UNIVERSITY OF NAMIBIA

FACULTY OF HEALTH SCIENCES

SCHOOL OF PHARMACY

Study Guide

P3511SO

Organic Chemistry

MBChB, BChD, BPTY and B.Pharm

(NQF 5 & Credits 14)

March, 2023

By

Dr. ANTHONY ISHOLA

School of Pharmacy

University of Namibia
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 Table of Contents

Lecturers ________________________________________________________________________ 2

Module description ________________________________________________________________ 3

Reference texts and related materials _________________________________________________ 4

Module outcomes _________________________________________________________________ 4

Examinations and assessments_______________________________________________________ 4

Module assignments _______________________________________________________________ 5

Module tests _____________________________________________________________________ 5

Module examination _______________________________________________________________ 5

How to study for this module ________________________________________________________ 5

Lecture schedule/content ___________________________________________________________ 6

Course coordinator/Lecturer: Lecturer:

Dr. Anthony Ishola Prof Jane Misihairabgwi

Office phone: 061 206 5037 Office phone: 061 206 5039

E-mail: [email protected] E-mail: [email protected]

Office: Room C 104, Life Sciences II Building, School Office: Room 1lS142, Life Sciences I Building, School of
of Medicine, Hage Geingob Campus Medicine, Hage Geingob Campus

Consultation Hours: Monday-Friday 15:00-16:30 Consultation Hours: By appointment: Please book via email
P.M., other times by appointment.

Technologist

Ms. Monde Lusepani

Office phone: 061-206 5057

E-mail: [email protected]

Office: C 119 Life Sciences II Building

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Module description:
Chemistry is an important discipline in medical, pharmacy and many other health practices. It plays a central
role in appreciating many medical disciplines including Biochemistry, Clinical medicine, Pharmacology and
therapeutics as well as Pathophysiology of a patient. It is also applicable in many other fields such as agriculture,
industry, bioengineering and many other disciplines.

The Biochemistry I & Organic Chemistry modules introduces students commencing studies in health sciences to
concepts of general and organic chemistry. The material covered in this module will be crucial for your success
in the subsequent modules of the MBChB, BChD, BPTY and BPharm programmes, as well as in the practice of
pharmacy, medicine, physiotherapy and dentistry.

The course is organised into two parts:

 In part 1 we review concepts in general chemistry that are relevant to understanding organic chemistry.
Topics covered include:

 Matter and Measurement Self-study

 Atomic Structure, Self-study
 The Periodic Table, Self-study
 Chemical Bonding, Self-study
 Chemical Formulas and Nomenclature, Self-study
 Molecular Shapes, Orbitals and Orbital Hybridisation,
 Resonance Structures,
 Intermolecular Forces and Physical Properties of Compounds, and
 Acids and Bases.

 In part 2 we discuss the concepts that are applicable to organic chemistry.

Topics covered include:

 Introduction to Organic Chemistry

 Molecular Representations and functional groups
 Organic Compounds: Alkanes and Cycloalkanes,
 Organic Compounds: Alkenes and Cycloalkenes,
 Organic Compounds: Alkynes,
 Organic Compounds: Arenes (aromatic hydrocarbons),
 Organic Compounds: Halo-alkanes (Alkyl Halides), Ethers and Amines,
 Organic Compounds: Alcohols and Phenols (Hydroxybenzenes),

 Organic Compounds: Carboxylic Acids and Carboxylic Acid Derivatives I,

 Organic Compounds: Carboxylic Acids and Carboxylic Acid Derivatives II,
 Heterocyclic Compounds,
 Stereochemistry,
 Introduction to Organic Reactions,
 Electrophilic Addition of Alkenes,
 Electrophilic Addition of Alkynes,
 Radical Reactions of Alkanes, and
 Nucleophilic Substitution and Elimination of Halo-alkanes.
 Major organic molecules (4)

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Reference text books and related materials:
1. Bettelheim, F.A., Brown, W.H., Campbell, M.K. & Farrell, S.O. 2006. Introduction to General,

Organic, and Biochemistry. 9th ed. Brooks/Cole.

2. Bruice, P.Y. 2010. Essential Organic Chemistry. 2nd ed. (Int. Ed.) Prentice Hall.

Course outcomes:
At the end of this module, students are expected to be able to:
1. Use scientific notation and significant figures in calculations
2. Describe the structure of an atom
3. Describe the arrangement of elements in the periodic table and determine the electron configuration
of the main group elements
4. Describe and explain the trends in the physical and chemical properties of elements
5. Distinguish between ionic and covalent bonding
6. Define and explain the terms empirical formula and molecular formula and determine these for a given
compound
7. Draw various representations of organic molecules, e.g. Lewis structures, line-bond structures, etc.
8. Predict the shape and bond angles for organic molecules
9. Classify organic compounds into chemical groups
10. Name organic compounds according to IUPAC rules
11. Identify the chemical and physical properties of organic compounds
12. Demonstrate understanding of the reactions of organic compounds
13. Discuss the use and significance of organic compounds in health sciences

Examination and assessments:

Assessments will be based on lecture material, assigned problems and text reading and will be given according
to the schedule noted below. There will be no make-up tests or exams given, except in case of extreme
emergency. Otherwise, a missed assessment receives a score of 0 points. No early or late final exams will be
given.
You are expected to score a continuous assessment (CA) mark of not less than 50% to be allowed to sit for the
final examination.

