diseases

● immune deficiency states

● Principles of immunization
● knowledge of vaccines currently used should also be known.
 ● Opportunistic infections
● Immunization policy

Pathophysiology

● ARDS

Epidemiology
You should have knowledge of the principles of epidemiology
relevant important topics, such as:

● Mechanisms of transmission of pathogens

● How epidemics happen
● Knowledge of carrier states, reservoirs, vectors and
zoonoses
● Elementary concepts of the control of communicable
diseases (including immunization, isolation, contact tracing,
chemoprophylaxis of close contacts)
● Broad awareness of geographical variation in disease
including TB, HIV, Hepatitis B, Malaria, Leishmaniasis.

Treatment
indications for, and major adverse effects of, commonly
employed antimicrobial agents.
you must read following topics :

● B-lactamas
● Tetracyclines
● Macrolides
● Aminoglycosides
● Quinolines
● Trimethoprim
● Metronidazole
 ● Antituberculous drugs
● Antimalarial drugs
● Antiviral agents
● Antifungal drug
● Antiparasitic drugs
● Specific infection

Knowledge of the characteristics, recognition, prevention,

eradication and pathological effects of all commonly encountered
bacteria, viruses, rickettsia, fungi, protozoa, parasites and toxins,
including and understanding of the principles of infection control,
will be required. Special attention to differential diagnosis,
appropriate investigations and awareness of when presumptive
therapy is indicated is essential of following topics –

● Tuberculosis
● Cholera and other infective Diarrhea
● Pneumococcal infections
● Meningitis
● Typhoid fever
● Sexually transmitted diseases
● Influenza
● Mumps
● Dengue
● AIDS
● Malaria
● Visceral leishmaniasis
● Amebiasis
● Candidiasis
● Tineas
● Subcutaneous and deep mycoses
 ● Scabies
● Leprosy

Envenomation

● Snakebite, scorpion & other stingers.

● Biological basis, pathophysiology of envenomation and
treatment.
● Venomous snakes
● Mode of action of venoms
● Anti snake venoms

4. NEPHROLOGY
Physiology

● Discrete functions of glomerular ultrafiltration and tubular

function.
● Proximal and distal parts of the nephron, with particular
reference to control of water and electrolyte balance.
● Renal tubular acidosis
● Fluid, electrolyte, and acid-balance disturbances.

Glomerular and tubular disorders

● Primary glomerular disorders

● Diabetic nephropathy
● Lupus nephritis
● Hypertensive nephrosclerosis
● metabolic sequelae of acute
● nephritis and nephrotic syndromes.
● investigation and assessment of glomerular and tubular
Hypertension and renal problems in pregnancy
 ● renal adaptation to pregnancy,
● the management and prophylaxis of renal disease and
hypertension in pregnancy.
● drugs cause nephrotoxic damage.
● Dose adjustment in kidney disease
● Renal replacement therapy Knowledge of different dialysis
modalities and their complications is expected.
● immunosuppressive therapy following renal transplantation.

5. FLUID, ELECTROLYTE AND ACID-BASE IMBALANCE

1. Hypokalaemia
2. hyperkalemia
3. Hyponatremia
4. hypernatremia
5. Acidosis
6. alkalosis
7. SIADH

6. Rheumatology
You should have a sound working knowledge of the basic
principles of the common musculoskeletal conditions :

● Inflammatory arthritis
● Back pain
● Periarticular disorder
● Osteoarthritis
● Connective tissue diseases
● Bone diseases

Physiology
 ● Physiology of pain
● Physiology of inflammation
● Urate metabolism
● Bone metabolism

Anatomy :

● Applied anatomy, particularly of cervical and lumbar nerve

roots, and of peripheral nerves commonly involved in
disease

Clinical Conditions:

A. The pathology of the common rheumatic conditions:

● Rheumatoid arthritis
● Osteoarthritis
● Connective tissue diseases
● Bone diseases
● Rheumatoid arthritis and associated syndromes
● Seronegative spondyloarthritis (ankylosing spondylitis,
● psoriatic arthritis, reactive arthritis, enteropathic arthritis)
● Osteoarthritis
● Crystal arthritis (gout, pyrophosphate arthritis)
● Connective tissue diseases (systemic lupus erythematosus,
Sjogren’s syndrome, scleroderma, polymyositis/
dermatomyositis)
● Polymyalgia rheumatica and giant-cell arteritis
● Systemic vasculitis syndromes
● Bone disorders (osteoporosis, osteomalacia)

B. Arthritis associated with other medical conditions:

 ● Sarcoidosis
● Erythema nodosum
● Infections and arthritis (e.g Parvovirus B 19)

Investigations

● Acute phase proteins

● Immunological tests relating to the connective tissue
diseases (rheumatoid factor, ANA, anti-dsDNA, ANCAs, etc.)
● Contemporary imaging techniques in rheumatology (x-ray,
ultrasound, MR imaging)

Management

1. Drug related therapies (indications and contra-indications,

adverse effects, drug interactions.
2. Simple analgesics
3. Non-steroidal anti-inflammatory drugs
4. Corticosteroids
5. Allopurinol
6. Disease modifying anti-rheumatic drugs
7. Immunosuppressive drugs

7. PRINCIPLES OF GERIATRIC MEDICINE

1. Physiological effects of aging
2. Immobility
3. Falls
4. Stroke rehabilitation
5. Drug treatment in the elderly