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Notable Contributions of Foreign Scientists

1. The document summarizes the contributions of several foreign and Filipino scientists in the fields of genetics, genomics, and molecular biology. Joachim Messing developed shotgun sequencing techniques that enabled studies of DNA and crop improvement. Craig Venter helped sequence the human genome and develop gene identification methods. Paul Nurse's work helped explain cell cycle control. Shinya Yamanaka developed a method to generate stem cells from adult cells. Among Filipino scientists profiled are Drs. Anita Bautista and Leslie Dalmacio, recognized for their research in genomics, microbiology, and probiotics.

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0% found this document useful (0 votes)
38 views3 pages

Notable Contributions of Foreign Scientists

1. The document summarizes the contributions of several foreign and Filipino scientists in the fields of genetics, genomics, and molecular biology. Joachim Messing developed shotgun sequencing techniques that enabled studies of DNA and crop improvement. Craig Venter helped sequence the human genome and develop gene identification methods. Paul Nurse's work helped explain cell cycle control. Shinya Yamanaka developed a method to generate stem cells from adult cells. Among Filipino scientists profiled are Drs. Anita Bautista and Leslie Dalmacio, recognized for their research in genomics, microbiology, and probiotics.

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Foreign Scientists

1. Joachim messing (shotgun sequencing)


- Joachim Messing, known as “Jo” (pronounced yoh), grew up in the town of Duisburg,
Germany, in the aftermath of World War II. The first person in his family to go to
college, he decided to study pharmacy as an undergraduate. Messing received a
bachelor’s degree in pharmacy in 1968 and a master’s degree in pharmacy in 1971.
When he decided to pursue a doctorate in biochemistry, he met Feodor Lynen, a
Nobel prize winner in 1964 for his work on Cholesterol and fatty acid metabolism.
Lynen advised him not to go into Lynen’s field where work has already been done.
And that the future would be in DNA. Messing then worked in a laboratory studying
DNA at the Max Planck Institute for biochemistry in Munich. He received his
doctorate in biochemistry in 1975.
- His DNA sequencing techniques enabled scientists to study the building blocks of
viruses, improve the yield of crop plants and understand the development of cancer in
humans. His work developed the production of recombinant erythropoietin for
treating anemia following chemotherapy.
- contributions to DNA sequencing and plant genetic engineering have won him
numerous awards, including the 2013 Wolf Prize in Agriculture and the 2014
Promega Biotechnology Research Award.

2. Craig Venter

- J. Craig Venter, (born Oct. 14, 1946, Salt Lake City, Utah, U.S.), American geneticist,
biochemist, and businessman who pioneered new techniques in genetics and genomics
research and headed the private-sector enterprise, Celera Genomics, in the Human
Genome Project (HGP). the Human Genome Project
- Identified the full set of human genes, sequenced them all and identified some of the
alleles, particularly those that can cause disease when they get mutated.
- He earned B.A in biochemistry on 1972 and a doctorate in physiology and pharmacology
on 1975 at the University of California, San Diego. And he joined the faculty of the State
University of New York at Buffalo, (1976) where he was involved in neurochemistry
research. In 1984 Venter moved to the National Institutes of Health (NIH), in Bethesda,
Md., and began studying genes involved in signal transmission between neurons.
- While at the NIH, Venter became frustrated with traditional methods of gene
identification, which were slow and time-consuming. He developed an alternative
technique using expressed sequence tags (ESTs), small segments of deoxyribonucleic
acid (DNA) found in expressed genes that are used as “tags” to identify unknown genes
in other organisms, cells, or tissues. Venter used ESTs to rapidly identify thousands of
human genes. Although first received with skepticism, the approach later gained
increased acceptance; in 1993 it was used to identify the gene responsible for a type of
colon cancer. Venter’s attempts to patent the gene fragments that he identified, however,
created a furor among those in the scientific community who believed that such
information belonged in the public domain.