Your continuous assessment (CA) mark will be calculated as follows:

Course Assignments (x3) 15%
Practical labs (x8) 25%
Class test (x3) 60%

For BPharm programme, CA mark contributes 60% and the final examination 40% to the FINAL MARK.
For MBChB, BChD & BPTY, CA mark contributes 40% and the final examination 60% to the FINAL MARK.
To pass the module, your FINAL MARK must be  50%.

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Module assignments & tests
Module assignments & tests dates will be announced by the respective lecturers.

Module examination:
Exam paper: The examination paper shall consist of MCQ only except otherwise communicated

Examination date: To be confirmed.

How to study for this module:

Learning chemistry requires you to develop disciplined study habits. To do well in this module you must study
regularly and intensively. There are a lot of material to be covered during this semester; therefore, it requires a
large time commitment from you. Class attendance is very important for your success in this course and
therefore you should plan to attend EVERY class. You need to achieve 80% attendance rate to qualify for
examination in this module. It is my suggestion that you study each chapter before as well as after it is discussed
in a lecture and that you revise each and every day. It is much better to learn the material as you go than to try
and “cram” just before the exam. Organic chemistry is a challenging subject which requires hard work and
diligence. The more effort you put into learning, the better.

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Lecture schedule / Content: Organic Chemistry P3511SO

Week/Lecture Date Content Responsible person/s

Monday 06/03/2023 LAB Session ALL Dr. A. Ishola

08:30 – 11:30 Division into groups & Ms. Lusepani

1/1: Tuesday 07/03/2023 Lab safety Dr. A. Ishola

07:30 – 08:30 Atomic Structure

Wednesday 08/03/2023 LAB Session : A, B, C & D Ms. Lusepani
General information
14:30 – 17:30

1/ 2-3: Friday 10/03/2023 Atomic properties Dr. A. Ishola

08:30 – 10:30 Periodicity (Periodic trend)

Chemical properties

Monday 13/03/2023 LAB Session 1: A & B Ms. Lusepani

08:30 – 11:30 Lab safety

2/1: Tuesday 14/03/2023 Quantum mechanics, Dr. A. Ishola

07:30 – 08:30 Atomic orbitals,

Electron spin

electron configuration

Wednesday 15/03/2023 LAB Session 1: C & D Ms. Haufiku

14:30 – 17:30 Lab safety Ms. Matheus

2 /2-3: Friday 17/03/2023 Molecular Shapes Dr. A. Ishola

08:30 – 10:30 Orbitals

VSEPR

Electronegativity

Bond polarity & molecular polarity

Monday 20/03/2023 LAB Session 2: Ms. Lusepani

08:30 – 11:30 Groups A & B

3/1: Tuesday 21/03/2023

PUBLIC HOLIDAY:
07:30 – 08:30
INDEPENDENCE DAY

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Wednesday 22/03/2023 Lab Session 2 Ms. Haufiku

14:30 – 17:30 Groups C & D Ms. Matheus

Matter and Measurements

3 /2-3: Friday 24/03/2023 Lewis structures Dr. A. Ishola

08:30 – 10:30 Resonance structures

Drawing Resonance Structures

Formal charges Orbital
Hybridization.

Acids and Bases.

Monday 27/03/2023 LAB Session 3: Ms. Lusepani

08: 30 - 11:30 Groups A & B

4/1: Tuesday 28/03/2023 Acids and Bases. Dr. A. Ishola

07:30 – 08:30 pH, pKa and pKb

Set a date for Assessment I

Wednesday 29/03/2023 LAB Session 3 Ms. Haufiku

14:30 – 17:30 Groups C & D Ms. Matheus

4/2-3: Friday 31/03/2023 Intermolecular Forces: gases, Dr. A. Ishola

liquids and solids. Types of
14:30 – 17:30 intermolecular forces. Properties of
liquids. Phase changes, vapour
pressure
Monday 03/04/2023 Lab Session 4 Ms. Lusepani

08: 30 - 11:30 Group A & B

5/1: Tuesday 04/04/2023 Introduction to Organic Chemistry Prof. J. Misihairabgwi

07:30 – 08:30

Wednesday 05/04/2023 Lab Session 4 Ms. Haufiku

07:30 – 08:30 Groups C & D Ms. Matheus

5/2-3: Friday 07/04/2023 PUBLIC HOLIDAY: GOOD FRIDAY

14:30 – 17:30

Monday 10/04/2023 PUBLIC HOLIDAY: EASTER MONDAY

08: 30 - 11:30

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6/1: Tuesday 11/04/2023 Molecular Representations and Prof. J. Misihairabgwi
Functional groups
07:30 – 08:30

