Annexure-06
UTILITIES REQUIREMENT
FIRST STEP : 100 Min + 7 Hrs. (Approx.)
19250 x 0.8 x 0.6 x 40
TS : = 725 Kg/Hr.
510
19250 X 0.8 X 0.6 X 40 x 0.2
CTW : = 25 TR
3024
TFE :
SH : (14000 x 0.8 x 0.6 x 40) = 268800
LH : 14000 x 0.8 x 250 = 2800000
TH : = 3068800 Kcal/kg c
3068800
T.S : = 6018 KG/HR
510
3068800 + [14000 X 0.8 X 0.6 X (78 - 60)]
CTW : = 1055 TR
3024
14000 x 0.8 x 0.6 x (60 -30)
CHW : = 67 TR
3024
SRP :
SH : 5831 x 0.8 x 0.6 x 40 = 111955.2
LH : 5831 x 0.8 x 250 = 1166200
TH : 1278155 Kcal/kg c
1278155
T.S = = 313 Kg/Hr
510 x 8 Hrs.
1278155 + (5831x 0.8 x 0.6 x (78-60)
CTW : = 55 TR
3024 x 8 Hrs.
5831x 0.8 x 0.6 x (60-30)
CHW : = 3.5 TR
3024 x 8 Hrs.
SECOND STEP :
21000 x 0.66 x 0.53 x 30
TS : = 432 Kg/Hr.
510
21000 x 0.66 x 0.53 x 30 x 0.2
CTW : = 15 TR
3024
RECOVERY
:
SH : 14000 x 0.66 x 0.53 x 30 = 146916
LH : 14000 x 0.66 x 80 = 739200
TH : 886116 Kcal/kg c
886116
T.S : = 1737 Kg/Hr
510
(1074080) + (14000 x 0.66 x 0.53 x 10)
CTW : = 371 TR
3024
14000 x 0.66 x 0.53 x 30
CHW : = 49 TR
3024
THIRD STEP :
SH : 28000 x 0.9 x 0.5 x 40 = 504000 Kcal/kg c
TS : 504000/510 = 989 Kg/Hr.
504000 X 0.2
CTW : = 33 TR
3024
RECOVERY
:
SH : 21000 x 0.9 x 0.5 x 37 = 349650
LH : 21000 x 0.9 x 88 = 1663200
TH : 2012850 Kcal/kg c
2012850
T.S = 3947 Kg/Hr
510
2182950
CTW : = 722 TR
3024
21000 X 0.9 X 0.5 X 30
CHW : = 94 TR
3024
RVD :
SH : 3500 x 1 x 1 x 70 = 245000
LH : 3500 x 1 x 529 = 1851500
TH : 2096500 Kcal/kg c
2096500
T.S = = 171 kg /HR
510 x 24 Hrs.
TOTAL UTILITIES :
FIRST STAGE :
STEAM : (1.5 Hrs x2 lots x725) + 7 hrs x2 lots (6018 + 313) = 90,812 KG
CTW : (1.5 Hrs x 2 lots x 25) + 7 hrs x 2 lots (1055 + 55) = 15,612 TR
CHW : 8 Hrs x 2 lots x (67 + 3.5) = 1123 TR
SECOND STAGE :
STEAM : 8 Hrs (524 + 2106) = 17357 KG
CTW : 8 Hrs (18 + 375) = 3088 TR
CHW : 8 Hrs (59) = 389 TR
THIRD STAGE :
STEAM : 13 Hrs (989 + 4466) = 64165 KG
CTW : 13 Hrs (33 + 809) = 9818 TR
CHW : 13 Hrs (94) = 1219 TR
RVD :
STEAM : 24 Hrs (171) = 4111 KG
For wet herb drying
SH : 4200 x 1 x 1 x45 = 189000
LH : 4200 x 1 x 545 = 2289000
TH : 2478000 Kcal/kg c
2289000
T.S = = 299 kg /HR
510 x 15Hrs.
GRAND TOTAL UTILITIES :
STEAM : 90812 + 21038 + 70910 + 4111+299 = 176744 KG
CTW : 15612 + 3140 + 10955 = 28518 TR
CHW : 1223 + 471 + 1219 = 2730 TR
GRAND TOTAL WITH 10 % FS :
STEAM : 186871x 1.1 = 194418 KG
CTW : 29707 x 1.1 = 31370 TR
CHW : 2813 x 1.1 = 3003 TR
SIZING OF UTILITIES FOR PROCESS :
(With 0.4
D.F)
1.10 (725 +6018 + 313 + 523 + 2106 + 989 +
STEAM : = 15766 KG 9460
4466+171.28)
CTW : 1.10 (25 + 1055 + 55 + 18 + 376 + 34 + 810) = 2504 TR 1502
CHW : 1.10 (67 + 3.5 + 59 + 94) = 234 TR 140
OTHER UTILITIES (APPROX.)