3. paul nurse (contributed to the understanding of the cell cycle)


- (born January 25, 1949, Norwich, Norfolk, England) British scientist who, with Leland
H. Hartwell and R. Timothy Hunt, won the Nobel Prize for Physiology or Medicine in
2001 for discovering key regulators of the cell cycle.
- Paul Nurse is a geneticist and cell biologist whose discoveries have helped to explain
how the cell controls its cycle of growth and division. Working in fission yeast, he
showed that the cdc2 gene encodes a protein kinase, which ensures the cell is ready to
copy its DNA and divide. Paul’s findings have broader significance since errors in cell
growth and division

4. shinya Yamanaka (generating stem cells from existing cells of the body.)
- (born September 4, 1962, Ōsaka, Japan), Japanese physician and researcher who
developed a revolutionary method for generating stem cells from existing cells of the
body. This method involved inserting specific genes into the nuclei of adult cells (e.g.,
connective-tissue cells), a process that resulted in the reversion of cells from an adult
state to a pluripotent state.
- Our lives begin when a fertilized egg divides and forms new cells that, in turn, also
divide. These cells are identical in the beginning, but become increasingly varied over
time. It was long thought that a mature or specialized cell could not return to an immature
state, but this has now been proven incorrect. In 2006, Shinya Yamanaka succeeded in
identifying a small number of genes within the genome of mice that proved decisive in
this process. When activated, skin cells from mice could be reprogrammed to immature
stem cells, which, in turn, can grow into different types of cells within the body.

5. Arturo Falaschi
- Graduated from the Faculty of Medicine, University of Milan, Italy, MD (Hons) in 1957.
is teaching activity spanned six decades, from 1966 (Professor of Molecular Biology at
the Univ. of Pavia), to 2010 (Professor of Molecular Biology at the Scuola Normale
Superiore SNS, Pisa).
- He developed procedures to isolate neosynthesized DNA generated from the activation of
DNA replication origins in mammalian chromosomes and established an innovative
method for origin mapping. He identified and characterized the Lamin B2 origin of DNA
replication, the first human origin known in molecular detail, now considered a standard
in the field.

Filipino

1. Dr. Ma. Anita M. Bautista


- Dr. Bautista is a entomology graduate from the University of Philippines Los Banos. She
obtained her master’s and doctorate degree from Nagoya University, Japan under the
MONBUKAGAKUSHO (Japanese Government) scholarship and went to pursue
postdoctoral studies at the Ohio Agricultural Research and Development Center
(OARDC), The Ohio State University, USA. Former staff of BIOTECH-UPLB but now
employed as a faculty member of the Natiinak institute of molecular biology and
biotechnology in UPD. She also worked as a laboratory manager of the Philippine
Genome Center DNA Core Sequencing Facility .
- Dr. Bautista currently handles research projects involving transcriptome
and genome analyses of termites and selected insect pests of coconut and
rice. She is also highly involved in the genome and transcriptome analyses
of an insect parasitoid, stingless bees, plant pathogens, and Philippine
coconut varieties.
2. Dr. Leslie Michelle M. Dalmacio
- Dr. Dalmacio is a molecular microbiologist, she studied in UP los banos, b.s. major in
cell biology 1994 and doctor of philosophy in molecular biology and biotechnology
2011, and and UP manila Major in Biochemistry 2001.
- Dr. Dalmacio Dalmacio is recognized of her significant researches focusing on the
human microbiome and probiotics studies, which helped elucidate the community
structure and role of these microorganisms in health and disease. Her involvement in the
studies of probiotic bacteria, their isolation, identification, and utilization through
metagenomics led to the discovery of microorganisms and potential probiotics missed out
by previous culture-based studies that were present in some of our traditional fermented
foods. Her molecular epidemiology study on an emerging hepatitis virus, Hepatitis G,
showed co-occurrence of this infectious agent with Hepatitis B or C in the country,
warranting an improvement in the screening of blood and blood products for blood
banking.

References:
https://www.britannica.com/biography/J-Craig-Venter
https://royalsociety.org/people/paul-nurse-12012/#:~:text=Paul%20Nurse%20is%20a%20geneticist,copy
%20its%20DNA%20and%20divide.
https://www.britannica.com/biography/Paul-Nurse
https://www.britannica.com/biography/Shinya-Yamanaka
https://www.nobelprize.org/prizes/medicine/2012/yamanaka/facts/
https://www.icgeb.org/governance/arturo-falaschi/

tbf
https://pgc.up.edu.ph/ma-anita-bautista-phd/
http://www.spheres.dost.gov.ph/profiles/424-leslie-michelle-malaluan-dalmacio
https://www.nytimes.com/2019/09/27/science/joachim-messing-dead.html

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