Wednesday 12/04/2023 Lab Session Ms. Haufiku

14:30 – 17:30 All Groups Ms. Matheus

6/2-3: Friday 14/04/2023 Hydrocarbons Prof. J. Misihairabgwi

Alkanes
08:30 – 10:30

Monday 17/04/2023 Lab Session 5 Ms. Lusepani

08: 30 - 11:30 Group A & B

7/1: Tuesday 18/04/2023 Hydrocarbons Prof. J. Misihairabgwi
Cycloalkanes
07:30 – 08:30

Wednesday 19/04/2023 Lab Session 5 Ms. Haufiku

14:30 – 17:30 Groups C & D Ms. Matheus

7/2-3: Friday 21/04/2023 Hydrocarbons: Alkenes and Prof. J. Misihairabgwi

cycloalkenes

Monday 24/04/2023 Lab Session 6 Ms. Lusepani

08: 30 - 11:30 Group A & B

08/1: Tuesday 25/04/2023 Hydrocarbons: Alkynes Prof. J. Misihairabgwi

07:30 – 08:30

Wednesday 26/04/2023 Lab Session 6 Ms. Haufiku

08: 30 - 11:30 Group C & D Ms. Matheus

8/2-3: Friday 28/04/2023 Hydrocarbons: Arenes (Aromatic Prof. J. Misihairabgwi

hydrocarbons)
08:30 – 10:30

Monday 01/05/2023 PUBLIC HOLIDAY WORKERS’ DAY

08: 30 - 11:30

9/1: Tuesday 02/05/2023 Halo-alkanes (Alkyl halides). Prof. J. Misihairabgwi

Ethers and Amines
07:30 – 08:30

Wednesday 03/05/2023 Alcohols and Phenols Prof. J. Misihairabgwi

14:30 – 17:30

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9/2-3: Friday 05/05/2023 Alcohols and Phenols Prof. J. Misihairabgwi

08:30 – 10:30

Monday 08/05/2023 Lab Session 7 Ms. Lusepani

08: 30 - 11:30 Group A & B

10/1: Tuesday 09/05/2023 Carboxylic Acids and Carboxylic Dr A. Ishola

Acid Derivatives I
07:30 – 08:30

Wednesday 10/05/2023 Lab Session 7 Ms. Haufiku

14:30 – 17:30 Groups C & D Ms. Matheus

10/2-3: Friday 12/05/2023 Carboxylic Acids and Carboxylic Dr A. Ishola

Acid Derivatives II
08:30 – 10:30
Assessment II
Monday 15/05/2023 Lab Session 8 Ms. Lusepani

08: 30 - 11:30 Group A & B

12/1: Tuesday 16/05/2023 Carboxylic Acids and Carboxylic Dr A. Ishola
Acid Derivatives II
07:30 – 08:30

Wednesday 17/05/2023 Lab Session 8 Ms. Haufiku

14: 30 - 17:30 Groups C & D Ms. Matheus

12/2-3: Friday 19/05/2023 Heterocyclic Compounds Dr A. Ishola

08:30 – 10:30

Monday 22/05/2023 Stereochemistry Dr A. Ishola

08: 30 - 11:30

13/1: Tuesday 23/05/2023 Stereochemistry Dr. A. Ishola

07:30 – 08:30

Wednesday 24/05/2023 Introduction to organic reactions Dr. A. Ishola

14:30 – 17:30

13/2-3: Friday 26/05/2023 Electrophilic addition reactions of Dr. A. Ishola

alkenes
08:30 – 10:30

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Monday 29/05/2023 Nucleophilic substitution and Dr. A. Ishola
elimination Reactions of Halo-
08: 30 - 11:30
Alkanes
14/1: Tuesday 30/05/2023 Electrophilic addition reactions of Dr. A. Ishola
alkenes Radical reactions of
07:30 – 08:30
alkanes

Wednesday 31/05/2023 Electrophilic addition reactions of Dr. A. Ishola

alkynes.
14:30 – 17:30

14/2-3: Friday 02/06/2023 Electrophilic addition reactions of Dr. A. Ishola

alkynes.
08:30 – 10:30
Radical reactions of alkanes

Monday 05/06/2023 Nucleophilic substitution & Dr. A. Ishola

Elimination of Halo-alkanes
08: 30 - 11:30

15/1: Tuesday 06/06/2023 Major Organic compounds Prof. J. Misihairabgwi

07:30 – 08:30 Lipids

Proteins and Nucleic acids

Carbohydrates
Wednesday 07/06/2023 Major Organic compounds Prof. J. Misihairabgwi

14:30 – 17:30 Lipids

Proteins and Nucleic acids

Carbohydrates

Friday 09/06/2023 Assessment III Dr. A. Ishola

09:00 – 10:30 Release CA marks

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