N2 = 300 CFM
Comp. Air = 300 CFM
PW = 20 KLPD
HVAC = 200 TR
WATER REQUIREMENT FOR EUPHORBIA PROSTRATA
S.No. Description Qty. UoM
DM Water Requirements
For Ethanolic Extraction 80% Ethyl
1 5,183,640.00 Liters/year
Alcohol
2 For Cleaning Purpose (@ 5%) 259,182.00 Liters/year
Soft Water Requirements
For Steam
1 10887405.19 Liters/year
(60% Recovery considered)
2 For CT (5 % Evaporation Loss) 381568948.992 Liters/year
3 For DM Plant (1:1.3) 7,075,668.60 Liters/year
4 Others @ 5% of total consumption 19976601.1389137 Liters/year
Total Requirements 419,508,623.92 Liters/year
Bore Well Water Requirements @ 1.75 % of 734,140,091.86 Liters
total consumption 734,140 m3/year
Total Ethyl alchohol with DM water = 117250 Liters of 80% Pure Ethyl alchohol
DM water required = 117250 - 98737 = 18513 Liters
For 280 Batches DM water required = 280 x 18513 = 5183 640 Liters Say 5200 kilo Liters
y 5200 kilo Liters
Electrical Load Details for Euphorbia Bulk Drug Plant
Motor
S.No DESCRIPTION MOC CAP QTY UoM Ratting in
HP
For Ethanol Extraction
1 Solvent Storage tank (Fresh Ethanol) MS 30 KL 3 EA 0.50
2 Solvent Storage tank (Recovered) MS 30 KL 4 EA 0.50
3 Solvent Storage tank (WIP) MS 30 KL 4 EA 0.50
4 Solvent Storage tank (Approved & Rejected) MS 30 KL 4 EA 0.50
5 Jkted Mixing Vessel with Agitator & HE's SS 304 20 KL 6 EA 30.00
6 3 Disc Percolator extractor SS 304 35 KL 2 EA 30.00
7 Heat Exchanger for Percolator SS 304 3 EA 0.50
8 Storage tank SS 304 7.5 KL 2 EA 0.50
9 Storage tank SS 304 10 KL 1 EA 0.50
10 Thin Film Evaporator with Tank with SS 304 Heat 10 KL /Hr
Exchanger
SS 304
Recovery
1 EA 5.00
11 Coarse filter, 5.0 KL SS 304 5 micron 2 EA 0.00
12 Storage tank SS 304 17.5 KL 2 EA 0.50
13 Storage tank SS 304 17.5 KL 2 EA 0.50
14 Concentrator SS 305 1 EA 5.00
15 SS316 Centrifugal Pump Wiith FLP motor SS 307 17.5 KL 12 EA 7.50
16 Sovent Recovery Column with Reboiler SS 308 17.5 KL 1 EA 5.00
For Hexane Washing
1 Solvent Storage tank (Fresh Hexane) MS 30 KL 2 EA 0.50
2 Solvent Storage tank (Recovered) MS 30 KL 4 EA 0.50
3 Solvent Storage tank (WIP) MS 30 KL 4 EA 0.50
4 Solvent Storage tank (Approved & Rejected) MS 30 KL 4 EA 0.50
5 Ethonolic Extract Collection tank SS 304 05 KL 3 EA 0.50
6 Jkted Mixing Vessel with Agitator & HE's SS 304 25.0 KL 1 EA 25.00
7 Storage tank (Aqueous soln. collection) SS 304 10 KL 1 EA 0.50
8 Storage tank (organic soln. collection) SS 304 17.5 KL 2 EA 0.50
9 Sovent Recovery Column with Reboiler SS 304 1 EA 0.50
10 Recovery tank SS 304 17.5 KL 2 EA 0.50
11 SS316 Centrifugal Pump Wiith FLP motor 14 EA 7.50
For Ethyl Acetate Washing
1 Solvent Storage tank (Fresh EA) SS 304 30 KL 4 EA 0.50
2 Solvent Storage tank (Recovered) SS 304 30 KL 8 EA 0.50
3 Solvent Storage tank (WIP) SS 304 30 KL 8 EA 0.50
4 Solvent Storage tank (Approved & Rejected) SS 304 30 KL 8 EA 0.50
5 Jkted Mixing Vessel with Agitator & HE's SS 316 35 KL 1 EA 30.00
6 Storage tank (Aquous soln. collection) SS 316 10 KL 1 EA 0.50
7 Storage tank (organic soln. collection) SS 316 25 KL 2 EA 0.50
8 Distillation Kettle with HE'S SS 316 25 KL 1 EA 15.00
9 Receiver SS 316 5.0 KL 2 EA 0.50
10 Receiver SS 316 6 KL 3 EA 0.50
11 Recovered Ethyle acetate Tank SS 316 25 KL 1 EA 0.50
12 Coarse filter, 5.0 KL SS 316 5 micron 2 EA 0.00
13 SS316 Centrifugal Pump Wiith FLP motor SS 316 14 EA 7.50
Other Equipments
1 Hot air dryers for herbs drying alongwith accessories
10000
3 EA 15.00
CFM
2 Ventilation unit for Dry herbs storage area
50000
3 EA 45.00
CFM
3 Storage racks for Dry herb: cosidering one rack size as 1.5
0.00
m W x 50 m L x 6m H(appx weight is 3 MT).
