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APO2

This document outlines the mitochondrial control of apoptosis, or programmed cell death. It shows that death stimuli like FasL or survival factor withdrawal can trigger apoptosis through the Fas/CD95 receptor or withdrawal of survival factors. This activates caspases and pro-apoptotic and pro-survival Bcl-2 family proteins located in the mitochondria, regulating the release of cytochrome c and other factors from the mitochondria to activate downstream caspases and cell death. The pathway diagram also shows various kinases, phosphatases and other regulators that control the mitochondrial and caspase apoptotic pathways in response to death stimuli or survival signals.

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Saheed Abdulkarim
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95 views1 page

APO2

This document outlines the mitochondrial control of apoptosis, or programmed cell death. It shows that death stimuli like FasL or survival factor withdrawal can trigger apoptosis through the Fas/CD95 receptor or withdrawal of survival factors. This activates caspases and pro-apoptotic and pro-survival Bcl-2 family proteins located in the mitochondria, regulating the release of cytochrome c and other factors from the mitochondria to activate downstream caspases and cell death. The pathway diagram also shows various kinases, phosphatases and other regulators that control the mitochondrial and caspase apoptotic pathways in response to death stimuli or survival signals.

Uploaded by

Saheed Abdulkarim
Copyright
© © All Rights Reserved
We take content rights seriously. If you suspect this is your content, claim it here.
Available Formats
Download as PDF, TXT or read online on Scribd

CELL SIGNALING TECHNOLOGY www.cellsignal.

com

Mitochondrial Control of Apoptosis


Death Stimuli:
FasL
Survival Factor Withdrawal
Survival Factors:
Growth Factors, Cytokines, etc.
Fas/
CD95

FADD Bim
LC8
Casp-8,-10

Microtubules
DLC2
PI3K HECTH9 JNK
Bmf
Erk1/2
BID Mcl-1
JNK
Hrk
PKC Bcl-xL Bim DP5
Bcl-2 ARD1
tBID
Bmf NatA
PKA p90RSK Akt p70 S6K Bak Hrk Bax
DP5 Acetyl-CoA
Bax
Bcl-2
tBID
CaMKII
Calcineurin Bax
Bad Bax Bak
14-3-3 Bak Casp-2
Bcl-2
RAIDD
Bad Noxa
PIDD
14-3-3 [NAD]
Bcl-xL Bcl-2
Bad Puma
Apaf-1
Mcl-1

Cytosolic SirT2
Cyto c
Sequestration Casp-9
p53
Arts HECTH9
HSP60 HtrA2

Smac/ Endo G
XIAP Diablo ATM/
AIF ATR ING2
Casp-3 ub

Bcl-2 Family
DNA Damage
Pro-Apoptotic Apoptosis Genotoxic Stress
Pro-Survival

Pathway Diagram Keys


Kinase Enzyme G-protein Direct Inhibitory Tentative Inhibitory Translocation
Modification Modification Transcriptional
Phosphatase pro-apoptotic Acetylase
Multistep Stimulatory Separation of Subunits Stimulatory Modification
Transcription Factor pro-survival Deacetylase Modification or Cleavage Products Transcriptional
Multistep Inhibitory Joining of Subunits Inhibitory Modification
Caspase GAP/GEF Ribosomal subunit Modification
Receptor Direct Stimulatory Tentative Stimulatory
GTPase
Modification Modification

© 2003 – 2014 Cell Signaling Technology, Inc.

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