Surat Municipal Institute of Medical Education & Research
Phase -1 MBBS
Preliminary examination Nov-2021
Biochemistry Paper-II (Section A)
Date: 26-11-2021
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Section A: MCQ (20 marks)
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Instructions:
1. All questions are compulsory
2. Each MCQ has only one correct answer
3. One mark for correct answer. No negative marking
4. If more than one answer is ticked, it will be treated as wrong answer
5. Any tempering with answer will be treated as wrong answer
6. Use only ball point black pen. Pencil is strictly prohibited
7. Correct answer must be marked on OMR sheet with black pen & submit in first
30 minutes
1 At isoelectric point, amino acids exists 5 All of the following statements
as regarding vitamin A are correct,
a) anions EXCEPT
b) cations a) It is a component of visual
c) zwitter ions pigment rhodopsin
d) none of the above b) It supports cell growth and
differentiation
2 Uncontrolled cell growth may be c) It maintains blood pressure and
because of cardiac output
a) Decreased telomerase activity d) It participates in glycoprotein
b) Increased telomerase activity synthesis
c) Increased topoisomerase
activity 6 Which one of the following minerals
d) Decreased topoisomerase has a sparing effect on the dietary
activity requirement of vitamin E?
a) Copper
3 In competitive inhibition of enzymes b) Chromium
a) Km increases & Vmax decreases c) Selenium
b) Km increases & Vmax remains d) Iron
unchanged
c) Km decreases & Vmax increases 7 All the following shift the oxygen
d) Km remains unchanged & Vmax dissociation curve to the right, EXCEPT
decreases a) High acidity
b) Life at high altitudes
4 Increased levels of lactate c) anemias
dehydrogenase (LDH) can be observed d) blood with no
in bisphosphoglycerate
a) myocardial infarction
b) Hemolytic anemia 8 Albumin performs all the following
c) Leukemia functions, EXCEPT
d) All of the above a) Maintains colloid osmotic
pressure
b) Plays a role in the body immune
response
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c) Serves as a transporter b) Tryptophan operon
d) acts as a buffer c) Both of the above
d) None of the above
9 Selenocysteine is synthesized from the
following amino acid 15 Northern blotting technique is used for
a) Cysteine the detection of
b) Methionine a) RNA
c) Serine b) DNA
d) Leucine c) Proteins
d) Lipids
10 Hartnup’s disease is associated with
the defective absorption of the 16 The receptor of the following hormone
following amino acid has intrinsic tyrosine kinase activity
a) Tryptophan a) Insulin
b) Proline b) ADH
c) Arginine c) Steroids
d) Lysine d) Glucagon
11 Lesch-Nyhan syndrome is caused by 17 Positive nitrogen balance is seen in
the deficiency of the following enzyme a) Starvation
a) Adenine b) Wasting diseases
phosphoribosyltransferase c) Growing age
b) IMP dehydrogenase d) Intestinal malabsorption
c) Hypoxanthine-guanine
phosphoribosyl transferase 18 Transmethylation of guanidoacetate
d) Xanthine oxidoreductase gives
a) Creatine
12 Methotrexate blocks the synthesis of b) Creatinine
thymidine monophosphate by c) Choline
inhibiting the activity of the enzyme: d) n-methyl nicotinamide
a) Dihydrofolate reductase
b) Orotate phosphoribosyl 19 Biotin is a coenzyme for all the
transferase following carbon dioxide fixation
c) Ribonucleotide reductase reactions, EXCEPT
d) Dihydroorotase a) Pyruvate carboxylase
b) Acetyl Co-A carboxylase
13 DNA replication occurs during the c) Propionate carboxylase
following phase of the cell cycle d) Carbamoyl phosphate
a) S phase synthetase
b) M phase
c) G1 phase 20 Xanthurenic acid is excreted in urine in
d) G2 phase the deficiency of
a) Folic acid
14 Catabolite gene activator protein along b) Vitamin B12
with cyclic AMP (CAP – cAMP) is c) Niacin
associated with the function of d) Pyridoxal phosphate
a) Lac operon
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