4 Trays for Drying of wet herb: considering One rack is
inclusive of 150 Trays ( each tray is having seed collection 0.00
tray and seev).
5 Pneumatic Conveyor SS 304 4000 kg/hr 2 EA 15.00
6 Chopper cum Multimill SS 304 2000 kg/hr 1 EA 10.00
7 RVD GMP Model SS 304 2500 ltr 1 EA 15.00
8 Multimill GMP Model SS 304 250 Kg/Hr 1 EA 7.50
9 Sifter GMP Model SS 304 250 Kg/Hr 1 EA 7.50
10 cGMP Blender SS 304 250 Kg/Hr 1 EA 15.00
11 Purified Water Plant (Gen. & Dist.) SS 316L 3000 Ltr/hr 1 EA 15.00
12 Material transfer systems 1000 kg/hr 1 EA 5.00
13 Material transfer systems 250 kg/hr 1 EA 5.00
14 Dust collection system LOT 1 EA 15.00
15 FLP Scrubber Systems Lot 1 EA 15.00
QC EQUIPMENTS
1 Oven (324 Ltrs) STD 1 EA 2.00
2 Sieve shaker with sieves 180,250,1700 Micron STD 1 EA 2.00
3 Bulk Density Appratus STD 1 EA 1.00
4 Muffle Furnace (up to 800 Deg. C) STD 1 EA 2.00
5 Microwave Oven ( 282 Ltrs) STD 1 EA 2.00
6 BOD Incubator STD 1 EA 2.00
7 Laminar Flow Chamber STD 1 EA 2.00
8 Autoclave STD 1 EA 5.00
9 Rotavapor Appratus(Medica Make) STD 1 EA 1.00
10 Analytical Balance(LC:0.1 mg) STD 1 EA 0.50
11 Microscope STD 1 EA 0.50
12 Melting Point Appratus STD 1 EA 0.50
13 Polarimeter STD 1 EA 0.50
14 Gas Chromatography STD 1 EA 3.50
15 HPLC with UV Detectors & Columns STD 1 EA 10.00
16 MICROBIOLOGY LAB EQUIPMENTS STD 1 LS 10.00
Utility Equipments
1 PSA Nitrogen Plant 300 CFM Capacity 2 EA 100.00
Air Compressor 300CFM Capacity With Drier &
2 EA 100.00
2 Reciever
3 Chiller 200 + 200 TR 2 EA 200.00
4 Boiler 15.0 TPH with Chimney & Acessories 2 EA 75.00
5 DG'S with Coil Cooler 1500 KVA 1 EA 20.00
6 Air Washers with Ducting 6 EA 30.00
7 AHU's with Ducting 8 EA 25.00
8 Dehumidifier 2 EA 30.00
9 Cooling Tower (600 TR) 4 EA 0.00
10 CHW Pumps 6 EA 75.00
11 CT Pumps 6 EA 100.00
12 Soft Water Plant with Pumps 1 EA 30.00
13 Raw Water Pumps 4 EA 35.00
14 Ritchele Vacuum Pump 2 EA 45.00
15 Fire Hydrant System Pumps 2 EA 45.00
16 Bore well pump 1 EA 25.00
Grand Total
Total Connected Load in KWH
Diversity Factor for Power 40%
Actual Consumption of Power in KWH per Year (Considering 350 days/Year)'1088X24X350
nt
Connected
Power(kw)
1.12
1.49
1.49
1.49
134.28
44.76
1.12
0.75
0.37
3.73
0.00
0.75
0.75
3.73
67.14
3.73
0.75
1.49
1.49
1.49
1.12
18.65
0.37
0.75
0.37
0.75
78.33
0.00
1.49
2.98
2.98
2.98
22.38
0.37
0.75
11.19
0.75
1.12
0.37
0.00
78.33
33.57
100.71
0.00
0.00
22.38
7.46
11.19
5.60
5.60
11.19
11.19
3.73
3.73
11.19
11.19
1.49
1.49
0.75
1.49
1.49
1.49
1.49
3.73
0.75
0.37
0.37
0.37
0.37
2.61
7.46
7.46
149.20
149.20
298.40
111.90
14.92
134.28
15.00
15.00
0.00
335.70
447.60
22.38
104.44
67.14
67.14
18.65
2720.82
1088.33
9141961.92
Annexure-07
PIPE LINE SIZING FOR UTILITY HEADERS
For Steam Header
Qty. Uom
Steam Required M 1200 Kg/hr
Considering Specific
Volume iof steam @ 8 s 0.244 m3/kg
kg/cm2
Flow of Steam Q = M*s 293 m3/hr
Considering Velocity
Q = A*V
V = 35 m/s
V 126000 m/hr
A Q/V 0.00232381
A 3.14/4*d2
d2 0.00
d SQRT(0.02) 0.05 Mtr
d 0.157*1000 54.41 mm
d 157.02/25.4 2.14 Inch
80 mm Std.
For Cooling Tower Water Header
CTW TR Required 1502 TR
TR = Q*ρ*Cp*ΔT/3024
Considering ΔT = 5,ρ =
1000 kg/m3, Cp =1 for
Water
Q 1502*3024/1000*1*5 908 M3/Hr
Manual 15
Considering Velocity
Q = A*V 7200 m/hr
V = 2 m/s
A Q/V 0.126180208
A 3.14/4*d2
d2 0.16
d SQRT(0.17) 0.40 Mtr
d 0.40*1000 400.92 mm
d 400.92/25.4 15.78 Inch
16 Inch Std.
For Chilled Water Header Process
CHW TR Required 140 TR
TR = Q*ρ*Cp*ΔT/3024
Considering ΔT = 5,ρ =
1000 kg/m3, Cp =1 for
Water
Q 140*3024/1000*1*5 84.8232 M3/Hr
Considering Velocity
Q = A*V 7200 m/hr
V = 2 m/s
A Q/V 0.011781
A 3.14/4*d2
d2 0.02
d SQRT(0.01) 0.12 Mtr
d 0.119.9*1000 122.51 mm
d 119.9/25.4 4.82 Inch
6 Inch Std.
For Nitrogen Gas Header
CFM Required 300 CFM
Q (CFM/35.29) *60 510 M3/Hr
Considering Velocity
Q = A*V 43200 m/hr
V = 12 m/s
A Q/V 0.011806933
A 3.14/4*d2
d2 0.02
d SQRT(0.02) 0.12 Mtr
d 0.122*1000 122.64 mm
d 122.64/25.4 4.83 Inch
6 Inch Std.
For Compressed Air Header
CFM Required 100 CFM
Q (CFM/35.29) *60 170 M3/Hr
Considering Velocity
Q = A*V 43200 m/hr
V = 15 m/s
A Q/V 0.003935644
A 3.14/4*d2
d2 0.01
d SQRT(0.02) 0.07 Mtr
d 0.122*1000 70.81 mm
d 122.64/25.4 2.79 Inch
80 mm Std.
For Chilled Water Header HVAC
CHW TR Required 100 TR
TR = Q*ρ*Cp*ΔT/3024
Considering ΔT = 5,ρ =
1000 kg/m3, Cp =1 for
Water
Q 100*3024/1000*1*5 60.48 M3/Hr
Considering Velocity
Q = A*V 7200 m/hr
V = 2 m/s
A Q/V 0.0084
A 3.14/4*d2
d2 0.01
d SQRT(0.01) 0.10 Mtr
d 0.15*1000 103.44 mm
d 146.29/25.4 4.07 Inch
100 mm Std.
For Soft Water
Q 15 M3/Hr
Considering Velocity
Q = A*V 7200 m/hr
V = 2 m/s
A Q/V 0.002083333
A 3.14/4*d2
d2 0.00265
d SQRT(0.02) 0.05 Mtr
d 0.15*1000 51.52 mm
d 146.29/25.4 2.03 Inch
80 mm Std.
Annexure - 9
COST ESTIMATION FOR UTILITIES FOR 175 KG FINAL BATCH SIZE
RATE
AMOUNT
S. No. DESCRIPTION QTY UoM (IN
RS)
(IN RS)
194418 KGS 2.00 388835.90
1 STEAM
31370 TR 1.00 31369.53
2 CTW
3003 TR 6.00 18018.55
3 CHW
14400 CFM 0.75 10800.00
4 COMPRESSED AIR
21600 CFM 2.00 43200.00
5 NITROGEN
5243.86 KL 2.10 11012.10
6 RAW WATER
19.44 KL 1500.00 29157.98
7 PURIFIED WATER
65299.7 KWH 5.50 359148.50
8 POWER
27.44 KL 120.00 3292.64
9 ETP/STP*
894835.20
Total (in RS)
TOTAL COST IN LACS 8.95
* Considering 8 KL/ batch for STP load and 19.44 KL/ Batch for ETP load.
